SUPERFAMILY 1.75 HMM library and genome assignments server


RNI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   RNI-like [ 52047] (3)
Families:   28-residue LRR [ 52048] (2)
  Rna1p (RanGAP1), N-terminal domain [ 52052]
  Cyclin A/CDK2-associated p19, Skp2 [ 52055]


Superfamily statistics
Genomes (678) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 50,540 38,664 12
Proteins 46,004 35,328 9


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.74971Least InformativeInherited
Biological Process (BP)response to stimulus10.1392Least InformativeInherited
Biological Process (BP)protein metabolic process0.56070.5774Least InformativeInherited
Biological Process (BP)cellular catabolic process0.26280.03172Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.41920.3975Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.078981Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.36370.1081Moderately InformativeInherited
Biological Process (BP)protein catabolic process8.252e-054.008e-15InformativeDirect
Biological Process (BP)proteolysis0.00023831.442e-10InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00061443.321e-11InformativeDirect
Biological Process (BP)response to light stimulus0.0037080.01686InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.0020060InformativeInherited
Biological Process (BP)response to external stimulus0.180.1442InformativeInherited
Biological Process (BP)protein ubiquitination0.00017570Highly InformativeDirect
Biological Process (BP)modification-dependent protein catabolic process9.104e-060.004797Highly InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds7.324e-051.738e-13InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity1.258e-050Highly InformativeDirect
Cellular Component (CC)protein complex0.85260.0002776Least InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.0002770InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1392 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.5774 Least Informative Inherited
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 4.008e-15 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 3.496e-09 Moderately Informative Direct
Biological Process (BP) immune system process 1.076e-06 Moderately Informative Direct
Biological Process (BP) signal transduction 2.758e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.7483 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1081 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9952 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.7918 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8481 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2745 Moderately Informative Inherited
Biological Process (BP) organ development 0.7732 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.03172 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3975 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.07711 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3344 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.9851 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01585 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 4.008e-15 Informative Direct
Biological Process (BP) proteolysis 1.442e-10 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 3.321e-11 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) response to other organism 3.156e-14 Informative Direct
Biological Process (BP) regulation of cytokine production 8.615e-13 Informative Direct
Biological Process (BP) immune response 8.496e-12 Informative Direct
Biological Process (BP) reproductive system development 1.862e-11 Informative Direct
Biological Process (BP) regulation of response to stress 4.085e-10 Informative Direct
Biological Process (BP) regulation of immune response 5.121e-08 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 4.597e-07 Informative Direct
Biological Process (BP) response to hormone stimulus 1.173e-06 Informative Direct
Biological Process (BP) positive regulation of immune system process 3.46e-06 Informative Direct
Biological Process (BP) developmental process involved in reproduction 2.557e-05 Informative Direct
Biological Process (BP) regulation of protein localization 5.862e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 6.464e-05 Informative Direct
Biological Process (BP) positive regulation of transport 0.0003428 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.05959 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.8826 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4773 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.01342 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.03999 Informative Inherited
Biological Process (BP) protein transport 0.3016 Informative Inherited
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of growth 0.4205 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.01686 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.07605 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6808 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.6965 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6952 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.04863 Informative Inherited
Biological Process (BP) response to lipid 0.1249 Informative Inherited
Biological Process (BP) response to organic nitrogen 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.009332 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) response to external stimulus 0.1442 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.315 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3066 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.4706 Informative Inherited
Biological Process (BP) regulation of locomotion 0.7474 Informative Inherited
Biological Process (BP) immune effector process 0.1438 Informative Inherited
Biological Process (BP) cell activation 0.1315 Informative Inherited
Biological Process (BP) cell cycle process 0.2388 Informative Inherited
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 8.08e-11 Highly Informative Direct
Biological Process (BP) post-embryonic development 8.394e-11 Highly Informative Direct
Biological Process (BP) cell cycle phase transition 5.327e-09 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 1.297e-08 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 7.678e-08 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 9.076e-08 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 2.522e-07 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 1.057e-06 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 2.243e-06 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 1.058e-05 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.309e-05 Highly Informative Direct
Biological Process (BP) mitotic cell cycle 1.83e-05 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 5.415e-05 Highly Informative Direct
Biological Process (BP) activation of immune response 5.436e-05 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 5.452e-05 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 0.0001151 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.0004414 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0005002 Highly Informative Direct
Biological Process (BP) innate immune response 0.0009909 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.03666 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.4231 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.01235 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0154 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.544 Highly Informative Inherited
Biological Process (BP) cell growth 0.05516 Highly Informative Inherited
Biological Process (BP) developmental growth 0.8379 Highly Informative Inherited
Biological Process (BP) epidermis development 0.5356 Highly Informative Inherited
Biological Process (BP) DNA replication 0.3101 Highly Informative Inherited
Biological Process (BP) response to UV 0.7334 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidase activity 0.004833 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.837 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.3263 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.01348 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.1357 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001397 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.004198 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.002137 Highly Informative Inherited
Biological Process (BP) ossification 0.001674 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.09933 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.004797 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.02728 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.02858 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.5181 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.02339 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.2928 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.004484 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.3634 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.06775 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 5.238e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1.738e-13 Informative Direct
Molecular Function (MF) lipid binding 0.4152 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.03055 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.8478 Informative Inherited
Molecular Function (MF) receptor activity 0.4807 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.7135 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 2.132e-06 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 2.069e-05 Highly Informative Direct
Molecular Function (MF) peptide binding 2.424e-05 Highly Informative Direct
Molecular Function (MF) iron ion binding 7.409e-05 Highly Informative Direct
Molecular Function (MF) glycosaminoglycan binding 0.0356 Highly Informative Inherited
Cellular Component (CC) protein complex 0.0002776 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) neuron part 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) contractile fiber part 0.4705 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.836 Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 2.333e-05 Highly Informative Direct
Cellular Component (CC) replisome 6.87e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 0.007815 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.3756 Highly Informative Inherited
Cellular Component (CC) cell body 0.1359 Highly Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.001541 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.9494 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.4543Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1.75e-08Moderately InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio2.328e-15Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.02957Moderately InformativeInherited
Disease Ontology (DO)syndrome0.3928Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0001411InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0003633InformativeDirect
Disease Ontology (DO)Crohn's disease6.738e-06Highly InformativeDirect
Disease Ontology (DO)irritable bowel syndrome0.0001478Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.214Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.0304Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1492Moderately InformativeInherited
Phenotypic Abnormality (PA)Arthralgia0.0001643Highly InformativeDirect
Phenotypic Abnormality (PA)Anemia0.0005689Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.02067Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.463Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.0002939Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0003238Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0003948Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.1206Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.2648Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection7.621e-05InformativeDirect
Mammalian Phenotype (MP)increased inflammatory response0.001075InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.06864InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.07444InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion8.393e-09Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-12b secretion9.739e-06Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.0003594Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.5926Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.9966Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.5472Moderately InformativeInherited
Worm Phenotype (WP)protein aggregation induced paralysis0.0003916InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001317Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)androecium0.8605Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)sporangium1Least InformativeInherited
Plant ANatomical entity (PAN)anther1.144e-05Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.5024Least InformativeInherited
Enzyme Commission (EC)Lyases0.7173Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen3.304e-08InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.009751InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors2.825e-15Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase6.554e-11Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase4.261e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis1.11e-12Moderately InformativeDirect
Biological processDifferentiation7.755e-05Moderately InformativeDirect
Biological processCell cycle0.3494Moderately InformativeInherited
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis2.155e-06InformativeDirect
Biological processAuxin signaling pathway0Highly InformativeDirect
Biological processBiological rhythms2.702e-07Highly InformativeDirect
Cellular componentNucleus1.963e-08Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton2.961e-12Moderately InformativeDirect
Cellular componentCell projection0.01495Moderately InformativeInherited
Cellular componentCilium0.002231Highly InformativeInherited
DomainRepeat0Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionActin-binding3.217e-10InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein2.692e-07Moderately InformativeDirect
Post-translational modificationKinase0.01507Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation2.683e-08InformativeDirect
Post-translational modificationDioxygenase0.0007358Highly InformativeDirect
Post-translational modificationGlycoprotein1.545e-06Least InformativeDirect
Post-translational modificationPhosphoprotein0.0003517Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the RNI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]