|
|
Phosphohistidine domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Regulation |
| Detailed category | Kinases/phosphatases |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR008279 SSF52009 Protein matches |
| Abstract | A number of enzymes that catalyze the transfer of a phosphoryl group from
phosphoenolpyruvate (PEP) via a phospho-histidine intermediate have been shown
to be structurally related [ 7686067, 8973315, 2176881, 1557039]. All these enzymes share the same catalytic mechanism: they bind PEP and
transfer the phosphoryl group from it to a histidine residue. This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all
proteins known to contain it [12083528]. It is often found associated with the pyruvate phosphate dikinase, PEP/pyruvate-binding domain at its N-terminus. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
|
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
|
Alignments of sequences to 4 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
|
|
Browse and view proteins in genomes which have
different domain combinations including a Phosphohistidine domain domain.
|
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
|
|
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
|
There are 4 hidden Markov models representing the Phosphohistidine domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
|
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
|
0
