SUPERFAMILY 1.75 HMM library and genome assignments server


Dihydropteroate synthetase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Dihydropteroate synthetase-like [ 51717] (2)
Families:   Dihydropteroate synthetase [ 51718]
  Methyltetrahydrofolate-utiluzing methyltransferases [ 51723] (2)


Superfamily statistics
Genomes (2,897) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,500 35,504 6
Proteins 6,483 35,476 6


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transferase activity1.997e-061.192e-05Least InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.00016271.977e-10InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 3.395e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 0.002133 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.005623 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.02168 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.01878 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1646 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1.702e-12 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 3.465e-05 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 1.989e-06 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 2.031e-10 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 1.084e-05 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.03142 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.02969 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.01666 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05234 Moderately Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.0002789 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.009645 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.004074 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 1.015e-10 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 1.024e-10 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.001024 Highly Informative Inherited
Molecular Function (MF) transferase activity 1.192e-05 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0002298 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 1.977e-10 Informative Direct
Molecular Function (MF) methyltransferase activity 2.255e-10 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.001444Least InformativeInherited
Enzyme Commission (EC)Methyltransferases3.249e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Diphosphotransferases2.027e-10InformativeDirect
Enzyme Commission (EC)2-amino-4-hydroxy-6-hydroxymethyldihydropteridine 0Highly InformativeDirect
Enzyme Commission (EC)Methionine synthase0Highly InformativeDirect
Enzyme Commission (EC)(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1.612e-06Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Methionine synthase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphotransferases4.317e-10Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.007408Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.8959Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processFolate biosynthesis0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processMethanogenesis0Highly InformativeDirect
Biological processMethionine biosynthesis9.352e-16Highly InformativeDirect
Biological processOne-carbon metabolism0.0002422Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionCobalt0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionCobalamin0Highly InformativeDirect
Post-translational modificationTransferase0.009204Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase3.945e-15InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis4.87e-15Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism6.837e-11Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)methanogenesis0InformativeDirect
UniPathway (UP)pteridine biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis4.49e-08InformativeDirect
UniPathway (UP)isopentenyl diphosphate biosynthesis via DXP pathway0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate biosynthesis0Highly InformativeDirect
UniPathway (UP)methanogenesis from acetate0.0001356Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011005 SSF51717 Protein matches
Abstract

All organisms require reduced folate cofactors for the synthesis of a variety of metabolites. The enzyme 7,8-dihydropteroate synthase (DHPS) catalyses the condensation of para-aminobenzoic acid (pABA) with 6-hydroxymethyl-7, 8-dihydropterin-pyrophosphate to form 7,8-dihydropteroate and pyrophosphate. DHPS is essential for the de novo synthesis of folate in prokaryotes, lower eukaryotes, and in plants, but is absent in mammals [PubMed11007651]. By contrast, higher vertebrates possess an active transport system that enables them to use dietary folates. DHPS is the target of sulphonamides, which are substrate analogues that compete with pABA, but which do not affect vertebrates as they lack the DHPS enzyme. DHPS is a single domain protein that forms an eight-stranded TIM alpha/beta barrel, where the 7,8-dihydropterin pyrophosphate substrate binds in a deep cleft in the barrel [PubMed9187658]. In the lower eukaryote Pneumocystis carinii, DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas) [PubMed1313386].

Other proteins contain a DHPS-like domain, including members of the methyltetrahydrofolate (corrinoid iron-sulphur protein methyltransferase (MeTr)) family. MeTr catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation [PubMed10997901]. Other members of this family that contain a DHPS-like domain include methionine synthase and methanogenic enzymes that activate the methyl group of methyltetrahydromethano(or -sarcino)pterin.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dihydropteroate synthetase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Dihydropteroate synthetase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]