SUPERFAMILY 1.75 HMM library and genome assignments server


Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,253) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 125,883 594,635 220
Proteins 72,833 359,207 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.47911Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0013920.5286Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.60571Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.41851Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.29881Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.59460Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.55041Least InformativeInherited
Biological Process (BP)single-organism cellular process0.1571Least InformativeInherited
Biological Process (BP)developmental process0.18881Least InformativeInherited
Biological Process (BP)protein metabolic process0.90971Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.89681Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00016950Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00018867.489e-05Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.3620.4284Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0078361Moderately InformativeInherited
Biological Process (BP)organelle organization0.0045357.278e-06Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0088321Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0053381Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.87461Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.39041Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.8091Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.33720.00757Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process2.482e-070.7243Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process9.028e-050.0358Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.47970.00782Moderately InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.00011241.177e-13InformativeDirect
Biological Process (BP)phosphorylation4.68e-059.664e-07InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process1.889e-080InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.00016380InformativeDirect
Biological Process (BP)vesicle-mediated transport0.10060.1363InformativeInherited
Biological Process (BP)cytoskeleton organization0.43710.0144InformativeInherited
Biological Process (BP)actin filament-based process0.011314.578e-06InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0018930.07744InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0095491InformativeInherited
Biological Process (BP)muscle structure development0.00035020.5927InformativeInherited
Biological Process (BP)organelle assembly0.008790.1952InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.051340.000132InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.11560.000125InformativeInherited
Biological Process (BP)organophosphate catabolic process0.096650.0002574InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.46770.06046InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.1240.0003352InformativeInherited
Biological Process (BP)glycosyl compound catabolic process0.083270.0003232InformativeInherited
Biological Process (BP)protein folding3.97e-060Highly InformativeDirect
Biological Process (BP)nucleoside monophosphate catabolic process5.893e-051.432e-14Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.00021491.954e-09Highly InformativeDirect
Biological Process (BP)carbohydrate phosphorylation1.045e-090Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis7.604e-050.002728Highly InformativeInherited
Biological Process (BP)actomyosin structure organization2.799e-060.001442Highly InformativeInherited
Biological Process (BP)purine ribonucleotide catabolic process0.75870.997Highly InformativeInherited
Biological Process (BP)purine ribonucleoside triphosphate catabolic process0.0023755.712e-10Highly InformativeInherited
Biological Process (BP)ATP metabolic process0.010730.0207Highly InformativeInherited
Biological Process (BP)purine ribonucleoside catabolic process0.62621Highly InformativeInherited
Molecular Function (MF)transferase activity0.00012870Least InformativeDirect
Molecular Function (MF)binding0.008271Least InformativeInherited
Molecular Function (MF)hydrolase activity0.99051Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups7.125e-060Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.037182.113e-05Moderately InformativeInherited
Molecular Function (MF)kinase activity7.335e-100InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor2.945e-110InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity0.022311InformativeInherited
Molecular Function (MF)carbohydrate kinase activity1.857e-090Highly InformativeDirect
Molecular Function (MF)unfolded protein binding5.381e-050Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.00026497.176e-05Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.76120.5178Least InformativeInherited
Cellular Component (CC)membrane0.94111Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.010891.982e-07Least InformativeInherited
Cellular Component (CC)cytosol0.00014630Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.00053510Moderately InformativeDirect
Cellular Component (CC)cell projection0.0015751Moderately InformativeInherited
Cellular Component (CC)cell cortex8.269e-077.163e-09InformativeDirect
Cellular Component (CC)contractile fiber part0.00017120.0002717InformativeDirect
Cellular Component (CC)cortical cytoskeleton6.711e-065.879e-09Highly InformativeDirect
Cellular Component (CC)membrane raft5.486e-070.0009626Highly InformativeDirect
Cellular Component (CC)sperm part1.466e-066.544e-06Highly InformativeDirect
Cellular Component (CC)cilium part1.719e-060.001043Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5286 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 7.278e-06 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 7.489e-05 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7763 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3875 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9352 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1709 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4284 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.7243 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.0358 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.04751 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.00757 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7799 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.00782 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0001343 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.000132 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1.177e-13 Informative Direct
Biological Process (BP) phosphorylation 9.664e-07 Informative Direct
Biological Process (BP) actin filament-based process 4.578e-06 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000125 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0002574 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 3.926e-05 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0003352 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.0003232 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 9.131e-07 Informative Direct
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.001343 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1363 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4612 Informative Inherited
Biological Process (BP) mitochondrion organization 0.05107 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) RNA modification 0.3591 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.9864 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) organelle localization 0.02444 Informative Inherited
Biological Process (BP) response to inorganic substance 0.7197 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1992 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.8739 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.1952 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.07744 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.0144 Informative Inherited
Biological Process (BP) muscle structure development 0.5927 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 0.512 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular component movement 0.8343 Informative Inherited
Biological Process (BP) cell cycle process 0.4106 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.8105 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.002477 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.4064 Informative Inherited
Biological Process (BP) protein transport 0.4225 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.06046 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.0001548 Highly Informative Direct
Biological Process (BP) glycolysis 1.803e-07 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0.0006214 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 1.381e-07 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0004797 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 1.432e-14 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 5.712e-10 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) coenzyme A metabolic process 3.709e-13 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 1.954e-09 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 3.714e-05 Highly Informative Direct
Biological Process (BP) ribonucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 1.796e-09 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0003415 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0001337 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.0001332 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.006788 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.02019 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0219 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.2216 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.1394 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.02761 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.6014 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.06627 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.1333 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.2944 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.2194 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.1892 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2994 Highly Informative Inherited
Biological Process (BP) cell division 0.005031 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.002021 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.007785 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.009752 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.002728 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.001442 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.01295 Highly Informative Inherited
Biological Process (BP) histone modification 0.6401 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.01108 Highly Informative Inherited
Biological Process (BP) meiosis 0.00133 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.03019 Highly Informative Inherited
Biological Process (BP) carbohydrate transport 0.001384 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.997 Highly Informative Inherited
Biological Process (BP) ATP metabolic process 0.0207 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 1 Highly Informative Inherited
Biological Process (BP) pentose metabolic process 0.004743 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.113e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.6963 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 3.013e-05 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 1.047e-05 Informative Direct
Molecular Function (MF) nucleotide binding 0.006607 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.7216 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) ATP binding 1.887e-09 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 0 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 6.035e-06 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 8.007e-05 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1.982e-07 Least Informative Direct
Cellular Component (CC) cytoplasmic part 7.176e-05 Least Informative Direct
Cellular Component (CC) protein complex 0.2276 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5178 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.2233 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.009898 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.3135 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell cortex 7.163e-09 Informative Direct
Cellular Component (CC) actin cytoskeleton 6.832e-12 Informative Direct
Cellular Component (CC) contractile fiber part 0.0002717 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.282e-07 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.006429 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) microtubule associated complex 2.904e-07 Highly Informative Direct
Cellular Component (CC) Arp2/3 protein complex 4.291e-11 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 5.879e-09 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0009626 Highly Informative Direct
Cellular Component (CC) sperm part 6.544e-06 Highly Informative Direct
Cellular Component (CC) cilium part 0.001043 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.6673 Highly Informative Inherited
Cellular Component (CC) chromatin 0.009257 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.009567 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides2.262e-07Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1331Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1512Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.396Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.08992Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.246Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.3625Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.02043InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.05607InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.00429Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.008306Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.01802Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2674Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5375Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1055Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1908Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6419Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.2803InformativeInherited
Mammalian Phenotype (MP)neurofibrillary tangles9.025e-08Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits2.113e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fatty acid level0.0005554Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.05236Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant1.016e-05Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant2.324e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1135Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant4.551e-09Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect2.562e-05Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005372Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.418Moderately InformativeInherited
Worm Phenotype (WP)brood size variant3.722e-05InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0002352InformativeDirect
Worm Phenotype (WP)cell division variant0.004155InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant0.005805InformativeInherited
Worm Phenotype (WP)metal response variant0.005973InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.01516InformativeInherited
Worm Phenotype (WP)egg laying variant0.3424InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased6.163e-05Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001294Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1993Least InformativeInherited
Yeast Phenotype (YP)vegetative growth0.2129InformativeInherited

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0.005874Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial cavity0.0004414InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit1.614e-05InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell4.147e-05InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage6.303e-07InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage1.049e-05InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0002973InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane5.772e-05InformativeDirect
Cellular componentChromosome0.1782InformativeInherited
Cellular componentTelomere7.767e-11Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationChromatin regulator4.637e-05InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0003247Least InformativeDirect
Post-translational modificationNitration2.307e-08InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism1.785e-10Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.8972Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation4.218e-07Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0001059Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.8649Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)amino-sugar metabolism0InformativeDirect
UniPathway (UP)amine and polyamine degradation0InformativeDirect
UniPathway (UP)polyol degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)L-rhamnose metabolism0Highly InformativeDirect
UniPathway (UP)L-arabinose degradation via L-ribulose0Highly InformativeDirect
UniPathway (UP)coenzyme A biosynthesis0Highly InformativeDirect
UniPathway (UP)acetyl-CoA biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis2.874e-07Highly InformativeDirect
UniPathway (UP)butanoate metabolism5.068e-07Highly InformativeDirect
UniPathway (UP)L-threonine degradation2.943e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]