SUPERFAMILY 1.75 HMM library and genome assignments server


L domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Families:   Internalin LRR domain [ 52059] (3)
  Leucine rich effector protein YopM [ 69433]
  Ngr ectodomain-like [ 75142] (6)
  Polygalacturonase inhibiting protein PGIP [ 89569]
  Rab geranylgeranyltransferase alpha-subunit, C-terminal domain [ 52062]
  mRNA export factor tap [ 52065]
  U2A'-like [ 52068]
  L domain [ 52071] (5)


Superfamily statistics
Genomes (1,113) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 90,502 88,101 63
Proteins 71,150 71,367 49


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.0017920Least InformativeInherited
Biological Process (BP)regulation of cellular process1.31e-050.3244Least InformativeInherited
Biological Process (BP)developmental process0.20790Least InformativeInherited
Biological Process (BP)multicellular organismal process0.27771.186e-13Least InformativeInherited
Biological Process (BP)localization0.98250.9408Least InformativeInherited
Biological Process (BP)response to stimulus0.45330Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.93641Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.92391Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)organ development0.15096.466e-05Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.42921.357e-07Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.086290.3582Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.20.3839Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.27331.971e-11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.085293.839e-06Moderately InformativeInherited
Biological Process (BP)cellular localization0.79360.7975Moderately InformativeInherited
Biological Process (BP)immune system process0.2280Moderately InformativeInherited
Biological Process (BP)RNA metabolic process0.0078331Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)nucleocytoplasmic transport0.00013141.582e-05InformativeDirect
Biological Process (BP)biological adhesion0.00041433.459e-10InformativeDirect
Biological Process (BP)regulation of response to stress0.093474.008e-15InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.56210.03399InformativeInherited
Biological Process (BP)cell activation0.0016730.003015InformativeInherited
Biological Process (BP)cell proliferation0.025990.5199InformativeInherited
Biological Process (BP)immune effector process0.027070.008144InformativeInherited
Biological Process (BP)immune response0.36220InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.15971InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.30471InformativeInherited
Biological Process (BP)B cell activation1.534e-057.294e-05Highly InformativeDirect
Biological Process (BP)nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay5.051e-052.497e-08Highly InformativeDirect
Biological Process (BP)post-embryonic organ development0.00031451.296e-11Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.0045828.726e-07Highly InformativeInherited
Biological Process (BP)leukocyte proliferation0.00072110.01397Highly InformativeInherited
Biological Process (BP)post-embryonic development0.01151.416e-11Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.01932.537e-06Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.025450.6937Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.74641Moderately InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.48940.009076InformativeInherited
Molecular Function (MF)nuclease activity0.011410.3936InformativeInherited
Molecular Function (MF)phosphatase regulator activity9.353e-061.209e-08Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.76311Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)nuclear part0.015161Moderately InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.26911Moderately InformativeInherited
Cellular Component (CC)small nuclear ribonucleoprotein complex0.0014920.06364Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.186e-13 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0.9408 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3244 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02142 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.839e-06 Moderately Informative Direct
Biological Process (BP) organ development 6.466e-05 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1.971e-11 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 8.057e-08 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.357e-07 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000114 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 5.976e-10 Moderately Informative Direct
Biological Process (BP) reproduction 1.208e-11 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.01255 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.008185 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01308 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.3839 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.3582 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7258 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3785 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.06752 Moderately Informative Inherited
Biological Process (BP) tissue development 0.06019 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.06904 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9131 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.003476 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3093 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.7975 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 1.582e-05 Informative Direct
Biological Process (BP) biological adhesion 3.459e-10 Informative Direct
Biological Process (BP) cell projection organization 1.459e-10 Informative Direct
Biological Process (BP) regulation of response to stress 4.008e-15 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 1.209e-11 Informative Direct
Biological Process (BP) response to other organism 5.503e-10 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 4.275e-08 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) reproductive system development 7.828e-14 Informative Direct
Biological Process (BP) developmental process involved in reproduction 1.009e-10 Informative Direct
Biological Process (BP) regulation of immune response 1.911e-10 Informative Direct
Biological Process (BP) regulation of growth 9.881e-08 Informative Direct
Biological Process (BP) positive regulation of immune system process 4.816e-07 Informative Direct
Biological Process (BP) locomotion 2.92e-06 Informative Direct
Biological Process (BP) localization of cell 3.636e-06 Informative Direct
Biological Process (BP) regulation of cell development 7.973e-06 Informative Direct
Biological Process (BP) regulation of cytokine production 1.401e-05 Informative Direct
Biological Process (BP) growth 2.002e-05 Informative Direct
Biological Process (BP) protein phosphorylation 3.501e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0004672 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0009486 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.7695 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.132 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1005 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1744 Informative Inherited
Biological Process (BP) response to external stimulus 0.008125 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.6976 Informative Inherited
Biological Process (BP) tube development 0.3389 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) protein oligomerization 0.5051 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.00443 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01548 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4332 Informative Inherited
Biological Process (BP) regulation of locomotion 0.2647 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.6707 Informative Inherited
Biological Process (BP) generation of neurons 0.07036 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.4438 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3528 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.03399 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.4215 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.003117 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.4784 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.6422 Informative Inherited
Biological Process (BP) response to lipid 0.1043 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.8638 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.07767 Informative Inherited
Biological Process (BP) gland development 0.003129 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.9517 Informative Inherited
Biological Process (BP) central nervous system development 0.4057 Informative Inherited
Biological Process (BP) cellular component movement 0.1536 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.5299 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.04424 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.1715 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1261 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.7739 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.002426 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.04777 Informative Inherited
Biological Process (BP) microtubule-based process 0.3534 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.6974 Informative Inherited
Biological Process (BP) protein transport 0.4134 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.6409 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.001314 Informative Inherited
Biological Process (BP) cell proliferation 0.5199 Informative Inherited
Biological Process (BP) cell activation 0.003015 Informative Inherited
Biological Process (BP) immune effector process 0.008144 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) B cell activation 7.294e-05 Highly Informative Direct
Biological Process (BP) nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2.497e-08 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 1.296e-11 Highly Informative Direct
Biological Process (BP) cell adhesion 4.036e-07 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 2.169e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 8.726e-07 Highly Informative Direct
Biological Process (BP) axonogenesis 0.0009763 Highly Informative Direct
Biological Process (BP) post-embryonic development 1.416e-11 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 2.537e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0001428 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 6.691e-13 Highly Informative Direct
Biological Process (BP) telencephalon development 2.496e-09 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 2.575e-09 Highly Informative Direct
Biological Process (BP) activation of immune response 4.74e-09 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 1.848e-07 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 2.679e-07 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 3.317e-07 Highly Informative Direct
Biological Process (BP) mRNA transport 3.74e-07 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 7.429e-07 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 1.154e-06 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 1.261e-06 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 3.893e-06 Highly Informative Direct
Biological Process (BP) developmental growth 5.389e-06 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 5.74e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 4.23e-05 Highly Informative Direct
Biological Process (BP) innate immune response 6.045e-05 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0002321 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0003713 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.0003932 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis 0.0004481 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.8608 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.8801 Highly Informative Inherited
Biological Process (BP) hormone transport 0.08444 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 0.06661 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.006646 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.02657 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.1476 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.9849 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.001245 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.1765 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) epidermis development 0.8829 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.05915 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.5873 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.7003 Highly Informative Inherited
Biological Process (BP) response to UV 0.05588 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.001716 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.06766 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.002197 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.0164 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.01397 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.1516 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.4666 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.9631 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.02515 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.07503 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.004289 Highly Informative Inherited
Biological Process (BP) RNA export from nucleus 0.009056 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.3661 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.9406 Highly Informative Inherited
Biological Process (BP) cell growth 0.007927 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.05157 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.007414 Highly Informative Inherited
Biological Process (BP) regulation of cellular component size 0.01547 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.8383 Highly Informative Inherited
Biological Process (BP) protein folding 0.296 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.01337 Highly Informative Inherited
Biological Process (BP) amide transport 0.06959 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01946 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.3656 Highly Informative Inherited
Biological Process (BP) kidney development 0.1069 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.4091 Highly Informative Inherited
Biological Process (BP) RNA 3'-end processing 0.04692 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0.0431 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.6937 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.007173 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.1769 Moderately Informative Inherited
Molecular Function (MF) receptor binding 8.228e-08 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.364e-05 Informative Direct
Molecular Function (MF) kinase activity 7.438e-05 Informative Direct
Molecular Function (MF) lipid binding 0.04153 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.009076 Informative Inherited
Molecular Function (MF) RNA binding 0.0273 Informative Inherited
Molecular Function (MF) enzyme binding 0.6242 Informative Inherited
Molecular Function (MF) nuclease activity 0.3936 Informative Inherited
Molecular Function (MF) phosphatase regulator activity 1.209e-08 Highly Informative Direct
Molecular Function (MF) peptide binding 4.745e-11 Highly Informative Direct
Molecular Function (MF) hormone binding 4.214e-10 Highly Informative Direct
Molecular Function (MF) protein kinase activity 3.033e-07 Highly Informative Direct
Molecular Function (MF) glycosaminoglycan binding 0.0002076 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 9.715e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region 3.777e-10 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.6378 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 6.265e-13 Informative Direct
Cellular Component (CC) cell surface 3.607e-07 Informative Direct
Cellular Component (CC) endosome 0.0004794 Informative Direct
Cellular Component (CC) synapse 0.1325 Informative Inherited
Cellular Component (CC) integral to membrane 0.9824 Informative Inherited
Cellular Component (CC) vacuole 0.05979 Informative Inherited
Cellular Component (CC) cell junction 0.005416 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.02283 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.9564 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) CCR4-NOT complex 7.536e-13 Highly Informative Direct
Cellular Component (CC) symplast 1.963e-10 Highly Informative Direct
Cellular Component (CC) receptor complex 1.898e-09 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 4.078e-07 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 2.164e-05 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 2.359e-05 Highly Informative Direct
Cellular Component (CC) host cell part 0.000441 Highly Informative Direct
Cellular Component (CC) lysosome 0.01216 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.006701 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.002059 Highly Informative Inherited
Cellular Component (CC) cell wall 0.01041 Highly Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.06364 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds7.56e-06Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3857Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase4.41e-09InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001357InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase3.813e-11Highly InformativeDirect
Enzyme Commission (EC)Peroxidase1.091e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.6319Moderately InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.02107InformativeInherited
Disease Ontology (DO)filariasis6.026e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.005977Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.341Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.7274Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1511Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3669Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3796Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.63Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.7583Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.8802Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.1299InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.3247InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.3687InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.4442InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6817InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-12b secretion2.274e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epididymis morphology0.02396Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.1559Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.2396Highly InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.5807Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.1715Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant0.000161InformativeDirect
Worm Phenotype (WP)myopodia present2.555e-05Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0005919Highly InformativeDirect
Worm Phenotype (WP)cuticle development variant0.0006407Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.3929Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0001334InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase3.505e-11Highly InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase4.344e-09Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0001271Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processVirulence2.748e-05InformativeDirect
Biological processmRNA splicing0.02423InformativeInherited
Biological processBlood coagulation7.211e-12Highly InformativeDirect
Biological processmRNA transport2.501e-11Highly InformativeDirect
Biological processSpliceosome3.743e-07Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0002181Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.000712Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndosome1.95e-11Moderately InformativeDirect
Cellular componentCytoskeleton7.152e-07Moderately InformativeDirect
Cellular componentCytoplasmic vesicle3.997e-06Moderately InformativeDirect
Cellular componentCell projection5.937e-06Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.69e-05Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentPostsynaptic cell membrane6.395e-16InformativeDirect
Cellular componentGPI-anchor2.724e-08InformativeDirect
Cellular componentSynapse3.704e-06InformativeDirect
Cellular componentHost cytoplasm0.0002362InformativeDirect
Cellular componentCell wall4.376e-13Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1.75e-09Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionNucleotide-binding0.04086Least InformativeInherited
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationNuclease0.1268Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationExonuclease7.531e-13InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond7.685e-05Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationSulfation1.329e-15InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0003809Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the L domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]