SUPERFAMILY 1.75 HMM library and genome assignments server


Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,248) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 124,316 0 220
Proteins 71,963 0 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.54631Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0026360.582Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.60051Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.41451Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.29181Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.58090Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.54271Least InformativeInherited
Biological Process (BP)single-organism cellular process0.15941Least InformativeInherited
Biological Process (BP)developmental process0.23411Least InformativeInherited
Biological Process (BP)protein metabolic process0.92351Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.90771Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00018350Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00017053.894e-05Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.37480.6116Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.007291Moderately InformativeInherited
Biological Process (BP)organelle organization0.004611.647e-05Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.015181Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0099371Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.87371Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.39091Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.81231Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.17461Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process1.323e-060.723Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process8.168e-050.02617Moderately InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.00020631.761e-14InformativeDirect
Biological Process (BP)phosphorylation5.259e-053.283e-06InformativeDirect
Biological Process (BP)cellular component disassembly0.00027581.728e-08InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process2.005e-080InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.00028880InformativeDirect
Biological Process (BP)vesicle-mediated transport0.14070.1923InformativeInherited
Biological Process (BP)cytoskeleton organization0.43740.01648InformativeInherited
Biological Process (BP)actin filament-based process0.011221.046e-05InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0019320.08323InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0092131InformativeInherited
Biological Process (BP)muscle structure development0.00050920.5979InformativeInherited
Biological Process (BP)organelle assembly0.0071550.1335InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.053128.355e-05InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.11734.681e-05InformativeInherited
Biological Process (BP)organophosphate catabolic process0.096537.997e-05InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.48230.04552InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.12340.0001161InformativeInherited
Biological Process (BP)glycosyl compound catabolic process0.082010.0001278InformativeInherited
Biological Process (BP)protein folding6.493e-060Highly InformativeDirect
Biological Process (BP)nucleoside monophosphate catabolic process9.255e-051.922e-15Highly InformativeDirect
Biological Process (BP)actomyosin structure organization4.393e-060.0007637Highly InformativeDirect
Biological Process (BP)carbohydrate phosphorylation1.13e-090Highly InformativeDirect
Biological Process (BP)cellular protein complex disassembly10.444Highly InformativeInherited
Biological Process (BP)cellular component assembly involved in morphogenesis8.261e-050.002421Highly InformativeInherited
Biological Process (BP)purine ribonucleotide catabolic process0.76720.9712Highly InformativeInherited
Biological Process (BP)purine ribonucleoside triphosphate catabolic process0.0035889.129e-11Highly InformativeInherited
Biological Process (BP)ATP metabolic process0.01120.01863Highly InformativeInherited
Biological Process (BP)purine ribonucleoside catabolic process0.64921Highly InformativeInherited
Molecular Function (MF)binding0.0051851Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups7.91e-060Moderately InformativeDirect
Molecular Function (MF)kinase activity3.19e-090InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor1.433e-100InformativeDirect
Molecular Function (MF)carbohydrate kinase activity2.112e-090Highly InformativeDirect
Molecular Function (MF)unfolded protein binding5.641e-050Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.64310.4007Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.016242.158e-08Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0017910.000152Least InformativeInherited
Cellular Component (CC)cytosol0.00012330Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.00053277.862e-14Moderately InformativeDirect
Cellular Component (CC)cell projection0.0020681Moderately InformativeInherited
Cellular Component (CC)cell cortex1.019e-061.019e-08InformativeDirect
Cellular Component (CC)contractile fiber part0.0002180.0002352InformativeDirect
Cellular Component (CC)cortical cytoskeleton6.986e-066.133e-09Highly InformativeDirect
Cellular Component (CC)sperm part1.636e-066.81e-06Highly InformativeDirect
Cellular Component (CC)cilium part4.138e-060.001128Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.582 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 1.647e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 3.894e-05 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7946 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4174 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9429 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.2213 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6116 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.723 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.02617 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.9949 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.05106 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8589 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0001099 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 8.355e-05 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1.761e-14 Informative Direct
Biological Process (BP) phosphorylation 3.283e-06 Informative Direct
Biological Process (BP) cellular component disassembly 1.728e-08 Informative Direct
Biological Process (BP) actin filament-based process 1.046e-05 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 4.681e-05 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 7.997e-05 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 3.522e-05 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0001161 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.0001278 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 7.965e-07 Informative Direct
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.001612 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1923 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4573 Informative Inherited
Biological Process (BP) mitochondrion organization 0.04951 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) RNA modification 0.3607 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.9998 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) organelle localization 0.02503 Informative Inherited
Biological Process (BP) response to inorganic substance 0.7319 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.214 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.6748 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.9434 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.1335 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.08323 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01648 Informative Inherited
Biological Process (BP) muscle structure development 0.5979 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 0.5002 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular component movement 0.8675 Informative Inherited
Biological Process (BP) cell cycle process 0.4547 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.835 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.002796 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.4054 Informative Inherited
Biological Process (BP) protein transport 0.4469 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.04552 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.0001935 Highly Informative Direct
Biological Process (BP) glycolysis 2.082e-07 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0.0005921 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 1.737e-07 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0005813 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 1.922e-15 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 9.129e-11 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0007637 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 4.091e-05 Highly Informative Direct
Biological Process (BP) nucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate metabolic process 2.909e-10 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 2.218e-09 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0001234 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00012 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.0001613 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.007076 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.01975 Highly Informative Inherited
Biological Process (BP) cellular protein complex disassembly 0.444 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.2185 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.1434 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.02954 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.6017 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.03693 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.1402 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.2776 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.3048 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.4149 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.3035 Highly Informative Inherited
Biological Process (BP) ribonucleoside bisphosphate metabolic process 1 Highly Informative Inherited
Biological Process (BP) cell division 0.005368 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.001613 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.00743 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.01306 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.002421 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.01252 Highly Informative Inherited
Biological Process (BP) histone modification 0.6564 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.01217 Highly Informative Inherited
Biological Process (BP) meiosis 0.001544 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide biosynthetic process 0.0325 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.03201 Highly Informative Inherited
Biological Process (BP) carbohydrate transport 0.002028 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.9712 Highly Informative Inherited
Biological Process (BP) ATP metabolic process 0.01863 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 1 Highly Informative Inherited
Biological Process (BP) pentose metabolic process 0.004488 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.7083 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 4.369e-05 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 1.56e-05 Informative Direct
Molecular Function (MF) nucleotide binding 0.007734 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.8286 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) ATP binding 2.94e-09 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 0 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 7.031e-06 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 9.075e-05 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 2.158e-08 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000152 Least Informative Direct
Cellular Component (CC) protein complex 0.1784 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4007 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 7.862e-14 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.3369 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.08627 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.3333 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell cortex 1.019e-08 Informative Direct
Cellular Component (CC) actin cytoskeleton 5.328e-12 Informative Direct
Cellular Component (CC) contractile fiber part 0.0002352 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.444e-05 Informative Direct
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.001292 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell wall 1.955e-05 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 4.448e-07 Highly Informative Direct
Cellular Component (CC) actin filament 0 Highly Informative Direct
Cellular Component (CC) Arp2/3 protein complex 5.346e-11 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 6.133e-09 Highly Informative Direct
Cellular Component (CC) SWI/SNF superfamily-type complex 0 Highly Informative Direct
Cellular Component (CC) blood microparticle 4.077e-05 Highly Informative Direct
Cellular Component (CC) sperm part 6.81e-06 Highly Informative Direct
Cellular Component (CC) cilium part 0.001128 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.6868 Highly Informative Inherited
Cellular Component (CC) chromatin 0.004873 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.005634 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides2.262e-07Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1365Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.155Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3972Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.09474Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.2543Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.3702Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.02233InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.05849InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.004889Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.009189Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.01957Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2699Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5384Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1054Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1913Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6387Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.2797InformativeInherited
Mammalian Phenotype (MP)neurofibrillary tangles9.248e-08Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits2.164e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fatty acid level0.0005703Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.05515Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant1.016e-05Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant2.324e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1135Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant4.551e-09Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect2.562e-05Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005372Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.418Moderately InformativeInherited
Worm Phenotype (WP)brood size variant3.722e-05InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0002352InformativeDirect
Worm Phenotype (WP)cell division variant0.004155InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant0.005805InformativeInherited
Worm Phenotype (WP)metal response variant0.005973InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.01516InformativeInherited
Worm Phenotype (WP)egg laying variant0.3424InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased6.163e-05Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001294Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.195Least InformativeInherited
Yeast Phenotype (YP)vegetative growth0.2172InformativeInherited

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0.005707Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial cavity0.0004006InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit1.614e-05InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell4.147e-05InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage6.303e-07InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage1.049e-05InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0002918InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane5.876e-05InformativeDirect
Cellular componentChromosome0.18InformativeInherited
Cellular componentTelomere7.955e-11Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationChromatin regulator4.759e-05InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0002512Least InformativeDirect
Post-translational modificationNitration2.391e-08InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism1.731e-10Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.8994Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation4.465e-07Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0001093Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.8632Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)amino-sugar metabolism0InformativeDirect
UniPathway (UP)amine and polyamine degradation0InformativeDirect
UniPathway (UP)polyol degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)L-rhamnose metabolism0Highly InformativeDirect
UniPathway (UP)L-arabinose degradation via L-ribulose0Highly InformativeDirect
UniPathway (UP)coenzyme A biosynthesis0Highly InformativeDirect
UniPathway (UP)acetyl-CoA biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis2.901e-07Highly InformativeDirect
UniPathway (UP)butanoate metabolism3.918e-07Highly InformativeDirect
UniPathway (UP)L-threonine degradation2.983e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]