SUPERFAMILY 1.75 HMM library and genome assignments server


P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,258) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,013,155 4,300,997 739
Proteins 869,871 3,740,022 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.093230.3188Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00013051Least InformativeInherited
Biological Process (BP)multicellular organismal process5.161e-051Least InformativeInherited
Biological Process (BP)developmental process01Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.9326Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)reproduction1.777e-091.493e-12Moderately InformativeDirect
Biological Process (BP)organelle organization00Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)macromolecule localization2.129e-083.352e-10Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)cellular localization00Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic cyclic compound catabolic process00Moderately InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.69461Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.74676.988e-07Moderately InformativeInherited
Biological Process (BP)nervous system development4.32e-071Moderately InformativeInherited
Biological Process (BP)regulation of localization00.03148Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.56341Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.063422.346e-12Moderately InformativeInherited
Biological Process (BP)organic substance transport10.06812Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.77381Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.054291Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.19681Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)homeostatic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00040531Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis2.146e-080.7562Moderately InformativeInherited
Biological Process (BP)tissue development0.83190.9794Moderately InformativeInherited
Biological Process (BP)signal transduction0.00070871Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.52490Moderately InformativeInherited
Biological Process (BP)cellular response to stress15.404e-12Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.73361Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization00.00106Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.093230.9044Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process00InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process5.67e-050InformativeDirect
Biological Process (BP)cellular membrane organization5.668e-068.844e-11InformativeDirect
Biological Process (BP)cell cycle process2.749e-050InformativeDirect
Biological Process (BP)actin filament-based process1.321e-131.259e-08InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process00InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process2.121e-090InformativeDirect
Biological Process (BP)organophosphate catabolic process00InformativeDirect
Biological Process (BP)cellular process involved in reproduction1.252e-070InformativeDirect
Biological Process (BP)epithelium development0.00016050.000441InformativeDirect
Biological Process (BP)organelle assembly1.405e-052.99e-08InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00InformativeDirect
Biological Process (BP)glycosyl compound catabolic process00InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.45551InformativeInherited
Biological Process (BP)proteolysis10.6779InformativeInherited
Biological Process (BP)protein catabolic process10.8633InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process11InformativeInherited
Biological Process (BP)cellular component morphogenesis1.78e-081InformativeInherited
Biological Process (BP)generation of neurons1.08e-051InformativeInherited
Biological Process (BP)organelle localization0.044464.644e-08InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)regulation of system process0.00057841InformativeInherited
Biological Process (BP)response to light stimulus0.75611InformativeInherited
Biological Process (BP)vesicle-mediated transport00.06499InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0037940.5675InformativeInherited
Biological Process (BP)secondary metabolic process0.67641InformativeInherited
Biological Process (BP)pigment metabolic process11InformativeInherited
Biological Process (BP)cell projection organization00.9712InformativeInherited
Biological Process (BP)regulation of organelle organization2.443e-090.005542InformativeInherited
Biological Process (BP)protein transport3.321e-150.004242InformativeInherited
Biological Process (BP)regulation of growth0.97531InformativeInherited
Biological Process (BP)negative regulation of cell communication0.89791InformativeInherited
Biological Process (BP)negative regulation of signaling0.86651InformativeInherited
Biological Process (BP)negative regulation of response to stimulus11InformativeInherited
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.1051InformativeInherited
Biological Process (BP)cytoskeleton organization0.029281InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.49952.753e-07InformativeInherited
Biological Process (BP)sexual reproduction0.37330.7243InformativeInherited
Biological Process (BP)single organism reproductive process0.83430.7075InformativeInherited
Biological Process (BP)multicellular organismal reproductive process10.03788InformativeInherited
Biological Process (BP)cellular cation homeostasis0.017070.097InformativeInherited
Biological Process (BP)growth1.428e-060.1669InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of secretion0.0711InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.22270.4791InformativeInherited
Biological Process (BP)regulation of hormone levels0.16071InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00021061InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching10.7098InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.001010.09492InformativeInherited
Biological Process (BP)intracellular signal transduction00.01025InformativeInherited
Biological Process (BP)cytoplasmic transport11InformativeInherited
Biological Process (BP)DNA metabolic process0.0027680InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.790InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process10InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process11InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process11InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.17660.3798InformativeInherited
Biological Process (BP)nucleotide biosynthetic process11InformativeInherited
Biological Process (BP)tissue morphogenesis0.0078991InformativeInherited
Biological Process (BP)double-strand break repair4.192e-052.197e-07Highly InformativeDirect
Biological Process (BP)DNA recombination3.345e-108.138e-11Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity3.321e-159.205e-11Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process1.472e-120Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate catabolic process1.91e-070Highly InformativeDirect
Biological Process (BP)regulation of autophagy0.0003820Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis7.986e-093.071e-11Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly1.854e-130.0004661Highly InformativeDirect
Biological Process (BP)regulation of exocytosis01.07e-10Highly InformativeDirect
Biological Process (BP)cell projection assembly5.352e-091.054e-05Highly InformativeDirect
Biological Process (BP)cell junction organization3.951e-110.0001416Highly InformativeDirect
Biological Process (BP)cilium organization3.194e-063.587e-11Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process00Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport8.688e-132.617e-05Highly InformativeDirect
Biological Process (BP)cell division00Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH9.211e-090Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process4.818e-062.464e-07Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process01.359e-08Highly InformativeDirect
Biological Process (BP)pH reduction2.267e-100.4918Highly InformativeInherited
Biological Process (BP)nucleus organization0.80230.9277Highly InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process11Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process10.8284Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.065951Highly InformativeInherited
Biological Process (BP)cell projection morphogenesis0.0040070.9561Highly InformativeInherited
Biological Process (BP)cell fate commitment0.89561Highly InformativeInherited
Biological Process (BP)neural precursor cell proliferation0.0024680.004378Highly InformativeInherited
Biological Process (BP)stem cell proliferation0.0020250.01425Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.032780.9826Highly InformativeInherited
Biological Process (BP)regulation of amine transport0.00013760.1404Highly InformativeInherited
Biological Process (BP)sensory perception10.1096Highly InformativeInherited
Biological Process (BP)detection of light stimulus0.57780.3403Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate metabolic process11Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate metabolic process0.83331Highly InformativeInherited
Biological Process (BP)deoxyribose phosphate metabolic process0.0030620.06633Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide metabolic process11Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.45171Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.96224.871e-05Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.030720.002655Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity1.763e-060.6729Highly InformativeInherited
Biological Process (BP)female gamete generation0.00049540.03237Highly InformativeInherited
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.36080.06495Highly InformativeInherited
Biological Process (BP)protein methylation0.69220.8182Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.00017071Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.0039631Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside monophosphate metabolic process0.068241Highly InformativeInherited
Biological Process (BP)pigment biosynthetic process0.89271Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.31140.1584Highly InformativeInherited
Biological Process (BP)meiosis0.019090Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.86171Highly InformativeInherited
Biological Process (BP)protein glycosylation0.01571Highly InformativeInherited
Biological Process (BP)nucleoside monophosphate biosynthetic process0.3671Highly InformativeInherited
Biological Process (BP)purine ribonucleotide biosynthetic process11Highly InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process0.031850.02496Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.0058530.008884Highly InformativeInherited
Biological Process (BP)phagocytosis0.79751Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity0.34021Least InformativeInherited
Molecular Function (MF)transporter activity0.00036550Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups01Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides00.0583Moderately InformativeInherited
Molecular Function (MF)nucleotide binding00InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity1.02e-120InformativeDirect
Molecular Function (MF)purine ribonucleoside binding00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.33030.0006611InformativeInherited
Molecular Function (MF)cytoskeletal protein binding14.37e-07InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.99271InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)kinase activity4.752e-130.635InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds11InformativeInherited
Molecular Function (MF)tubulin binding2.497e-064.484e-09Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)metal cluster binding5.37e-080.000794Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.0099070.2846Highly InformativeInherited
Cellular Component (CC)membrane01.063e-10Least InformativeDirect
Cellular Component (CC)cytoplasmic part04.055e-05Least InformativeDirect
Cellular Component (CC)protein complex0.83440.2334Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle1.109e-051Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.70690Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)cytoskeleton8.424e-154.115e-11Moderately InformativeDirect
Cellular Component (CC)cell projection01.495e-14Moderately InformativeDirect
Cellular Component (CC)vesicle00.0299Moderately InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)plasma membrane6.36e-051Moderately InformativeInherited
Cellular Component (CC)nuclear part10.6392Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen11Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum11Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.043631Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.0047123.811e-07Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus00.0001426InformativeDirect
Cellular Component (CC)cell cortex8.577e-145.834e-14InformativeDirect
Cellular Component (CC)microtubule cytoskeleton1.15e-131.337e-13InformativeDirect
Cellular Component (CC)cell-cell junction0.90820.0003568InformativeInherited
Cellular Component (CC)secretory granule10.8063InformativeInherited
Cellular Component (CC)extracellular membrane-bounded organelle0.72480.972InformativeInherited
Cellular Component (CC)nucleoplasm part11InformativeInherited
Cellular Component (CC)coated vesicle0.72851InformativeInherited
Cellular Component (CC)synapse part00.02821InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.29041InformativeInherited
Cellular Component (CC)spindle4.285e-150Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane0.0005210Highly InformativeDirect
Cellular Component (CC)endocytic vesicle4.887e-051.871e-10Highly InformativeDirect
Cellular Component (CC)midbody2.871e-150Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle2.505e-083.279e-08Highly InformativeDirect
Cellular Component (CC)cell division site part1.438e-067.407e-12Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex4.593e-080Highly InformativeDirect
Cellular Component (CC)cilium part02.644e-05Highly InformativeDirect
Cellular Component (CC)nuclear body0.15270.6096Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.010170.001035Highly InformativeInherited
Cellular Component (CC)microtubule associated complex0.0036120Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)