SUPERFAMILY 1.73 HMM library and genome assignments server


Rhodanese/Cell cycle control phosphatase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   Rhodanese/Cell cycle control phosphatase [ 52820]
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32451
Superfamily:   Rhodanese/Cell cycle control phosphatase [ 52821] (4)
Families:   Cell cycle control phosphatase, catalytic domain [ 52822] (4)
  Single-domain sulfurtransferase [ 69509] (3)
  Multidomain sulfurtransferase (rhodanese) [ 52827] (4)
  duplication: consists of two domains of this fold
  Ubiquitin carboxyl-terminal hydrolase 8, USP8 [ 117586]


Superfamily statistics
Genomes (1,160) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 9,952 9,821 29
Proteins 8,285 8,089 19


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Function annotation of SCOP domain superfamilies
InterPro annotation
Cross references IPR001763 SSF52821 Protein matches
Abstract

Rhodanese, a sulphurtransferase involved in cyanide detoxification (see ) shares evolutionary relationship with a large family of proteins [PubMed9733650], including

  • Cdc25 phosphatase catalytic domain.
  • non-catalytic domains of eukaryotic dual-specificity MAPK-phosphatases.
  • non-catalytic domains of yeast PTP-type MAPK-phosphatases.
  • non-catalytic domains of yeast Ubp4, Ubp5, Ubp7.
  • non-catalytic domains of mammalian Ubp-Y.
  • Drosophila heat shock protein HSP-67BB.
  • several bacterial cold-shock and phage shock proteins.
  • plant senescence associated proteins.
  • catalytic and non-catalytic domains of rhodanese (see ).

Rhodanese has an internal duplication. This domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases [PubMed8702871].


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Rhodanese/Cell cycle control phosphatase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the Rhodanese/Cell cycle control phosphatase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]