SUPERFAMILY 1.75 HMM library and genome assignments server


Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [ 52417]
Superfamily:   Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [ 52418]
Families:   Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [ 52419] (3)


Superfamily statistics
Genomes (2,747) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,811 30,423 6
Proteins 4,807 30,417 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 3.851e-06 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.706e-05 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 7.283e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.002362 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.006546 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 4.212e-05 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0006188 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0004227 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 8.925e-05 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.001262 Moderately Informative Inherited
Biological Process (BP) aromatic amino acid family biosynthetic process 3.372e-09 Highly Informative Direct
Molecular Function (MF) transferase activity 1.711e-10 Least Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 8.869e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Thymidine phosphorylase0Highly InformativeDirect
Enzyme Commission (EC)Pyrimidine-nucleoside phosphorylase3.315e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic amino acid biosynthesis0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000312 SSF52418 Protein matches
Abstract

The glycosyl transferase family includes anthranilate phosphoribosyltransferase (TrpD, ) and thymidine phosphorylase . All these proteins can transfer a phosphorylated ribose substrate. Thymidine phosphorylase catalyses the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate. This enzyme regulates the availability of thymidine and is therefore essential to nucleic acid metabolism.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]