SUPERFAMILY 1.75 HMM library and genome assignments server


Aldolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Aldolase [ 51569] (8)
Families:   Class I aldolase [ 51570] (12)
  Class II FBP aldolase [ 51591] (2)
  5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [ 51594]
  Class I DAHP synthetase [ 51599] (2)
  HMGL-like [ 89494] (3)
  NeuB-like [ 110368] (2)
  GatZ-like [ 141837]
  Class-II DAHP synthetase [ 141840]


Superfamily statistics
Genomes (3,204) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 44,838 115,846 106
Proteins 44,711 115,739 106


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00047761.155e-11Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00094353.63e-12Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.47930.2982Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.11640.8454Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.1330.8276Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.87251Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process1.446e-120Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.00013140.0006468Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process4.963e-107.333e-15Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.00019672.388e-11Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.0036632.533e-13Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.075720.1415Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.3942.549e-10Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0010040.005697Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.12190.3418Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.04830.2031Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.80031Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.041290.1305Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.35540.6946Moderately InformativeInherited
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)pigment metabolic process3.257e-084.921e-07InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process1.917e-061.093e-08InformativeDirect
Biological Process (BP)hexose metabolic process0.17830.2975InformativeInherited
Biological Process (BP)glycolysis1.722e-077.57e-08Highly InformativeDirect
Biological Process (BP)porphyrin-containing compound biosynthetic process1.385e-112.988e-09Highly InformativeDirect
Biological Process (BP)aromatic amino acid family biosynthetic process5.726e-078.837e-11Highly InformativeDirect
Biological Process (BP)heme metabolic process3.753e-064.012e-06Highly InformativeDirect
Biological Process (BP)pigment biosynthetic process2.61e-096.869e-09Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process9.624e-083.719e-10Highly InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)cation binding1.054e-052.614e-07Moderately InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity00InformativeDirect
Molecular Function (MF)hydro-lyase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.13831.563e-06InformativeInherited
Molecular Function (MF)aldehyde-lyase activity9.933e-100Highly InformativeDirect
Molecular Function (MF)oxo-acid-lyase activity0.17413.744e-05Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 1.155e-11 Least Informative Direct
Biological Process (BP) single-organism metabolic process 3.63e-12 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2982 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.8454 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.8276 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 2.549e-10 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0006468 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 2.533e-13 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 7.333e-15 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 2.388e-11 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1415 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.005697 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.3418 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2031 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.1305 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.6946 Moderately Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 7.577e-07 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) pigment metabolic process 4.921e-07 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 1.093e-08 Informative Direct
Biological Process (BP) response to inorganic substance 0.3577 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.0549 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.02323 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.2949 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.2561 Informative Inherited
Biological Process (BP) hexose metabolic process 0.2975 Informative Inherited
Biological Process (BP) glycolysis 7.57e-08 Highly Informative Direct
Biological Process (BP) porphyrin-containing compound biosynthetic process 2.988e-09 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 2.049e-05 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 8.837e-11 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 4.378e-07 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0001995 Highly Informative Direct
Biological Process (BP) heme metabolic process 4.012e-06 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 6.869e-09 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0008059 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 3.719e-10 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0007149 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 2.614e-07 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 1.563e-06 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.2991 Informative Inherited
Molecular Function (MF) aldehyde-lyase activity 0 Highly Informative Direct
Molecular Function (MF) oxo-acid-lyase activity 3.744e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.211 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9256 Least Informative Inherited
Cellular Component (CC) plastid 0.0005993 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Oxo-acid-lyases0InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)2-isopropylmalate synthase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0001411Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.22Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.02481Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.4108Moderately InformativeInherited
Phenotypic Abnormality (PA)Visceromegaly0.0001459InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia0.0005826InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.3076Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2912Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.0002235InformativeDirect
Xenopus ANatomical entity (XAN)kidney0.002507InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0004677Least InformativeDirect
Plant ANatomical entity (PAN)leaf0.0004951Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0.0005109Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0.005372Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.005949Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01078Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.0618Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.6297Least InformativeInherited
Plant ANatomical entity (PAN)cotyledon2.614e-06Moderately InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0.0001467Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0002512InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0Highly InformativeDirect
Enzyme Commission (EC)Oxo-acid-lyases0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0003083Highly InformativeDirect
Enzyme Commission (EC)Acting on phosphates0.08098Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processHeme biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processPorphyrin biosynthesis1.795e-05Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0.003272Moderately InformativeInherited
UniPathway (UP)organic acid metabolism0.06326Moderately InformativeInherited
UniPathway (UP)L-lysine biosynthesis via DAP pathway0InformativeDirect
UniPathway (UP)chorismate biosynthesis0InformativeDirect
UniPathway (UP)organic acid degradation0.03353InformativeInherited
UniPathway (UP)carbohydrate acid metabolism0.3826InformativeInherited
UniPathway (UP)organic acid biosynthesis0.7694InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis1.507e-06Highly InformativeDirect
UniPathway (UP)glyoxylate and dicarboxylate metabolism5.409e-05Highly InformativeDirect
UniPathway (UP)2-oxosuberate biosynthesis0.000109Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aldolase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Aldolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]