SUPERFAMILY 1.75 HMM library and genome assignments server


Phosphotyrosine protein phosphatases I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphotyrosine protein phosphatases I-like [ 52787] (2)
Superfamily:   Phosphotyrosine protein phosphatases I [ 52788]
Families:   Low-molecular-weight phosphotyrosine protein phosphatases [ 52789] (2)


Superfamily statistics
Genomes (2,508) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,015 30,048 14
Proteins 5,007 30,037 14


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process3.247e-099.054e-08Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process7.091e-087.558e-06Least InformativeDirect
Biological Process (BP)cellular protein modification process2.06e-123.363e-10Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process3.161e-101.111e-09Moderately InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)protein dephosphorylation00Highly InformativeDirect
Molecular Function (MF)hydrolase activity2.83e-071.346e-06Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity00InformativeDirect
Molecular Function (MF)phosphoprotein phosphatase activity7.245e-050.01323Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 9.054e-08 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 7.558e-06 Least Informative Direct
Biological Process (BP) cellular protein modification process 3.363e-10 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 1.111e-09 Moderately Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 1.346e-06 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.01323 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acid phosphatase5.636e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
DomainRedox-active center0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationOxidoreductase1.028e-13Moderately InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationDisulfide bond2.746e-08Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000106 SSF52788 Protein matches
Abstract

This entry represents the low molecular weight (LMW) protein-tyrosine phosphatases (or acid phosphatase), which act on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [PubMed1587862, PubMed1304913]. The structure of a LMW PTPase has been solved by X-ray crystallography [PubMed8052313] and is found to form a single structural domain. It belongs to the alpha/beta class, with 6 alpha-helices and 4 beta-strands forming a 3-layer alpha-beta-alpha sandwich architecture.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphotyrosine protein phosphatases I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Phosphotyrosine protein phosphatases I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]