CoA-dependent acyltransferases superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a/b) [ 51349] (147)
Fold:	CoA-dependent acyltransferases [ 52776]
Superfamily:	CoA-dependent acyltransferases [ 52777] (3)
Families:	CAT-like [ 52778] (3)
	Choline/Carnitine O-acyltransferase [ 82424] (3)
	NRPS condensation domain (amide synthase) [ 75229] (2)

Superfamily statistics

	Genomes (2,141)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	36,768	87,136	39
Proteins	15,989	39,404	26

Functional annotation

General category	Metabolism
Detailed category	Transferases

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Molecular Function (MF)	transferase activity	0.0007706	0	Least Informative	Direct
Molecular Function (MF)	transferase activity, transferring acyl groups	5.596e-07	0	Informative	Direct
Cellular Component (CC)	intracellular membrane-bounded organelle	0.005231	0.000244	Least Informative	Inherited
Cellular Component (CC)	cytoplasmic part	0.005318	0	Least Informative	Inherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	biosynthetic process	9.242e-09	Least Informative	Direct
Biological Process (BP)	single-organism metabolic process	0	Least Informative	Direct
Biological Process (BP)	nitrogen compound metabolic process	0.4604	Least Informative	Inherited
Biological Process (BP)	localization	0.7824	Least Informative	Inherited
Biological Process (BP)	ion transport	8.475e-05	Moderately Informative	Direct
Biological Process (BP)	cellular lipid metabolic process	1.841e-06	Moderately Informative	Direct
Biological Process (BP)	cofactor metabolic process	0	Moderately Informative	Direct
Biological Process (BP)	organonitrogen compound biosynthetic process	0.0006572	Moderately Informative	Direct
Biological Process (BP)	organic hydroxy compound metabolic process	0.0003304	Moderately Informative	Direct
Biological Process (BP)	cellular nitrogen compound biosynthetic process	0.06507	Moderately Informative	Inherited
Biological Process (BP)	organic substance transport	0.007093	Moderately Informative	Inherited
Biological Process (BP)	macromolecule localization	0.04029	Moderately Informative	Inherited
Biological Process (BP)	cellular catabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	organic substance catabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	cellular amino acid metabolic process	0.09353	Moderately Informative	Inherited
Biological Process (BP)	oxidation-reduction process	0.2584	Moderately Informative	Inherited
Biological Process (BP)	monocarboxylic acid metabolic process	0.001643	Moderately Informative	Inherited
Biological Process (BP)	anion transport	4.419e-09	Informative	Direct
Biological Process (BP)	lipid transport	2.048e-12	Informative	Direct
Biological Process (BP)	organic acid transport	9.578e-12	Informative	Direct
Biological Process (BP)	cellular amide metabolic process	0	Informative	Direct
Biological Process (BP)	coenzyme biosynthetic process	0.6969	Informative	Inherited
Biological Process (BP)	fatty acid metabolic process	0.1576	Informative	Inherited
Biological Process (BP)	lipid catabolic process	0.0043	Informative	Inherited
Biological Process (BP)	carboxylic acid catabolic process	0.0205	Informative	Inherited
Biological Process (BP)	aspartate family amino acid metabolic process	0.006931	Informative	Inherited
Biological Process (BP)	energy derivation by oxidation of organic compounds	0.111	Informative	Inherited
Biological Process (BP)	amino-acid betaine metabolic process	2.335e-10	Highly Informative	Direct
Biological Process (BP)	acyl-CoA metabolic process	0	Highly Informative	Direct
Biological Process (BP)	monocarboxylic acid transport	9.281e-06	Highly Informative	Direct
Biological Process (BP)	nonribosomal peptide biosynthetic process	0	Highly Informative	Direct
Biological Process (BP)	thioester biosynthetic process	2.881e-13	Highly Informative	Direct
Biological Process (BP)	secondary metabolite biosynthetic process	1.35e-10	Highly Informative	Direct
Biological Process (BP)	lipid modification	0.03992	Highly Informative	Inherited
Biological Process (BP)	monocarboxylic acid catabolic process	0.3886	Highly Informative	Inherited
Biological Process (BP)	dicarboxylic acid metabolic process	0.414	Highly Informative	Inherited
Biological Process (BP)	aerobic respiration	0.019	Highly Informative	Inherited
Molecular Function (MF)	transferase activity	0	Least Informative	Direct
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	anion binding	0.7266	Moderately Informative	Inherited
Molecular Function (MF)	oxidoreductase activity	1	Moderately Informative	Inherited
Molecular Function (MF)	transferase activity, transferring acyl groups	0	Informative	Direct
Molecular Function (MF)	carboxylic acid binding	2.672e-05	Informative	Direct
Molecular Function (MF)	cofactor binding	0.0003074	Informative	Direct
Molecular Function (MF)	O-acyltransferase activity	3.07e-15	Highly Informative	Direct
Molecular Function (MF)	oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.453e-08	Highly Informative	Direct
Molecular Function (MF)	acetyltransferase activity	1	Highly Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	0.000244	Least Informative	Direct
Cellular Component (CC)	cytoplasmic part	0	Least Informative	Direct
Cellular Component (CC)	protein complex	0.2892	Least Informative	Inherited
Cellular Component (CC)	intracellular organelle part	1	Least Informative	Inherited
Cellular Component (CC)	membrane	0.0894	Least Informative	Inherited
Cellular Component (CC)	organelle envelope	0.0002657	Moderately Informative	Direct
Cellular Component (CC)	mitochondrial part	2.605e-08	Moderately Informative	Direct
Cellular Component (CC)	intracellular organelle lumen	0.3923	Moderately Informative	Inherited
Cellular Component (CC)	organelle membrane	0.1273	Moderately Informative	Inherited
Cellular Component (CC)	external encapsulating structure	0.0002958	Informative	Direct
Cellular Component (CC)	microbody	8.851e-08	Informative	Direct
Cellular Component (CC)	cell wall	6.802e-06	Highly Informative	Direct
Cellular Component (CC)	mitochondrial outer membrane	0.0003129	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Ligases	1	Least Informative	Inherited
Enzyme Commission (EC)	Isomerases	1	Least Informative	Inherited
Enzyme Commission (EC)	Lyases	1	Least Informative	Inherited
Enzyme Commission (EC)	Oxidoreductases	1	Least Informative	Inherited
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	Moderately Informative	Direct
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0.9887	Moderately Informative	Inherited
Enzyme Commission (EC)	Racemases and epimerases	0.001299	Moderately Informative	Inherited
Enzyme Commission (EC)	Carboxy-lyases	0.01725	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0.06325	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on amino acids and derivatives	3.344e-05	Informative	Direct
Enzyme Commission (EC)	Acid--D-amino-acid ligases (peptide synthases)	0.08881	Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.566	Informative	Inherited
Enzyme Commission (EC)	Dihydrolipoyllysine-residue succinyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin	0	Highly Informative	Direct
Enzyme Commission (EC)	Dihydrolipoyllysine-residue acetyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	L-aminoadipate-semialdehyde dehydrogenase	1.237e-14	Highly Informative	Direct
Enzyme Commission (EC)	Phenylalanine racemase (ATP-hydrolyzing)	2.79e-13	Highly Informative	Direct
Enzyme Commission (EC)	Dihydrolipoyllysine-residue (2-methylpropanoyl)tra	5.46e-09	Highly Informative	Direct

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the central nervous system	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of muscle physiology	0	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Muscular hypotonia	0	Informative	Direct

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	alimentary system	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	male genitalia	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	viscus	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	portion of tissue	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	gonad	0	Least Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	1	Least Informative	Inherited
Enzyme Commission (EC)	Lyases	1	Least Informative	Inherited
Enzyme Commission (EC)	Acyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Carbon-carbon lyases	0.1388	Moderately Informative	Inherited
Enzyme Commission (EC)	Isomerases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Ligases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	5.741e-07	Informative	Direct
Enzyme Commission (EC)	Racemases and epimerases	0.002127	Informative	Inherited
Enzyme Commission (EC)	Carboxy-lyases	0.01741	Informative	Inherited
Enzyme Commission (EC)	Acid--D-amino-acid ligases (peptide synthases)	0.09128	Informative	Inherited
Enzyme Commission (EC)	Acting on amino acids and derivatives	3.45e-05	Highly Informative	Direct
Enzyme Commission (EC)	Transketolases and transaldolases	1	Highly Informative	Inherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)

	DB term	FDR (all)	SDDB level	Annotation (direct or inherited)
Drugbank ATC_code (DB)	levocarnitine	0	Highly Informative	Direct

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Lipid metabolism	0	Moderately Informative	Direct
Biological process	Antibiotic resistance	0	Informative	Direct
Biological process	Glycolysis	0	Informative	Direct
Biological process	Tricarboxylic acid cycle	0	Informative	Direct
Biological process	Virulence	2.667e-10	Informative	Direct
Biological process	Fatty acid metabolism	4.237e-06	Informative	Direct
Biological process	Antibiotic biosynthesis	0	Highly Informative	Direct
Biological process	Glycerol metabolism	4.622e-16	Highly Informative	Direct
Cellular component	Mitochondrion	0	Moderately Informative	Direct
Cellular component	Peroxisome	6.74e-11	Informative	Direct
Cellular component	Mitochondrion outer membrane	1.917e-05	Informative	Direct
Domain	Transit peptide	2.618e-11	Moderately Informative	Direct
Molecular function	Phosphopantetheine	0	Highly Informative	Direct
Post-translational modification	Transferase	0	Least Informative	Direct
Post-translational modification	Ligase	3.545e-10	Moderately Informative	Direct
Post-translational modification	Isomerase	0.0003282	Moderately Informative	Direct
Post-translational modification	Lyase	1	Moderately Informative	Inherited
Post-translational modification	Acyltransferase	0	Informative	Direct
Post-translational modification	Decarboxylase	9.664e-05	Informative	Direct
Post-translational modification	Acetylation	2.194e-09	Moderately Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	lipid metabolism	2.215e-08	Least Informative	Direct
UniPathway (UP)	amino-acid metabolism	0.01022	Least Informative	Inherited
UniPathway (UP)	carbohydrate metabolism	1	Least Informative	Inherited
UniPathway (UP)	amino-acid degradation	0	Moderately Informative	Direct
UniPathway (UP)	alcohol metabolism	1.322e-11	Moderately Informative	Direct
UniPathway (UP)	fatty acid metabolism	2.915e-06	Moderately Informative	Direct
UniPathway (UP)	secondary metabolite metabolism	0.01079	Moderately Informative	Inherited
UniPathway (UP)	proteinogenic amino-acid biosynthesis	1	Moderately Informative	Inherited
UniPathway (UP)	lipid biosynthesis	1	Moderately Informative	Inherited
UniPathway (UP)	antibiotic biosynthesis	0	Informative	Direct
UniPathway (UP)	siderophore metabolism	0	Informative	Direct
UniPathway (UP)	glycerol metabolism	4.392e-15	Informative	Direct
UniPathway (UP)	tricarboxylic acid cycle	2.717e-07	Informative	Direct
UniPathway (UP)	polyketide biosynthesis	5.16e-07	Informative	Direct
UniPathway (UP)	L-lysine biosynthesis	0.1394	Informative	Inherited
UniPathway (UP)	fatty acid degradation	0	Highly Informative	Direct
UniPathway (UP)	glycerolipid biosynthesis	0	Highly Informative	Direct
UniPathway (UP)	L-lysine degradation via saccharopine pathway	0	Highly Informative	Direct
UniPathway (UP)	penicillin G biosynthesis	1.767e-15	Highly Informative	Direct
UniPathway (UP)	L-lysine biosynthesis via AAA pathway	3.752e-08	Highly Informative	Direct
UniPathway (UP)	gramicidin S biosynthesis	8.637e-07	Highly Informative	Direct

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a CoA-dependent acyltransferases domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the CoA-dependent acyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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CoA-dependent acyltransferases superfamily