SUPERFAMILY 1.75 HMM library and genome assignments server


Toll/Interleukin receptor TIR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Toll/Interleukin receptor TIR domain [ 52200]
Families:   Toll/Interleukin receptor TIR domain [ 52201] (2)


Superfamily statistics
Genomes (774) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,667 13,980 4
Proteins 9,246 13,589 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00431 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9835 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1666 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.149e-11 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 4.498e-08 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 3.587e-06 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 1.074e-05 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 5.886e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0004543 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9042 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.004686 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.01441 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5361 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4842 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) response to other organism 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 1.035e-12 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 9.604e-12 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 7.212e-10 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 8.064e-09 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 2.748e-07 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 1.79e-05 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 3.402e-05 Informative Direct
Biological Process (BP) regulation of kinase activity 0.2077 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.4412 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.003366 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.4704 Informative Inherited
Biological Process (BP) regulation of secretion 0.1531 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7814 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5848 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.0763 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3602 Informative Inherited
Biological Process (BP) regulation of growth 0.04576 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.5595 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3298 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to lipid 0.002953 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8742 Informative Inherited
Biological Process (BP) regulation of locomotion 0.9152 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.01058 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.08048 Informative Inherited
Biological Process (BP) immune effector process 0.2132 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02326 Informative Inherited
Biological Process (BP) generation of neurons 0.08504 Informative Inherited
Biological Process (BP) regulation of cell development 0.191 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.07657 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) phosphorylation 0.5642 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9473 Informative Inherited
Biological Process (BP) leukocyte activation 0.4234 Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 1.439e-14 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 1.439e-14 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 2.87e-12 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 1.102e-11 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 2.311e-11 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 4.8e-11 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 8.768e-09 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 2.764e-07 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 6.695e-07 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 3.519e-06 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 3.539e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 4.988e-06 Highly Informative Direct
Biological Process (BP) defense response to bacterium 2.164e-05 Highly Informative Direct
Biological Process (BP) gonad development 6.143e-05 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 6.244e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 6.28e-05 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0002094 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0007011 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000772 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.02382 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.2756 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.005799 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.02932 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.04604 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.001216 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.002588 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.0882 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.008827 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.04358 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.2888 Highly Informative Inherited
Biological Process (BP) response to fungus 0.3315 Highly Informative Inherited
Biological Process (BP) innate immune response 0.06383 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.298 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.4071 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.895 Highly Informative Inherited
Molecular Function (MF) binding 5.491e-11 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.001977 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 1.513e-10 Informative Direct
Molecular Function (MF) amide binding 2.051e-10 Informative Direct
Molecular Function (MF) RNA binding 2.472e-09 Informative Direct
Molecular Function (MF) receptor binding 2.127e-05 Informative Direct
Molecular Function (MF) protein dimerization activity 0.01874 Informative Inherited
Molecular Function (MF) enzyme binding 0.07241 Informative Inherited
Molecular Function (MF) peptide binding 4.364e-14 Highly Informative Direct
Molecular Function (MF) kinase binding 5.09e-07 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 2.716e-06 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3607 Least Informative Inherited
Cellular Component (CC) protein complex 0.01455 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 5.547e-10 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 2.053e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.143 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.6032 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.05794 Moderately Informative Inherited
Cellular Component (CC) endosome 9.224e-13 Informative Direct
Cellular Component (CC) cell surface 1.427e-10 Informative Direct
Cellular Component (CC) integral to membrane 8.772e-06 Informative Direct
Cellular Component (CC) lytic vacuole 0.02655 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) endosomal part 6.567e-10 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 4.239e-08 Highly Informative Direct
Cellular Component (CC) lysosome 4.792e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1354Least InformativeInherited
Disease Ontology (DO)lung disease2.887e-10Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.02197Moderately InformativeInherited
Disease Ontology (DO)asthma4.535e-12InformativeDirect
Disease Ontology (DO)opportunistic mycosis2.102e-08InformativeDirect
Disease Ontology (DO)malaria3.339e-06InformativeDirect
Disease Ontology (DO)liver disease0.0008094InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0008367InformativeDirect
Disease Ontology (DO)muscle tissue disease0.01482InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.02214InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03514InformativeInherited
Disease Ontology (DO)aspergillosis1.672e-10Highly InformativeDirect
Disease Ontology (DO)filariasis9.58e-10Highly InformativeDirect
Disease Ontology (DO)dermatomyositis5.717e-05Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0006127Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype1.07e-08Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.2266Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2697Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3088Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7299Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.7813Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology9.173e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level1.793e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.002515Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.01084Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.01191Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.01448Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.02961Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.0463Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.05346Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1199Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1446Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1934Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.2672Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3043Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3574Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3903Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.5196Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection1.369e-10InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000185InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0002034InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0004772InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage physiology0.001089InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.001847InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.001951InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.01731InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.03004InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04117InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.08137InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.08238InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.185InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.1895InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.1927InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.2069InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.301InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.3572InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3961InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4535InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.5836InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.6768InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.808InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.9667InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion1.424e-14Highly InformativeDirect
Mammalian Phenotype (MP)colitis2.841e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion6.153e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating alanine transaminase level9.735e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.0002535Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.000273Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.0003459Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.0003459Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0003706Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0003979Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular wound healing0.0005172Highly InformativeDirect
Mammalian Phenotype (MP)gastrointestinal hemorrhage0.003062Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.003764Highly InformativeInherited
Mammalian Phenotype (MP)decreased inflammatory response0.006264Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.06149Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.09716Highly InformativeInherited
Mammalian Phenotype (MP)abnormal immune organ physiology0.1038Highly InformativeInherited
Mammalian Phenotype (MP)abnormal acute inflammation0.2999Highly InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.3206Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense1.787e-09InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle1.278e-15Moderately InformativeDirect
Cellular componentEndoplasmic reticulum3.508e-09Moderately InformativeDirect
Cellular componentCell projection1.425e-06Moderately InformativeDirect
Cellular componentLysosome1.238e-10InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000157 SSF52200 Protein matches
Abstract

In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate antibacterial and antifungal immunity in insects as well as in mammals. These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 receptor (IL-1R), the Toll/IL-1R homologous region (TIR). The similarity between Toll-like receptors (LTRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase [PubMed8621445]. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain (see ) [PubMed8621445, PubMed9374458, PubMed10679407]. Besides the mammalian and Drosophila melanogaster proteins, a TIR domain is also found in a number of plant proteins implicated in host defense [PubMed9868361]. As MyD88, these proteins are cytoplasmic.

Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements [PubMed10671496].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Toll/Interleukin receptor TIR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Toll/Interleukin receptor TIR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]