SUPERFAMILY 1.75 HMM library and genome assignments server

tRNA-guanine transglycosylase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   tRNA-guanine transglycosylase [ 51713]
Families:   tRNA-guanine transglycosylase [ 51714] (2)


Superfamily statistics
Genomes (2,879) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,801 18,054 9
Proteins 3,757 18,024 9


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.0000000013540Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.000000013590Least InformativeDirect
Biological Process (BP)biosynthetic process0.00059940.00000000000002089Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.0000000040220.00000003179Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0000000012830Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0000000034020Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0018560.0000000000002965Least InformativeInherited
Biological Process (BP)single-organism cellular process0.055870.001859Least InformativeInherited
Biological Process (BP)gene expression0.00000000000019840Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.000000000000012480Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.000028780Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.000011780Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process0.000021410Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00000011270Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.0000022350Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000047520Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.00000000012720Moderately InformativeDirect
Biological Process (BP)RNA processing00InformativeDirect
Biological Process (BP)RNA modification00InformativeDirect
Biological Process (BP)ncRNA metabolic process00InformativeDirect
Biological Process (BP)glycosyl compound biosynthetic process00InformativeDirect
Biological Process (BP)tRNA modification00Highly InformativeDirect
Molecular Function (MF)transferase activity0.00000000031540Least InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups00InformativeDirect
Molecular Function (MF)transferase activity, transferring pentosyl groups00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00000000000002089 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000003179 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000000000002965 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.001859 Least Informative Inherited
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA processing 0 Informative Direct
Biological Process (BP) RNA modification 0 Informative Direct
Biological Process (BP) ncRNA metabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0 Informative Direct
Biological Process (BP) tRNA modification 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.6517 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.2981 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processtRNA processing0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)tRNA modification0InformativeDirect
UniPathway (UP)tRNA-queuosine biosynthesis0Highly InformativeDirect
UniPathway (UP)archaeosine-tRNA biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR002616 SSF51713 Protein matches
Abstract queuosine at position 34 in bacterial tRNAs and This is a family of queuine, archaeosine and general tRNA-ribosyltransferases , also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine at position 34 and with archaeosine at position 15 in archaeal tRNAs. In bacterial it catalyses the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified base queuine in the wobble position [PubMed8654383, PubMed8323579]. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H, and important tRNA and 7-aminomethyl-7deazaguanine binding residues [PubMed8654383].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a tRNA-guanine transglycosylase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the tRNA-guanine transglycosylase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]