SUPERFAMILY 1.75 HMM library and genome assignments server

Class I glutamine amidotransferase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Class I glutamine amidotransferase-like [ 52317] (9)
Families:   Class I glutamine amidotransferases (GAT) [ 52318] (11)
  A4 beta-galactosidase middle domain [ 82351]
  DJ-1/PfpI [ 52325] (9)
  Catalase, C-terminal domain [ 52328]
  Aspartyl dipeptidase PepE [ 52331]
  ThuA-like [ 110486]
  LD-carboxypeptidase A N-terminal domain-like [ 142074]
  HTS-like [ 142077]
  STM3548-like [ 159492]


Superfamily statistics
Genomes (3,255) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,898 248,652 68
Proteins 47,313 248,123 68


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00000012340Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00037940Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.23041Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.32311Least InformativeInherited
Biological Process (BP)regulation of cellular process0.91291Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0057640.00000000005047Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.013510.00000000001776Least InformativeInherited
Biological Process (BP)single-organism cellular process0.04280.01145Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0096120.0000000000003378Least InformativeInherited
Biological Process (BP)response to stimulus0.73011Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0027390.00000000005059Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.000011930Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.00000040940Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.00000018760Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0000067220Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.0000000000000094410.000000000139Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.0000015730Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.000058580Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.00082040.0001034Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.061131Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.084521Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.10421Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.68771Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.75451Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.050131Moderately InformativeInherited
Biological Process (BP)ion transport0.11241Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.47211Moderately InformativeInherited
Biological Process (BP)regulation of localization0.071031Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.0000016980.009645Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0000018510.003876Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0069550.4474Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.31371Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.000000017340.006191Moderately InformativeInherited
Biological Process (BP)organic substance transport0.19090.9871Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.014510.1082Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.030480.03093Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.73881Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0076971Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.0000000090430.0000003583InformativeDirect
Biological Process (BP)cellular biogenic amine metabolic process0.000000091360.00000000000001071InformativeDirect
Biological Process (BP)response to oxidative stress0.0000000000000016820.00000000000005833InformativeDirect
Biological Process (BP)response to inorganic substance0.000007180.000000008176InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.00000047220.00002207InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00056910.00001092InformativeDirect
Biological Process (BP)regulation of apoptotic process0.0000013250.06223InformativeInherited
Biological Process (BP)positive regulation of transport0.00070370.1459InformativeInherited
Biological Process (BP)regulation of ion transport0.00038230.02007InformativeInherited
Biological Process (BP)positive regulation of cell death0.0045750.167InformativeInherited
Biological Process (BP)positive regulation of intracellular signal transduction0.010070.3212InformativeInherited
Biological Process (BP)pyridine-containing compound metabolic process0.001380.05189InformativeInherited
Biological Process (BP)vitamin metabolic process0.0082790.02288InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0000017630.04615InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.017220.008771InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.00000059010.005884InformativeInherited
Biological Process (BP)nitrogen compound transport0.0098870.1529InformativeInherited
Biological Process (BP)alcohol metabolic process0.21171InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.18490.8513InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.000010830.0302InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.011010.02728InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.0014660InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.14240.6473InformativeInherited
Biological Process (BP)single-organism behavior0.0000069710.05856InformativeInherited
Biological Process (BP)synaptic transmission0.000018110.1908InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.00000070920.0001178Highly InformativeDirect
Biological Process (BP)lactate metabolic process00Highly InformativeDirect
Biological Process (BP)folic acid-containing compound metabolic process0.00000061290.00000005599Highly InformativeDirect
Biological Process (BP)neurotransmitter transport0.000000066590.0000831Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process0.00000029620.000000000004236Highly InformativeDirect
Biological Process (BP)methylglyoxal metabolic process0.0000024990.000003748Highly InformativeDirect
Biological Process (BP)regulation of proton transport0.000000000012260.0000000007618Highly InformativeDirect
Biological Process (BP)dopamine transport0.00000000000092880.0000000000005168Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transporter activity0.0000000029520.000007188Highly InformativeDirect
Biological Process (BP)adult behavior0.0000000034910.0001842Highly InformativeDirect
Biological Process (BP)regulation of protein stability0.000000004920.000001478Highly InformativeDirect
Biological Process (BP)positive regulation of transporter activity0.0000000000074490.00000001101Highly InformativeDirect
Biological Process (BP)primary alcohol metabolic process0.00000035580.000005556Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.0000024390.00000000004909Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.00000000027470.000000141Highly InformativeDirect
Biological Process (BP)regulation of membrane potential0.00000013560.0002106Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process0.000033190.00000002173Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process0.00000013620.0000000003528Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.0000000058390.00000000216Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.0000034590.00001222Highly InformativeDirect
Biological Process (BP)thiamine-containing compound metabolic process0.00000011060.00000003704Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process0.00000000056150.0000000002634Highly InformativeDirect
Biological Process (BP)vitamin B6 metabolic process0.0000047310.00000004144Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.00000021510.00008649Highly InformativeDirect
Biological Process (BP)aldehyde catabolic process0.0000000000030730.00000000002628Highly InformativeDirect
Biological Process (BP)regulation of reactive oxygen species metabolic process0.00000000075980.00000154Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.0000028980.0001551Highly InformativeDirect
Biological Process (BP)regulation of intrinsic apoptotic signaling pathway0.00000000026410.0000001153Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.0000022360.01136Highly InformativeInherited
Biological Process (BP)regulation of binding0.00000091150.001612Highly InformativeInherited
Biological Process (BP)cellular modified amino acid biosynthetic process0.0086520.06548Highly InformativeInherited
Biological Process (BP)locomotory behavior0.00000027740.00232Highly InformativeInherited
Biological Process (BP)tryptophan metabolic process0.0021270.0003473Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity0.68241Least InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)lyase activity0.00000000000019720.000000000009293Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity0.8581Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding0.0000089181Moderately InformativeInherited
Molecular Function (MF)peptidase activity0.000000020380.000000001307InformativeDirect
Molecular Function (MF)hydro-lyase activity0.00000000000069240.00000000000008223InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity0.3750.02753InformativeInherited
Molecular Function (MF)RNA binding0.000000015790.06589InformativeInherited
Molecular Function (MF)mRNA binding0.00000000019690.0002213Highly InformativeDirect
Molecular Function (MF)transaminase activity0.000075380.0000000136Highly InformativeDirect
Molecular Function (MF)antioxidant activity0.00011730.00000000003155Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on peroxide as acceptor0.000000098540Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity0.000000000016940Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00000000001776 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000000000003378 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000000005047 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000005059 Least Informative Direct
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01145 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00008792 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000000000139 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0006824 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0001034 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.003504 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.009645 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.003876 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4474 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.006191 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9871 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1082 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.03093 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.0000003583 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0.00000000000001071 Informative Direct
Biological Process (BP) response to oxidative stress 0.00000000000005833 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00000000001498 Informative Direct
Biological Process (BP) response to inorganic substance 0.000000008176 Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.00002207 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.00000009685 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00001092 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.06223 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1459 Informative Inherited
Biological Process (BP) regulation of ion transport 0.02007 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.167 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.3212 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.05189 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.02288 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.04615 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.008771 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.005884 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.1529 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.8513 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.0302 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.02728 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.6473 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.05856 Informative Inherited
Biological Process (BP) synaptic transmission 0.1908 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.8263 Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.0001178 Highly Informative Direct
Biological Process (BP) lactate metabolic process 0 Highly Informative Direct
Biological Process (BP) pyrimidine nucleotide metabolic process 0.000000000007701 Highly Informative Direct
Biological Process (BP) tryptophan metabolic process 0.0003473 Highly Informative Direct
Biological Process (BP) folic acid-containing compound metabolic process 0.00000005599 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.0000831 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.000000000004236 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0.0000000006522 Highly Informative Direct
Biological Process (BP) methylglyoxal metabolic process 0.000003748 Highly Informative Direct
Biological Process (BP) regulation of proton transport 0.0000000007618 Highly Informative Direct
Biological Process (BP) dopamine transport 0.0000000000005168 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.000007188 Highly Informative Direct
Biological Process (BP) adult behavior 0.0001842 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000001478 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.00000001101 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.000005556 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.00000000004909 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.000000141 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0002106 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 0.00000002173 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.0000000003528 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.00000000216 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.00001222 Highly Informative Direct
Biological Process (BP) thiamine-containing compound metabolic process 0.00000003704 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.0000000002634 Highly Informative Direct
Biological Process (BP) vitamin B6 metabolic process 0.00000004144 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00008649 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleoside metabolic process 0.000000000000093 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.00000000002628 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.00009331 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.00000154 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.0001551 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.0000001153 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.01136 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.001612 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.05385 Highly Informative Inherited
Biological Process (BP) guanosine-containing compound metabolic process 0.01443 Highly Informative Inherited
Biological Process (BP) cellular modified amino acid biosynthetic process 0.06548 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.002937 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.00232 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0.000000000009293 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0.000000001307 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0005571 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.000001104 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.00000000000008223 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.003888 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.02753 Informative Inherited
Molecular Function (MF) RNA binding 0.06589 Informative Inherited
Molecular Function (MF) mRNA binding 0.0002213 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.000001811 Highly Informative Direct
Molecular Function (MF) transaminase activity 0.0000000136 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0.00000000003155 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.0003714 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.06455 Least Informative Inherited
Cellular Component (CC) cytosol 0.00002 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.9975Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases0.2799Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.8592Moderately InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0.000000007861InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups1InformativeInherited
Enzyme Commission (EC)Peroxidases0.165InformativeInherited
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Anthranilate synthase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)locomotion variant0.0001427Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to enzymatic treatment0.00005155Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)male fertile0.0003711Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.2651Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.8517Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0.00001533InformativeDirect
Enzyme Commission (EC)Omega peptidases0.1303InformativeInherited
Enzyme Commission (EC)Acting on a peroxide as acceptor0.1426InformativeInherited
Enzyme Commission (EC)Hexosyltransferases1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.002005Highly InformativeInherited
Enzyme Commission (EC)Peroxidases0.1371Highly InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups1Highly InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis2.372e-16Highly InformativeDirect
Biological processFolate biosynthesis0.0000000007797Highly InformativeDirect
Biological processFertilization0.000012Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionPyridoxal phosphate0Highly InformativeDirect
Post-translational modificationTransferase0.0255Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationProtease0.013Moderately InformativeInherited
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationSerine protease0.00000000000001434InformativeDirect
Post-translational modificationCarboxypeptidase0.0003431Highly InformativeDirect
Post-translational modificationOxidation0.00008962Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.000000000529Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)L-histidine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis0InformativeDirect
UniPathway (UP)nucleotide biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)L-arginine biosynthesis0.00000000000003266InformativeDirect
UniPathway (UP)polyketide biosynthesis0.5398InformativeInherited
UniPathway (UP)antibiotic biosynthesis0.8005InformativeInherited
UniPathway (UP)GMP biosynthesis0Highly InformativeDirect
UniPathway (UP)CTP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Class I glutamine amidotransferase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Class I glutamine amidotransferase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]