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Dihydropteroate synthetase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Dihydropteroate synthetase-like [ 51717] (2)
Families:   Dihydropteroate synthetase [ 51718]
  Methyltetrahydrofolate-utiluzing methyltransferases [ 51723] (2)


Superfamily statistics
Genomes (2,897) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,497 35,504 6
Proteins 6,480 35,476 6


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.001380.00000004274Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0028880.01176Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0028280.01006Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0480.1109Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.051720.00313Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.000061850.00000000000006059Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.0000097370.00000000001708Moderately InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.0000016420.001667InformativeInherited
Biological Process (BP)folic acid-containing compound metabolic process0.00000000065340.000000000005984Highly InformativeDirect
Molecular Function (MF)transferase activity0.000000030.000002162Least InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.000014860.000000000001622InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000004274 Least Informative Direct
Biological Process (BP) biosynthetic process 0.001042 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.00313 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.01176 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.01006 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1109 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00000000000006059 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.00006083 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0000005293 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000000001708 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.000003342 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.01358 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01268 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.006612 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.02479 Moderately Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.0001531 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.001667 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.005016 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 0.000000000005984 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.0002552 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.00000000000262 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000002162 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0005762 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.000000000001622 Informative Direct
Molecular Function (MF) methyltransferase activity 0.0000000002149 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.001444Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.000003249Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0.0000000002027InformativeDirect
Enzyme Commission (EC)2-amino-4-hydroxy-6-hydroxymethyldihydropteridine 0Highly InformativeDirect
Enzyme Commission (EC)Methionine synthase0Highly InformativeDirect
Enzyme Commission (EC)(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.000001611Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Methionine synthase0Highly InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0.0000000004292Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.007393Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.8959Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processFolate biosynthesis0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processMethanogenesis0Highly InformativeDirect
Biological processMethionine biosynthesis9.352e-16Highly InformativeDirect
Biological processOne-carbon metabolism0.0002422Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionCobalt0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionCobalamin0Highly InformativeDirect
Post-translational modificationTransferase0.009204Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0.000000000000003945InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)cofactor biosynthesis8.257e-16Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0InformativeDirect
UniPathway (UP)pteridine biosynthesis0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011005 SSF51717 Protein matches
Abstract

All organisms require reduced folate cofactors for the synthesis of a variety of metabolites. The enzyme 7,8-dihydropteroate synthase (DHPS) catalyses the condensation of para-aminobenzoic acid (pABA) with 6-hydroxymethyl-7, 8-dihydropterin-pyrophosphate to form 7,8-dihydropteroate and pyrophosphate. DHPS is essential for the de novo synthesis of folate in prokaryotes, lower eukaryotes, and in plants, but is absent in mammals [PubMed11007651]. By contrast, higher vertebrates possess an active transport system that enables them to use dietary folates. DHPS is the target of sulphonamides, which are substrate analogues that compete with pABA, but which do not affect vertebrates as they lack the DHPS enzyme. DHPS is a single domain protein that forms an eight-stranded TIM alpha/beta barrel, where the 7,8-dihydropterin pyrophosphate substrate binds in a deep cleft in the barrel [PubMed9187658]. In the lower eukaryote Pneumocystis carinii, DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas) [PubMed1313386].

Other proteins contain a DHPS-like domain, including members of the methyltetrahydrofolate (corrinoid iron-sulphur protein methyltransferase (MeTr)) family. MeTr catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation [PubMed10997901]. Other members of this family that contain a DHPS-like domain include methionine synthase and methanogenic enzymes that activate the methyl group of methyltetrahydromethano(or -sarcino)pterin.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dihydropteroate synthetase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Dihydropteroate synthetase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]