SUPERFAMILY 1.75 HMM library and genome assignments server


Isochorismatase-like hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Isochorismatase-like hydrolases [ 52498]
Superfamily:   Isochorismatase-like hydrolases [ 52499]
Families:   Isochorismatase-like hydrolases [ 100948] (6)


Superfamily statistics
Genomes (2,556) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 8,915 22,781 8
Proteins 8,907 22,773 8


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.067050.1007Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.026730.05043Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0048320.1096Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.26290.2164Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.013050.02487Least InformativeInherited
Biological Process (BP)cofactor metabolic process5.692e-061.339e-05Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process2.623e-050.0004608Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.015190.181Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.00064890.008188Moderately InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process1.689e-102.447e-14InformativeDirect
Molecular Function (MF)hydrolase activity0.00042232.357e-05Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides0.0042870.002346InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.1007 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.05043 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1096 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.2164 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.02487 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 1.339e-05 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0004608 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.181 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.008188 Moderately Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 2.447e-14 Informative Direct
Molecular Function (MF) hydrolase activity 2.357e-05 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.002346 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ether bonds9.88e-07InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1.183e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMitochondrion6.213e-05Moderately InformativeDirect
DomainTransit peptide1.036e-06Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000868 SSF52499 Protein matches
Abstract This is a family of hydrolase enzymes. Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Isochorismatase-like hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Isochorismatase-like hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]