SUPERFAMILY 1.75 HMM library and genome assignments server

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L domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Families:   Internalin LRR domain [ 52059] (3)
  Leucine rich effector protein YopM [ 69433]
  Ngr ectodomain-like [ 75142] (6)
  Polygalacturonase inhibiting protein PGIP [ 89569]
  Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [ 52062]
  mRNA export factor tap [ 52065]
  U2A'-like [ 52068]
  L domain [ 52071] (5)


Superfamily statistics
Genomes (1,410) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 119,682 124,782 63
Proteins 93,765 101,598 49


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.0000041360Least InformativeDirect
Biological Process (BP)regulation of cellular process0.28860.6457Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.27670.0001714Least InformativeInherited
Biological Process (BP)multicellular organismal process0.034330Least InformativeInherited
Biological Process (BP)developmental process0.0024940Least InformativeInherited
Biological Process (BP)localization0.76710.768Least InformativeInherited
Biological Process (BP)response to stimulus0.22280Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.69971Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.94161Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.84911Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.88921Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.69091Least InformativeInherited
Biological Process (BP)RNA metabolic process0.0068611Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.81460.2073Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.99091Moderately InformativeInherited
Biological Process (BP)nervous system development0.20260.02516Moderately InformativeInherited
Biological Process (BP)cell differentiation0.39421Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.87980.0008192Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.75730.00000000001635Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.018371Moderately InformativeInherited
Biological Process (BP)cellular localization0.58270.8909Moderately InformativeInherited
Biological Process (BP)immune system process0.180Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.81321Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.94951Moderately InformativeInherited
Biological Process (BP)biological adhesion0.00064140.0000000001887InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.068390.9658InformativeInherited
Biological Process (BP)regulation of growth0.33670.000000001196InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.037610.1101InformativeInherited
Biological Process (BP)generation of neurons0.21780.04756InformativeInherited
Biological Process (BP)regulation of nervous system development0.074530.2167InformativeInherited
Biological Process (BP)regulation of cell development0.12710.0000005468InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.36850.02396InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.028260.00000105InformativeInherited
Biological Process (BP)leukocyte activation0.023480.9447InformativeInherited
Biological Process (BP)immune effector process0.045840.2559InformativeInherited
Biological Process (BP)immune response0.2610InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.060661InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.15931InformativeInherited
Biological Process (BP)regulation of cell size0.00042050.000003025Highly InformativeDirect
Biological Process (BP)B cell activation0.0000084680.00001195Highly InformativeDirect
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.0012710.000000000005587Highly InformativeInherited
Biological Process (BP)regulation of neuron projection development0.0020190.00000000003075Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.011560.00009695Highly InformativeInherited
Biological Process (BP)leukocyte proliferation0.0011380.006514Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.01860.1425Highly InformativeInherited
Biological Process (BP)mRNA catabolic process0.34960.0004893Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0048470.5784Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.69271Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.26240.001037InformativeInherited
Molecular Function (MF)nuclease activity0.0093540.3886InformativeInherited
Molecular Function (MF)phosphatase regulator activity0.0000016070.000000006957Highly InformativeDirect
Cellular Component (CC)protein complex0.55141Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.69491Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.2241Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.23621Moderately InformativeInherited
Cellular Component (CC)nuclear part0.0040141Moderately InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.000071260.000003474Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0001714 Least Informative Direct
Biological Process (BP) localization 0.768 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6457 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.000000000001828 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.00009967 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0005192 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.00007205 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001334 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000000003282 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0008192 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000001635 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000001845 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.05321 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3413 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.004316 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7687 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.2019 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3478 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02516 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2073 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.001388 Moderately Informative Inherited
Biological Process (BP) organ development 0.002485 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02373 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8909 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.00002931 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.000009546 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.00000000157 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0004852 Informative Direct
Biological Process (BP) response to bacterium 0.00009408 Informative Direct
Biological Process (BP) phosphorylation 0.0000002546 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00000509 Informative Direct
Biological Process (BP) biological adhesion 0.0000000001887 Informative Direct
Biological Process (BP) cell projection organization 0.000000000001295 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000014 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000001345 Informative Direct
Biological Process (BP) growth 0.00002338 Informative Direct
Biological Process (BP) regulation of growth 0.000000001196 Informative Direct
Biological Process (BP) locomotion 0.00000004827 Informative Direct
Biological Process (BP) gland development 0.0001581 Informative Direct
Biological Process (BP) regulation of immune response 0.0000000001523 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.000000000000007347 Informative Direct
Biological Process (BP) localization of cell 0.000004295 Informative Direct
Biological Process (BP) regulation of cell development 0.0000005468 Informative Direct
Biological Process (BP) reproductive system development 0.000000000002578 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.000173 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0005471 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000105 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000001644 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.1744 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3432 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.9658 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.001058 Informative Inherited
Biological Process (BP) tube development 0.6652 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.9475 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) protein oligomerization 0.4453 Informative Inherited
Biological Process (BP) regulation of protein localization 0.05866 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.08903 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.783 Informative Inherited
Biological Process (BP) regulation of locomotion 0.3777 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2167 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.08662 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.3093 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1035 Informative Inherited
Biological Process (BP) sensory organ development 0.7212 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.02396 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9611 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02945 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.7237 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.005765 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.3378 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.4797 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8153 Informative Inherited
Biological Process (BP) response to nutrient levels 0.0689 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.6411 Informative Inherited
Biological Process (BP) response to lipid 0.1194 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01392 Informative Inherited
Biological Process (BP) generation of neurons 0.04756 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1101 Informative Inherited
Biological Process (BP) central nervous system development 0.2579 Informative Inherited
Biological Process (BP) cellular component movement 0.1035 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.5707 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) anion transport 0.4152 Informative Inherited
Biological Process (BP) organic acid transport 0.1031 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2069 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1389 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.6522 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.7449 Informative Inherited
Biological Process (BP) microtubule-based process 0.773 Informative Inherited
Biological Process (BP) protein transport 0.477 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8962 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.00354 Informative Inherited
Biological Process (BP) response to wounding 0.07817 Informative Inherited
Biological Process (BP) leukocyte activation 0.9447 Informative Inherited
Biological Process (BP) immune effector process 0.2559 Informative Inherited
Biological Process (BP) cellular membrane organization 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0002844 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.000004967 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.00000001125 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0002599 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 0.0004893 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.000000001311 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0001474 Highly Informative Direct
Biological Process (BP) cell adhesion 0.00001346 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000003025 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000000004973 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000000005587 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00000000003075 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000000008607 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.0000008648 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.00002087 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.00000000000001435 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.00002982 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) B cell activation 0.00001195 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.00009709 Highly Informative Direct
Biological Process (BP) sulfur compound catabolic process 0.000007086 Highly Informative Direct
Biological Process (BP) innate immune response 0.00001193 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0.0000013 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.000000001509 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.000992 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.00000000105 Highly Informative Direct
Biological Process (BP) developmental growth 0.0001322 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.000115 Highly Informative Direct
Biological Process (BP) nuclear export 0.0000008595 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.000001379 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0000002211 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000003264 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00009695 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0008204 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.0000009259 Highly Informative Direct
Biological Process (BP) neuron projection development 0.002249 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.01523 Highly Informative Inherited
Biological Process (BP) hormone transport 0.0896 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.3755 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.004832 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.02339 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 0.002593 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.9815 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2369 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.2108 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.06256 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.004669 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.0256 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.06083 Highly Informative Inherited
Biological Process (BP) interaction with host 0.004955 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.6864 Highly Informative Inherited
Biological Process (BP) response to UV 0.09548 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.104 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.006514 Highly Informative Inherited
Biological Process (BP) cell division 0.2672 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.01719 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01174 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.08321 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.07177 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.004832 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.09758 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.1629 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cell growth 0.03662 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.001765 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.1192 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.4428 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.001189 Highly Informative Inherited
Biological Process (BP) protein folding 0.4553 Highly Informative Inherited
Biological Process (BP) amide transport 0.08138 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.08137 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1098 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.1425 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.352 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.6674 Highly Informative Inherited
Biological Process (BP) renal system development 0.7725 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.3709 Highly Informative Inherited
Molecular Function (MF) binding 0.001081 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.5784 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.005013 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.2462 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.000000002472 Informative Direct
Molecular Function (MF) kinase activity 0.00005202 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00002358 Informative Direct
Molecular Function (MF) amide binding 0.0000000431 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.164 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.04991 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.001037 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.009222 Informative Inherited
Molecular Function (MF) RNA binding 0.006322 Informative Inherited
Molecular Function (MF) enzyme binding 0.1317 Informative Inherited
Molecular Function (MF) nuclease activity 0.3886 Informative Inherited
Molecular Function (MF) protein kinase activity 0.00000001198 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.000000006957 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000000001133 Highly Informative Direct
Molecular Function (MF) hormone binding 0.000000000004728 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.406 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.000000001423 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000000002602 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.02394 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.4354 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0000005815 Informative Direct
Cellular Component (CC) cell surface 0.00000001315 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0005791 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) neuron projection 0.7298 Informative Inherited
Cellular Component (CC) synapse part 0.005292 Informative Inherited
Cellular Component (CC) integral to membrane 0.8445 Informative Inherited
Cellular Component (CC) vacuolar part 0.01851 Informative Inherited
Cellular Component (CC) lytic vacuole 0.006699 Informative Inherited
Cellular Component (CC) cell junction 0.004633 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.5472 Informative Inherited
Cellular Component (CC) nuclear envelope 0.01335 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.000003474 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0005949 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000000000000003095 Highly Informative Direct
Cellular Component (CC) symplast 0.00000000002433 Highly Informative Direct
Cellular Component (CC) lysosome 0.02418 Highly Informative Inherited
Cellular Component (CC) dendrite 0.06312 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.08449 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.01048 Highly Informative Inherited
Cellular Component (CC) pore complex 0.002854 Highly Informative Inherited
Cellular Component (CC) chromatin 0.9673 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.9027 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000756Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3857Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000000441InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001357InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000000003813Highly InformativeDirect
Enzyme Commission (EC)Peroxidase0.0000000001091Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.06362Least InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.007405InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.01948InformativeInherited
Disease Ontology (DO)filariasis0.00004916Highly InformativeDirect
Disease Ontology (DO)aspergillosis0.0004935Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Hyperpituitarism0.0001278Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1916Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.6416Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4779Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.6552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7074Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.7683Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.7995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8059Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9462Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.07827InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.204InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.3929InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.3986InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.4462InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.8092InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion0.00009261Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cornea morphology0.0003493Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epididymis morphology0.107Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.1419Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.2438Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.1715Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant0.000161InformativeDirect
Worm Phenotype (WP)myopodia present0.00002555Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0005919Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.0006407Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.7947Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0001465InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.00000000004485Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.000000004956Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001397Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processHemostasis0.00000000001674InformativeDirect
Biological processVirulence0.0000819InformativeDirect
Biological processWnt signaling pathway0.000207InformativeDirect
Biological processSensory transduction0.1327InformativeInherited
Biological processBlood coagulation0.00000000001518Highly InformativeDirect
Biological processmRNA transport0.000000000112Highly InformativeDirect
Biological processRNA-mediated gene silencing0.00001665Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0005286Highly InformativeDirect
Biological processVision0.0005651Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0001156Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndosome0.000000000007261Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000035Moderately InformativeDirect
Cellular componentCytoskeleton0.0000001189Moderately InformativeDirect
Cellular componentCell projection0.0000005517Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000001077Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.00000001693InformativeDirect
Cellular componentSynapse0.000002151InformativeDirect
Cellular componentSpliceosome0.00001095InformativeDirect
Cellular componentHost cytoplasm0.0003202InformativeDirect
Cellular componentLysosome0.0004726InformativeDirect
Cellular componentCell wall0.0000000000002405Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.00000000000003154Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionNucleotide-binding0.0693Least InformativeInherited
Molecular functionATP-binding0.0000009989Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationNuclease0.2048Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationExonuclease0.000000000002108InformativeDirect
Post-translational modificationIon channel0.000000001492InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.000001634Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationSulfation0.000000000000001355InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0003957Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the L domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]