SUPERFAMILY 1.75 HMM library and genome assignments server


Methylglyoxal synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Methylglyoxal synthase-like [ 52334]
Superfamily:   Methylglyoxal synthase-like [ 52335] (3)
Families:   Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain [ 52336]
  Methylglyoxal synthase, MgsA [ 52339]
  Inosicase [ 63971]


Superfamily statistics
Genomes (2,877) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,997 39,441 12
Proteins 6,958 39,320 12


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0001727 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 8.326e-12 Least Informative Direct
Biological Process (BP) biosynthetic process 2.8e-14 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1.347e-12 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001178 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0004325 Least Informative Direct
Biological Process (BP) response to stimulus 0.8569 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1.018e-08 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.407e-06 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 9.002e-09 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 3.77e-15 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.032e-10 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 8.368e-08 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.002234 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.01041 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.05971 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1035 Moderately Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 5.527e-06 Informative Direct
Biological Process (BP) response to lipid 0.0008521 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.312e-08 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.001958 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.06646 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.00351 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 9.239e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 0.0001013 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Highly Informative Direct
Molecular Function (MF) binding 0.5095 Least Informative Inherited
Molecular Function (MF) transferase activity 0.003646 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.02721 Least Informative Inherited
Molecular Function (MF) cation binding 0.01603 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.2225 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.464e-07 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0003071 Informative Direct
Molecular Function (MF) amino acid binding 6.183e-09 Highly Informative Direct
Molecular Function (MF) hydroxymethyl-, formyl- and related transferase activity 9.431e-10 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0006637 Least Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Lyases4.493e-09Least InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Acting on phosphates0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases0InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)IMP cyclohydrolase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases2.27e-08Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (ammonia)2.273e-11Highly InformativeDirect
Enzyme Commission (EC)Carboxyl- and carbamoyltransferases1Highly InformativeInherited
Enzyme Commission (EC)In cyclic amides1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionNucleotide-binding6.658e-06Least InformativeDirect
Molecular functionMetal-binding0.0007632Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionATP-binding2.914e-12Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.1174Least InformativeInherited
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis6.622e-15Moderately InformativeDirect
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Methylglyoxal synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Methylglyoxal synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]