FabD/lysophospholipase-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a/b) [ 51349] (147)
Fold:	FabD/lysophospholipase-like [ 52150]
Superfamily:	FabD/lysophospholipase-like [ 52151] (3)
Families:	FabD-like [ 52152]
	Lysophospholipase [ 53645]
	Patatin [ 89729]

Superfamily statistics

	Genomes (2,274)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	18,277	39,612	4
Proteins	17,171	37,236	4

Functional annotation

General category	Metabolism
Detailed category	Transferases

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	single-organism metabolic process	0.02922	0	Least Informative	Inherited
Biological Process (BP)	cellular lipid metabolic process	1.74e-07	0	Moderately Informative	Direct
Biological Process (BP)	cellular catabolic process	0.03139	0.1129	Moderately Informative	Inherited
Biological Process (BP)	organic substance catabolic process	0.06059	0.3823	Moderately Informative	Inherited
Biological Process (BP)	lipid catabolic process	8.693e-05	8.599e-08	Informative	Direct
Biological Process (BP)	glycerolipid metabolic process	0.01519	6.236e-08	Informative	Inherited
Biological Process (BP)	acylglycerol metabolic process	0.009018	0.06479	Highly Informative	Inherited
Molecular Function (MF)	hydrolase activity	0.04326	1.244e-13	Least Informative	Inherited
Molecular Function (MF)	hydrolase activity, acting on ester bonds	0.0001025	0	Moderately Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	single-organism metabolic process	0	Least Informative	Direct
Biological Process (BP)	biosynthetic process	3.458e-07	Least Informative	Direct
Biological Process (BP)	cellular component organization or biogenesis	0.8017	Least Informative	Inherited
Biological Process (BP)	response to stimulus	1	Least Informative	Inherited
Biological Process (BP)	regulation of metabolic process	1	Least Informative	Inherited
Biological Process (BP)	cellular aromatic compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	organic cyclic compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	localization	1	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	1	Least Informative	Inherited
Biological Process (BP)	nitrogen compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	cellular lipid metabolic process	0	Moderately Informative	Direct
Biological Process (BP)	monocarboxylic acid metabolic process	1.283e-08	Moderately Informative	Direct
Biological Process (BP)	lipid biosynthetic process	7.411e-13	Moderately Informative	Direct
Biological Process (BP)	organic hydroxy compound metabolic process	9.858e-14	Moderately Informative	Direct
Biological Process (BP)	organophosphate metabolic process	8.096e-10	Moderately Informative	Direct
Biological Process (BP)	small molecule biosynthetic process	4.316e-05	Moderately Informative	Direct
Biological Process (BP)	cellular response to chemical stimulus	0.3645	Moderately Informative	Inherited
Biological Process (BP)	aromatic compound biosynthetic process	0.9561	Moderately Informative	Inherited
Biological Process (BP)	organic cyclic compound biosynthetic process	1	Moderately Informative	Inherited
Biological Process (BP)	ion transport	0.3324	Moderately Informative	Inherited
Biological Process (BP)	cellular catabolic process	0.1129	Moderately Informative	Inherited
Biological Process (BP)	organic substance catabolic process	0.3823	Moderately Informative	Inherited
Biological Process (BP)	phosphate-containing compound metabolic process	0.8373	Moderately Informative	Inherited
Biological Process (BP)	positive regulation of metabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	cellular component biogenesis	0.06168	Moderately Informative	Inherited
Biological Process (BP)	organic substance transport	0.4333	Moderately Informative	Inherited
Biological Process (BP)	macromolecule localization	0.4683	Moderately Informative	Inherited
Biological Process (BP)	regulation of localization	0.4863	Moderately Informative	Inherited
Biological Process (BP)	multi-organism process	0.01634	Moderately Informative	Inherited
Biological Process (BP)	carbohydrate derivative metabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	cellular amino acid metabolic process	0.821	Moderately Informative	Inherited
Biological Process (BP)	lipid catabolic process	8.599e-08	Informative	Direct
Biological Process (BP)	glycerolipid metabolic process	6.236e-08	Informative	Direct
Biological Process (BP)	fatty acid metabolic process	0.0001038	Informative	Direct
Biological Process (BP)	cellular biogenic amine metabolic process	0	Informative	Direct
Biological Process (BP)	phospholipid metabolic process	1.711e-13	Informative	Direct
Biological Process (BP)	alcohol metabolic process	3.571e-09	Informative	Direct
Biological Process (BP)	monocarboxylic acid biosynthetic process	2.058e-08	Informative	Direct
Biological Process (BP)	lipid transport	6.85e-06	Informative	Direct
Biological Process (BP)	cellular membrane organization	3.208e-05	Informative	Direct
Biological Process (BP)	regulation of lipid metabolic process	0.0001319	Informative	Direct
Biological Process (BP)	organic acid transport	0.000272	Informative	Direct
Biological Process (BP)	cellular modified amino acid metabolic process	0.0003542	Informative	Direct
Biological Process (BP)	apoptotic process	0.3481	Informative	Inherited
Biological Process (BP)	organic hydroxy compound biosynthetic process	0.02502	Informative	Inherited
Biological Process (BP)	anion transport	0.01073	Informative	Inherited
Biological Process (BP)	secretion	0.01073	Informative	Inherited
Biological Process (BP)	organophosphate catabolic process	0.1009	Informative	Inherited
Biological Process (BP)	cell wall biogenesis	2.484e-13	Highly Informative	Direct
Biological Process (BP)	ethanolamine-containing compound metabolic process	5.624e-13	Highly Informative	Direct
Biological Process (BP)	regulation of lipid storage	1.428e-09	Highly Informative	Direct
Biological Process (BP)	phenol-containing compound metabolic process	1.859e-08	Highly Informative	Direct
Biological Process (BP)	monocarboxylic acid transport	8.472e-08	Highly Informative	Direct
Biological Process (BP)	positive regulation of lipid metabolic process	2.407e-06	Highly Informative	Direct
Biological Process (BP)	diol metabolic process	2.948e-06	Highly Informative	Direct
Biological Process (BP)	pathogenesis	5.33e-05	Highly Informative	Direct
Biological Process (BP)	response to toxic substance	0.0003846	Highly Informative	Direct
Biological Process (BP)	acylglycerol metabolic process	0.06479	Highly Informative	Inherited
Biological Process (BP)	polyol metabolic process	0.5437	Highly Informative	Inherited
Biological Process (BP)	alcohol biosynthetic process	0.6378	Highly Informative	Inherited
Biological Process (BP)	phosphatidylinositol metabolic process	1	Highly Informative	Inherited
Biological Process (BP)	secondary metabolite biosynthetic process	0.4945	Highly Informative	Inherited
Biological Process (BP)	icosanoid biosynthetic process	0.003349	Highly Informative	Inherited
Biological Process (BP)	unsaturated fatty acid metabolic process	0.4337	Highly Informative	Inherited
Molecular Function (MF)	hydrolase activity	1.244e-13	Least Informative	Direct
Molecular Function (MF)	transferase activity	1	Least Informative	Inherited
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	hydrolase activity, acting on ester bonds	0	Moderately Informative	Direct
Molecular Function (MF)	anion binding	0.0214	Moderately Informative	Inherited
Molecular Function (MF)	cation binding	0.2905	Moderately Informative	Inherited
Molecular Function (MF)	transferase activity, transferring acyl groups	0	Informative	Direct
Molecular Function (MF)	lipid binding	0.0007935	Informative	Direct
Molecular Function (MF)	carboxylic ester hydrolase activity	0	Highly Informative	Direct
Molecular Function (MF)	calcium ion binding	0.000133	Highly Informative	Direct
Molecular Function (MF)	phospholipase activity	0.01452	Highly Informative	Inherited
Cellular Component (CC)	cytoplasmic part	2.344e-08	Least Informative	Direct
Cellular Component (CC)	intracellular organelle part	1	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	1	Least Informative	Inherited
Cellular Component (CC)	membrane	0.05123	Least Informative	Inherited
Cellular Component (CC)	protein complex	1	Least Informative	Inherited
Cellular Component (CC)	endoplasmic reticulum	7.894e-08	Moderately Informative	Direct
Cellular Component (CC)	endomembrane system	2.477e-05	Moderately Informative	Direct
Cellular Component (CC)	organelle membrane	0.0002716	Moderately Informative	Direct
Cellular Component (CC)	cytosol	0.01748	Moderately Informative	Inherited
Cellular Component (CC)	endoplasmic reticulum membrane	1.65e-10	Informative	Direct
Cellular Component (CC)	external encapsulating structure	3.062e-09	Informative	Direct
Cellular Component (CC)	cell wall	5.832e-11	Highly Informative	Direct
Cellular Component (CC)	lipid particle	1.032e-08	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on ester bonds	0	Least Informative	Direct
Enzyme Commission (EC)	Lyases	1	Least Informative	Inherited
Enzyme Commission (EC)	Oxidoreductases	1	Least Informative	Inherited
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	Moderately Informative	Direct
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on the CH-CH group of donors	2.604e-06	Moderately Informative	Direct
Enzyme Commission (EC)	Hydro-lyases	0.0623	Moderately Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.09129	Moderately Informative	Inherited
Enzyme Commission (EC)	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat	0	Informative	Direct
Enzyme Commission (EC)	[Acyl-carrier-protein] S-acetyltransferase	0	Informative	Direct
Enzyme Commission (EC)	Fatty-acid synthase	2.991e-11	Informative	Direct
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s	8.493e-10	Informative	Direct
Enzyme Commission (EC)	Thiolester hydrolases	0.004241	Informative	Inherited
Enzyme Commission (EC)	[Acyl-carrier-protein] S-malonyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	0	Highly Informative	Direct
Enzyme Commission (EC)	Lysophospholipase	0	Highly Informative	Direct
Enzyme Commission (EC)	Beta-ketoacyl-acyl-carrier-protein synthase I	3.708e-15	Highly Informative	Direct

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of metabolism	3.943e-05	Moderately Informative	Direct
Disease Ontology (DO)	overnutrition	2.432e-06	Informative	Direct
Disease Ontology (DO)	lysosomal storage disease	0.0004505	Informative	Direct

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0	Moderately Informative	Direct

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)

	FA term	FDR (all)	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organ system	0	Least Informative	Direct

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	viscus	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	gonad	0	Least Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	Least Informative	Direct
Enzyme Commission (EC)	Oxidoreductases	1	Least Informative	Inherited
Enzyme Commission (EC)	Lyases	1	Least Informative	Inherited
Enzyme Commission (EC)	Acyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.01305	Moderately Informative	Inherited
Enzyme Commission (EC)	Carbon-oxygen lyases	0.2869	Moderately Informative	Inherited
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	3.882e-09	Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.006405	Informative	Inherited
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	0	Highly Informative	Direct
Enzyme Commission (EC)	[Acyl-carrier-protein] S-acetyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	[Acyl-carrier-protein] S-malonyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	Beta-ketoacyl-[acyl-carrier-protein] synthase I	0	Highly Informative	Direct
Enzyme Commission (EC)	Fatty-acyl-CoA synthase	0	Highly Informative	Direct
Enzyme Commission (EC)	Lysophospholipase	0	Highly Informative	Direct
Enzyme Commission (EC)	Oleoyl-[acyl-carrier-protein] hydrolase	0	Highly Informative	Direct
Enzyme Commission (EC)	Fatty-acid synthase	3.673e-11	Highly Informative	Direct
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)	1.135e-09	Highly Informative	Direct

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Lipid metabolism	0	Moderately Informative	Direct
Biological process	Plant defense	0	Informative	Direct
Biological process	Neurogenesis	7.433e-10	Informative	Direct
Biological process	Sporulation	2.597e-05	Informative	Direct
Biological process	Lipid biosynthesis	1	Informative	Inherited
Biological process	Lipid degradation	0	Highly Informative	Direct
Biological process	Antibiotic biosynthesis	3.859e-15	Highly Informative	Direct
Cellular component	Membrane	0	Least Informative	Direct
Cellular component	Endoplasmic reticulum	0	Moderately Informative	Direct
Cellular component	Cytoplasmic vesicle	7.816e-11	Moderately Informative	Direct
Cellular component	Vacuole	0	Informative	Direct
Cellular component	Lysosome	1.093e-06	Informative	Direct
Cellular component	Lipid droplet	9.575e-16	Highly Informative	Direct
Domain	Transmembrane	8.385e-07	Least Informative	Direct
Domain	Coiled coil	1.245e-05	Moderately Informative	Direct
Molecular function	Calcium	9.113e-08	Moderately Informative	Direct
Molecular function	NADP	1.831e-15	Informative	Direct
Molecular function	Phosphopantetheine	0	Highly Informative	Direct
Post-translational modification	Hydrolase	0	Least Informative	Direct
Post-translational modification	Transferase	6.34e-07	Least Informative	Direct
Post-translational modification	Acyltransferase	0	Informative	Direct
Post-translational modification	Storage protein	0	Highly Informative	Direct
Post-translational modification	Glycoprotein	4.498e-16	Least Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	lipid metabolism	0	Least Informative	Direct
UniPathway (UP)	secondary metabolite metabolism	0	Moderately Informative	Direct
UniPathway (UP)	fatty acid metabolism	1.387e-13	Moderately Informative	Direct
UniPathway (UP)	alcohol metabolism	2.663e-06	Moderately Informative	Direct
UniPathway (UP)	lipid biosynthesis	0.09092	Moderately Informative	Inherited
UniPathway (UP)	fatty acid biosynthesis	0	Informative	Direct
UniPathway (UP)	antibiotic biosynthesis	0	Informative	Direct
UniPathway (UP)	toxin biosynthesis	1.461e-12	Informative	Direct
UniPathway (UP)	polyketide biosynthesis	1.842e-09	Informative	Direct
UniPathway (UP)	glycerol metabolism	6.195e-08	Informative	Direct
UniPathway (UP)	mycotoxin biosynthesis	3.219e-13	Highly Informative	Direct
UniPathway (UP)	bacillaene biosynthesis	5.986e-05	Highly Informative	Direct
UniPathway (UP)	erythromycin biosynthesis	0.0003015	Highly Informative	Direct

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a FabD/lysophospholipase-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the FabD/lysophospholipase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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FabD/lysophospholipase-like superfamily