SUPERFAMILY 1.75 HMM library and genome assignments server


FabD/lysophospholipase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FabD/lysophospholipase-like [ 52150]
Superfamily:   FabD/lysophospholipase-like [ 52151] (3)
Families:   FabD-like [ 52152]
  Lysophospholipase [ 53645]
  Patatin [ 89729]


Superfamily statistics
Genomes (2,962) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,111 73,264 4
Proteins 20,707 70,062 4


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.091230Least InformativeInherited
Biological Process (BP)cellular lipid metabolic process9.565e-070Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.067730.6772Moderately InformativeInherited
Biological Process (BP)lipid catabolic process8.383e-051.094e-07InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.011975.371e-07InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.010080.01367Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0052340Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds8.159e-070Moderately InformativeDirect
Molecular Function (MF)lipase activity6.793e-160Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity1.046e-050Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.009249 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.006e-08 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 3.776e-11 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 4.026e-09 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.1222 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.722 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.1888 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6772 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.866 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7624 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7938 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2871 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.7572 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 2.484e-05 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0009476 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 1.936e-15 Informative Direct
Biological Process (BP) fatty acid metabolic process 1.064e-05 Informative Direct
Biological Process (BP) phospholipid metabolic process 9.952e-13 Informative Direct
Biological Process (BP) lipid localization 0.0004546 Informative Direct
Biological Process (BP) lipid catabolic process 1.094e-07 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 6.875e-10 Informative Direct
Biological Process (BP) amide biosynthetic process 1.205e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 5.371e-07 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 2.79e-14 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 8.321e-05 Informative Direct
Biological Process (BP) apoptotic process 0.2267 Informative Inherited
Biological Process (BP) peptide metabolic process 0.02011 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.006821 Informative Inherited
Biological Process (BP) anion transport 0.182 Informative Inherited
Biological Process (BP) organic acid transport 0.007825 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.6208 Informative Inherited
Biological Process (BP) icosanoid metabolic process 3.38e-05 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.0001574 Highly Informative Direct
Biological Process (BP) pathogenesis 1.651e-06 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 2.298e-07 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 7.563e-06 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 7.341e-15 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 1.936e-15 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 3.733e-05 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 2.203e-13 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 2.997e-06 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0001202 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 1.461e-09 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 3.569e-05 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.03755 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.003301 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.9759 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.01367 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.8345 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.7828 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.12 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.6645 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.5503 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0003101 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 4.605e-06 Informative Direct
Molecular Function (MF) lipid binding 0.03482 Informative Inherited
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0001038 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 6.054e-07 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.4681 Highly Informative Inherited
Molecular Function (MF) C-acyltransferase activity 0.07703 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1864 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1.599e-05 Moderately Informative Direct
Cellular Component (CC) endomembrane system 6.206e-05 Moderately Informative Direct
Cellular Component (CC) cytosol 0.1008 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.1253 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 7.359e-08 Informative Direct
Cellular Component (CC) external encapsulating structure 1.671e-06 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors2.604e-06Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0623Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.09129Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase2.991e-11InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s8.493e-10InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.004241InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I3.708e-15Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism3.174e-05Moderately InformativeDirect
Disease Ontology (DO)overnutrition2.223e-06InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.000416InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal total tissue mass0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.01258Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.2858Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor4.198e-09InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.006119InformativeInherited
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase4.053e-11Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)7.005e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processNeurogenesis2.462e-09InformativeDirect
Biological processSporulation3.517e-05InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processLipid degradation0Highly InformativeDirect
Biological processAntibiotic biosynthesis7.064e-14Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle2.151e-10Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome1.485e-06InformativeDirect
Cellular componentLipid droplet6.928e-15Highly InformativeDirect
DomainTransmembrane5.646e-08Least InformativeDirect
DomainCoiled coil6.03e-06Moderately InformativeDirect
Molecular functionCalcium4.301e-07Moderately InformativeDirect
Molecular functionNADP4.572e-15InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1.69e-06Least InformativeDirect
Post-translational modificationAcyltransferase4.442e-16InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein2.729e-12Least InformativeDirect
Post-translational modificationGlycoprotein0.0004123Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism3.685e-14Moderately InformativeDirect
UniPathway (UP)alcohol metabolism2.991e-06Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.08663Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis3.433e-12InformativeDirect
UniPathway (UP)polyketide biosynthesis2.107e-08InformativeDirect
UniPathway (UP)glycerol metabolism7.266e-08InformativeDirect
UniPathway (UP)glycerolipid degradation0Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis9.314e-13Highly InformativeDirect
UniPathway (UP)bacillaene biosynthesis1.48e-05Highly InformativeDirect
UniPathway (UP)erythromycin biosynthesis0.0001355Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FabD/lysophospholipase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the FabD/lysophospholipase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]