SUPERFAMILY 1.75 HMM library and genome assignments server


BRCT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Families:   BRCT domain [ 63955]
  53BP1 [ 75148]
  DNA-repair protein XRCC1 [ 52114]
  DNA ligase [ 52117] (2)
  DNA topoisomerase II binding protein 1, TopBP1 [ 117468]


Superfamily statistics
Genomes (2,328) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 14,347 18,591 22
Proteins 10,262 14,935 14


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.651e-10 Least Informative Direct
Biological Process (BP) developmental process 0.0002158 Least Informative Direct
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8305 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.005281 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.02414 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) organelle organization 3.946e-11 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 5.398e-05 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.0001119 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.0001247 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.857 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4302 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.002666 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.009502 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7256 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.005616 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.8597 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.288 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8581 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2356 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2907 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.5104 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.043 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.9843 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001106 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7527 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.0708 Moderately Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cell cycle process 2.076e-15 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 6.857e-09 Informative Direct
Biological Process (BP) ncRNA processing 5.494e-08 Informative Direct
Biological Process (BP) chromosome organization 1.536e-05 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 3.463e-05 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.0001768 Informative Direct
Biological Process (BP) protein localization to organelle 0.0002243 Informative Direct
Biological Process (BP) immune effector process 0.0004021 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0006585 Informative Direct
Biological Process (BP) apoptotic process 0.0008668 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0009436 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.1336 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.02564 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.6812 Informative Inherited
Biological Process (BP) tube development 0.8343 Informative Inherited
Biological Process (BP) epithelium development 0.8131 Informative Inherited
Biological Process (BP) microtubule-based process 0.01007 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.6489 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.9296 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.00343 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.9907 Informative Inherited
Biological Process (BP) regulation of cell development 0.4803 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.9718 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.4652 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.003362 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.2068 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.7121 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.001195 Informative Inherited
Biological Process (BP) cell activation 0.01392 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.2925 Informative Inherited
Biological Process (BP) mitochondrion organization 0.9061 Informative Inherited
Biological Process (BP) localization of cell 0.4203 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) regulation of growth 0.5501 Informative Inherited
Biological Process (BP) regulation of protein localization 0.002867 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.3988 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.05091 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.02632 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.7736 Informative Inherited
Biological Process (BP) central nervous system development 0.004942 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.02272 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4729 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.002668 Informative Inherited
Biological Process (BP) immune response 0.567 Informative Inherited
Biological Process (BP) actin filament-based process 0.9685 Informative Inherited
Biological Process (BP) rRNA processing 0 Highly Informative Direct
Biological Process (BP) DNA repair 1.158e-14 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1.385e-13 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 3.666e-13 Highly Informative Direct
Biological Process (BP) B cell activation 1.486e-12 Highly Informative Direct
Biological Process (BP) protein ubiquitination 8.988e-09 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 4.118e-08 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 1.827e-07 Highly Informative Direct
Biological Process (BP) nuclear division 1.738e-06 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 3.839e-05 Highly Informative Direct
Biological Process (BP) telencephalon development 4.709e-05 Highly Informative Direct
Biological Process (BP) response to insulin stimulus 9.518e-05 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0001238 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 0.0001365 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000183 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0002047 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0002465 Highly Informative Direct
Biological Process (BP) protein complex localization 0.0007601 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0008295 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 0.0009229 Highly Informative Direct
Biological Process (BP) stem cell development 0.001359 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.1548 Highly Informative Inherited
Biological Process (BP) organelle localization 0.02958 Highly Informative Inherited
Biological Process (BP) organelle assembly 0.1143 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.3207 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.5429 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.8252 Highly Informative Inherited
Biological Process (BP) regulation of cellular component size 0.1082 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle checkpoint 0.001956 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide catabolic process 0.001599 Highly Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.1754 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.2029 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.2537 Highly Informative Inherited
Biological Process (BP) gastrulation 0.01239 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.08963 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.3487 Highly Informative Inherited
Biological Process (BP) meiosis 0.04057 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.005674 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.3186 Highly Informative Inherited
Biological Process (BP) cell division 0.02067 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Highly Informative Inherited
Molecular Function (MF) binding 3.251e-09 Least Informative Direct
Molecular Function (MF) transferase activity 0.9008 Least Informative Inherited
Molecular Function (MF) protein binding 0.0002399 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.504 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.03156 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.1395 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.1715 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 1.456e-07 Informative Direct
Molecular Function (MF) DNA binding 2.911e-06 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.003354 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.03737 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 3.734e-10 Highly Informative Direct
Molecular Function (MF) transcription factor binding 1.138e-07 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 3.045e-05 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 3.609e-05 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0001729 Highly Informative Direct
Molecular Function (MF) DNA polymerase activity 0.1211 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 3.129e-15 Least Informative Direct
Cellular Component (CC) protein complex 9.98e-07 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.09735 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.4705 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.001119 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 2.155e-13 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 1.612e-08 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 5.315e-05 Informative Direct
Cellular Component (CC) 90S preribosome 2.195e-12 Highly Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 2.541e-11 Highly Informative Direct
Cellular Component (CC) cell division site part 5.178e-06 Highly Informative Direct
Cellular Component (CC) nucleolar part 0.0006026 Highly Informative Direct
Cellular Component (CC) condensed chromosome 0.2562 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.7137 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)DNA nucleotidylexotransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1101Least InformativeInherited
Disease Ontology (DO)genetic disease3.231e-06Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease4.542e-10InformativeDirect
Disease Ontology (DO)breast carcinoma0.02207InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3113Least InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cell physiology0.0003355InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.001672Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.06211Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.0715Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3199Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.000404Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.001794Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.002317Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.01459Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.04287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.04748Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.07537Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.0003496InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.001747InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.002097InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.005011InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.1297InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.1917InformativeInherited
Mammalian Phenotype (MP)chromosomal instability4.647e-10Highly InformativeDirect
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation9.454e-09Highly InformativeDirect
Mammalian Phenotype (MP)abnormal DNA repair4.184e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle8.756e-05Highly InformativeDirect
Mammalian Phenotype (MP)T cell derived lymphoma0.0002139Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.0007926Highly InformativeDirect
Mammalian Phenotype (MP)abnormal induced cell death0.001118Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.08114Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3357Moderately InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.0007298Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.009926InformativeInherited
Yeast Phenotype (YP)cell cycle progression in S phase0.0004199Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)radiation sensitive4.328e-06InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.5945InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing3.254e-09InformativeDirect
Biological processDNA recombination2.951e-05InformativeDirect
Biological processMeiosis0.0007002InformativeDirect
Biological processDNA synthesis1.986e-09Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
DiseaseTumor suppressor4.422e-07Moderately InformativeDirect
DomainCoiled coil3.842e-12Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.9447Moderately InformativeInherited
Post-translational modificationUbl conjugation6.574e-06Moderately InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect
Post-translational modificationS-nitrosylation4.275e-05InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the BRCT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]