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FabD/lysophospholipase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FabD/lysophospholipase-like [ 52150]
Superfamily:   FabD/lysophospholipase-like [ 52151] (3)
Families:   FabD-like [ 52152]
  Lysophospholipase [ 53645]
  Patatin [ 89729]


Superfamily statistics
Genomes (2,963) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,114 73,264 4
Proteins 20,710 70,062 4


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.092760Least InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.0000009540Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.067650.678Moderately InformativeInherited
Biological Process (BP)lipid catabolic process0.00008360.0000001054InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.011790.0000005863InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.0097230.01236Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0053520Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.00000088950Moderately InformativeDirect
Molecular Function (MF)lipase activity6.78e-160Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity0.0000097330Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.008998 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00000001027 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00000000004747 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.000000003781 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.1222 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.7223 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.1894 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.678 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.8661 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7591 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7906 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2882 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.7568 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.00002526 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0009683 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0.000000000000001931 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000008561 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.000000000001041 Informative Direct
Biological Process (BP) lipid localization 0.0004508 Informative Direct
Biological Process (BP) lipid catabolic process 0.0000001054 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000000006938 Informative Direct
Biological Process (BP) amide biosynthetic process 0.00001193 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000005863 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00000000000002112 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00008084 Informative Direct
Biological Process (BP) apoptotic process 0.2347 Informative Inherited
Biological Process (BP) peptide metabolic process 0.0208 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.006778 Informative Inherited
Biological Process (BP) anion transport 0.1823 Informative Inherited
Biological Process (BP) organic acid transport 0.007773 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.6232 Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.0000321 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.0001557 Highly Informative Direct
Biological Process (BP) pathogenesis 0.000001629 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.0000002279 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000007497 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.000000000000005576 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.000000000000001931 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.000037 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.0000000000002154 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.000002973 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0001195 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0.000000001439 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.00003566 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.03941 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.003368 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.9748 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 1 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.01236 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.8346 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.7773 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.1185 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.6656 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.5495 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0003064 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.000004552 Informative Direct
Molecular Function (MF) lipid binding 0.03482 Informative Inherited
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0001025 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.0000005986 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.4548 Highly Informative Inherited
Molecular Function (MF) C-acyltransferase activity 0.07704 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1812 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00001542 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.00005988 Moderately Informative Direct
Cellular Component (CC) cytosol 0.1026 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.124 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00000007206 Informative Direct
Cellular Component (CC) external encapsulating structure 0.000001636 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000002604Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0623Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.09129Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000002991InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000008493InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.004241InformativeInherited
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0.000000000000003708Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.00003176Moderately InformativeDirect
Disease Ontology (DO)overnutrition0.000002221InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.0004166InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal total tissue mass0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.01158Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.2856Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000000422InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.006134InformativeInherited
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0000000000404Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.00000000006965Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processNeurogenesis0.000000002462InformativeDirect
Biological processSporulation0.00003517InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processLipid degradation0Highly InformativeDirect
Biological processAntibiotic biosynthesis0.00000000000007064Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000002151Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome0.000001485InformativeDirect
Cellular componentLipid droplet0.000000000000006928Highly InformativeDirect
DomainTransmembrane0.00000005646Least InformativeDirect
DomainCoiled coil0.00000603Moderately InformativeDirect
Molecular functionCalcium0.0000004301Moderately InformativeDirect
Molecular functionNADP0.000000000000004572InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.00000169Least InformativeDirect
Post-translational modificationAcyltransferase4.442e-16InformativeDirect
Post-translational modificationStorage protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000000000002729Least InformativeDirect
Post-translational modificationGlycoprotein0.0004123Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)polyketide biosynthesis0InformativeDirect
UniPathway (UP)bacillaene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FabD/lysophospholipase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the FabD/lysophospholipase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]