SUPERFAMILY 1.75 HMM library and genome assignments server


N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) [ 52255]
Families:   N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) [ 52256]


Superfamily statistics
Genomes (2,734) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,391 7,932 6
Proteins 3,381 7,919 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000208 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 6.916e-07 Least Informative Direct
Biological Process (BP) single-organism metabolic process 4.008e-07 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001711 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0003408 Least Informative Direct
Biological Process (BP) biosynthetic process 0.003571 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 3.778e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 4.363e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000175 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 2.017e-12 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0001339 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.001874 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.001763 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.003762 Moderately Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.0005005 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 3.014e-07 Informative Direct
Biological Process (BP) nucleobase metabolic process 1.509e-11 Highly Informative Direct
Molecular Function (MF) lyase activity 4.459e-14 Moderately Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) carboxy-lyase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Lyases4.208e-09Least InformativeDirect
Enzyme Commission (EC)Ligases0.1166Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.0002403Moderately InformativeDirect
Enzyme Commission (EC)Transferring other groups0InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)9.136e-08InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases6.659e-09Least InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0.1262Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)7.375e-08InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0.001621Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationLyase4.842e-12Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000031 SSF52255 Protein matches
Abstract

Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. PurK, N5-carboxyaminoimidazole ribonucleotide (N5_CAIR) synthetase, catalyzes the conversion of 5-aminoimidazole ribonucleotide (AIR), ATP, and bicarbonate to N5-CAIR, ADP, and Pi. PurE converts N5-CAIR to CAIR, the sixth step of de novo purine biosynthesis. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP. Some members of this family contain two copies of this domain [PubMed10074353]. The crystal structure of PurE indicates a unique quaternary structure that confirms the octameric nature of the enzyme [PubMed10574791].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]