SUPERFAMILY 1.75 HMM library and genome assignments server


Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,213) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 121,536 289,856 220
Proteins 70,479 175,185 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.74651Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.20471Least InformativeInherited
Biological Process (BP)developmental process0.59061Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.84511Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.66641Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.49371Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.77870Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.77931Least InformativeInherited
Biological Process (BP)protein metabolic process0.81341Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.77961Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process6.16e-050Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.0016450.0001909Moderately InformativeInherited
Biological Process (BP)organelle organization0.013289.502e-05Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.14331Moderately InformativeInherited
Biological Process (BP)cell differentiation0.08451Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.29291Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.60811Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.72661Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.21760.003294Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process3.366e-050.7562Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.00092910.06712Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.047771Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.35270.001533Moderately InformativeInherited
Biological Process (BP)phosphorylation0.00033721.306e-05InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process5.379e-090InformativeDirect
Biological Process (BP)cytoskeleton organization0.20790.007493InformativeInherited
Biological Process (BP)actin filament-based process0.0031621.664e-05InformativeInherited
Biological Process (BP)cellular component morphogenesis0.01070.18InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0075631InformativeInherited
Biological Process (BP)muscle structure development0.00048590.5394InformativeInherited
Biological Process (BP)organelle assembly0.0021260.1032InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.0065393.184e-06InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.031494.088e-05InformativeInherited
Biological Process (BP)organophosphate catabolic process0.046442.049e-05InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process0.11040.005984InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.010447.13e-13InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.01270InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.061213.252e-05InformativeInherited
Biological Process (BP)glycosyl compound catabolic process0.03423.606e-05InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.043181InformativeInherited
Biological Process (BP)hexose metabolic process2.311e-061InformativeInherited
Biological Process (BP)glycolysis3.107e-063.805e-08Highly InformativeDirect
Biological Process (BP)protein folding5.436e-060Highly InformativeDirect
Biological Process (BP)nucleoside monophosphate catabolic process8.81e-050Highly InformativeDirect
Biological Process (BP)actomyosin structure organization4.553e-060.0003273Highly InformativeDirect
Biological Process (BP)carbohydrate phosphorylation2.88e-110Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis7.838e-050.002085Highly InformativeInherited
Biological Process (BP)purine ribonucleotide catabolic process0.0045430.6285Highly InformativeInherited
Biological Process (BP)purine ribonucleoside triphosphate catabolic process0.0036325.147e-11Highly InformativeInherited
Biological Process (BP)ATP metabolic process5.224e-050.002718Highly InformativeInherited
Biological Process (BP)purine ribonucleoside catabolic process0.0048511Highly InformativeInherited
Molecular Function (MF)binding0.0040851Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups5.491e-050Moderately InformativeDirect
Molecular Function (MF)kinase activity3.423e-070InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor2.739e-080InformativeDirect
Molecular Function (MF)carbohydrate kinase activity6.687e-110Highly InformativeDirect
Molecular Function (MF)unfolded protein binding4.909e-050Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.46710.3547Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0055550.0003705Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0025772.73e-13Least InformativeInherited
Cellular Component (CC)cell projection0.0013721Moderately InformativeInherited
Cellular Component (CC)cytoskeleton0.0011452.24e-11Moderately InformativeInherited
Cellular Component (CC)cell cortex5.292e-076.016e-09InformativeDirect
Cellular Component (CC)contractile fiber part0.00015870.0001998InformativeDirect
Cellular Component (CC)cortical cytoskeleton1.318e-054.638e-08Highly InformativeDirect
Cellular Component (CC)membrane raft9.149e-070.0009028Highly InformativeDirect
Cellular Component (CC)sperm part1.28e-065.437e-06Highly InformativeDirect
Cellular Component (CC)cilium2.568e-050.1041Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 9.502e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0001909 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3493 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7469 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9955 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1615 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.7562 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.06712 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.04341 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.003294 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8012 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.001533 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0004871 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 3.184e-06 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 7.13e-13 Informative Direct
Biological Process (BP) phosphorylation 1.306e-05 Informative Direct
Biological Process (BP) actin filament-based process 1.664e-05 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 4.088e-05 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 2.049e-05 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 3.252e-05 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 3.606e-05 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.0001122 Informative Direct
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.001448 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4619 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) RNA modification 0.3638 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.9533 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) organelle localization 0.02429 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8104 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1997 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5952 Informative Inherited
Biological Process (BP) growth 0.9415 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.9857 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.002054 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.1032 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.007493 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.18 Informative Inherited
Biological Process (BP) muscle structure development 0.5394 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 0.3348 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 1 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.03714 Informative Inherited
Biological Process (BP) response to light stimulus 0.978 Informative Inherited
Biological Process (BP) protein transport 0.4217 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.005984 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) cell cycle process 0.5596 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.0001436 Highly Informative Direct
Biological Process (BP) glycolysis 3.805e-08 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0.0005897 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 2.054e-07 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate catabolic process 5.147e-11 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) coenzyme A metabolic process 7.168e-10 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0003273 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0001047 Highly Informative Direct
Biological Process (BP) ribonucleoside bisphosphate biosynthetic process 3.746e-15 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate biosynthetic process 3.746e-15 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 2.774e-09 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.000389 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 0 Highly Informative Direct
Biological Process (BP) interaction with host 0.0002209 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0001188 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00687 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.22 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.03632 Highly Informative Inherited
Biological Process (BP) response to ionizing radiation 0.3503 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.2575 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.03004 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.1226 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.2646 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.2608 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.384 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.2647 Highly Informative Inherited
Biological Process (BP) cell division 0.006034 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.001656 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.01554 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.001053 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.002085 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.0103 Highly Informative Inherited
Biological Process (BP) histone modification 0.6088 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide biosynthetic process 0.1764 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.03196 Highly Informative Inherited
Biological Process (BP) carbohydrate transport 0.001912 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.6285 Highly Informative Inherited
Biological Process (BP) ATP metabolic process 0.002718 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 1 Highly Informative Inherited
Biological Process (BP) pentose metabolic process 0.003274 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.7998 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0001007 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 3.704e-05 Informative Direct
Molecular Function (MF) nucleotide binding 0.01382 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.7751 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) ATP binding 1.208e-08 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 0 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 5.599e-06 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 9.229e-05 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 2.73e-13 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0003705 Least Informative Direct
Cellular Component (CC) protein complex 0.2088 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3547 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 6.706e-14 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 2.24e-11 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.1339 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.0158 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.3166 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell cortex 6.016e-09 Informative Direct
Cellular Component (CC) actin cytoskeleton 2.171e-12 Informative Direct
Cellular Component (CC) contractile fiber part 0.0001998 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 4.141e-09 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.001297 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell wall 2.271e-05 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 1.555e-07 Highly Informative Direct
Cellular Component (CC) actin filament 0 Highly Informative Direct
Cellular Component (CC) Arp2/3 protein complex 6.116e-11 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 4.638e-08 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0009028 Highly Informative Direct
Cellular Component (CC) blood microparticle 8.557e-05 Highly Informative Direct
Cellular Component (CC) sperm part 5.437e-06 Highly Informative Direct
Cellular Component (CC) cilium 0.1041 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.6586 Highly Informative Inherited
Cellular Component (CC) chromatin 0.003111 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.003072 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides2.262e-07Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.1552Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.1558Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3977Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.0955Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.2538Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.3698Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.02249InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.05815InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.004911Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.009238Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.01968Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3949Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5768Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1922Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.7233Moderately InformativeInherited
Mammalian Phenotype (MP)neurofibrillary tangles9.436e-08Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits2.206e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fatty acid level0.0005848Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant1.016e-05Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant2.324e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1135Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant4.551e-09Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect2.562e-05Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005372Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.418Moderately InformativeInherited
Worm Phenotype (WP)brood size variant3.722e-05InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0002352InformativeDirect
Worm Phenotype (WP)cell division variant0.004155InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant0.005805InformativeInherited
Worm Phenotype (WP)metal response variant0.005973InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.01516InformativeInherited
Worm Phenotype (WP)egg laying variant0.3424InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased6.163e-05Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001294Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)vegetative growth0.2229InformativeInherited

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0.005468Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial cavity0.0004138InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit1.614e-05InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell4.147e-05InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage6.303e-07InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage1.049e-05InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides8.261e-08InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane5.43e-05InformativeDirect
Cellular componentChromosome0.1642InformativeInherited
Cellular componentTelomere3.059e-11Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationChromatin regulator3.816e-05InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0003888Least InformativeDirect
Post-translational modificationNitration2.356e-08InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism2.282e-12Least InformativeDirect
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis1.269e-15Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.6122Moderately InformativeInherited
UniPathway (UP)organic acid metabolism0.6503Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism1Moderately InformativeInherited
UniPathway (UP)heterocycle metabolism1Moderately InformativeInherited
UniPathway (UP)coenzyme A biosynthesis0InformativeDirect
UniPathway (UP)cell wall biogenesis0InformativeDirect
UniPathway (UP)alcohol degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)purine nucleotide metabolism1.712e-07InformativeDirect
UniPathway (UP)carbohydrate biosynthesis1InformativeInherited
UniPathway (UP)purine biosynthesis1InformativeInherited
UniPathway (UP)L-arabinose degradation via L-ribulose0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis7.225e-07Highly InformativeDirect
UniPathway (UP)butanoate metabolism2.891e-05Highly InformativeDirect
UniPathway (UP)N-acetylneuraminate metabolism1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]