SUPERFAMILY 1.75 HMM library and genome assignments server

Isochorismatase-like hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Isochorismatase-like hydrolases [ 52498]
Superfamily:   Isochorismatase-like hydrolases [ 52499]
Families:   Isochorismatase-like hydrolases [ 100948] (6)


Superfamily statistics
Genomes (2,604) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,083 56,981 8
Proteins 9,071 56,968 8


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.074780.1149Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.030460.05742Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.01530.02892Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0056650.122Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.52560.5684Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cofactor metabolic process0.000010880.00001999Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.000047290.0007246Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.01990.225Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.00094820.01065Moderately InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.00000000015090.000000002957InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process0.00000000034220.00000000000003576InformativeDirect
Molecular Function (MF)hydrolase activity0.00040120.00002795Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.1149 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.05742 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.02892 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.122 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5684 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0.00001999 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0007246 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.225 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.01065 Moderately Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.000000002957 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0.00000000000003576 Informative Direct
Molecular Function (MF) hydrolase activity 0.00002795 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.000000988InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.000001104Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMitochondrion0.00006349Moderately InformativeDirect
DomainTransit peptide0.000001121Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.02252Least InformativeInherited
UniPathway (UP)siderophore metabolism0.0000000000008865InformativeDirect
UniPathway (UP)nicotinate metabolism4.527e-16Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000868 SSF52499 Protein matches
Abstract This is a family of hydrolase enzymes. Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Isochorismatase-like hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Isochorismatase-like hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]