SUPERFAMILY 1.75 HMM library and genome assignments server


(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,989) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 93,899 323,608 385
Proteins 91,546 319,943 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.16191Least InformativeInherited
Biological Process (BP)response to stimulus0.70461Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0048261Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.25951Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00012720.7891Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)developmental process0.0037331Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus5.579e-061.986e-05Moderately InformativeDirect
Biological Process (BP)multi-organism process2.058e-103.487e-05Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00014670Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00014011Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00050861Moderately InformativeInherited
Biological Process (BP)tissue development2.52e-061Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0015281Moderately InformativeInherited
Biological Process (BP)organ development0.0019261Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.28451Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process1.051e-050.6089Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00088720.1429Moderately InformativeInherited
Biological Process (BP)response to organic substance0.014360.1463Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus2.103e-050.006872Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.020241Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.029471Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00032930.2221Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00InformativeDirect
Biological Process (BP)response to oxidative stress1.3e-057.281e-06InformativeDirect
Biological Process (BP)response to light stimulus8e-111.209e-05InformativeDirect
Biological Process (BP)response to wounding1.3e-082.518e-06InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)response to cytokine stimulus3.493e-110InformativeDirect
Biological Process (BP)regulation of locomotion8.667e-100.0003782InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process7.047e-130InformativeDirect
Biological Process (BP)regulation of cellular component movement2.45e-100.0001287InformativeDirect
Biological Process (BP)cell wall organization or biogenesis00InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.00013930InformativeDirect
Biological Process (BP)positive regulation of cellular component organization6.938e-100.9281InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis1.91e-100.6255InformativeInherited
Biological Process (BP)regulation of cell proliferation2.461e-051InformativeInherited
Biological Process (BP)lipid catabolic process0.81750.008028InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.0058350InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis6.416e-050.01609InformativeInherited
Biological Process (BP)positive regulation of developmental process1.169e-080.007654InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus3.156e-090.004469InformativeInherited
Biological Process (BP)regulation of growth2.24e-080.004213InformativeInherited
Biological Process (BP)defense response3.986e-080.001978InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.010292.013e-08InformativeInherited
Biological Process (BP)muscle system process0.01560.7729InformativeInherited
Biological Process (BP)polysaccharide catabolic process00Highly InformativeDirect
Biological Process (BP)skeletal system development00Highly InformativeDirect
Biological Process (BP)aminoglycan biosynthetic process04.158e-08Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process2.076e-053.621e-09Highly InformativeDirect
Biological Process (BP)inflammatory response1.892e-090Highly InformativeDirect
Biological Process (BP)lysosome organization4.343e-060Highly InformativeDirect
Biological Process (BP)response to UV2.997e-082.458e-14Highly InformativeDirect
Biological Process (BP)response to virus7.496e-092.281e-11Highly InformativeDirect
Biological Process (BP)response to toxic substance1.253e-142.076e-06Highly InformativeDirect
Biological Process (BP)negative regulation of cell growth00Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process1.318e-090Highly InformativeDirect
Biological Process (BP)external encapsulating structure organization0.00014440Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis00Highly InformativeDirect
Biological Process (BP)positive regulation of epithelial cell proliferation02.849e-05Highly InformativeDirect
Biological Process (BP)connective tissue development1.482e-130Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus1.445e-102.413e-09Highly InformativeDirect
Biological Process (BP)cellular response to radiation4.532e-130Highly InformativeDirect
Biological Process (BP)amino sugar metabolic process0.0034240Highly InformativeInherited
Biological Process (BP)neuromuscular process0.0015612.758e-05Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.0043683.954e-13Highly InformativeInherited
Biological Process (BP)regulation of cell adhesion00.03828Highly InformativeInherited
Biological Process (BP)multi-organism cellular process0.0019542.774e-08Highly InformativeInherited
Biological Process (BP)cell wall polysaccharide metabolic process0.00058830.009255Highly InformativeInherited
Biological Process (BP)positive regulation of growth00.006643Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process11Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration6.398e-150.7743Highly InformativeInherited
Biological Process (BP)striated muscle contraction0.0020830.03282Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups9.629e-090InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)receptor activity1.209e-070.56InformativeInherited
Molecular Function (MF)UDP-glycosyltransferase activity0.00010721Highly InformativeInherited
Molecular Function (MF)transferase activity, transferring hexosyl groups0.027040.008147Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle0.00036960.00016Moderately InformativeDirect
Cellular Component (CC)extracellular region part4.528e-051.108e-11Moderately InformativeDirect
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.065040.0177Moderately InformativeInherited
Cellular Component (CC)extracellular space0.00014658.219e-09InformativeDirect
Cellular Component (CC)cell surface0.00071340.0004279InformativeDirect
Cellular Component (CC)external encapsulating structure5.348e-100InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.05180.0004985InformativeInherited
Cellular Component (CC)lytic vacuole0.0066484.175e-06InformativeInherited
Cellular Component (CC)lysosome2.824e-153.417e-07Highly InformativeDirect
Cellular Component (CC)anchored to membrane1.821e-120Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7891 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.986e-05 Moderately Informative Direct
Biological Process (BP) multi-organism process 3.487e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6089 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9513 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.01864 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.9737 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.862 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.006872 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1429 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1463 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.2989 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2221 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0007202 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 7.281e-06 Informative Direct
Biological Process (BP) response to light stimulus 1.209e-05 Informative Direct
Biological Process (BP) response to wounding 2.518e-06 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0001712 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 9.583e-13 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 7.493e-05 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0003782 Informative Direct
Biological Process (BP) regulation of kinase activity 2.919e-05 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001287 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 2.013e-08 Informative Direct
Biological Process (BP) positive regulation of transport 0.09898 Informative Inherited
Biological Process (BP) regulation of secretion 0.03046 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9281 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.6255 Informative Inherited
Biological Process (BP) protein transport 0.3455 Informative Inherited
Biological Process (BP) secretion by cell 0.0282 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.6128 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.9716 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.048 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.00703 Informative Inherited
Biological Process (BP) regulation of defense response 0.01295 Informative Inherited
Biological Process (BP) regulation of protein localization 0.01081 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) lipid catabolic process 0.008028 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01609 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.007654 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.004469 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.05521 Informative Inherited
Biological Process (BP) leukocyte activation 0.1081 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.06095 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.8719 Informative Inherited
Biological Process (BP) tube development 0.4551 Informative Inherited
Biological Process (BP) regulation of growth 0.004213 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6136 Informative Inherited
Biological Process (BP) lipid localization 0.007951 Informative Inherited
Biological Process (BP) secondary metabolic process 0.2733 Informative Inherited
Biological Process (BP) anion transport 0.9482 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9954 Informative Inherited
Biological Process (BP) organic acid transport 0.1475 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.4778 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.9131 Informative Inherited
Biological Process (BP) defense response 0.001978 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.002431 Informative Inherited
Biological Process (BP) muscle system process 0.7729 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 7.209e-10 Highly Informative Direct
Biological Process (BP) galactose metabolic process 0.0003657 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 4.158e-08 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 3.621e-09 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 3.954e-13 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0 Highly Informative Direct
Biological Process (BP) response to UV 2.458e-14 Highly Informative Direct
Biological Process (BP) response to virus 2.281e-11 Highly Informative Direct
Biological Process (BP) response to toxic substance 2.076e-06 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 8.507e-05 Highly Informative Direct
Biological Process (BP) pentose metabolic process 3.224e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 1.839e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 3.353e-05 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0003791 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 4.112e-05 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 1.107e-05 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.678e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0007655 Highly Informative Direct
Biological Process (BP) sulfur compound catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 2.774e-08 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 2.849e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 6.001e-12 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 9.752e-12 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.0001662 Highly Informative Direct
Biological Process (BP) neuromuscular process 2.758e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 4.176e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0 Highly Informative Direct
Biological Process (BP) membrane fusion 1.839e-06 Highly Informative Direct
Biological Process (BP) connective tissue development 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 2.413e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.5663 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.6726 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.03828 Highly Informative Inherited
Biological Process (BP) interaction with host 0.004852 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.1849 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.3759 Highly Informative Inherited
Biological Process (BP) cell wall polysaccharide metabolic process 0.009255 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.5635 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.002307 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.006643 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.01162 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.008216 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.7743 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.03952 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1603 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.4624 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.03282 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 8.739e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.8999 Informative Inherited
Molecular Function (MF) receptor activity 0.56 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 3.623e-08 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001806 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.008147 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0001858 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00016 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1.108e-11 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.0177 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 4.175e-06 Informative Direct
Cellular Component (CC) extracellular space 8.219e-09 Informative Direct
Cellular Component (CC) cell surface 0.0004279 Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.0004985 Informative Direct
Cellular Component (CC) vacuolar part 0.0001912 Informative Direct
Cellular Component (CC) cell junction 1 Informative Inherited
Cellular Component (CC) lysosome 3.417e-07 Highly Informative Direct
Cellular Component (CC) brush border 0.0004631 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0002779 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0005267 Highly Informative Direct
Cellular Component (CC) anchored to membrane 0 Highly Informative Direct
Cellular Component (CC) symplast 8.876e-05 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.155 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase5.295e-14InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase1.012e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase9.899e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism3.619e-07Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.05303InformativeInherited
Disease Ontology (DO)sphingolipidosis2.963e-09Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.0009376Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7594Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.0009215Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.001231Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.007883Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01657Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.02884Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.03406Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1035Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1112Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.3836Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.8317Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.0004799InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0.004718InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.006038InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.006929InformativeInherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.01412InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.03416InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.04007InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0.1016InformativeInherited
Phenotypic Abnormality (PA)Angiokeratoma7.559e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion5.762e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex1.235e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Opacification of the corneal stroma0.0001422Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.0002533Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomegaly0.000302Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature of the conjunctiva0.0005069Highly InformativeDirect
Phenotypic Abnormality (PA)Hearing impairment0.0006749Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the abdominal wall musculature0.0007953Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.2276Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.04469Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.05931Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.07477Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1108Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1131Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.138Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4066Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype9.603e-06Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype5.522e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.003771Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.05509Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2535Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.000337InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0006612InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.001705InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.008942InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.09646InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1117InformativeInherited
Mammalian Phenotype (MP)abnormal gait9.437e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycosaminoglycan level1.957e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased vertical activity5.013e-05Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis6.536e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.0001641Highly InformativeDirect
Mammalian Phenotype (MP)impaired hearing0.001476Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0665Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2956Least InformativeInherited
Worm Phenotype (WP)transgene expression reduced4.242e-06InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.03921InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0002063Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.02576Least InformativeInherited
Plant ANatomical entity (PAN)root system0.5269Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit7.076e-07InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle7.238e-05Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase5.589e-14Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004678Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell cycle3.081e-06Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processInflammatory response5.909e-07InformativeDirect
Biological processVirulence0.000549InformativeDirect
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processFertilization1.802e-06Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole2.198e-08InformativeDirect
Cellular componentCell wall7.418e-06Highly InformativeDirect
DiseaseGlycogen storage disease6.94e-10InformativeDirect
DiseaseDental caries2.708e-13Highly InformativeDirect
DiseaseMucopolysaccharidosis2.501e-08Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor1.383e-07InformativeDirect
DomainEGF-like domain6.808e-06InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin4.532e-05InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationAntimicrobial8.744e-07InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism4.007e-15Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.0001896Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)cellulose metabolism0InformativeDirect
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)cellulose degradation0Highly InformativeDirect
UniPathway (UP)glycogen degradation1.671e-08Highly InformativeDirect
UniPathway (UP)N-glycan degradation0.0007999Highly InformativeDirect
UniPathway (UP)sphingolipid metabolism0.001902Highly InformativeInherited
UniPathway (UP)trehalose metabolism1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]