SUPERFAMILY 1.75 HMM library and genome assignments server


Toll/Interleukin receptor TIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Toll/Interleukin receptor TIR domain [ 52200]
Families:   Toll/Interleukin receptor TIR domain [ 52201] (2)


Superfamily statistics
Genomes (734) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 8,092 9,252 4
Proteins 7,814 8,975 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.003458 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1697 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.09e-10 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 4.889e-08 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1.948e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 9.184e-07 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0005641 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.001933 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.02122 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9085 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.009692 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.0132 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4361 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.3845 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) cell activation 2.368e-13 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 5.158e-13 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 2.981e-12 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 6.208e-11 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 6.782e-10 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.008e-08 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 1.505e-07 Informative Direct
Biological Process (BP) response to bacterium 1.19e-05 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 3.908e-05 Informative Direct
Biological Process (BP) regulation of kinase activity 0.2248 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.4359 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.444 Informative Inherited
Biological Process (BP) regulation of secretion 0.1561 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6999 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5096 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.08714 Informative Inherited
Biological Process (BP) regulation of growth 0.09539 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.7152 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2802 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.002501 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8965 Informative Inherited
Biological Process (BP) regulation of locomotion 0.9359 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.005826 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.04561 Informative Inherited
Biological Process (BP) immune effector process 0.2618 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.008475 Informative Inherited
Biological Process (BP) generation of neurons 0.06922 Informative Inherited
Biological Process (BP) regulation of cell development 0.1894 Informative Inherited
Biological Process (BP) reproductive structure development 0.1476 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) phosphorylation 0.5536 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) activation of immune response 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 7.333e-15 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 1.574e-12 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 2.078e-12 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 2.005e-11 Highly Informative Direct
Biological Process (BP) negative regulation of growth 3.259e-11 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 3.927e-11 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 1.027e-10 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 1.426e-10 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 9.552e-09 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 5.409e-08 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 3.408e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 3.947e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 6.47e-06 Highly Informative Direct
Biological Process (BP) development of primary male sexual characteristics 2.194e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 3.879e-05 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 4.8e-05 Highly Informative Direct
Biological Process (BP) defense response to bacterium 8.372e-05 Highly Informative Direct
Biological Process (BP) interaction with host 0.0002415 Highly Informative Direct
Biological Process (BP) gonad development 0.0003351 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0003568 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0005616 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.00069 Highly Informative Direct
Biological Process (BP) regulation of response to biotic stimulus 0.02036 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.02412 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.1144 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.4311 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.04353 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.001299 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.002598 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.09929 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.007007 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.04232 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.1086 Highly Informative Inherited
Biological Process (BP) response to fungus 0.2729 Highly Informative Inherited
Biological Process (BP) innate immune response 0.03541 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.288 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.3724 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.8613 Highly Informative Inherited
Molecular Function (MF) binding 1.148e-11 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.001899 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) amide binding 1.349e-10 Informative Direct
Molecular Function (MF) lipid binding 1.969e-10 Informative Direct
Molecular Function (MF) RNA binding 3.489e-09 Informative Direct
Molecular Function (MF) receptor binding 2.181e-05 Informative Direct
Molecular Function (MF) protein dimerization activity 0.01779 Informative Inherited
Molecular Function (MF) enzyme binding 0.05644 Informative Inherited
Molecular Function (MF) peptide binding 2.032e-14 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 3.001e-06 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.4643 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.006591 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000159 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.000415 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0443 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.5185 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.05186 Moderately Informative Inherited
Cellular Component (CC) endosome 6.759e-13 Informative Direct
Cellular Component (CC) cell surface 7.511e-11 Informative Direct
Cellular Component (CC) integral to membrane 5.681e-06 Informative Direct
Cellular Component (CC) lytic vacuole 0.02396 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) endosomal part 5.272e-10 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 3.291e-08 Highly Informative Direct
Cellular Component (CC) lysosome 3.825e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1228Least InformativeInherited
Disease Ontology (DO)lung disease2.923e-10Moderately InformativeDirect
Disease Ontology (DO)musculoskeletal system disease0.01692Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.02028Moderately InformativeInherited
Disease Ontology (DO)asthma4.555e-12InformativeDirect
Disease Ontology (DO)opportunistic mycosis2.037e-08InformativeDirect
Disease Ontology (DO)malaria3.465e-06InformativeDirect
Disease Ontology (DO)liver disease0.0008254InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0009087InformativeDirect
Disease Ontology (DO)parasitic helminthiasis infectious disease0.02343InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03655InformativeInherited
Disease Ontology (DO)muscular disease0.2627InformativeInherited
Disease Ontology (DO)aspergillosis1.611e-10Highly InformativeDirect
Disease Ontology (DO)filariasis9.362e-10Highly InformativeDirect
Disease Ontology (DO)dermatomyositis5.609e-05Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0006616Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype1.066e-08Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2222Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2689Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.297Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7249Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.7815Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection1.772e-09Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology7.754e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level1.511e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.001076Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.0111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.01225Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.01473Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.02934Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.03911Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.05253Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1193Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1408Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.244Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.274Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.2951Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.356Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3823Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.433Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection1.444e-10InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001838InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.000203InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000469InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.001053InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.001926InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.001932InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.01632InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.02984InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.0405InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue morphology0.04073InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06903InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.08039InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.08172InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.09284InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.1291InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.1818InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.1896InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.1901InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.1908InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.1981InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.2101InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3794InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4631InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.5243InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.6835InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion6.999e-15Highly InformativeDirect
Mammalian Phenotype (MP)colitis3.132e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion5.669e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating alanine transaminase level7.121e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.0001585Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0002887Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0003602Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0003611Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.0003611Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.0004161Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.000445Highly InformativeDirect
Mammalian Phenotype (MP)gastrointestinal hemorrhage0.00276Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.003687Highly InformativeInherited
Mammalian Phenotype (MP)decreased inflammatory response0.00676Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.05606Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.0893Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.105Highly InformativeInherited
Mammalian Phenotype (MP)abnormal acute inflammation0.2985Highly InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.304Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense2.716e-08InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle9.547e-16Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.541e-09Moderately InformativeDirect
Cellular componentCell projection1.133e-06Moderately InformativeDirect
Cellular componentLysosome1.211e-10InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000157 SSF52200 Protein matches
Abstract

In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate antibacterial and antifungal immunity in insects as well as in mammals. These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 receptor (IL-1R), the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (LTRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase [PubMed8621445]. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain (see ) [PubMed8621445, PubMed9374458, PubMed10679407]. Besides the mammalian and Drosophila melanogaster proteins, a TIR domain is also found in a number of plant proteins implicated in host defense [PubMed9868361]. As MyD88, these proteins are cytoplasmic.

Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements [PubMed10671496].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Toll/Interleukin receptor TIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Toll/Interleukin receptor TIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]