SUPERFAMILY 1.75 HMM library and genome assignments server


L domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Families:   Internalin LRR domain [ 52059] (3)
  Leucine rich effector protein YopM [ 69433]
  Ngr ectodomain-like [ 75142] (6)
  Polygalacturonase inhibiting protein PGIP [ 89569]
  Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [ 52062]
  mRNA export factor tap [ 52065]
  U2A'-like [ 52068]
  L domain [ 52071] (5)


Superfamily statistics
Genomes (1,402) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 112,913 124,782 63
Proteins 88,386 101,598 49


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process6.969e-060Least InformativeDirect
Biological Process (BP)regulation of cellular process0.34570.8942Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.42970.0001248Least InformativeInherited
Biological Process (BP)multicellular organismal process0.046890Least InformativeInherited
Biological Process (BP)developmental process0.0038070Least InformativeInherited
Biological Process (BP)localization0.8380.6043Least InformativeInherited
Biological Process (BP)response to stimulus0.22940Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.63281Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.88941Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.78711Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.94581Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.62091Least InformativeInherited
Biological Process (BP)RNA metabolic process0.0055161Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.80380.1889Moderately InformativeInherited
Biological Process (BP)nervous system development0.45720.03699Moderately InformativeInherited
Biological Process (BP)cell differentiation0.44490.9056Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.86770.0005196Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.72365.442e-12Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.020241Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.23255.302e-08Moderately InformativeInherited
Biological Process (BP)organ development0.29850.00233Moderately InformativeInherited
Biological Process (BP)cellular localization0.71980.885Moderately InformativeInherited
Biological Process (BP)immune system process0.17010Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.7711Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.91771Moderately InformativeInherited
Biological Process (BP)biological adhesion0.0004884.634e-11InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.069390.8483InformativeInherited
Biological Process (BP)regulation of growth0.27185.792e-10InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.038280.1509InformativeInherited
Biological Process (BP)generation of neurons0.32980.05572InformativeInherited
Biological Process (BP)regulation of nervous system development0.07570.2524InformativeInherited
Biological Process (BP)regulation of cell development0.1196.819e-07InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.35090.03748InformativeInherited
Biological Process (BP)regulation of response to stress0.073791.145e-12InformativeInherited
Biological Process (BP)gland development0.020246.719e-05InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.027675.001e-07InformativeInherited
Biological Process (BP)leukocyte activation0.02390.9423InformativeInherited
Biological Process (BP)immune effector process0.046260.2699InformativeInherited
Biological Process (BP)immune response0.25010InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.048641InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.15241InformativeInherited
Biological Process (BP)regulation of cell size0.00031091.704e-06Highly InformativeDirect
Biological Process (BP)B cell activation7.7e-067e-06Highly InformativeDirect
Biological Process (BP)regulation of cell growth0.082527.286e-06Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.0011811.797e-11Highly InformativeInherited
Biological Process (BP)regulation of neuron projection development0.0017817.483e-11Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.0094753.431e-05Highly InformativeInherited
Biological Process (BP)leukocyte proliferation0.0011980.00614Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.018590.1369Highly InformativeInherited
Biological Process (BP)mRNA catabolic process0.33820.0004819Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.003390.4901Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.64941Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.26270.0002626InformativeInherited
Molecular Function (MF)nuclease activity0.007790.3401InformativeInherited
Molecular Function (MF)phosphatase regulator activity1.141e-063.703e-09Highly InformativeDirect
Cellular Component (CC)protein complex0.5441Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.72191Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.27641Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.22221Moderately InformativeInherited
Cellular Component (CC)nuclear part0.0027551Moderately InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex6.639e-052.169e-06Highly InformativeDirect
Cellular Component (CC)small nuclear ribonucleoprotein complex0.0038010.06587Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0001248 Least Informative Direct
Biological Process (BP) localization 0.6043 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8942 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 3.869e-13 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) tissue development 5.736e-05 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0005786 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.000534 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001796 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 5.302e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 7.818e-10 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0005196 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 5.442e-12 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.381e-10 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03364 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.2129 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.00204 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7474 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1381 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9056 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03699 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1889 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002699 Moderately Informative Inherited
Biological Process (BP) organ development 0.00233 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4066 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06125 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.885 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 2.914e-05 Informative Direct
Biological Process (BP) positive regulation of immune system process 8.039e-06 Informative Direct
Biological Process (BP) developmental process involved in reproduction 1.594e-09 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0001102 Informative Direct
Biological Process (BP) phosphorylation 9.716e-06 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 7.357e-06 Informative Direct
Biological Process (BP) biological adhesion 4.634e-11 Informative Direct
Biological Process (BP) cell projection organization 1.713e-11 Informative Direct
Biological Process (BP) cellular component morphogenesis 3.585e-11 Informative Direct
Biological Process (BP) growth 1.626e-07 Informative Direct
Biological Process (BP) regulation of growth 5.792e-10 Informative Direct
Biological Process (BP) locomotion 5.796e-08 Informative Direct
Biological Process (BP) gland development 6.719e-05 Informative Direct
Biological Process (BP) regulation of immune response 9.747e-11 Informative Direct
Biological Process (BP) localization of cell 3.742e-06 Informative Direct
Biological Process (BP) response to other organism 3.969e-09 Informative Direct
Biological Process (BP) regulation of cell development 6.819e-07 Informative Direct
Biological Process (BP) reproductive system development 3.45e-12 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0003092 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0003202 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0003152 Informative Direct
Biological Process (BP) regulation of response to stress 1.145e-12 Informative Direct
Biological Process (BP) regulation of anatomical structure size 5.001e-07 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 4.61e-08 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.3881 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1684 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3373 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.8483 Informative Inherited
Biological Process (BP) tube development 0.6561 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.9102 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.08229 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7331 Informative Inherited
Biological Process (BP) regulation of locomotion 0.354 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2524 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.07684 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.3012 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.102 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.03748 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9056 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.01719 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.6385 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.001921 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.2157 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.4828 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8773 Informative Inherited
Biological Process (BP) response to nutrient levels 0.04819 Informative Inherited
Biological Process (BP) response to lipid 0.07048 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01317 Informative Inherited
Biological Process (BP) generation of neurons 0.05572 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1509 Informative Inherited
Biological Process (BP) central nervous system development 0.2841 Informative Inherited
Biological Process (BP) cellular component movement 0.1038 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.489 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2114 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.09556 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.4559 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.3432 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.4722 Informative Inherited
Biological Process (BP) programmed cell death 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.6282 Informative Inherited
Biological Process (BP) microtubule-based process 0.7531 Informative Inherited
Biological Process (BP) protein transport 0.4623 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8972 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.00338 Informative Inherited
Biological Process (BP) response to wounding 0.08394 Informative Inherited
Biological Process (BP) leukocyte activation 0.9423 Informative Inherited
Biological Process (BP) immune effector process 0.2699 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of cell growth 7.286e-06 Highly Informative Direct
Biological Process (BP) activation of immune response 1.158e-08 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 4.933e-06 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 8e-09 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 9.185e-09 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0001979 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 0.0004819 Highly Informative Direct
Biological Process (BP) protein phosphorylation 1.563e-07 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001483 Highly Informative Direct
Biological Process (BP) cell adhesion 4.918e-06 Highly Informative Direct
Biological Process (BP) regulation of cell size 1.704e-06 Highly Informative Direct
Biological Process (BP) gonad development 0.0008885 Highly Informative Direct
Biological Process (BP) post-embryonic development 7.358e-10 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1.797e-11 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 7.483e-11 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 1.371e-11 Highly Informative Direct
Biological Process (BP) telencephalon development 4.414e-08 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 3.408e-07 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 3.591e-14 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 3.141e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) B cell activation 7e-06 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 7.225e-05 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 8.945e-05 Highly Informative Direct
Biological Process (BP) innate immune response 1.633e-05 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 2.827e-06 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 9.013e-10 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0007133 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 7.463e-10 Highly Informative Direct
Biological Process (BP) developmental growth 0.0001451 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0001073 Highly Informative Direct
Biological Process (BP) nuclear export 3.12e-07 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 2.057e-07 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 3.108e-07 Highly Informative Direct
Biological Process (BP) axon development 0.0006774 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 1.77e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 3.431e-05 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0007989 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.006046 Highly Informative Inherited
Biological Process (BP) hormone transport 0.07797 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.5394 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.9998 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.003367 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.02008 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 0.001024 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.9888 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2343 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1975 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.2957 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.002497 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.04099 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002979 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.01929 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.05227 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.6181 Highly Informative Inherited
Biological Process (BP) response to UV 0.09977 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.00614 Highly Informative Inherited
Biological Process (BP) cell division 0.2604 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.7285 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.1054 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.6087 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01036 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.03349 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.03996 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.06168 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.002954 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cell growth 0.03356 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.05287 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.001704 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.0972 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.1578 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.002492 Highly Informative Inherited
Biological Process (BP) protein folding 0.2773 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.02012 Highly Informative Inherited
Biological Process (BP) amide transport 0.06903 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.09093 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1233 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.1369 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.5419 Highly Informative Inherited
Biological Process (BP) renal system development 0.7596 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.1471 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.3212 Highly Informative Inherited
Molecular Function (MF) binding 0.0001127 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.4901 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.002183 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.2002 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.0002626 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 1.199e-09 Informative Direct
Molecular Function (MF) kinase activity 1.91e-05 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 2.755e-05 Informative Direct
Molecular Function (MF) amide binding 3.13e-08 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.1484 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.04515 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.008866 Informative Inherited
Molecular Function (MF) RNA binding 0.003682 Informative Inherited
Molecular Function (MF) enzyme binding 0.1001 Informative Inherited
Molecular Function (MF) nuclease activity 0.3401 Informative Inherited
Molecular Function (MF) protein kinase activity 1.369e-08 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 3.703e-09 Highly Informative Direct
Molecular Function (MF) peptide binding 4.895e-10 Highly Informative Direct
Molecular Function (MF) hormone binding 6.376e-12 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.4031 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 7.096e-09 Moderately Informative Direct
Cellular Component (CC) extracellular region part 5.412e-14 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.07172 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.2322 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endosome 4.556e-07 Informative Direct
Cellular Component (CC) cell surface 5.061e-08 Informative Direct
Cellular Component (CC) external encapsulating structure 1.801e-05 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) integral to membrane 0.8267 Informative Inherited
Cellular Component (CC) vacuolar part 0.01386 Informative Inherited
Cellular Component (CC) lytic vacuole 0.006828 Informative Inherited
Cellular Component (CC) neuron projection 0.8466 Informative Inherited
Cellular Component (CC) cell-cell junction 0.002943 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.4851 Informative Inherited
Cellular Component (CC) nuclear envelope 0.009769 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) cell wall 0.0004762 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 1.627e-07 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 2.169e-06 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0003815 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 3.762e-14 Highly Informative Direct
Cellular Component (CC) receptor complex 1.608e-15 Highly Informative Direct
Cellular Component (CC) neuron spine 0.0008158 Highly Informative Direct
Cellular Component (CC) pore complex 0.0007122 Highly Informative Direct
Cellular Component (CC) symplast 1.294e-11 Highly Informative Direct
Cellular Component (CC) SWI/SNF superfamily-type complex 0.09378 Highly Informative Inherited
Cellular Component (CC) lysosome 0.02294 Highly Informative Inherited
Cellular Component (CC) dendrite 0.06951 Highly Informative Inherited
Cellular Component (CC) host cell part 0.001732 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.07048 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.008173 Highly Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.06587 Highly Informative Inherited
Cellular Component (CC) chromatin 0.9214 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.8511 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds7.56e-06Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3857Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase4.41e-09InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001357InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase3.813e-11Highly InformativeDirect
Enzyme Commission (EC)Peroxidase1.091e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.06955Least InformativeInherited
Disease Ontology (DO)brain disease0.3123Moderately InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.006068InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.0204InformativeInherited
Disease Ontology (DO)filariasis4.871e-05Highly InformativeDirect
Disease Ontology (DO)aspergillosis0.0004763Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.007243Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2465Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.6556Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05532Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1629Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2727Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4325Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5919Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.6242Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6966Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.7033Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.7619Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9484Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.0187InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.111InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.1896InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.3946InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.4363InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.7998InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion8.691e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.000918Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cornea morphology0.000982Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epididymis morphology0.1002Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.2081Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.1715Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant0.000161InformativeDirect
Worm Phenotype (WP)myopodia present2.555e-05Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0005919Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.0006407Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.7962Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0001441InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase4.181e-11Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase4.977e-09Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001374Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processHemostasis1.418e-11InformativeDirect
Biological processVirulence6.959e-05InformativeDirect
Biological processWnt signaling pathway0.0002108InformativeDirect
Biological processSensory transduction0.131InformativeInherited
Biological processBlood coagulation1.285e-11Highly InformativeDirect
Biological processmRNA transport1.162e-10Highly InformativeDirect
Biological processRNA-mediated gene silencing1.699e-05Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0004948Highly InformativeDirect
Biological processVision0.0005737Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0001138Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndosome1.318e-10Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.004e-08Moderately InformativeDirect
Cellular componentCytoskeleton1.186e-07Moderately InformativeDirect
Cellular componentCell projection5.662e-06Moderately InformativeDirect
Cellular componentCytoplasmic vesicle1.043e-05Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor1.807e-08InformativeDirect
Cellular componentSynapse2.053e-06InformativeDirect
Cellular componentSpliceosome1.119e-05InformativeDirect
Cellular componentHost cytoplasm0.0003182InformativeDirect
Cellular componentCell wall1.904e-13Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane2.651e-14Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionNucleotide-binding0.07041Least InformativeInherited
Molecular functionATP-binding1.018e-06Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationNuclease0.1975Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationExonuclease1.958e-12InformativeDirect
Post-translational modificationIon channel1.535e-09InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond1.957e-06Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationSulfation1.349e-15InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.000405Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the L domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]