Caspase-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a/b) [ 51349] (147)
Fold:	Caspase-like [ 52128]
Superfamily:	Caspase-like [ 52129] (2)
Families:	Caspase catalytic domain [ 52130] (7)
	Gingipain R (RgpB), N-terminal domain [ 52137]

Superfamily statistics

	Genomes (802)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	3,819	5,414	38
Proteins	3,756	5,364	38

Functional annotation

General category	Processes_IC
Detailed category	Proteases

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	protein metabolic process	3.949e-10	0	Least Informative	Direct
Biological Process (BP)	single-organism cellular process	2.369e-05	5.313e-12	Least Informative	Direct
Biological Process (BP)	response to stimulus	0.08455	2.491e-08	Least Informative	Inherited
Biological Process (BP)	cellular macromolecule metabolic process	0.986	1	Least Informative	Inherited
Biological Process (BP)	regulation of cellular process	5.47e-08	0.001847	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	0.0066	0.4577	Least Informative	Inherited
Biological Process (BP)	response to abiotic stimulus	0.0004747	2.253e-06	Moderately Informative	Direct
Biological Process (BP)	positive regulation of cellular process	1.846e-07	5.966e-15	Moderately Informative	Direct
Biological Process (BP)	signal transduction	0.1888	0.1209	Moderately Informative	Inherited
Biological Process (BP)	cellular catabolic process	0.04322	0.04866	Moderately Informative	Inherited
Biological Process (BP)	organic substance catabolic process	0.4832	0.9253	Moderately Informative	Inherited
Biological Process (BP)	gene expression	0.2266	0.8364	Moderately Informative	Inherited
Biological Process (BP)	proteolysis	1.715e-09	0	Informative	Direct
Biological Process (BP)	cellular component disassembly	5.209e-08	2.292e-07	Informative	Direct
Biological Process (BP)	cellular macromolecule catabolic process	0.0002102	7.215e-05	Informative	Direct
Biological Process (BP)	apoptotic process	0	0.001157	Informative	Inherited
Biological Process (BP)	intracellular signal transduction	0.02245	9.606e-05	Informative	Inherited
Biological Process (BP)	response to light stimulus	0.8671	0.5839	Informative	Inherited
Biological Process (BP)	regulation of apoptotic process	0	0.1903	Informative	Inherited
Biological Process (BP)	cellular component disassembly involved in execution phase of apoptosis	2.128e-12	1.081e-05	Highly Informative	Direct
Biological Process (BP)	response to UV	4.882e-07	0	Highly Informative	Direct
Biological Process (BP)	protein processing	5.229e-10	0	Highly Informative	Direct
Biological Process (BP)	positive regulation of apoptotic process	2.545e-08	1.492e-11	Highly Informative	Direct
Biological Process (BP)	apoptotic signaling pathway	7.857e-05	1.203e-12	Highly Informative	Direct
Molecular Function (MF)	hydrolase activity	0	0	Least Informative	Direct
Molecular Function (MF)	peptidase activity	0	0	Informative	Direct
Molecular Function (MF)	endopeptidase activity	0.1795	0.0005559	Highly Informative	Inherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	protein metabolic process	0	Least Informative	Direct
Biological Process (BP)	single-organism cellular process	5.313e-12	Least Informative	Direct
Biological Process (BP)	response to stimulus	2.491e-08	Least Informative	Direct
Biological Process (BP)	regulation of metabolic process	1	Least Informative	Inherited
Biological Process (BP)	developmental process	0.03169	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	0.3072	Least Informative	Inherited
Biological Process (BP)	cellular macromolecule metabolic process	1	Least Informative	Inherited
Biological Process (BP)	regulation of cellular process	0.001847	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	0.4577	Least Informative	Inherited
Biological Process (BP)	immune system process	0.0001187	Moderately Informative	Direct
Biological Process (BP)	response to abiotic stimulus	2.253e-06	Moderately Informative	Direct
Biological Process (BP)	tissue development	0.0006763	Moderately Informative	Direct
Biological Process (BP)	response to organic substance	0.0002983	Moderately Informative	Direct
Biological Process (BP)	positive regulation of cellular process	5.966e-15	Moderately Informative	Direct
Biological Process (BP)	regulation of molecular function	5.933e-05	Moderately Informative	Direct
Biological Process (BP)	anatomical structure morphogenesis	0.5418	Moderately Informative	Inherited
Biological Process (BP)	cellular catabolic process	0.04866	Moderately Informative	Inherited
Biological Process (BP)	organic substance catabolic process	0.9253	Moderately Informative	Inherited
Biological Process (BP)	regulation of cell communication	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of signaling	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of response to stimulus	1	Moderately Informative	Inherited
Biological Process (BP)	signal transduction	0.1209	Moderately Informative	Inherited
Biological Process (BP)	cellular response to stress	0.00228	Moderately Informative	Inherited
Biological Process (BP)	cellular response to chemical stimulus	0.05171	Moderately Informative	Inherited
Biological Process (BP)	gene expression	0.8364	Moderately Informative	Inherited
Biological Process (BP)	multi-organism process	0.2289	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	0.3934	Moderately Informative	Inherited
Biological Process (BP)	proteolysis	0	Informative	Direct
Biological Process (BP)	cellular component disassembly	2.292e-07	Informative	Direct
Biological Process (BP)	intracellular signal transduction	9.606e-05	Informative	Direct
Biological Process (BP)	cellular macromolecule catabolic process	7.215e-05	Informative	Direct
Biological Process (BP)	apoptotic process	0.001157	Informative	Inherited
Biological Process (BP)	regulation of hydrolase activity	0.0011	Informative	Inherited
Biological Process (BP)	protein catabolic process	0.5848	Informative	Inherited
Biological Process (BP)	positive regulation of signal transduction	0.02672	Informative	Inherited
Biological Process (BP)	positive regulation of catalytic activity	0.002743	Informative	Inherited
Biological Process (BP)	regulation of intracellular protein kinase cascade	0.007228	Informative	Inherited
Biological Process (BP)	response to inorganic substance	0.3049	Informative	Inherited
Biological Process (BP)	response to other organism	0.01124	Informative	Inherited
Biological Process (BP)	response to light stimulus	0.5839	Informative	Inherited
Biological Process (BP)	regulation of apoptotic process	0.1903	Informative	Inherited
Biological Process (BP)	cellular component disassembly involved in execution phase of apoptosis	1.081e-05	Highly Informative	Direct
Biological Process (BP)	ER-nucleus signaling pathway	1.419e-07	Highly Informative	Direct
Biological Process (BP)	response to UV	0	Highly Informative	Direct
Biological Process (BP)	positive regulation of peptidase activity	0	Highly Informative	Direct
Biological Process (BP)	protein processing	0	Highly Informative	Direct
Biological Process (BP)	response to endoplasmic reticulum stress	0.0001592	Highly Informative	Direct
Biological Process (BP)	response to topologically incorrect protein	5.836e-05	Highly Informative	Direct
Biological Process (BP)	positive regulation of apoptotic process	1.492e-11	Highly Informative	Direct
Biological Process (BP)	apoptotic signaling pathway	1.203e-12	Highly Informative	Direct
Biological Process (BP)	post-embryonic development	0.08955	Highly Informative	Inherited
Biological Process (BP)	regulation of neuron apoptotic process	0.1087	Highly Informative	Inherited
Molecular Function (MF)	hydrolase activity	0	Least Informative	Direct
Molecular Function (MF)	binding	0.001314	Least Informative	Inherited
Molecular Function (MF)	protein binding	3.761e-10	Moderately Informative	Direct
Molecular Function (MF)	enzyme regulator activity	0.0003796	Moderately Informative	Direct
Molecular Function (MF)	peptidase activity	0	Informative	Direct
Molecular Function (MF)	endopeptidase activity	0.0005559	Highly Informative	Direct
Cellular Component (CC)	protein complex	0.001893	Least Informative	Inherited
Cellular Component (CC)	cytoplasmic part	0.007021	Least Informative	Inherited
Cellular Component (CC)	cytosol	6.51e-06	Moderately Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	Least Informative	Direct
Enzyme Commission (EC)	Cysteine endopeptidases	0	Moderately Informative	Direct

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	cell type cancer	0.07076	Moderately Informative	Inherited
Disease Ontology (DO)	melanoma	0.0008764	Highly Informative	Direct

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	cellular phenotype	0.0009807	Least Informative	Direct
Mammalian Phenotype (MP)	immune system phenotype	0.002032	Least Informative	Inherited
Mammalian Phenotype (MP)	nervous system phenotype	0.01858	Least Informative	Inherited
Mammalian Phenotype (MP)	mortality/aging	0.1355	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal homeostasis	0.7663	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal cell death	0.001405	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal protein level	0.02521	Moderately Informative	Inherited
Mammalian Phenotype (MP)	altered susceptibility to infection	0.04968	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.06522	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.0678	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.07389	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.2127	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.5009	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal T cell physiology	1.928e-07	Informative	Direct
Mammalian Phenotype (MP)	abnormal neuron physiology	3.473e-05	Informative	Direct
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.001102	Informative	Inherited
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.007049	Informative	Inherited
Mammalian Phenotype (MP)	abnormal interleukin level	0.007844	Informative	Inherited
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.1066	Informative	Inherited
Mammalian Phenotype (MP)	decreased apoptosis	1.486e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased physiological sensitivity to xenobiotic	8.26e-05	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal immune organ physiology	0.0001113	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal interleukin-1 beta secretion	0.0001297	Highly Informative	Direct
Mammalian Phenotype (MP)	decreased susceptibility to bacterial infection	0.0003677	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal neuron apoptosis	0.000516	Highly Informative	Direct
Mammalian Phenotype (MP)	altered susceptibility to infection induced morbidity/mortality	0.009285	Highly Informative	Inherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	cell physiology variant	0.01783	Least Informative	Inherited
Worm Phenotype (WP)	cell death variant	0.0001827	Moderately Informative	Direct

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)

	FP term	FDR (all)	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	visible	8.485e-05	Moderately Informative	Direct
Fly Phenotype (FP)	cell death defective	3.754e-08	Informative	Direct

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)

	FA term	FDR (all)	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organ system	0	Least Informative	Direct
Fly Anatomy (FA)	multi-tissue structure	0.2056	Least Informative	Inherited
Fly Anatomy (FA)	cell	0.4396	Least Informative	Inherited
Fly Anatomy (FA)	gonad	0.0107	Moderately Informative	Inherited
Fly Anatomy (FA)	developing material anatomical entity	0.3747	Moderately Informative	Inherited
Fly Anatomy (FA)	germline cyst	0.003356	Informative	Inherited
Fly Anatomy (FA)	testis	0.2228	Informative	Inherited
Fly Anatomy (FA)	gland	0.0001177	Highly Informative	Direct

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot internode	0	Least Informative	Direct
Plant ANatomical entity (PAN)	root	0	Least Informative	Direct
Plant ANatomical entity (PAN)	microsporophyll	0	Least Informative	Direct
Plant ANatomical entity (PAN)	stem	0	Least Informative	Direct
Plant ANatomical entity (PAN)	sporangium	0	Least Informative	Direct
Plant ANatomical entity (PAN)	microgametophyte	0	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	C globular stage	0	Least Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	Least Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	Moderately Informative	Direct
Enzyme Commission (EC)	Cysteine endopeptidases	0	Informative	Direct

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Apoptosis	0	Moderately Informative	Direct
Biological process	Virulence	4.063e-05	Informative	Direct
Post-translational modification	Hydrolase	0	Least Informative	Direct
Post-translational modification	Protease	0	Moderately Informative	Direct
Post-translational modification	Thiol protease	0	Informative	Direct
Post-translational modification	S-nitrosylation	0	Informative	Direct
Post-translational modification	Zymogen	0	Informative	Direct

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Caspase-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Caspase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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Caspase-like superfamily