SUPERFAMILY 1.75 HMM library and genome assignments server


RNI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   RNI-like [ 52047] (3)
Families:   28-residue LRR [ 52048] (2)
  Rna1p (RanGAP1), N-terminal domain [ 52052]
  Cyclin A/CDK2-associated p19, Skp2 [ 52055]


Superfamily statistics
Genomes (769) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 51,040 38,664 12
Proteins 46,433 35,328 9


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.71771Least InformativeInherited
Biological Process (BP)response to stimulus10.3478Least InformativeInherited
Biological Process (BP)protein metabolic process0.4840.3854Least InformativeInherited
Biological Process (BP)cellular catabolic process0.24410.1591Moderately InformativeInherited
Biological Process (BP)macromolecule catabolic process0.0028331.428e-11Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.11611Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.57050.349Moderately InformativeInherited
Biological Process (BP)protein catabolic process2.684e-050InformativeDirect
Biological Process (BP)proteolysis0.00010653.873e-10InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.0002951.347e-10InformativeDirect
Biological Process (BP)response to light stimulus0.0052970.01484InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process2.347e-060Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.00021070Highly InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.00011139.647e-13InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity2.124e-050Highly InformativeDirect
Cellular Component (CC)protein complex0.99630.0006682Least InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.00031450InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.3478 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3854 Least Informative Inherited
Biological Process (BP) macromolecule catabolic process 1.428e-11 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.111e-13 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1.426e-09 Moderately Informative Direct
Biological Process (BP) immune system process 2.806e-06 Moderately Informative Direct
Biological Process (BP) signal transduction 4.102e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0006647 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.9144 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.349 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.7535 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9663 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3665 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1591 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.6668 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.4151 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3638 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.957 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9414 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.761 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2122 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) proteolysis 3.873e-10 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 1.347e-10 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) regulation of defense response 2.447e-14 Informative Direct
Biological Process (BP) regulation of cytokine production 9.862e-14 Informative Direct
Biological Process (BP) response to bacterium 1.721e-12 Informative Direct
Biological Process (BP) reproductive structure development 4.328e-10 Informative Direct
Biological Process (BP) immune response 1.387e-09 Informative Direct
Biological Process (BP) regulation of immune response 1.205e-08 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 2.257e-08 Informative Direct
Biological Process (BP) positive regulation of immune system process 1.824e-06 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 2.798e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 6.089e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 5.616e-05 Informative Direct
Biological Process (BP) cell death 0.0002903 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.004451 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.5547 Informative Inherited
Biological Process (BP) regulation of locomotion 0.7967 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.02298 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9589 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1268 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8245 Informative Inherited
Biological Process (BP) positive regulation of transport 0.001057 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.01717 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of growth 0.5049 Informative Inherited
Biological Process (BP) response to light stimulus 0.01484 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.1603 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03522 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.03808 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.01573 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2518 Informative Inherited
Biological Process (BP) response to lipid 0.08436 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1344 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.6907 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.01216 Informative Inherited
Biological Process (BP) immune effector process 0.7295 Informative Inherited
Biological Process (BP) cell activation 0.3084 Informative Inherited
Biological Process (BP) cell cycle process 0.2353 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 8.124e-11 Highly Informative Direct
Biological Process (BP) post-embryonic development 1.194e-10 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 4.123e-10 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 5.948e-09 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 1.687e-08 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 3.099e-08 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 2.21e-07 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 1.043e-06 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 1.236e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 1.338e-06 Highly Informative Direct
Biological Process (BP) activation of immune response 2.908e-06 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 5.445e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 8.548e-06 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 1.089e-05 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 4.297e-05 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 5.967e-05 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 7.496e-05 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.0001215 Highly Informative Direct
Biological Process (BP) innate immune response 0.0002467 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0003075 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.6506 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.06131 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 1 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.7599 Highly Informative Inherited
Biological Process (BP) regulation of interleukin-1 beta production 0.7681 Highly Informative Inherited
Biological Process (BP) cell growth 0.0901 Highly Informative Inherited
Biological Process (BP) developmental growth 0.92 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.2887 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 1 Highly Informative Inherited
Biological Process (BP) DNA replication 0.451 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.03317 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.07004 Highly Informative Inherited
Biological Process (BP) response to UV 0.7038 Highly Informative Inherited
Biological Process (BP) positive regulation of peptidase activity 0.00348 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01733 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.0459 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.6977 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.001243 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.0706 Highly Informative Inherited
Biological Process (BP) ossification 0.001027 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.1827 Highly Informative Inherited
Biological Process (BP) regulation of response to biotic stimulus 0.1451 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 0.2199 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.05714 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.578 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.04135 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.06959 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.2876 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.001161 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.4346 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.7907 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 8.995e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 9.647e-13 Informative Direct
Molecular Function (MF) amide binding 1.24e-06 Informative Direct
Molecular Function (MF) lipid binding 0.574 Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1477 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.05958 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.994 Informative Inherited
Molecular Function (MF) receptor activity 0.4044 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.6081 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 5.207e-07 Highly Informative Direct
Molecular Function (MF) hormone binding 6.865e-06 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 4.035e-05 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0002048 Highly Informative Direct
Cellular Component (CC) protein complex 0.0006682 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) contractile fiber part 0.512 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.2558 Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 1.029e-05 Highly Informative Direct
Cellular Component (CC) myofilament 4.617e-05 Highly Informative Direct
Cellular Component (CC) replisome 7.157e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 0.02066 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.4842 Highly Informative Inherited
Cellular Component (CC) cell body 0.2843 Highly Informative Inherited
Cellular Component (CC) transcription elongation factor complex 0.002544 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.9456 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.4543Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1.75e-08Moderately InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio2.328e-15Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.01394Moderately InformativeInherited
Disease Ontology (DO)syndrome0.2825Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0001595InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0003838InformativeDirect
Disease Ontology (DO)Crohn's disease7.976e-06Highly InformativeDirect
Disease Ontology (DO)irritable bowel syndrome0.0001967Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.3805Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1636Moderately InformativeInherited
Phenotypic Abnormality (PA)Arthralgia0.0003323Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.06361Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0001974Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.001584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1671Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.2315Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0004351InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.04773InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.05664InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.9653InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion3.643e-08Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-12b secretion2.355e-05Highly InformativeDirect
Mammalian Phenotype (MP)colitis9.081e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.4794Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.9966Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.5472Moderately InformativeInherited
Worm Phenotype (WP)protein aggregation induced paralysis0.0003916InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001317Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)sporangium1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)anther8.324e-05Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.524Least InformativeInherited
Enzyme Commission (EC)Lyases0.7108Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen4.235e-08InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.009354InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors5.199e-15Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase6.124e-11Highly InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase4.079e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis2.041e-12Moderately InformativeDirect
Biological processDifferentiation0.0001094Moderately InformativeDirect
Biological processCell cycle0.3634Moderately InformativeInherited
Biological processInflammatory response0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis3.153e-06InformativeDirect
Biological processBiological rhythms4.57e-07Highly InformativeDirect
Cellular componentNucleus4.081e-08Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton1.236e-11Moderately InformativeDirect
Cellular componentCell projection0.009057Moderately InformativeInherited
Cellular componentCilium0.008101Highly InformativeInherited
DomainRepeat0Least InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
Molecular functionActin-binding1.029e-09InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein4.091e-07Moderately InformativeDirect
Post-translational modificationKinase0.01692Moderately InformativeInherited
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGTPase activation3.679e-08InformativeDirect
Post-translational modificationDioxygenase0.0008626Highly InformativeDirect
Post-translational modificationGlycoprotein1.349e-06Least InformativeDirect
Post-translational modificationPhosphoprotein3.251e-06Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the RNI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]