SUPERFAMILY 1.75 HMM library and genome assignments server


P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (2,490) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 818,588 2,078,183 739
Proteins 700,163 1,810,192 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process02.6e-09Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.20120.5662Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process10.004529Least InformativeInherited
Biological Process (BP)multicellular organismal process0.010681Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00072091Least InformativeInherited
Biological Process (BP)developmental process8.22e-091Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11.555e-05Least InformativeInherited
Biological Process (BP)reproduction3.815e-050.0003206Moderately InformativeDirect
Biological Process (BP)organelle organization6.361e-090Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.00056457.497e-05Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)cellular localization4.632e-151.036e-13Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis1.812e-061Moderately InformativeInherited
Biological Process (BP)nervous system development3.028e-061Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)multi-organism process10.3861Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)system process0.97881Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.04414.192e-08Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process11Moderately InformativeInherited
Biological Process (BP)homeostatic process11Moderately InformativeInherited
Biological Process (BP)organic substance transport10.8202Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of localization5.53e-110.7356Moderately InformativeInherited
Biological Process (BP)regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.73822.109e-06Moderately InformativeInherited
Biological Process (BP)organ development11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.28951Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization3.099e-150.05119Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.021911Moderately InformativeInherited
Biological Process (BP)signal transduction6.31e-061Moderately InformativeInherited
Biological Process (BP)ion transport11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.52860Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.66791Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process11Moderately InformativeInherited
Biological Process (BP)tissue development11Moderately InformativeInherited
Biological Process (BP)purine nucleotide metabolic process00InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process00InformativeDirect
Biological Process (BP)cellular membrane organization0.00035193.107e-06InformativeDirect
Biological Process (BP)ribose phosphate metabolic process00InformativeDirect
Biological Process (BP)cell cycle process4.458e-090InformativeDirect
Biological Process (BP)actin filament-based process1.501e-111.055e-05InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process00InformativeDirect
Biological Process (BP)purine nucleoside metabolic process00InformativeDirect
Biological Process (BP)organophosphate catabolic process00InformativeDirect
Biological Process (BP)cellular process involved in reproduction1.843e-060InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process00InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.1090.5324InformativeInherited
Biological Process (BP)cellular component morphogenesis4.109e-081InformativeInherited
Biological Process (BP)regulation of hydrolase activity11InformativeInherited
Biological Process (BP)regulation of protein localization11InformativeInherited
Biological Process (BP)cell proliferation0.99161InformativeInherited
Biological Process (BP)biological adhesion6.491e-061InformativeInherited
Biological Process (BP)response to light stimulus0.77791InformativeInherited
Biological Process (BP)response to external stimulus0.31481InformativeInherited
Biological Process (BP)vesicle-mediated transport3.212e-120.2469InformativeInherited
Biological Process (BP)embryonic morphogenesis0.013361InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.98241InformativeInherited
Biological Process (BP)positive regulation of gene expression0.98241InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.98361InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)cell projection organization1.747e-120.8343InformativeInherited
Biological Process (BP)regulation of organelle organization0.77270.8799InformativeInherited
Biological Process (BP)protein transport4.481e-110.01243InformativeInherited
Biological Process (BP)regulation of growth11InformativeInherited
Biological Process (BP)positive regulation of transport0.58461InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)protein localization to organelle0.98251InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.041541InformativeInherited
Biological Process (BP)cellular cation homeostasis0.10181InformativeInherited
Biological Process (BP)generation of neurons0.00011191InformativeInherited
Biological Process (BP)central nervous system development0.99241InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of secretion0.013230.967InformativeInherited
Biological Process (BP)ribonucleoside metabolic process0.039583.053e-06InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.81051InformativeInherited
Biological Process (BP)nucleotide biosynthetic process11InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process0.97331InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.025480.001763InformativeInherited
Biological Process (BP)regulation of hormone levels0.29081InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis2.957e-051InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.001860.7913InformativeInherited
Biological Process (BP)sexual reproduction0.070240.6003InformativeInherited
Biological Process (BP)single organism reproductive process0.73431InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.43410.3913InformativeInherited
Biological Process (BP)intracellular signal transduction00.02521InformativeInherited
Biological Process (BP)cytoplasmic transport0.98451InformativeInherited
Biological Process (BP)metal ion transport0.23331InformativeInherited
Biological Process (BP)pigment metabolic process0.8741InformativeInherited
Biological Process (BP)DNA metabolic process0.013110InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.00051360.7293InformativeInherited
Biological Process (BP)tissue morphogenesis0.15071InformativeInherited
Biological Process (BP)epithelium development0.056180.8516InformativeInherited
Biological Process (BP)DNA recombination8.11e-091.394e-10Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity3.764e-135.654e-09Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)female gamete generation0.0009761.194e-05Highly InformativeDirect
Biological Process (BP)nucleoside triphosphate catabolic process00Highly InformativeDirect
Biological Process (BP)nucleotide catabolic process00Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis1.326e-061.145e-05Highly InformativeDirect
Biological Process (BP)endosomal transport01.218e-13Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly2.574e-120.0006869Highly InformativeDirect
Biological Process (BP)cell projection assembly6.265e-083.345e-07Highly InformativeDirect
Biological Process (BP)pH reduction7.04e-080.0001087Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process00Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport3.79e-125.06e-05Highly InformativeDirect
Biological Process (BP)cell division00Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH6.981e-071.339e-09Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport07.794e-12Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process4.243e-051.564e-06Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process8.27e-139.206e-11Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.81640.8861Highly InformativeInherited
Biological Process (BP)regulation of calcium ion transport0.58121Highly InformativeInherited
Biological Process (BP)cell fate commitment0.76321Highly InformativeInherited
Biological Process (BP)neural precursor cell proliferation0.0019760.03997Highly InformativeInherited
Biological Process (BP)stem cell proliferation0.0016360.09863Highly InformativeInherited
Biological Process (BP)organelle localization0.59295.957e-13Highly InformativeInherited
Biological Process (BP)symbiosis, encompassing mutualism through parasitism0.77330.3865Highly InformativeInherited
Biological Process (BP)sensory perception10.002911Highly InformativeInherited
Biological Process (BP)detection of visible light0.18960.001607Highly InformativeInherited
Biological Process (BP)deoxyribose phosphate metabolic process0.016530.01303Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide metabolic process11Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.71031Highly InformativeInherited
Biological Process (BP)purine ribonucleoside triphosphate metabolic process0.000350.002767Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transport11Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity2.354e-060.6969Highly InformativeInherited
Biological Process (BP)telencephalon development0.41951Highly InformativeInherited
Biological Process (BP)protein methylation0.68520.6859Highly InformativeInherited
Biological Process (BP)coenzyme A metabolic process0.73461Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process0.81060.2683Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process0.022534.22e-05Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.0057221Highly InformativeInherited
Biological Process (BP)nucleoside triphosphate biosynthetic process11Highly InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process0.38320.2463Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis5.206e-050.09142Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.45671Highly InformativeInherited
Biological Process (BP)pigment biosynthetic process0.54681Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.085120.4533Highly InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.27040.0001034Highly InformativeInherited
Biological Process (BP)meiosis0.0093280Highly InformativeInherited
Biological Process (BP)transition metal ion transport0.032640.1865Highly InformativeInherited
Biological Process (BP)protein glycosylation0.026451Highly InformativeInherited
Biological Process (BP)phagocytosis0.81311Highly InformativeInherited
Biological Process (BP)organelle assembly0.14742.046e-05Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity0.41281Least InformativeInherited
Molecular Function (MF)transporter activity1.809e-050Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding00Moderately InformativeDirect
Molecular Function (MF)heterocyclic compound binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups5.305e-131Moderately InformativeInherited
Molecular Function (MF)protein binding0.97461Moderately InformativeInherited
Molecular Function (MF)nucleotide binding00InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity4.111e-110InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)kinase activity2.312e-090.6468InformativeInherited
Molecular Function (MF)cytoskeletal protein binding11.363e-05InformativeInherited
Molecular Function (MF)anion transmembrane transporter activity0.39190.0001696InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.76031InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds11InformativeInherited
Molecular Function (MF)tubulin binding0.00012421.857e-09Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)metal cluster binding1.447e-110.0001264Highly InformativeDirect
Molecular Function (MF)protein complex binding0.41895.521e-05Highly InformativeInherited
Molecular Function (MF)amine transmembrane transporter activity0.078980.1587Highly InformativeInherited
Molecular Function (MF)amino acid transmembrane transporter activity0.033020.232Highly InformativeInherited
Cellular Component (CC)membrane1.28e-120.0001766Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.05891Least InformativeInherited
Cellular Component (CC)intracellular organelle part10Least InformativeInherited
Cellular Component (CC)protein complex0.9960.008762Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)cytoplasmic part5.567e-110.01462Least InformativeInherited
Cellular Component (CC)cytoskeleton1.278e-085.829e-13Moderately InformativeDirect
Cellular Component (CC)vesicle01.436e-05Moderately InformativeDirect
Cellular Component (CC)cell projection01.597e-12Moderately InformativeDirect
Cellular Component (CC)extracellular region11Moderately InformativeInherited
Cellular Component (CC)plasma membrane1.069e-060.8056Moderately InformativeInherited
Cellular Component (CC)nuclear part10.9678Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen11Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.037120.0001537Moderately InformativeInherited
Cellular Component (CC)organelle envelope10.2357Moderately InformativeInherited
Cellular Component (CC)mitochondrial part10.1828Moderately InformativeInherited
Cellular Component (CC)endosome04.066e-10InformativeDirect
Cellular Component (CC)Golgi apparatus00.000218InformativeDirect
Cellular Component (CC)cell cortex3.871e-134.764e-12InformativeDirect
Cellular Component (CC)microtubule cytoskeleton4.669e-122.775e-14InformativeDirect
Cellular Component (CC)cell projection part4.084e-086.293e-06InformativeDirect
Cellular Component (CC)cell junction0.005241.013e-08InformativeInherited
Cellular Component (CC)nucleoplasm part11InformativeInherited
Cellular Component (CC)mitochondrial outer membrane0.00083251.278e-07Highly InformativeDirect
Cellular Component (CC)spindle2.67e-146.149e-15Highly InformativeDirect
Cellular Component (CC)cytoplasmic microtubule0.00013480.0006157Highly InformativeDirect
Cellular Component (CC)internal side of plasma membrane5.702e-080Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane3.192e-080Highly InformativeDirect
Cellular Component (CC)endocytic vesicle0.00014761.758e-09Highly InformativeDirect
Cellular Component (CC)midbody00Highly InformativeDirect
Cellular Component (CC)cell division site part2.616e-075.513e-10Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex9.363e-080Highly InformativeDirect
Cellular Component (CC)cilium part1.897e-090.0002557Highly InformativeDirect
Cellular Component (CC)recycling endosome1.466e-067.29e-13Highly InformativeDirect
Cellular Component (CC)cell-cell junction0.75643.22e-05Highly InformativeInherited
Cellular Component (CC)nonmotile primary cilium11Highly InformativeInherited
Cellular Component (CC)host cell part0.0026830.0007505Highly InformativeInherited
Cellular Component (CC)extracellular membrane-bounded organelle0.021180.0002179Highly InformativeInherited
Cellular Component (CC)nuclear body0.16440.3875Highly InformativeInherited
Cellular Component (CC)microtubule associated complex0.019270Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)