SUPERFAMILY 1.75 HMM library and genome assignments server


Thioredoxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Families:   Thioltransferase [ 52834] (15)
  PDI-like [ 52849] (2)
  Calsequestrin [ 52855]
  DsbA-like [ 100953] (3)
  Glutathione S-transferase (GST), N-terminal domain [ 52862] (18)
  Phosducin [ 52888]
  ERP29 N domain-like [ 52892] (2)
  spliceosomal protein U5-15Kd [ 52895]
  SH3BGR (SH3-binding, glutamic acid-rich protein-like) [ 102446]
  KaiB-like [ 102449] (2)
  DsbC/DsbG C-terminal domain-like [ 52898] (2)
  Glutathione peroxidase-like [ 52901] (28)
  Thioredoxin-like 2Fe-2S ferredoxin [ 52918]
  ArsC-like [ 69518] (3)
  Txnl5-like [ 110612]
  YuzD-like [ 117605]
  YKR049C-like [ 142395]
  Atu2684-like [ 142398]
  HyaE-like [ 142401]
  NQO2-like [ 142405]
  Mitochondrial ribosomal protein L51/S25/CI-B8 domain [ 142408]
  Selenoprotein W-related [ 142411] (3)
  UAS domain [ 159589]


Superfamily statistics
Genomes (3,240) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 131,751 0 301
Proteins 120,027 0 292


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process0.8431Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.79911Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.1020Least InformativeInherited
Biological Process (BP)response to stimulus0.0014990.1033Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular response to stress1.486e-132.852e-11Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus1.649e-092.168e-11Moderately InformativeDirect
Biological Process (BP)regulation of localization0.06081Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.00029221Moderately InformativeInherited
Biological Process (BP)organ development0.79071Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.91171Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.56451Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.059681Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.43731Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.087270.4161Moderately InformativeInherited
Biological Process (BP)homeostatic process0.00074410.04052Moderately InformativeInherited
Biological Process (BP)reproduction0.18761Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.13855.208e-09Moderately InformativeInherited
Biological Process (BP)organelle organization0.8771Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.002190.006004Moderately InformativeInherited
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)response to inorganic substance2.953e-090InformativeDirect
Biological Process (BP)regulation of intracellular transport2.269e-071.395e-09InformativeDirect
Biological Process (BP)developmental process involved in reproduction0.0089941InformativeInherited
Biological Process (BP)reproductive system development0.00032720.5901InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0065950.00895InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0023520.01503InformativeInherited
Biological Process (BP)regulation of establishment of protein localization5.295e-060.008398InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.011980.0125InformativeInherited
Biological Process (BP)secondary metabolic process0.23974.401e-14InformativeInherited
Biological Process (BP)protein folding1.243e-120Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process9.675e-092.017e-07Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species5.625e-060Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide4.459e-061.65e-10Highly InformativeDirect
Biological Process (BP)cell redox homeostasis00Highly InformativeDirect
Biological Process (BP)regulation of binding2.808e-110.0001346Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus1.756e-124.328e-10Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process6.093e-101.335e-09Highly InformativeDirect
Biological Process (BP)post-embryonic development0.0018931Highly InformativeInherited
Biological Process (BP)post-embryonic organ development8.811e-070.08507Highly InformativeInherited
Biological Process (BP)icosanoid metabolic process1.883e-090.005947Highly InformativeInherited
Biological Process (BP)hydrogen peroxide metabolic process0.0053781.747e-05Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport1.38e-060.002236Highly InformativeInherited
Biological Process (BP)regulation of nucleocytoplasmic transport3.982e-060.03399Highly InformativeInherited
Biological Process (BP)response to superoxide0.25130.01783Highly InformativeInherited
Biological Process (BP)superoxide metabolic process11Highly InformativeInherited
Biological Process (BP)toxin metabolic process0.0018230Highly InformativeInherited
Biological Process (BP)nucleus organization0.0072280.0184Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity1.317e-060Moderately InformativeDirect
Molecular Function (MF)anion binding11Moderately InformativeInherited
Molecular Function (MF)electron carrier activity0.00070440.0001254InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity3.918e-140InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors11InformativeInherited
Molecular Function (MF)carboxylic acid binding0.26781.081e-13InformativeInherited
Molecular Function (MF)amide binding0.0069898.548e-12InformativeInherited
Molecular Function (MF)sulfur compound binding0.045587.52e-15InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.0050040InformativeInherited
Molecular Function (MF)glutathione transferase activity3.558e-100Highly InformativeDirect
Molecular Function (MF)antioxidant activity00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on peroxide as acceptor00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.00027810.003961Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.022220.4435Highly InformativeInherited
Molecular Function (MF)amino acid binding0.029910Highly InformativeInherited
Molecular Function (MF)peptide binding0.0051421.739e-12Highly InformativeInherited
Cellular Component (CC)cytoplasmic part9.961e-060Least InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00034680.04658Least InformativeInherited
Cellular Component (CC)respiratory chain0.27050.5777InformativeInherited
Cellular Component (CC)plastid0.088998.263e-14InformativeInherited
Cellular Component (CC)chloroplast stroma8.553e-062.524e-07Highly InformativeDirect
Cellular Component (CC)respiratory chain complex I1.142e-052.036e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1033 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 2.852e-11 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 5.208e-09 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 2.168e-11 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.4161 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.04052 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.8273 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.006004 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) response to inorganic substance 0 Informative Direct
Biological Process (BP) secondary metabolic process 4.401e-14 Informative Direct
Biological Process (BP) regulation of intracellular transport 1.395e-09 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) protein complex assembly 0.1382 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.2613 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 0.5901 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.00895 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.01503 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9453 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01373 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.008398 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.8105 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.0125 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.544 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.2192 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.3163 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.001628 Informative Inherited
Biological Process (BP) response to other organism 0.5235 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.6753 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.2649 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0001483 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 2.017e-07 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 1.65e-10 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 1.747e-05 Highly Informative Direct
Biological Process (BP) cell redox homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0001346 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 4.328e-10 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 1.335e-09 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.002814 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.2675 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.056 Highly Informative Inherited
Biological Process (BP) regulation of muscle contraction 0.5906 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.08507 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.005947 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.002236 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.03399 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.8194 Highly Informative Inherited
Biological Process (BP) cell projection assembly 1 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) peptidyl-proline modification 0.03336 Highly Informative Inherited
Biological Process (BP) response to superoxide 0.01783 Highly Informative Inherited
Biological Process (BP) superoxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.0539 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7631 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.001072 Highly Informative Inherited
Biological Process (BP) innate immune response 0.07675 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.02997 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.0184 Highly Informative Inherited
Biological Process (BP) inorganic anion transport 0.01624 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.1986 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0.0001254 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.081e-13 Informative Direct
Molecular Function (MF) amide binding 8.548e-12 Informative Direct
Molecular Function (MF) sulfur compound binding 7.52e-15 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.6127 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) glutathione transferase activity 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 0 Highly Informative Direct
Molecular Function (MF) peptide binding 1.739e-12 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.4435 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.003961 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0.005621 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.04658 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.504 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.426 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.02816 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.4437 Moderately Informative Inherited
Cellular Component (CC) plastid 8.263e-14 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0008329 Informative Direct
Cellular Component (CC) respiratory chain 0.5777 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.01131 Informative Inherited
Cellular Component (CC) microbody 0.04518 Informative Inherited
Cellular Component (CC) chloroplast stroma 2.524e-07 Highly Informative Direct
Cellular Component (CC) organelle subcompartment 3.607e-07 Highly Informative Direct
Cellular Component (CC) respiratory chain complex I 2.036e-05 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.00952 Highly Informative Inherited
Cellular Component (CC) microbody part 0.0565 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases4.463e-09Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.7939Moderately InformativeInherited
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)9.784e-11InformativeDirect
Enzyme Commission (EC)With other acceptors1.562e-10InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.31e-06InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002113InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other oxidoreductases1.046e-09Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases4.643e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.02862Least InformativeInherited
Disease Ontology (DO)immune system disease0.9939Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.006397Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.02941Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.466Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.5601Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5696Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.8545Moderately InformativeInherited
Disease Ontology (DO)esophageal disease0.0001515InformativeDirect
Disease Ontology (DO)adenoma0.0003098InformativeDirect
Disease Ontology (DO)anemia0.139InformativeInherited
Disease Ontology (DO)malignant glioma0.5792InformativeInherited
Disease Ontology (DO)peptic esophagitis0.000116Highly InformativeDirect
Disease Ontology (DO)vitiligo0.0003579Highly InformativeDirect
Disease Ontology (DO)normocytic anemia0.02346Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2992Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.002776Moderately InformativeInherited
Mammalian Phenotype (MP)oxidative stress2.705e-07Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.002023Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02693Least InformativeInherited
Worm Phenotype (WP)organism stress response variant1.958e-10InformativeDirect
Worm Phenotype (WP)metal response variant0.0002078InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.002611Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.02655Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0001234Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.07228Moderately InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.07632InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.1104InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.0003572Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell6.211e-06Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.000211Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0008895Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.001641Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.006633Least InformativeInherited
Plant ANatomical entity (PAN)flower0.02078Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.05778Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.09687Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1687Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.6222Least InformativeInherited
Plant ANatomical entity (PAN)vascular system0.389InformativeInherited
Plant ANatomical entity (PAN)phloem0.0003851Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1.431e-10Moderately InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.9147InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Peroxidases0Highly InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)4.907e-11Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase4.823e-07Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases3.719e-06Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1.244e-05Highly InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002007Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0003948Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor0.1267Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processDifferentiation0.001745Moderately InformativeInherited
Biological processIon transport1Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processStress response5.216e-08InformativeDirect
Biological processSensory transduction0.02973InformativeInherited
Biological processFatty acid metabolism0.4519InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSpermatogenesis6.881e-12Highly InformativeDirect
Biological processPhenylalanine catabolism4.979e-11Highly InformativeDirect
Biological processTwo-component regulatory system8.169e-11Highly InformativeDirect
Biological processUnfolded protein response5.36e-09Highly InformativeDirect
Biological processSodium transport4.233e-08Highly InformativeDirect
Biological processNitrate assimilation7.146e-08Highly InformativeDirect
Biological processVision5.69e-05Highly InformativeDirect
Biological processAntiport7.89e-05Highly InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion5.361e-15Moderately InformativeDirect
Cellular componentPlastid5.493e-05Moderately InformativeDirect
Cellular componentCell projection0.4109Moderately InformativeInherited
Cellular componentPeriplasm1.125e-14InformativeDirect
Cellular componentChloroplast1.173e-07InformativeDirect
Cellular componentPeroxisome7.22e-07InformativeDirect
Cellular componentSarcoplasmic reticulum1.74e-13Highly InformativeDirect
Cellular componentLipid droplet1.128e-06Highly InformativeDirect
Cellular componentCilium6.287e-05Highly InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DiseaseAllergen0.0001097Moderately InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainTransit peptide1.221e-15Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainSH3-binding1.888e-06InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular function2Fe-2S0InformativeDirect
Molecular functionIron-sulfur1.283e-12InformativeDirect
Molecular functionSodium0.0001636InformativeDirect
Molecular functionCopper0.0008141InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Molecular functionUbiquinone5.691e-05Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIsomerase1.746e-10Moderately InformativeDirect
Post-translational modificationIon channel1.131e-05InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel1.367e-14Highly InformativeDirect
Post-translational modificationEye lens protein4.498e-08Highly InformativeDirect
Post-translational modificationMuscle protein6.235e-06Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationS-nitrosylation0.0007124InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0001096Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.1667Least InformativeInherited
UniPathway (UP)lipid metabolism0.7627Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.9604Least InformativeInherited
UniPathway (UP)amino-acid degradation2.589e-09Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation8.235e-07Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism9.857e-05Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.01849Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.4581Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0.003995InformativeInherited
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect
UniPathway (UP)methylamine degradation1.921e-14Highly InformativeDirect
UniPathway (UP)prostaglandin biosynthesis9.914e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR012336 SSF52833 Protein matches
Abstract

Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system [PubMed15862094]. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin, thioltransferase, phosducin, glutathione peroxidase-like enzymes, arsenate reductase, disulphide bond isomerase DsbC (C-terminal domain), disulphide bond facilitator DsbA (contains an alpha-helical insertion), glutathione S-transferase (N-terminal domain), Endoplasmic reticulum protein ERP29 (N-terminal domain), spliceosomal protein U5-15Kd, circadian oscillation regulator KaiB, protein disulphide isomerase PDI (contains two tandem repeats of this fold), and calsequestrin (contains three tandem repeats of this fold).

This entry differs from the thioredoxin fold protein, the classification of this fold is in the glutathione S-transferase enzymes, where this entry defines two regions containing this fold, and the thioredoxin fold protein defines only the N-terminal as containing this fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 171 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 171 hidden Markov models representing the Thioredoxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]