SUPERFAMILY 1.75 HMM library and genome assignments server


BRCT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Families:   BRCT domain [ 63955]
  53BP1 [ 75148]
  DNA-repair protein XRCC1 [ 52114]
  DNA ligase [ 52117] (2)
  DNA topoisomerase II binding protein 1, TopBP1 [ 117468]


Superfamily statistics
Genomes (3,039) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 16,634 34,129 22
Proteins 11,945 29,023 14


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.043e-11 Least Informative Direct
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6922 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.01323 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.08724 Least Informative Inherited
Biological Process (BP) developmental process 0.001882 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) organelle organization 1.295e-09 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 2.4e-06 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4374 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.006536 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.5858 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.008917 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02636 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6802 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.2016 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.004568 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.892 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.5841 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03145 Moderately Informative Inherited
Biological Process (BP) organ development 0.358 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01638 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7467 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1339 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4121 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001208 Moderately Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 3.504e-10 Informative Direct
Biological Process (BP) ncRNA metabolic process 3.473e-07 Informative Direct
Biological Process (BP) leukocyte activation 9.074e-06 Informative Direct
Biological Process (BP) RNA processing 1.413e-05 Informative Direct
Biological Process (BP) chromosome organization 1.819e-05 Informative Direct
Biological Process (BP) regulation of cell cycle process 4.538e-05 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 5.429e-05 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 7.145e-05 Informative Direct
Biological Process (BP) apoptotic process 0.0001172 Informative Direct
Biological Process (BP) immune effector process 0.0005713 Informative Direct
Biological Process (BP) intracellular signal transduction 0.2525 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.8927 Informative Inherited
Biological Process (BP) tube development 0.7513 Informative Inherited
Biological Process (BP) protein localization to organelle 0.04847 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.0529 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.02703 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.8475 Informative Inherited
Biological Process (BP) epithelium development 0.9556 Informative Inherited
Biological Process (BP) microtubule-based process 0.0222 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.6859 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.572 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.01531 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01344 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.6094 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.002777 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.1346 Informative Inherited
Biological Process (BP) mitochondrion organization 0.774 Informative Inherited
Biological Process (BP) localization of cell 0.5503 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) regulation of growth 0.5731 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.682 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001595 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1227 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.655 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.07424 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.9004 Informative Inherited
Biological Process (BP) central nervous system development 0.001634 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03563 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6224 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.009759 Informative Inherited
Biological Process (BP) immune response 0.7822 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.9991 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.01915 Informative Inherited
Biological Process (BP) organelle localization 0.1816 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) rRNA processing 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 7.02e-14 Highly Informative Direct
Biological Process (BP) B cell activation 3.154e-12 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 6.675e-12 Highly Informative Direct
Biological Process (BP) response to superoxide 3.539e-09 Highly Informative Direct
Biological Process (BP) protein ubiquitination 3.265e-08 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 4.841e-08 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 1.766e-05 Highly Informative Direct
Biological Process (BP) double-strand break repair 3.007e-05 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 4.572e-05 Highly Informative Direct
Biological Process (BP) telencephalon development 6.016e-05 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 8.941e-05 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0001011 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0001326 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.0002235 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0002698 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0003552 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.0005256 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 0.0005319 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0008469 Highly Informative Direct
Biological Process (BP) stem cell development 0.001432 Highly Informative Inherited
Biological Process (BP) renal system development 0.2843 Highly Informative Inherited
Biological Process (BP) spindle organization 0.3672 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.04203 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.1342 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.1844 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.6561 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.008344 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.03828 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.1999 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.4061 Highly Informative Inherited
Biological Process (BP) meiosis 0.0817 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.009091 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.1615 Highly Informative Inherited
Biological Process (BP) cell division 0.01153 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.001999 Highly Informative Inherited
Molecular Function (MF) binding 2.061e-06 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.3297 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.7324 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.01963 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.01567 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 3.585e-07 Informative Direct
Molecular Function (MF) DNA binding 1.475e-06 Informative Direct
Molecular Function (MF) lipid binding 0.3969 Informative Inherited
Molecular Function (MF) receptor binding 0.9927 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.00563 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.06403 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 7.009e-10 Highly Informative Direct
Molecular Function (MF) transcription factor binding 7.658e-08 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 5.704e-05 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 8.155e-05 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0004402 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.002071 Highly Informative Inherited
Molecular Function (MF) DNA polymerase activity 0.08618 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) protein complex 2.69e-06 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001118 Least Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 4.18e-05 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.5865 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 5.375e-08 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 6.614e-05 Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 4.258e-11 Highly Informative Direct
Cellular Component (CC) cell division site part 1.281e-05 Highly Informative Direct
Cellular Component (CC) nucleolar part 0.001493 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.3744 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)DNA nucleotidylexotransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.08672Least InformativeInherited
Disease Ontology (DO)genetic disease9.361e-07Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease1.429e-10InformativeDirect
Disease Ontology (DO)breast carcinoma0.02501InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3102Least InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cell physiology0.0003367InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.01416Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.03869Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06628Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1035Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1489Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism1.506e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.0009829Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0.002587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.03132Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal response to radiation0.0002265InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0004377InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.00115InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.003679InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.006771InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.01304InformativeInherited
Mammalian Phenotype (MP)abnormal preimplantation embryo development0.05715InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2005InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.2508InformativeInherited
Mammalian Phenotype (MP)abnormal DNA repair5.042e-10Highly InformativeDirect
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation6.85e-09Highly InformativeDirect
Mammalian Phenotype (MP)chromosomal instability1.672e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death6.322e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immunoglobulin V(D)J recombination7.661e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle7.849e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0.0001959Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blastocyst morphology0.0004424Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.0009809Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.08114Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3357Moderately InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.0007298Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.009848InformativeInherited
Yeast Phenotype (YP)cell cycle progression in S phase0.0003589Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)radiation sensitive8.986e-06Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.5063InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing3.927e-09InformativeDirect
Biological processDNA recombination2.872e-05InformativeDirect
Biological processMeiosis0.0002806InformativeDirect
Biological processDNA synthesis2.054e-09Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
DiseaseTumor suppressor4.646e-07Moderately InformativeDirect
DomainCoiled coil8.268e-12Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationUbl conjugation2.02e-05Moderately InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the BRCT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]