SUPERFAMILY 1.75 HMM library and genome assignments server

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Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,254) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 125,908 594,635 220
Proteins 72,848 359,207 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.48271Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0014570.5818Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.10031Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.15671Least InformativeInherited
Biological Process (BP)developmental process0.18981Least InformativeInherited
Biological Process (BP)protein metabolic process0.90911Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.89481Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00017550Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.36070.4448Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.002690.1111Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0045560.0005414Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.11911Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.11261Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.000012540.7509Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.12591Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.13881Moderately InformativeInherited
Biological Process (BP)organelle organization0.0045410.00001109Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0098911Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0059091Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.87731Moderately InformativeInherited
Biological Process (BP)phosphorylation0.0000011670.00000009535InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.00000002210InformativeDirect
Biological Process (BP)vesicle-mediated transport0.1070.1553InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.0059151InformativeInherited
Biological Process (BP)cytoskeleton organization0.43220.01309InformativeInherited
Biological Process (BP)actin filament-based process0.011360.00000545InformativeInherited
Biological Process (BP)cellular component morphogenesis0.001930.08385InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0099181InformativeInherited
Biological Process (BP)muscle structure development0.0003950.6129InformativeInherited
Biological Process (BP)organelle assembly0.009210.2015InformativeInherited
Biological Process (BP)protein folding0.0000040430Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.00021380.000000002296Highly InformativeDirect
Biological Process (BP)carbohydrate phosphorylation0.00000000095950Highly InformativeDirect
Biological Process (BP)regulation of mRNA processing0.000000097570.00000004159Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis0.000083920.003321Highly InformativeInherited
Biological Process (BP)actomyosin structure organization0.0000030140.001437Highly InformativeInherited
Molecular Function (MF)transferase activity0.00012650Least InformativeDirect
Molecular Function (MF)binding0.0087551Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0000070170Moderately InformativeDirect
Molecular Function (MF)kinase activity0.00000000092520InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.000000000037390InformativeDirect
Molecular Function (MF)carbohydrate kinase activity0.0000000018560Highly InformativeDirect
Molecular Function (MF)unfolded protein binding0.000056480Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.70290.4729Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.023270.0000002111Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0079110.0001343Least InformativeInherited
Cellular Component (CC)cytosol0.00015660.000000000000001589Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.00053460.000000000000003095Moderately InformativeDirect
Cellular Component (CC)cell projection0.0027121Moderately InformativeInherited
Cellular Component (CC)cell cortex0.00000086720.000000009491InformativeDirect
Cellular Component (CC)contractile fiber part0.00020630.000287InformativeDirect
Cellular Component (CC)cortical cytoskeleton0.0000067790.000000005444Highly InformativeDirect
Cellular Component (CC)sperm part0.0000022210.000008324Highly InformativeDirect
Cellular Component (CC)cilium part0.0000044490.001237Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5818 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00001109 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0005414 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7962 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4279 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1343 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4448 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.7509 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1111 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.04777 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8402 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0001332 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0008073 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0000000000396 Informative Direct
Biological Process (BP) phosphorylation 0.00000009535 Informative Direct
Biological Process (BP) actin filament-based process 0.00000545 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.0000396 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.000001115 Informative Direct
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.00152 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1553 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4857 Informative Inherited
Biological Process (BP) mitochondrion organization 0.05132 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) RNA modification 0.3652 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.9938 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) organelle localization 0.02515 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6541 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.2146 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5753 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.8888 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.2015 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.08385 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01309 Informative Inherited
Biological Process (BP) muscle structure development 0.6129 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 0.5182 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular component movement 0.8463 Informative Inherited
Biological Process (BP) cell cycle process 0.4234 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.6308 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.001062 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.4056 Informative Inherited
Biological Process (BP) protein transport 0.441 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.03975 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.002959 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.002709 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.003238 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.1633 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.0001047 Highly Informative Direct
Biological Process (BP) glycolysis 0.0000001845 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0.0006247 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0000001485 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0004809 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.00000000001446 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.000000195 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.0000000006649 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.0000001512 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.0000007932 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) coenzyme A metabolic process 0.0000000000001052 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000000002296 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00007394 Highly Informative Direct
Biological Process (BP) ribonucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000000002112 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0001181 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of mRNA processing 0.00000004159 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0001651 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 0.0001395 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.007763 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.02422 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.02314 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.2249 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.1441 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.02837 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.6227 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.1786 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.3051 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.2252 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.2017 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.3113 Highly Informative Inherited
Biological Process (BP) cell division 0.005148 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.002144 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.01002 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.00909 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.003321 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.001437 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.01359 Highly Informative Inherited
Biological Process (BP) histone modification 0.6549 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.01168 Highly Informative Inherited
Biological Process (BP) meiosis 0.00146 Highly Informative Inherited
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.001558 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.03295 Highly Informative Inherited
Biological Process (BP) carbohydrate transport 0.001908 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 1 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 1 Highly Informative Inherited
Biological Process (BP) pentose metabolic process 0.005134 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.7312 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00003473 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00001214 Informative Direct
Molecular Function (MF) nucleotide binding 0.007779 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.7341 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) ATP binding 0.000000002383 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 0 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 0.000008833 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.0000832 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0000002111 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0001343 Least Informative Direct
Cellular Component (CC) protein complex 0.1979 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4729 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.000000000000001589 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000000000000003095 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.2425 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.0121 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.3178 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.000000009491 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000000009289 Informative Direct
Cellular Component (CC) contractile fiber part 0.000287 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000001521 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.007127 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) microtubule associated complex 0.0000003286 Highly Informative Direct
Cellular Component (CC) Arp2/3 protein complex 0.00000000004811 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.000000005444 Highly Informative Direct
Cellular Component (CC) sperm part 0.000008324 Highly Informative Direct
Cellular Component (CC) cilium part 0.001237 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.6733 Highly Informative Inherited
Cellular Component (CC) chromatin 0.00946 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.01107 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000002262Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.133Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1512Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3976Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.09045Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.2457Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.3634Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.02037InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.05647InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.004265Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.008501Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.01824Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2735Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.498Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1091Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6434Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.2833InformativeInherited
Mammalian Phenotype (MP)neurofibrillary tangles0.00000008974Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits0.0000007548Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fatty acid level0.0005686Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.05351Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.00001016Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00002324Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1135Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.000000004551Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.00002562Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005372Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.418Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.00003722InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0002352InformativeDirect
Worm Phenotype (WP)cell division variant0.004155InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant0.005805InformativeInherited
Worm Phenotype (WP)metal response variant0.005973InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.01516InformativeInherited
Worm Phenotype (WP)egg laying variant0.3424InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.00006163Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001294Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.3127Least InformativeInherited
Yeast Phenotype (YP)vegetative growth0.1327InformativeInherited

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0.005968Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial cavity0.0004541InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.00001614InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.00004147InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000006303InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.00001049InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0002805InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0.00006546InformativeDirect
Cellular componentChromosome0.1786InformativeInherited
Cellular componentTelomere0.00000000007642Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationChromatin regulator0.00005477InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0003284Least InformativeDirect
Post-translational modificationNitration0.00000002259InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.0000000001785Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.8951Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0.0000004111Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0001079Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.8636Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)amino-sugar metabolism0InformativeDirect
UniPathway (UP)amine and polyamine degradation0InformativeDirect
UniPathway (UP)polyol degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)L-rhamnose metabolism0Highly InformativeDirect
UniPathway (UP)L-arabinose degradation via L-ribulose0Highly InformativeDirect
UniPathway (UP)coenzyme A biosynthesis0Highly InformativeDirect
UniPathway (UP)acetyl-CoA biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis0.0000002875Highly InformativeDirect
UniPathway (UP)butanoate metabolism0.0000005051Highly InformativeDirect
UniPathway (UP)L-threonine degradation0.00002929Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]