SUPERFAMILY 1.75 HMM library and genome assignments server

BRCT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Families:   BRCT domain [ 63955]
  53BP1 [ 75148]
  DNA-repair protein XRCC1 [ 52114]
  DNA ligase [ 52117] (2)
  DNA topoisomerase II binding protein 1, TopBP1 [ 117468]


Superfamily statistics
Genomes (3,041) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 16,652 34,129 22
Proteins 11,959 29,023 14


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000002396 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002166 Least Informative Direct
Biological Process (BP) developmental process 0.0003248 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.7915 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.04444 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.01667 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000000000001552 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000001666 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0003197 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.9658 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02765 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4639 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.701 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.05816 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2854 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.3507 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.7081 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.854 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1937 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2439 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8783 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.982 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7128 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4271 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.6247 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8148 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7915 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.008439 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8959 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001753 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3835 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.05167 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1502 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0 Informative Direct
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0.0000000008672 Informative Direct
Biological Process (BP) cell division 0.00000002025 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.000005061 Informative Direct
Biological Process (BP) leukocyte activation 0.00001043 Informative Direct
Biological Process (BP) cell proliferation 0.00003426 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0.00005496 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.00008013 Informative Direct
Biological Process (BP) RNA processing 0.0000923 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0001049 Informative Direct
Biological Process (BP) chromosome organization 0.000131 Informative Direct
Biological Process (BP) apoptotic process 0.0001363 Informative Direct
Biological Process (BP) immune effector process 0.0005854 Informative Direct
Biological Process (BP) organelle fission 0.0009082 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.7125 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.05336 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3473 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.04816 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.02218 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.02783 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.06007 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) organelle localization 0.1884 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.3403 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.00299 Informative Inherited
Biological Process (BP) regulation of cell development 0.04288 Informative Inherited
Biological Process (BP) sexual reproduction 0.4516 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.01998 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.2392 Informative Inherited
Biological Process (BP) single organism reproductive process 0.292 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.06545 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.578 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.002605 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.2788 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.0798 Informative Inherited
Biological Process (BP) mitochondrion organization 0.8505 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of growth 0.5555 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.01801 Informative Inherited
Biological Process (BP) regulation of protein localization 0.01625 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.02582 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.1664 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1126 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0794 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of protein processing 0.002557 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.3002 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.6838 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) central nervous system development 0.002549 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.6988 Informative Inherited
Biological Process (BP) immune response 0.8305 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001884 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03915 Informative Inherited
Biological Process (BP) localization of cell 0.5754 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7553 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) generation of neurons 0.8678 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.872 Informative Inherited
Biological Process (BP) microtubule-based process 0.007304 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.4433 Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0 Highly Informative Direct
Biological Process (BP) rRNA processing 0 Highly Informative Direct
Biological Process (BP) DNA integrity checkpoint 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0000000000002581 Highly Informative Direct
Biological Process (BP) B cell activation 0.00000000000362 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.00000000002446 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.00000000004105 Highly Informative Direct
Biological Process (BP) response to superoxide 0.000000003607 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0000000452 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.00001057 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.00001919 Highly Informative Direct
Biological Process (BP) negative regulation of protein catabolic process 0.00001957 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.00004525 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00009779 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0001114 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0001389 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.000158 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.0002237 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.000262 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0002819 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0002861 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.4472 Highly Informative Inherited
Biological Process (BP) spindle organization 0.4206 Highly Informative Inherited
Biological Process (BP) germ cell development 0.01998 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1558 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.05002 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.1075 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.00202 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.008639 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.0123 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.01762 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.001421 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.1145 Highly Informative Inherited
Biological Process (BP) stem cell development 0.004245 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.03852 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.1978 Highly Informative Inherited
Biological Process (BP) cell recognition 0.03987 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.4255 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.0233 Highly Informative Inherited
Biological Process (BP) nuclear division 0.001931 Highly Informative Inherited
Biological Process (BP) cytokinesis 0.6221 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.01354 Highly Informative Inherited
Molecular Function (MF) binding 0.000001793 Least Informative Direct
Molecular Function (MF) transferase activity 0.08186 Least Informative Inherited
Molecular Function (MF) anion binding 0.3544 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.01873 Moderately Informative Inherited
Molecular Function (MF) ligase activity 0.0000003808 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.0000004209 Informative Direct
Molecular Function (MF) DNA binding 0.000003214 Informative Direct
Molecular Function (MF) lipid binding 0.4203 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.1552 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0.0000000009259 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0000001372 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.00006127 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00009003 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.002413 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.9868 Highly Informative Inherited
Molecular Function (MF) DNA polymerase activity 0.08574 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000006049 Least Informative Direct
Cellular Component (CC) protein complex 0.002118 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.0000002249 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000007796 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.5945 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0000001842 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00008803 Informative Direct
Cellular Component (CC) cell surface 0.6638 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.000000006808 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00001393 Highly Informative Direct
Cellular Component (CC) nucleolar part 0.002556 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.5304 Highly Informative Inherited
Cellular Component (CC) chromosome, centromeric region 0.491 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)DNA nucleotidylexotransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0892Least InformativeInherited
Disease Ontology (DO)genetic disease0.0000009509Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0000000001452InformativeDirect
Disease Ontology (DO)breast carcinoma0.0253InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3101Least InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cell physiology0.0003327InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01541Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.03968Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06768Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1056Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1503Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.000001728Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0.002849Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.004275Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.04539Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.0479Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal chromosome stability0.000001456InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.0002129InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0004502InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.001234InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.003792InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.006849InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.0129InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2017InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.2514InformativeInherited
Mammalian Phenotype (MP)abnormal DNA repair0.0000000004603Highly InformativeDirect
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation0.000000006824Highly InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.00000001564Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0000006609Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0.00007317Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immunoglobulin V(D)J recombination0.00007834Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0.0001974Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blastocyst morphology0.0004571Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.001022Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.08114Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3357Moderately InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.0007298Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.009887InformativeInherited
Yeast Phenotype (YP)cell cycle progression in S phase0.0003584Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)radiation sensitive0.000008992Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.5077InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0.000000003885InformativeDirect
Biological processDNA recombination0.00002799InformativeDirect
Biological processMeiosis0.0002844InformativeDirect
Biological processDNA synthesis0.000000002022Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
DiseaseTumor suppressor0.0000004667Moderately InformativeDirect
DomainCoiled coil0.000000000009063Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00002265Moderately InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the BRCT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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