SUPERFAMILY 1.75 HMM library and genome assignments server


P-loop containing nucleoside triphosphate hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Families:   Nucleotide and nucleoside kinases [ 52541] (20)
  Shikimate kinase (AroK) [ 52566]
  Chloramphenicol phosphotransferase [ 52569]
  Gluconate kinase [ 75195]
  Plasmid maintenance system epsilon/zeta, toxin zeta subunit [ 82395]
  Adenosine-5'phosphosulfate kinase (APS kinase) [ 52572]
  ATP sulfurylase C-terminal domain [ 64011]
  PAPS sulfotransferase [ 52575] (14)
  Phosphoribulokinase/pantothenate kinase [ 52584] (5)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [ 52589]
  G proteins [ 52592] (78)
  Motor proteins [ 52641] (4)
  Nitrogenase iron protein-like [ 52652] (15)
  RecA protein-like (ATPase-domain) [ 52670] (17)
  Bacterial cell division inhibitor SulA [ 89678]
  ABC transporter ATPase domain-like [ 52686] (23)
  Tandem AAA-ATPase domain [ 81268] (23)
  Extended AAA-ATPase domain [ 81269] (28)
  RNA helicase [ 52724] (3)
  Helicase-like "domain" of reverse gyrase [ 69496]
  DNA helicase UvsW [ 102396]
  YjeE-like [ 75213]
  Type II thymidine kinase [ 117558]
  Atu3015-like [ 142332] (2)


Superfamily statistics
Genomes (3,252) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 999,857 0 739
Proteins 858,627 0 703


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.079990.5319Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00049051Least InformativeInherited
Biological Process (BP)multicellular organismal process5.498e-051Least InformativeInherited
Biological Process (BP)developmental process01Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.822Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)reproduction1.784e-095.016e-11Moderately InformativeDirect
Biological Process (BP)organelle organization00Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)macromolecule localization1.141e-081.445e-10Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)cellular localization00Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.62041Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.75751.401e-05Moderately InformativeInherited
Biological Process (BP)nervous system development2.483e-071Moderately InformativeInherited
Biological Process (BP)regulation of localization3.3e-150.04791Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.76221Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.06471.725e-12Moderately InformativeInherited
Biological Process (BP)organic substance transport10.0634Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.66051Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.053241Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.21221Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.071561Moderately InformativeInherited
Biological Process (BP)homeostatic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00058141Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis1.167e-080.9175Moderately InformativeInherited
Biological Process (BP)tissue development0.82511Moderately InformativeInherited
Biological Process (BP)signal transduction0.00052071Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.58880Moderately InformativeInherited
Biological Process (BP)cellular response to stress12.084e-12Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.73151Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization00.003851Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.062380.9234Moderately InformativeInherited
Biological Process (BP)nucleoside triphosphate metabolic process00InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process3.517e-050InformativeDirect
Biological Process (BP)cellular membrane organization3.056e-063.787e-11InformativeDirect
Biological Process (BP)cell cycle process4.63e-050InformativeDirect
Biological Process (BP)actin filament-based process2.098e-133.963e-07InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process00InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process2.916e-090InformativeDirect
Biological Process (BP)organophosphate catabolic process00InformativeDirect
Biological Process (BP)cellular process involved in reproduction9.348e-080InformativeDirect
Biological Process (BP)epithelium development0.00011470.0008764InformativeDirect
Biological Process (BP)organelle assembly2.709e-057.128e-05InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process00InformativeDirect
Biological Process (BP)glycosyl compound catabolic process00InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.54061InformativeInherited
Biological Process (BP)proteolysis10.7315InformativeInherited
Biological Process (BP)protein catabolic process10.8948InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process11InformativeInherited
Biological Process (BP)cellular component morphogenesis1.343e-081InformativeInherited
Biological Process (BP)generation of neurons9.519e-061InformativeInherited
Biological Process (BP)organelle localization0.040372.643e-08InformativeInherited
Biological Process (BP)regulation of ion transport11InformativeInherited
Biological Process (BP)regulation of system process0.0017031InformativeInherited
Biological Process (BP)response to light stimulus0.78351InformativeInherited
Biological Process (BP)vesicle-mediated transport1.707e-150.07684InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0033450.6079InformativeInherited
Biological Process (BP)secondary metabolic process0.67231InformativeInherited
Biological Process (BP)pigment metabolic process11InformativeInherited
Biological Process (BP)cell projection organization00.9585InformativeInherited
Biological Process (BP)regulation of organelle organization8.222e-090.01374InformativeInherited
Biological Process (BP)protein transport3.3e-150.005005InformativeInherited
Biological Process (BP)regulation of growth0.85651InformativeInherited
Biological Process (BP)negative regulation of cell communication0.89771InformativeInherited
Biological Process (BP)negative regulation of signaling0.87461InformativeInherited
Biological Process (BP)negative regulation of response to stimulus11InformativeInherited
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.076671InformativeInherited
Biological Process (BP)cytoskeleton organization0.024981InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.50124.353e-06InformativeInherited
Biological Process (BP)sexual reproduction0.32640.7916InformativeInherited
Biological Process (BP)single organism reproductive process0.81020.8201InformativeInherited
Biological Process (BP)multicellular organismal reproductive process10.04609InformativeInherited
Biological Process (BP)cellular cation homeostasis0.071380.2372InformativeInherited
Biological Process (BP)growth2.146e-090.7395InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of secretion0.085611InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.24180.5138InformativeInherited
Biological Process (BP)regulation of hormone levels0.15391InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.00023911InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching10.7049InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0010790.1572InformativeInherited
Biological Process (BP)intracellular signal transduction00.01496InformativeInherited
Biological Process (BP)cytoplasmic transport11InformativeInherited
Biological Process (BP)DNA metabolic process0.0044630InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.81350InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process10InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process11InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process11InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.18180.4021InformativeInherited
Biological Process (BP)nucleotide biosynthetic process11InformativeInherited
Biological Process (BP)tissue morphogenesis0.0059731InformativeInherited
Biological Process (BP)double-strand break repair4.955e-052.917e-07Highly InformativeDirect
Biological Process (BP)DNA recombination2.548e-106.919e-11Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity3.3e-153.685e-11Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction00Highly InformativeDirect
Biological Process (BP)purine ribonucleotide catabolic process2.818e-120Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate catabolic process1.942e-070Highly InformativeDirect
Biological Process (BP)regulation of autophagy0.00043520Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis2.068e-084.568e-08Highly InformativeDirect
Biological Process (BP)iron-sulfur cluster assembly2.746e-130.0005704Highly InformativeDirect
Biological Process (BP)cell projection assembly4.477e-092.276e-06Highly InformativeDirect
Biological Process (BP)cell junction organization4.016e-110.000133Highly InformativeDirect
Biological Process (BP)cilium organization4.212e-065.842e-11Highly InformativeDirect
Biological Process (BP)purine ribonucleoside catabolic process00Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport7.173e-132.361e-05Highly InformativeDirect
Biological Process (BP)cell division00Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH6.844e-070Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process5.945e-063.649e-07Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process03.734e-08Highly InformativeDirect
Biological Process (BP)nucleus organization0.79330.7721Highly InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process11Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process10.8589Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.03991Highly InformativeInherited
Biological Process (BP)cell projection morphogenesis0.0043440.9672Highly InformativeInherited
Biological Process (BP)cell fate commitment0.90121Highly InformativeInherited
Biological Process (BP)neural precursor cell proliferation0.0024730.005341Highly InformativeInherited
Biological Process (BP)stem cell proliferation0.0020310.01709Highly InformativeInherited
Biological Process (BP)establishment of vesicle localization0.0012341Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.041461Highly InformativeInherited
Biological Process (BP)regulation of amine transport8.698e-050.1408Highly InformativeInherited
Biological Process (BP)sensory perception10.1295Highly InformativeInherited
Biological Process (BP)detection of light stimulus0.59120.3538Highly InformativeInherited
Biological Process (BP)ribonucleoside bisphosphate metabolic process11Highly InformativeInherited
Biological Process (BP)purine nucleoside bisphosphate metabolic process0.81Highly InformativeInherited
Biological Process (BP)deoxyribose phosphate metabolic process0.0029760.06812Highly InformativeInherited
Biological Process (BP)pyrimidine nucleotide metabolic process11Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.45021Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.9565.963e-05Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.032180.003036Highly InformativeInherited
Biological Process (BP)regulation of phospholipase activity2.112e-060.6882Highly InformativeInherited
Biological Process (BP)female gamete generation0.00022780.03413Highly InformativeInherited
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.35010.0658Highly InformativeInherited
Biological Process (BP)protein methylation0.71030.8475Highly InformativeInherited
Biological Process (BP)cellular hormone metabolic process0.00016651Highly InformativeInherited
Biological Process (BP)hormone biosynthetic process0.004081Highly InformativeInherited
Biological Process (BP)deoxyribonucleoside monophosphate metabolic process0.068241Highly InformativeInherited
Biological Process (BP)pigment biosynthetic process0.90191Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.33080.1865Highly InformativeInherited
Biological Process (BP)meiosis0.01590Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.87771Highly InformativeInherited
Biological Process (BP)protein glycosylation0.01871Highly InformativeInherited
Biological Process (BP)nucleoside monophosphate biosynthetic process0.37221Highly InformativeInherited
Biological Process (BP)purine ribonucleotide biosynthetic process11Highly InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process0.031680.02567Highly InformativeInherited
Biological Process (BP)regulation of endocytosis0.0059530.01059Highly InformativeInherited
Biological Process (BP)phagocytosis0.93941Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transporter activity0.00032330Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups01Moderately InformativeInherited
Molecular Function (MF)nucleotide binding00InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity00InformativeDirect
Molecular Function (MF)active transmembrane transporter activity1.937e-120InformativeDirect
Molecular Function (MF)purine ribonucleoside binding00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.35520.0008908InformativeInherited
Molecular Function (MF)cytoskeletal protein binding12.52e-07InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.98381InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor11InformativeInherited
Molecular Function (MF)kinase activity6.363e-130.7819InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds11InformativeInherited
Molecular Function (MF)tubulin binding2.718e-061.051e-08Highly InformativeDirect
Molecular Function (MF)nucleobase-containing compound kinase activity00Highly InformativeDirect
Molecular Function (MF)metal cluster binding4.432e-080.0007518Highly InformativeDirect
Molecular Function (MF)amino acid transmembrane transporter activity0.011980.3077Highly InformativeInherited
Cellular Component (CC)membrane01.94e-07Least InformativeDirect
Cellular Component (CC)cytoplasmic part00.0001063Least InformativeDirect
Cellular Component (CC)protein complex0.88520.2962Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle9.404e-061Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.76010Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle10Least InformativeInherited
Cellular Component (CC)cytoskeleton1.677e-143.956e-12Moderately InformativeDirect
Cellular Component (CC)cell projection03.132e-15Moderately InformativeDirect
Cellular Component (CC)vesicle00.0127Moderately InformativeInherited
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)plasma membrane2.029e-061Moderately InformativeInherited
Cellular Component (CC)nuclear part10.6416Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen11Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.99761Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.049671Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.0084892.522e-07Moderately InformativeInherited
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)Golgi apparatus00.0001281InformativeDirect
Cellular Component (CC)cell cortex2.568e-132.923e-14InformativeDirect
Cellular Component (CC)microtubule cytoskeleton1.325e-132.906e-13InformativeDirect
Cellular Component (CC)cell-cell junction0.72650.001232InformativeInherited
Cellular Component (CC)secretory granule10.8045InformativeInherited
Cellular Component (CC)extracellular membrane-bounded organelle0.71790.8877InformativeInherited
Cellular Component (CC)nucleoplasm part11InformativeInherited
Cellular Component (CC)coated vesicle0.72671InformativeInherited
Cellular Component (CC)synapse part00.03602InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.24471InformativeInherited
Cellular Component (CC)spindle4.327e-150Highly InformativeDirect
Cellular Component (CC)cytoplasmic microtubule0.00024463.898e-06Highly InformativeDirect
Cellular Component (CC)lateral plasma membrane2.378e-071.937e-11Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane0.00052870Highly InformativeDirect
Cellular Component (CC)endocytic vesicle4.902e-052.049e-10Highly InformativeDirect
Cellular Component (CC)midbody4.327e-150Highly InformativeDirect
Cellular Component (CC)intraflagellar transport particle3.005e-083.005e-08Highly InformativeDirect
Cellular Component (CC)cell division site part1.871e-064.852e-12Highly InformativeDirect
Cellular Component (CC)insulin-responsive compartment0.00010355.36e-09Highly InformativeDirect
Cellular Component (CC)host cell part0.00024522.637e-06Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex4.838e-080Highly InformativeDirect
Cellular Component (CC)apical junction complex0.0006915.422e-07Highly InformativeDirect
Cellular Component (CC)cilium part02.398e-05Highly InformativeDirect
Cellular Component (CC)recycling endosome2.696e-090Highly InformativeDirect
Cellular Component (CC)nuclear body0.1590.6388Highly InformativeInherited
Cellular Component (CC)clathrin-coated vesicle0.010140.00137Highly InformativeInherited
Cellular Component (CC)microtubule associated complex0.0037870Highly InformativeInherited
Cellular Component (CC)rough endoplasmic reticulum0.34750.2811Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)