SUPERFAMILY 1.75 HMM library and genome assignments server

Malate synthase G superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Malate synthase G [ 51645]
Families:   Malate synthase G [ 51646]


Superfamily statistics
Genomes (1,349) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,699 9,689 4
Proteins 1,697 9,679 4


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.18340.22Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0090640.0009474Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00065360.00008104Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.0000073650.000000133Moderately InformativeDirect
Biological Process (BP)cellular aldehyde metabolic process0.0000000057240.000000000002234InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.000059710.00001396InformativeDirect
Biological Process (BP)glyoxylate metabolic process0.000000000000047780Highly InformativeDirect
Molecular Function (MF)transferase activity0.000000096790.00000001265Least InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0009474 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.22 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.00008104 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000000133 Moderately Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.000000000002234 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00001396 Informative Direct
Biological Process (BP) glyoxylate metabolic process 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0.00000001265 Least Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTricarboxylic acid cycle0InformativeDirect
Cellular componentCytoplasm0.000000001547Least InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011076 SSF51645 Protein matches
Abstract

This entry represents the core TIM beta/alpha barrel found in malate synthase and in related proteins such as the beta subunit of citrate lyase.

Malate synthase catalyses the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. Malate synthase has a TIM beta/alpha-barrel fold [PubMed10715138].

This entry is also represented by citrate lyase beta subunit , a component of citrate lyase , which catalyses the interconversion of citrate with acetate and oxaloacetate.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Malate synthase G domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Malate synthase G superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]