SUPERFAMILY 1.75 HMM library and genome assignments server


Carbamoyl phosphate synthetase, small subunit N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   Carbamoyl phosphate synthetase, small subunit N-terminal domain [ 52021]
Families:   Carbamoyl phosphate synthetase, small subunit N-terminal domain [ 52022]


Superfamily statistics
Genomes (2,825) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,406 0 6
Proteins 3,405 0 6


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0009894 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.922e-15 Least Informative Direct
Biological Process (BP) biosynthetic process 1.024e-10 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0007629 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.001868 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 3.732e-09 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.602e-06 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.04e-12 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 1.533e-07 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 7.034e-06 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 7.281e-15 Moderately Informative Direct
Biological Process (BP) cellular amide metabolic process 0.0007116 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0.001682 Highly Informative Inherited
Molecular Function (MF) binding 0.7719 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.226 Least Informative Inherited
Molecular Function (MF) cation binding 0.02983 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 5.523e-14 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.753e-10 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)In cyclic amides0.0002974InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Dihydroorotase2.381e-06Highly InformativeDirect
Enzyme Commission (EC)Carboxyl- and carbamoyltransferases2.517e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.7455Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (ammonia)2.747e-14Highly InformativeDirect
Enzyme Commission (EC)Carboxyl- and carbamoyltransferases1.986e-07Highly InformativeDirect
Enzyme Commission (EC)In cyclic amides2.868e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR002474 SSF52021 Protein matches
Abstract The carbamoyl-phosphate synthase domain is in the N terminus of the protein. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamoyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines [PubMed1972379]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Carbamoyl phosphate synthetase, small subunit N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Carbamoyl phosphate synthetase, small subunit N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]