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Nucleotidylyl transferase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Nucleotidylyl transferase [ 52374] (5)
Families:   Class I aminoacyl-tRNA synthetases (RS), catalytic domain [ 52375] (12)
  Cytidylyltransferase [ 52394]
  Adenylyltransferase [ 52397] (5)
  Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) [ 63976]
  ATP sulfurylase catalytic domain [ 63979]

 Superfamily statistics
Genomes (2,488) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 46,416 128,264 81
Proteins 45,657 127,617 81

 Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00018640Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process3.879e-140Least InformativeDirect
Biological Process (BP)biosynthetic process6.596e-120Least InformativeDirect
Biological Process (BP)single-organism metabolic process8.538e-100Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00014120Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00071850Least InformativeDirect
Biological Process (BP)protein metabolic process0.9838.513e-11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process10.085Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process1.482e-060Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process2.067e-101.783e-08Moderately InformativeDirect
Biological Process (BP)gene expression2.677e-050Moderately InformativeDirect
Biological Process (BP)RNA metabolic process1.678e-050Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process2.144e-091.132e-08Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process01.642e-06Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.91081Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.70620.5471Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.045710.01957Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.28341Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.5511Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00030460.6164Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process2.28e-060.9791Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0070421Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.012941Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process7.961e-070.1992Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.001311Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.13620Moderately InformativeInherited
Biological Process (BP)tRNA metabolic process3.911e-120InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process0.00012292.076e-15InformativeDirect
Biological Process (BP)coenzyme biosynthetic process9.524e-077.49e-10InformativeDirect
Biological Process (BP)ribonucleoside metabolic process0.00025527.899e-06InformativeDirect
Biological Process (BP)nucleotide biosynthetic process8.992e-072.434e-12InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.00028212.231e-12InformativeDirect
Biological Process (BP)alcohol metabolic process0.13930.7773InformativeInherited
Biological Process (BP)phospholipid metabolic process0.084035.957e-09InformativeInherited
Biological Process (BP)glycosyl compound biosynthetic process0.020490.002204InformativeInherited
Biological Process (BP)purine nucleoside metabolic process0.00014830.003289InformativeInherited
Biological Process (BP)purine-containing compound biosynthetic process0.028223.431e-06InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process1.378e-060.01452InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.21480.7438InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.30281InformativeInherited
Biological Process (BP)vitamin metabolic process3.565e-050.1354InformativeInherited
Biological Process (BP)cellular amide metabolic process0.022441InformativeInherited
Biological Process (BP)purine nucleotide metabolic process10.9204InformativeInherited
Biological Process (BP)ribose phosphate metabolic process0.058730.00399InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.093810.4033InformativeInherited
Biological Process (BP)coenzyme A metabolic process0.00013681.657e-08Highly InformativeDirect
Biological Process (BP)ribonucleoside bisphosphate biosynthetic process4.925e-110Highly InformativeDirect
Biological Process (BP)purine nucleoside bisphosphate biosynthetic process4.925e-110Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process3.242e-072.313e-05Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process1.343e-087.835e-15Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process2.759e-054.31e-08Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process2.212e-132.06e-08Highly InformativeDirect
Biological Process (BP)pyridine-containing compound biosynthetic process1.606e-074.101e-09Highly InformativeDirect
Biological Process (BP)alcohol biosynthetic process0.011581.161e-06Highly InformativeInherited
Molecular Function (MF)transferase activity4.657e-050.3485Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)nucleotidyltransferase activity00InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.98271InformativeInherited
Molecular Function (MF)adenylyltransferase activity1.612e-101.368e-12Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0005930.0007284Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 8.513e-11 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.085 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 1.783e-08 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.132e-08 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 1.642e-06 Moderately Informative Direct
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.5471 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.01957 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.6164 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.1992 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.9791 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8705 Moderately Informative Inherited
Biological Process (BP) tRNA metabolic process 0 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 2.076e-15 Informative Direct
Biological Process (BP) phospholipid metabolic process 5.957e-09 Informative Direct
Biological Process (BP) mitochondrion organization 3.586e-08 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 7.49e-10 Informative Direct
Biological Process (BP) ribonucleoside metabolic process 7.899e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 2.434e-12 Informative Direct
Biological Process (BP) glycerolipid metabolic process 2.231e-12 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 3.431e-06 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.7773 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.4033 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.5212 Informative Inherited
Biological Process (BP) reproductive system development 0.06765 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.01452 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.7438 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 1 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.1354 Informative Inherited
Biological Process (BP) cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) purine nucleoside metabolic process 0.003289 Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.00399 Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 0.9204 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.002204 Informative Inherited
Biological Process (BP) coenzyme A metabolic process 1.657e-08 Highly Informative Direct
Biological Process (BP) ribonucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 2.313e-05 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 7.835e-15 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 1.161e-06 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 4.31e-08 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 2.06e-08 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0002476 Highly Informative Direct
Biological Process (BP) pyridine-containing compound biosynthetic process 4.101e-09 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.01639 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.3485 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) RNA binding 0.01234 Informative Inherited
Molecular Function (MF) adenylyltransferase activity 1.368e-12 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0007284 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) plastid 1.262e-07 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Tryptophan--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Isoleucine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Methionine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Leucine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0Highly InformativeDirect
Enzyme Commission (EC)Arginine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Glutamate--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)1.827e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.4694Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.003905Moderately InformativeInherited
Phenotypic Abnormality (PA)Acidosis0.002969InformativeInherited
Phenotypic Abnormality (PA)Increased serum lactate5.424e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.002319Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.4024Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0112Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.04175Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.1746Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2959Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5054Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb3.354e-07InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0003724InformativeDirect
Worm Phenotype (WP)brood size variant0.0004107InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0193InformativeInherited
Worm Phenotype (WP)organism stress response variant0.03735InformativeInherited
Worm Phenotype (WP)oxidative stress response variant0.0003Highly InformativeDirect
Worm Phenotype (WP)oocyte number decreased0.0005038Highly InformativeDirect
Worm Phenotype (WP)pesticide response variant0.0005572Highly InformativeDirect
Worm Phenotype (WP)organism oxidative stress response variant0.001512Highly InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.06148Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell size defective0.0002469InformativeDirect
Fly Phenotype (FP)decreased cell size6.688e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)eye0Moderately InformativeDirect
Zebrafish Anatomy (ZA)digestive system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)gut0InformativeDirect
Zebrafish Anatomy (ZA)liver0Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf lamina0.0004808Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0.0004933Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0.003375Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.1871Least InformativeInherited
Plant structure DEvelopment stage (PDE)F mature embryo stage0.0003447Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups2.196e-05Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)3.607e-09Highly InformativeDirect
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0.002575Moderately InformativeInherited
Drugbank ATC_code (DB)other antidepressants0.0001692InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processCysteine biosynthesis2.95e-10Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainCoiled coil5.057e-11Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionRNA-binding1Moderately InformativeInherited
Molecular functiontRNA-binding0InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.9821Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism3.962e-06Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.01028Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis0.0448Moderately InformativeInherited
UniPathway (UP)NAD(+) biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis9.085e-10InformativeDirect
UniPathway (UP)phospholipid metabolism0.1768InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)(R)-pantothenate biosynthesis0Highly InformativeDirect
UniPathway (UP)coenzyme A biosynthesis0Highly InformativeDirect
UniPathway (UP)FAD biosynthesis0Highly InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis0Highly InformativeDirect
UniPathway (UP)phosphatidylcholine biosynthesis7.772e-13Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis0.0004408Highly InformativeDirect
UniPathway (UP)Lipooligosaccharide metabolism0.0005071Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleotidylyl transferase domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Nucleotidylyl transferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.