SUPERFAMILY 1.75 HMM library and genome assignments server


L domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Families:   Internalin LRR domain [ 52059] (3)
  Leucine rich effector protein YopM [ 69433]
  Ngr ectodomain-like [ 75142] (6)
  Polygalacturonase inhibiting protein PGIP [ 89569]
  Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [ 52062]
  mRNA export factor tap [ 52065]
  U2A'-like [ 52068]
  L domain [ 52071] (5)


Superfamily statistics
Genomes (1,363) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 92,318 88,101 63
Proteins 72,709 71,367 49


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process6.409e-060Least InformativeDirect
Biological Process (BP)response to stimulus0.33970Least InformativeInherited
Biological Process (BP)regulation of cellular process0.10290.9016Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.51610.0004022Least InformativeInherited
Biological Process (BP)multicellular organismal process0.094580Least InformativeInherited
Biological Process (BP)developmental process0.010830Least InformativeInherited
Biological Process (BP)localization0.90310.8849Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.64281Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.89821Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.79621Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.94511Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.62941Least InformativeInherited
Biological Process (BP)RNA metabolic process0.0055391Moderately InformativeInherited
Biological Process (BP)response to organic substance0.77020.0007559Moderately InformativeInherited
Biological Process (BP)multi-organism process0.76030Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.67530.04559Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.75040.4289Moderately InformativeInherited
Biological Process (BP)nervous system development0.29310.02782Moderately InformativeInherited
Biological Process (BP)cell differentiation0.46750.8939Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.93730.0003326Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.76181.647e-11Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.34693.638e-07Moderately InformativeInherited
Biological Process (BP)organ development0.2460.0005615Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.019671Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.43450.0008696Moderately InformativeInherited
Biological Process (BP)cellular localization0.81360.9885Moderately InformativeInherited
Biological Process (BP)immune system process0.24440Moderately InformativeInherited
Biological Process (BP)macromolecule catabolic process0.3430.858Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.78171Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.18721Moderately InformativeInherited
Biological Process (BP)biological adhesion0.00043958.498e-11InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.070840.8588InformativeInherited
Biological Process (BP)response to bacterium0.16360.000511InformativeInherited
Biological Process (BP)response to lipid0.11630.09549InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.20912.006e-09InformativeInherited
Biological Process (BP)regulation of growth0.22644.412e-10InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.090870.2478InformativeInherited
Biological Process (BP)generation of neurons0.32640.08245InformativeInherited
Biological Process (BP)regulation of nervous system development0.021510.1573InformativeInherited
Biological Process (BP)regulation of cell development0.11768.969e-07InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.36660.04596InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.026551.578e-08InformativeInherited
Biological Process (BP)cell activation0.0032430.007264InformativeInherited
Biological Process (BP)immune effector process0.022850.2236InformativeInherited
Biological Process (BP)immune response0.39070InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.051151InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.15021InformativeInherited
Biological Process (BP)regulation of cell size0.00024522.098e-06Highly InformativeDirect
Biological Process (BP)B cell activation7.733e-067.794e-06Highly InformativeDirect
Biological Process (BP)post-embryonic organ development0.00069093.254e-11Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide0.0024550.01382Highly InformativeInherited
Biological Process (BP)cellular response to biotic stimulus0.0017128.17e-09Highly InformativeInherited
Biological Process (BP)regulation of cell growth0.075865.421e-06Highly InformativeInherited
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.0010714.335e-11Highly InformativeInherited
Biological Process (BP)regulation of neuron projection development0.0015969.603e-11Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.0083791.76e-05Highly InformativeInherited
Biological Process (BP)post-embryonic development0.032156.225e-11Highly InformativeInherited
Biological Process (BP)cell proliferation0.036760.6297Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.019270.151Highly InformativeInherited
Biological Process (BP)RNA catabolic process0.0072770.002012Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.012290.5062Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.661Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.37680.001801InformativeInherited
Molecular Function (MF)nuclease activity0.0078280.3399InformativeInherited
Molecular Function (MF)phosphatase regulator activity1.21e-054.867e-09Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.78881Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.39711Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.21191Moderately InformativeInherited
Cellular Component (CC)nuclear part0.0029531Moderately InformativeInherited
Cellular Component (CC)small nuclear ribonucleoprotein complex0.0036780.07141Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0004022 Least Informative Direct
Biological Process (BP) localization 0.8849 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9016 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 2.009e-12 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0008696 Moderately Informative Direct
Biological Process (BP) tissue development 1.621e-05 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0007559 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0007977 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 3.638e-07 Moderately Informative Direct
Biological Process (BP) organ development 0.0005615 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 7.084e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0003326 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.647e-11 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.661e-09 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04559 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.2425 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.9487 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.006529 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1572 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8939 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02782 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4289 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.8399 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3263 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1019 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9885 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.858 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 9.779e-06 Informative Direct
Biological Process (BP) positive regulation of immune system process 4.337e-06 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) response to bacterium 0.000511 Informative Direct
Biological Process (BP) phosphorylation 3.716e-05 Informative Direct
Biological Process (BP) biological adhesion 8.498e-11 Informative Direct
Biological Process (BP) cell projection organization 6.639e-11 Informative Direct
Biological Process (BP) regulation of defense response 7.105e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 3.848e-11 Informative Direct
Biological Process (BP) growth 1.033e-07 Informative Direct
Biological Process (BP) regulation of growth 4.412e-10 Informative Direct
Biological Process (BP) locomotion 9.304e-08 Informative Direct
Biological Process (BP) reproductive structure development 3.746e-15 Informative Direct
Biological Process (BP) gland development 0.0001428 Informative Direct
Biological Process (BP) regulation of immune response 2.926e-10 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 1.491e-12 Informative Direct
Biological Process (BP) localization of cell 1.392e-06 Informative Direct
Biological Process (BP) regulation of cell development 8.969e-07 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0002568 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0005869 Informative Direct
Biological Process (BP) regulation of anatomical structure size 1.578e-08 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 2.006e-09 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.4994 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1339 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2747 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.8588 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.8265 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) protein complex assembly 0.999 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.002296 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0536 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7053 Informative Inherited
Biological Process (BP) regulation of locomotion 0.4539 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1573 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1155 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.2238 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.06019 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.04596 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.8083 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.003931 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.2531 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.5305 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) response to lipid 0.09549 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.06204 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.578 Informative Inherited
Biological Process (BP) generation of neurons 0.08245 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2478 Informative Inherited
Biological Process (BP) central nervous system development 0.3774 Informative Inherited
Biological Process (BP) cellular component movement 0.08127 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.001185 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.5075 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.1343 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.08139 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.5547 Informative Inherited
Biological Process (BP) cell death 0.321 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.001012 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.617 Informative Inherited
Biological Process (BP) microtubule-based process 0.6387 Informative Inherited
Biological Process (BP) protein transport 0.33 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9908 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.007785 Informative Inherited
Biological Process (BP) response to wounding 0.2386 Informative Inherited
Biological Process (BP) cell activation 0.007264 Informative Inherited
Biological Process (BP) immune effector process 0.2236 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 2.668e-05 Highly Informative Direct
Biological Process (BP) regulation of cell growth 5.421e-06 Highly Informative Direct
Biological Process (BP) activation of immune response 5.636e-08 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 3.391e-06 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 1.53e-10 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 6.796e-08 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0002158 Highly Informative Direct
Biological Process (BP) protein phosphorylation 7.621e-07 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0002252 Highly Informative Direct
Biological Process (BP) cell adhesion 2.012e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0006623 Highly Informative Direct
Biological Process (BP) regulation of cell size 2.098e-06 Highly Informative Direct
Biological Process (BP) gonad development 0.0009961 Highly Informative Direct
Biological Process (BP) post-embryonic development 6.225e-11 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 4.335e-11 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 9.603e-11 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 2.089e-08 Highly Informative Direct
Biological Process (BP) telencephalon development 1.67e-08 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 4.137e-07 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0007222 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 1.39e-13 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) B cell activation 7.794e-06 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0002379 Highly Informative Direct
Biological Process (BP) innate immune response 9.264e-07 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 2.72e-06 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 8.669e-09 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0008176 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 3.254e-11 Highly Informative Direct
Biological Process (BP) developmental growth 4.081e-05 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0 Highly Informative Direct
Biological Process (BP) nuclear export 1.053e-05 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 2.504e-05 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 3.547e-07 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 8.17e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1.76e-05 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0007231 Highly Informative Direct
Biological Process (BP) regulation of response to biotic stimulus 0.002753 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.03454 Highly Informative Inherited
Biological Process (BP) hormone transport 0.07427 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.4413 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.003187 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.04763 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 0.01218 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.9926 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.3164 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.003556 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1953 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.2616 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.001199 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.6219 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.04581 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.06247 Highly Informative Inherited
Biological Process (BP) interaction with host 0.003031 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.6151 Highly Informative Inherited
Biological Process (BP) response to UV 0.08637 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.114 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.2418 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.475 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.5385 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01382 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.07455 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.696 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.008097 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.06258 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.003235 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cell growth 0.0228 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.005614 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.09918 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.001978 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.003585 Highly Informative Inherited
Biological Process (BP) protein folding 0.2624 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.0181 Highly Informative Inherited
Biological Process (BP) amide transport 0.05735 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.07752 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.066 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.6297 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.151 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.4975 Highly Informative Inherited
Biological Process (BP) renal system development 0.6917 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.3362 Highly Informative Inherited
Biological Process (BP) RNA catabolic process 0.002012 Highly Informative Inherited
Biological Process (BP) cell division 0.6556 Highly Informative Inherited
Molecular Function (MF) binding 0.006087 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.5062 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.006878 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.167 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 1.289e-10 Informative Direct
Molecular Function (MF) kinase activity 9.915e-05 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.863e-05 Informative Direct
Molecular Function (MF) amide binding 5.834e-09 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.1147 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.03333 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.001801 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.00604 Informative Inherited
Molecular Function (MF) RNA binding 0.01425 Informative Inherited
Molecular Function (MF) enzyme binding 0.04148 Informative Inherited
Molecular Function (MF) nuclease activity 0.3399 Informative Inherited
Molecular Function (MF) protein kinase activity 6.224e-10 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 4.867e-09 Highly Informative Direct
Molecular Function (MF) peptide binding 2.121e-10 Highly Informative Direct
Molecular Function (MF) hormone binding 6.965e-12 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.4366 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 8.062e-08 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 3.567e-14 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.1167 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endosome 1.547e-05 Informative Direct
Cellular Component (CC) cell surface 6.833e-08 Informative Direct
Cellular Component (CC) external encapsulating structure 2.386e-05 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) integral to membrane 0.9242 Informative Inherited
Cellular Component (CC) vacuolar part 0.01586 Informative Inherited
Cellular Component (CC) lytic vacuole 0.01439 Informative Inherited
Cellular Component (CC) cell-cell junction 0.01248 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.7215 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) cell wall 0.0005972 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 1.966e-07 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 1.415e-05 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0002975 Highly Informative Direct
Cellular Component (CC) host cell part 0.0004987 Highly Informative Direct
Cellular Component (CC) receptor complex 1.521e-15 Highly Informative Direct
Cellular Component (CC) symplast 2.453e-11 Highly Informative Direct
Cellular Component (CC) lysosome 0.03332 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.06315 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.007638 Highly Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.07141 Highly Informative Inherited
Cellular Component (CC) chromatin 0.8832 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.7864 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds7.56e-06Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3857Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase4.41e-09InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001357InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase3.813e-11Highly InformativeDirect
Enzyme Commission (EC)Peroxidase1.091e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)opportunistic mycosis0.006097InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.02054InformativeInherited
Disease Ontology (DO)filariasis4.863e-05Highly InformativeDirect
Disease Ontology (DO)aspergillosis0.0004763Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.007289Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.235Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.7274Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2762Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5139Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5846Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.6336Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.7622Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9472Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1854InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.1865InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.4861InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.5069InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.7947InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion6.613e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cornea morphology0.003499Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.09903Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.1161Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.1981Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.1715Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant0.000161InformativeDirect
Worm Phenotype (WP)myopodia present2.555e-05Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0005919Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.0006407Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.7891Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0001555InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase4.009e-11Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase5.106e-09Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001484Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processHemostasis1.433e-11InformativeDirect
Biological processVirulence5.952e-05InformativeDirect
Biological processWnt signaling pathway0.000212InformativeDirect
Biological processSensory transduction0.1257InformativeInherited
Biological processBlood coagulation1.297e-11Highly InformativeDirect
Biological processmRNA transport1.11e-10Highly InformativeDirect
Biological processRNA-mediated gene silencing1.483e-05Highly InformativeDirect
Biological processCilium biogenesis/degradation0.000432Highly InformativeDirect
Biological processVision0.0005339Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0002225Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndosome5.117e-10Moderately InformativeDirect
Cellular componentCytoskeleton9.072e-08Moderately InformativeDirect
Cellular componentCell projection3.792e-06Moderately InformativeDirect
Cellular componentCytoplasmic vesicle8.005e-06Moderately InformativeDirect
Cellular componentEndoplasmic reticulum2.813e-05Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor1.274e-08InformativeDirect
Cellular componentSynapse1.472e-06InformativeDirect
Cellular componentSpliceosome6.826e-06InformativeDirect
Cellular componentHost cytoplasm0.0002515InformativeDirect
Cellular componentCell wall2.097e-13Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane8.703e-14Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionNucleotide-binding0.122Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationNuclease0.1918Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationExonuclease1.361e-12InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond1.947e-05Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationSulfation1.788e-15InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0004128Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the L domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]