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Toll/Interleukin receptor TIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Toll/Interleukin receptor TIR domain [ 52200]
Families:   Toll/Interleukin receptor TIR domain [ 52201] (2)


Superfamily statistics
Genomes (774) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,667 13,980 4
Proteins 9,246 13,589 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.9828 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1854 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.004017 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000001078 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000006047 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000003586 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00006451 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0005138 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.01382 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9096 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.005023 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.002939 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.01672 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5532 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4873 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) response to other organism 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000000000009147 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000000000009796 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0000000007247 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000000008196 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0000003281 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00001756 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00003943 Informative Direct
Biological Process (BP) regulation of kinase activity 0.1948 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.4417 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.003687 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.7136 Informative Inherited
Biological Process (BP) regulation of secretion 0.1569 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7842 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5778 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.07875 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3686 Informative Inherited
Biological Process (BP) regulation of growth 0.0465 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.565 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3135 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.002954 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8728 Informative Inherited
Biological Process (BP) regulation of locomotion 0.9128 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.0112 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.08458 Informative Inherited
Biological Process (BP) immune effector process 0.205 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02273 Informative Inherited
Biological Process (BP) generation of neurons 0.08889 Informative Inherited
Biological Process (BP) regulation of cell development 0.1891 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.08032 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) phosphorylation 0.5686 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9607 Informative Inherited
Biological Process (BP) leukocyte activation 0.4251 Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0000000000000126 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.00000000000001429 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.000000000003146 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.00000000001067 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.00000000002389 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.00000000004477 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.00000000738 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.0000002863 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.0000008128 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000003515 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.00000394 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000005788 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.0000302 Highly Informative Direct
Biological Process (BP) gonad development 0.00006599 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00006697 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00007207 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0002062 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0007383 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000825 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.02094 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.2966 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.007691 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.02853 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.04466 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.001184 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.002385 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.08464 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.009168 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.04248 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.3426 Highly Informative Inherited
Biological Process (BP) response to fungus 0.3024 Highly Informative Inherited
Biological Process (BP) innate immune response 0.05674 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.2996 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.3919 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.877 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000001463 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.001944 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.0000000001483 Informative Direct
Molecular Function (MF) amide binding 0.0000000001967 Informative Direct
Molecular Function (MF) RNA binding 0.000000002542 Informative Direct
Molecular Function (MF) receptor binding 0.00002152 Informative Direct
Molecular Function (MF) protein dimerization activity 0.01832 Informative Inherited
Molecular Function (MF) enzyme binding 0.0761 Informative Inherited
Molecular Function (MF) peptide binding 0.00000000000004974 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0000005977 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000268 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3904 Least Informative Inherited
Cellular Component (CC) protein complex 0.01688 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.0000000006329 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.00002275 Moderately Informative Direct
Cellular Component (CC) vesicle 0.1513 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.5739 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.05805 Moderately Informative Inherited
Cellular Component (CC) endosome 0.000000000001302 Informative Direct
Cellular Component (CC) cell surface 0.0000000001192 Informative Direct
Cellular Component (CC) integral to membrane 0.000008265 Informative Direct
Cellular Component (CC) lytic vacuole 0.0259 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) endosomal part 0.0000000007058 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.00000004709 Highly Informative Direct
Cellular Component (CC) lysosome 0.0000005236 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1219Least InformativeInherited
Disease Ontology (DO)lung disease0.0000000003098Moderately InformativeDirect
Disease Ontology (DO)muscular disease0.5343Moderately InformativeInherited
Disease Ontology (DO)asthma0.00000000000425InformativeDirect
Disease Ontology (DO)opportunistic mycosis0.00000002906InformativeDirect
Disease Ontology (DO)malaria0.000003356InformativeDirect
Disease Ontology (DO)myositis0.0006598InformativeDirect
Disease Ontology (DO)liver disease0.0008711InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0009669InformativeDirect
Disease Ontology (DO)parasitic helminthiasis infectious disease0.02209InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03764InformativeInherited
Disease Ontology (DO)aspergillosis0.0000000001649Highly InformativeDirect
Disease Ontology (DO)filariasis0.0000000009502Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.00005072Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0006914Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000001101Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2269Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2695Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3203Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7298Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.7817Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000009528Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0000187Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.002536Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.01075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.01179Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.01436Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.02922Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.04662Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.05358Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1422Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1935Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.2621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3084Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3589Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3902Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.507Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0000000001455InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0001889InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0002038InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0004975InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.001147InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.001859InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.001923InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.01725InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.02981InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04146InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06293InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.08069InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.0826InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.138InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.1862InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.1894InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.1936InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.2046InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.2991InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.3609InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3983InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4612InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.5844InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.6772InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.8078InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.00000000000001428Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.0000002787Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00006516Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating alanine transaminase level0.00009638Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.0002516Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0002706Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0003437Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0003676Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.0003692Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0003954Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.0005135Highly InformativeDirect
Mammalian Phenotype (MP)gastrointestinal hemorrhage0.003059Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.003725Highly InformativeInherited
Mammalian Phenotype (MP)decreased inflammatory response0.006005Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.06149Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.1006Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.1025Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.2647Highly InformativeInherited
Mammalian Phenotype (MP)abnormal acute inflammation0.2977Highly InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.3241Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0.000000001787InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000000000001278Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000000003508Moderately InformativeDirect
Cellular componentCell projection0.000001425Moderately InformativeDirect
Cellular componentLysosome0.0000000001238InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000157 SSF52200 Protein matches
Abstract

In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate antibacterial and antifungal immunity in insects as well as in mammals. These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 receptor (IL-1R), the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (LTRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase [PubMed8621445]. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain (see ) [PubMed8621445, PubMed9374458, PubMed10679407]. Besides the mammalian and Drosophila melanogaster proteins, a TIR domain is also found in a number of plant proteins implicated in host defense [PubMed9868361]. As MyD88, these proteins are cytoplasmic.

Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements [PubMed10671496].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Toll/Interleukin receptor TIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Toll/Interleukin receptor TIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]