SUPERFAMILY 1.75 HMM library and genome assignments server


(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,983) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 91,960 323,608 385
Proteins 89,753 319,943 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.16471Least InformativeInherited
Biological Process (BP)response to stimulus0.74011Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0066971Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.29181Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00017850.5867Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)developmental process0.0037231Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus1.372e-055.548e-06Moderately InformativeDirect
Biological Process (BP)multi-organism process2.296e-101.245e-05Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00010180Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00012521Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00047441Moderately InformativeInherited
Biological Process (BP)tissue development2.291e-061Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0011791Moderately InformativeInherited
Biological Process (BP)organ development0.001751Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.24971Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process7.683e-060.4664Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00088360.05223Moderately InformativeInherited
Biological Process (BP)response to organic substance0.01160.1063Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus1.433e-050.004951Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.017321Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.9412Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.94240.09987Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.023331Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00028060.1518Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00InformativeDirect
Biological Process (BP)response to oxidative stress7.985e-062.551e-06InformativeDirect
Biological Process (BP)response to light stimulus8.673e-117.12e-06InformativeDirect
Biological Process (BP)response to wounding7.669e-091.367e-06InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)response to cytokine stimulus2.064e-110InformativeDirect
Biological Process (BP)regulation of locomotion7.721e-100.0002378InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process5.661e-130InformativeDirect
Biological Process (BP)regulation of cellular component movement2.122e-108.362e-05InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process9.605e-050InformativeDirect
Biological Process (BP)positive regulation of cellular component organization4.007e-100.8621InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis1.728e-100.5275InformativeInherited
Biological Process (BP)regulation of cell proliferation2.551e-051InformativeInherited
Biological Process (BP)lipid catabolic process0.82220.00716InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.0052020InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis6.813e-050.01107InformativeInherited
Biological Process (BP)positive regulation of developmental process1.132e-080.005614InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus2.723e-090.001924InformativeInherited
Biological Process (BP)regulation of growth6.731e-090.002517InformativeInherited
Biological Process (BP)response to other organism0.0028760.02985InformativeInherited
Biological Process (BP)defense response3.218e-080.001018InformativeInherited
Biological Process (BP)muscle system process0.015620.7437InformativeInherited
Biological Process (BP)polysaccharide catabolic process00Highly InformativeDirect
Biological Process (BP)skeletal system development00Highly InformativeDirect
Biological Process (BP)regulation of cell growth4.259e-131.255e-09Highly InformativeDirect
Biological Process (BP)aminoglycan biosynthetic process01.931e-08Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process2.169e-053.176e-09Highly InformativeDirect
Biological Process (BP)inflammatory response2.399e-090Highly InformativeDirect
Biological Process (BP)lysosome organization4.583e-060Highly InformativeDirect
Biological Process (BP)response to UV2.889e-083.095e-14Highly InformativeDirect
Biological Process (BP)response to virus1.223e-081.829e-11Highly InformativeDirect
Biological Process (BP)response to toxic substance6.477e-158.784e-07Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process2.244e-090Highly InformativeDirect
Biological Process (BP)external encapsulating structure organization0.00012310Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis00Highly InformativeDirect
Biological Process (BP)negative regulation of growth2.291e-135.894e-13Highly InformativeDirect
Biological Process (BP)positive regulation of epithelial cell proliferation02.487e-05Highly InformativeDirect
Biological Process (BP)connective tissue development1.351e-130Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus9.546e-111.183e-09Highly InformativeDirect
Biological Process (BP)cellular response to radiation3.947e-140Highly InformativeDirect
Biological Process (BP)amino sugar metabolic process0.0041240Highly InformativeInherited
Biological Process (BP)neuromuscular process0.0014291.735e-05Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.0051537.487e-13Highly InformativeInherited
Biological Process (BP)regulation of cell adhesion00.02601Highly InformativeInherited
Biological Process (BP)positive regulation of growth00.005574Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process11Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration4.92e-150.7771Highly InformativeInherited
Biological Process (BP)striated muscle contraction0.0021580.0277Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups5.167e-090InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)receptor activity1.183e-070.5196InformativeInherited
Molecular Function (MF)UDP-glycosyltransferase activity0.00012461Highly InformativeInherited
Molecular Function (MF)transferase activity, transferring hexosyl groups0.030150.00895Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle0.00023017.899e-05Moderately InformativeDirect
Cellular Component (CC)extracellular region part1.321e-054.782e-13Moderately InformativeDirect
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.033970.00772Moderately InformativeInherited
Cellular Component (CC)cell surface0.00076290.0001274InformativeDirect
Cellular Component (CC)external encapsulating structure2.28e-110InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.019610.0001039InformativeInherited
Cellular Component (CC)lytic vacuole0.0064614.406e-06InformativeInherited
Cellular Component (CC)lysosome2.915e-152.78e-07Highly InformativeDirect
Cellular Component (CC)anchored to membrane8.293e-140Highly InformativeDirect
Cellular Component (CC)cell wall0.015643.381e-05Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5867 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 5.548e-06 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.245e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.4664 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.8787 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.01203 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9412 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.9107 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8058 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.004951 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.05223 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1063 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.2985 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.09987 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.001329 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.2831 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1518 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0004899 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 2.551e-06 Informative Direct
Biological Process (BP) response to light stimulus 7.12e-06 Informative Direct
Biological Process (BP) response to wounding 1.367e-06 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 5.686e-05 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 9.186e-12 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0002378 Informative Direct
Biological Process (BP) regulation of kinase activity 1.805e-05 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 8.362e-05 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.07067 Informative Inherited
Biological Process (BP) regulation of secretion 0.01697 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.8621 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.5275 Informative Inherited
Biological Process (BP) protein transport 0.3083 Informative Inherited
Biological Process (BP) secretion by cell 0.02202 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5155 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.06273 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.04119 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.003987 Informative Inherited
Biological Process (BP) regulation of response to stress 0.7618 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) lipid catabolic process 0.00716 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01107 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.005614 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.001924 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.04582 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) leukocyte activation 0.09309 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.001091 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.04127 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.8202 Informative Inherited
Biological Process (BP) tube development 0.4329 Informative Inherited
Biological Process (BP) regulation of growth 0.002517 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5712 Informative Inherited
Biological Process (BP) lipid localization 0.006772 Informative Inherited
Biological Process (BP) secondary metabolic process 0.2629 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 1 Informative Inherited
Biological Process (BP) anion transport 0.927 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9788 Informative Inherited
Biological Process (BP) organic acid transport 0.1449 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.9359 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.3828 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to other organism 0.02985 Informative Inherited
Biological Process (BP) single-organism behavior 0.9462 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) defense response 0.001018 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.00195 Informative Inherited
Biological Process (BP) muscle system process 0.7437 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) regulation of cell growth 1.255e-09 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 5.151e-10 Highly Informative Direct
Biological Process (BP) galactose metabolic process 0.0003901 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 1.931e-08 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 3.176e-09 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 7.487e-13 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 7.281e-15 Highly Informative Direct
Biological Process (BP) response to UV 3.095e-14 Highly Informative Direct
Biological Process (BP) response to virus 1.829e-11 Highly Informative Direct
Biological Process (BP) response to toxic substance 8.784e-07 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 5.402e-05 Highly Informative Direct
Biological Process (BP) pentose metabolic process 2.676e-06 Highly Informative Direct
Biological Process (BP) respiratory tube development 1.564e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0002345 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0003654 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 1.551e-05 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 3.315e-05 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 5.178e-07 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.137e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0008342 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 2.702e-08 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 1.834e-09 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 6.606e-08 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) negative regulation of growth 5.894e-13 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 2.487e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 2.988e-12 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 3.633e-12 Highly Informative Direct
Biological Process (BP) neuromuscular process 1.735e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 2.933e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0 Highly Informative Direct
Biological Process (BP) connective tissue development 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 1.183e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.5276 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.6323 Highly Informative Inherited
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.007193 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.02601 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.228 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.3289 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.4886 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.002123 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.005574 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.007766 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.7771 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.02664 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1507 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.5264 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.0277 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 7.014e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.8649 Informative Inherited
Molecular Function (MF) receptor activity 0.5196 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 2.971e-08 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001479 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.00895 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0001094 Moderately Informative Direct
Cellular Component (CC) vesicle 7.899e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 4.782e-13 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.00772 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 4.406e-06 Informative Direct
Cellular Component (CC) cell surface 0.0001274 Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.0001039 Informative Direct
Cellular Component (CC) vacuolar part 0.0001539 Informative Direct
Cellular Component (CC) cell-cell junction 0.4124 Informative Inherited
Cellular Component (CC) cell wall 3.381e-05 Highly Informative Direct
Cellular Component (CC) lysosome 2.78e-07 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 7.039e-13 Highly Informative Direct
Cellular Component (CC) microvillus 4.721e-11 Highly Informative Direct
Cellular Component (CC) brush border 0.0004309 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0002017 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0004571 Highly Informative Direct
Cellular Component (CC) anchored to membrane 0 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 0.0003624 Highly Informative Direct
Cellular Component (CC) membrane raft 8.041e-10 Highly Informative Direct
Cellular Component (CC) symplast 5.283e-05 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.1633 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase5.295e-14InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase1.012e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase9.899e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism8.135e-07Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.05061InformativeInherited
Disease Ontology (DO)sphingolipidosis3.672e-09Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.0009653Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.761Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.0009119Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.005296Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.007642Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.03047Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.0433Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.04972Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1663Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.8695Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.0003912InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0.004767InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.02421InformativeInherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.04129InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.09952InformativeInherited
Phenotypic Abnormality (PA)Angiokeratoma7.524e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex1.701e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion3.545e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomegaly0.0001681Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature of the conjunctiva0.0005212Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the abdominal wall musculature0.0006705Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.04315Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.0512Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.07333Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1077Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1138Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1611Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4022Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype9.382e-06Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype6.061e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.003138Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.003591Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.05354Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2455Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology6.876e-06InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0006009InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.001836InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.008508InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.09573InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1077InformativeInherited
Mammalian Phenotype (MP)abnormal gait7.918e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycosaminoglycan level2.04e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased vertical activity4.446e-05Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis6.756e-05Highly InformativeDirect
Mammalian Phenotype (MP)impaired hearing0.001467Highly InformativeInherited
Mammalian Phenotype (MP)abnormal impulse conducting system conduction0.001734Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0665Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2956Least InformativeInherited
Worm Phenotype (WP)transgene expression reduced4.242e-06InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.03921InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0002063Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.02576Least InformativeInherited
Plant ANatomical entity (PAN)root system0.5269Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit7.076e-07InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle7.238e-05Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase5.317e-14Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004626Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell cycle4.541e-06Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processInflammatory response5.105e-07InformativeDirect
Biological processVirulence0.0004427InformativeDirect
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processFertilization1.792e-06Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole2.18e-08InformativeDirect
Cellular componentCell wall5.669e-06Highly InformativeDirect
DiseaseGlycogen storage disease7.062e-10InformativeDirect
DiseaseDental caries2.757e-13Highly InformativeDirect
DiseaseMucopolysaccharidosis2.551e-08Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor1.309e-07InformativeDirect
DomainEGF-like domain1.833e-05InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin2.919e-05InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationAntimicrobial8.817e-07InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond7.494e-14Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.0004066Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)cellulose metabolism0InformativeDirect
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)cellulose degradation0Highly InformativeDirect
UniPathway (UP)glycogen degradation1.817e-08Highly InformativeDirect
UniPathway (UP)N-glycan degradation0.0008316Highly InformativeDirect
UniPathway (UP)sphingolipid metabolism0.001725Highly InformativeInherited
UniPathway (UP)trehalose metabolism1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]