SUPERFAMILY 1.73 HMM library and genome assignments server


Phosphotyrosine protein phosphatases I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   Phosphotyrosine protein phosphatases I-like [ 52787] (2)
  3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134
Superfamily:   Phosphotyrosine protein phosphatases I [ 52788]
Families:   Low-molecular-weight phosphotyrosine protein phosphatases [ 52789] (2)


Superfamily statistics
Genomes (969) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 1,936 2,357 14
Proteins 1,934 2,356 14


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Function annotation of SCOP domain superfamilies
InterPro annotation
Cross references IPR000106 SSF52788 Protein matches
Abstract

This entry represents the low molecular weight (LMW) protein-tyrosine phosphatases (or acid phosphatase), which act on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [PubMed1587862, PubMed1304913]. The structure of a LMW PTPase has been solved by X-ray crystallography [PubMed8052313] and is found to form a single structural domain. It belongs to the alpha/beta class, with 6 alpha-helices and 4 beta-strands forming a 3-layer alpha-beta-alpha sandwich architecture.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphotyrosine protein phosphatases I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Phosphotyrosine protein phosphatases I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]