SUPERFAMILY 1.75 HMM library and genome assignments server

Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,255) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 126,076 594,635 220
Proteins 72,951 359,207 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)positive regulation of biological process0.028551Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)localization0.51611Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.066730Least InformativeInherited
Biological Process (BP)single-organism cellular process0.010730.000000000009959Least InformativeInherited
Biological Process (BP)developmental process0.19081Least InformativeInherited
Biological Process (BP)protein metabolic process0.91051Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.11921Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00010620.2835Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.8841Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00017120Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.52841Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.29620.2696Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.20011Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0063151Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.23850.06588Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0031170.1534Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0053720.001466Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0031291Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.23971Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.11741Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.19121Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0099971Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization0.021021Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.97931Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.000019870.7843Moderately InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.000000020570InformativeDirect
Biological Process (BP)phosphorylation0.000004650.000006244InformativeDirect
Biological Process (BP)positive regulation of RNA metabolic process0.0036681InformativeInherited
Biological Process (BP)vesicle-mediated transport0.10750.1672InformativeInherited
Biological Process (BP)hexose metabolic process0.00000033390.9548InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.017771InformativeInherited
Biological Process (BP)positive regulation of gene expression0.01151InformativeInherited
Biological Process (BP)muscle structure development0.00046620.3692InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0090080.09385InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.009821InformativeInherited
Biological Process (BP)actin filament-based process0.015460.01849InformativeInherited
Biological Process (BP)organelle assembly0.021050.2703InformativeInherited
Biological Process (BP)cytoskeleton organization0.62790.01919InformativeInherited
Biological Process (BP)carbohydrate phosphorylation0.00000000036430Highly InformativeDirect
Biological Process (BP)regulation of mRNA processing0.000000096460.00000006177Highly InformativeDirect
Biological Process (BP)protein folding0.0000039550Highly InformativeDirect
Biological Process (BP)glycolytic process0.000027650.00000000008512Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.00035860.000004373Highly InformativeDirect
Biological Process (BP)glucose metabolic process0.000000080410.2239Highly InformativeInherited
Biological Process (BP)monosaccharide catabolic process0.011910.006423Highly InformativeInherited
Biological Process (BP)actomyosin structure organization0.0000029890.001209Highly InformativeInherited
Biological Process (BP)cellular component assembly involved in morphogenesis0.00010640.004223Highly InformativeInherited
Molecular Function (MF)transferase activity0.00023350Least InformativeDirect
Molecular Function (MF)binding0.009221Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0000038330Moderately InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.000000000040690InformativeDirect
Molecular Function (MF)kinase activity0.00000000092460InformativeDirect
Molecular Function (MF)carbohydrate kinase activity0.0000000018710Highly InformativeDirect
Molecular Function (MF)unfolded protein binding0.000056350Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.060810.0000006349Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0082640.0006565Least InformativeInherited
Cellular Component (CC)cytosol0.00015520Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.00038180.000000000000003071Moderately InformativeDirect
Cellular Component (CC)cell projection0.0029721Moderately InformativeInherited
Cellular Component (CC)cell cortex0.00000085960.000000003213InformativeDirect
Cellular Component (CC)contractile fiber part0.00021050.0003404InformativeDirect
Cellular Component (CC)cortical cytoskeleton0.000006090.000000000917Highly InformativeDirect
Cellular Component (CC)ciliary part0.000038310.016Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.000000000009959 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2835 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2696 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.06588 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1534 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4911 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.7843 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8606 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.04073 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.01039 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1413 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.001466 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0.000006244 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0000000006285 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000000000003411 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.000001165 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.0000403 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0002588 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0007018 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1672 Informative Inherited
Biological Process (BP) response to cytokine 0.4948 Informative Inherited
Biological Process (BP) mitochondrion organization 0.05839 Informative Inherited
Biological Process (BP) RNA modification 0.3695 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.4877 Informative Inherited
Biological Process (BP) protein transport 0.4561 Informative Inherited
Biological Process (BP) cell division 0.749 Informative Inherited
Biological Process (BP) hexose metabolic process 0.9548 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.007432 Informative Inherited
Biological Process (BP) organelle localization 0.03299 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6632 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.002065 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.2976 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.9386 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5803 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.09385 Informative Inherited
Biological Process (BP) actin filament-based process 0.01849 Informative Inherited
Biological Process (BP) muscle structure development 0.3692 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01919 Informative Inherited
Biological Process (BP) organelle assembly 0.2703 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) organelle fission 0.5651 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.5117 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.2751 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.002793 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.002251 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.003724 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.001848 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) chromosome organization 0.5639 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.03404 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) carbohydrate phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of mRNA processing 0.00000006177 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) glycolytic process 0.00000000008512 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000004373 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) alditol metabolic process 0 Highly Informative Direct
Biological Process (BP) ribonucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) coenzyme A metabolic process 0.00000000000003735 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.00000000001486 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000000002434 Highly Informative Direct
Biological Process (BP) mitochondrion morphogenesis 0.00000008363 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.000000156 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0000001616 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.0000002012 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.00006712 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00007211 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0001223 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0002 Highly Informative Direct
Biological Process (BP) cytokinesis 0.0004316 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0005132 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0.0006453 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.02669 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.03102 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.002841 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.09136 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.2695 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.02935 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 0.2239 Highly Informative Inherited
Biological Process (BP) monosaccharide catabolic process 0.006423 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.08121 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.2518 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.2103 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.1794 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.311 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.486 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.2264 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.2571 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.03445 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.2166 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.008178 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.02409 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.007373 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.001209 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.004223 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.01388 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.004622 Highly Informative Inherited
Biological Process (BP) nuclear division 0.2297 Highly Informative Inherited
Biological Process (BP) carbohydrate transport 0.001932 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.5144 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.7987 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 1 Highly Informative Inherited
Biological Process (BP) pentose metabolic process 0.008128 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.7374 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.01666 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.1499 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00001275 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000036 Informative Direct
Molecular Function (MF) nucleotide binding 0.00799 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.7391 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) carbohydrate kinase activity 0 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000000002507 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 0.000009833 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.00008501 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0006565 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000006349 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7728 Least Informative Inherited
Cellular Component (CC) protein complex 0.2292 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000000000000003071 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.2077 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01092 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.3223 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.000000003213 Informative Direct
Cellular Component (CC) contractile fiber part 0.0003404 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000001122 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000000007852 Informative Direct
Cellular Component (CC) nucleoplasm part 0.3915 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) transporter complex 0.9983 Informative Inherited
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.007234 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.000000000917 Highly Informative Direct
Cellular Component (CC) Arp2/3 protein complex 0.00000000003725 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 0.0000002132 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.000003394 Highly Informative Direct
Cellular Component (CC) ciliary part 0.016 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.6762 Highly Informative Inherited
Cellular Component (CC) chromatin 0.009811 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.01129 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000002262Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.133Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1512Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3976Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.09045Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.2457Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.3634Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.02037InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.05647InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.004265Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.008501Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.01824Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2735Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.498Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1091Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6434Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.2833InformativeInherited
Mammalian Phenotype (MP)neurofibrillary tangles0.00000008974Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits0.0000007548Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fatty acid level0.0005686Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.05351Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.00001016Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00002324Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1135Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.000000004551Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.00002562Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005372Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.418Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.00003722InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0002352InformativeDirect
Worm Phenotype (WP)cell division variant0.004155InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant0.005805InformativeInherited
Worm Phenotype (WP)metal response variant0.005973InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.01516InformativeInherited
Worm Phenotype (WP)egg laying variant0.3424InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.00006163Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001294Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.3127Least InformativeInherited
Yeast Phenotype (YP)vegetative growth0.1327InformativeInherited

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0.005968Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial cavity0.0004541InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.00001614InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.00004147InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000006303InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.00001049InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0002805InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0.00006546InformativeDirect
Cellular componentChromosome0.1786InformativeInherited
Cellular componentTelomere0.00000000007642Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationChromatin regulator0.00005477InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0003284Least InformativeDirect
Post-translational modificationNitration0.00000002259InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.0000000001785Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.8951Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0.0000004111Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0001079Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.8636Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)amino-sugar metabolism0InformativeDirect
UniPathway (UP)amine and polyamine degradation0InformativeDirect
UniPathway (UP)polyol degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)L-rhamnose metabolism0Highly InformativeDirect
UniPathway (UP)L-arabinose degradation via L-ribulose0Highly InformativeDirect
UniPathway (UP)coenzyme A biosynthesis0Highly InformativeDirect
UniPathway (UP)acetyl-CoA biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis0.0000002875Highly InformativeDirect
UniPathway (UP)butanoate metabolism0.0000005051Highly InformativeDirect
UniPathway (UP)L-threonine degradation0.00002929Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]