SUPERFAMILY 1.75 HMM library and genome assignments server

(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,990) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 94,156 323,608 385
Proteins 91,794 319,943 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.0042281Least InformativeInherited
Biological Process (BP)multicellular organismal process0.13211Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.00006293Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.96411Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.29171Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.73351Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.64291Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)defense response0.0000000084870.0003761Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.0000058740.00002384Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.000062170Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)tissue development0.0000012651Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0000000018710.001912Moderately InformativeInherited
Biological Process (BP)regulation of localization0.001861Moderately InformativeInherited
Biological Process (BP)organ development0.0015321Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.42451Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00014931Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0000035030.3708Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.000000066630.07544Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00095770.1481Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.000024340.007603Moderately InformativeInherited
Biological Process (BP)response to organic substance0.015510.1539Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.041611Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.10950.0000000008063Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.031871Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.90420.01991Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00093671Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0003410.2328Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00InformativeDirect
Biological Process (BP)response to oxidative stress0.000022590.000007218InformativeDirect
Biological Process (BP)response to light stimulus0.000000000079630.00001267InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)response to cytokine0.000000000036310InformativeDirect
Biological Process (BP)regulation of locomotion0.00000000094030.0004121InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.00000000000060090InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.0000019790.00004725InformativeDirect
Biological Process (BP)regulation of cellular component movement0.00000000026640.0001464InformativeDirect
Biological Process (BP)cell wall organization or biogenesis00InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000024340InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.0000000034691InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.00000000030820.6899InformativeInherited
Biological Process (BP)neurological system process0.55471InformativeInherited
Biological Process (BP)regulation of cell proliferation0.000027951InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.0033440.000000002429InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.10820.000000000001219InformativeInherited
Biological Process (BP)positive regulation of developmental process0.000000062130.03309InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.000054940.01369InformativeInherited
Biological Process (BP)regulation of growth0.000000016410.003132InformativeInherited
Biological Process (BP)lipid catabolic process0.80860.005095InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.0058650InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds0.1770.0000000000008941InformativeInherited
Biological Process (BP)muscle system process0.015650.7652InformativeInherited
Biological Process (BP)polysaccharide catabolic process00Highly InformativeDirect
Biological Process (BP)skeletal system development00Highly InformativeDirect
Biological Process (BP)aminoglycan biosynthetic process00.0000004001Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process0.000020870.000000003604Highly InformativeDirect
Biological Process (BP)inflammatory response0.000000058460Highly InformativeDirect
Biological Process (BP)lysosome organization0.0000043770Highly InformativeDirect
Biological Process (BP)response to UV0.000000047040.00000000000005349Highly InformativeDirect
Biological Process (BP)response to virus0.000000019020.00000000004506Highly InformativeDirect
Biological Process (BP)response to toxic substance0.000000000000014010.000002538Highly InformativeDirect
Biological Process (BP)negative regulation of cell growth00Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process0.00001290Highly InformativeDirect
Biological Process (BP)external encapsulating structure organization0.000040250Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis00Highly InformativeDirect
Biological Process (BP)positive regulation of epithelial cell proliferation00.00003083Highly InformativeDirect
Biological Process (BP)connective tissue development0.00000000000024520Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus0.00000000022420.000000003068Highly InformativeDirect
Biological Process (BP)cellular response to radiation0.00000000000090950Highly InformativeDirect
Biological Process (BP)amino sugar metabolic process0.0038290Highly InformativeInherited
Biological Process (BP)positive regulation of cellular component biogenesis0.0000000000000032510.009097Highly InformativeInherited
Biological Process (BP)multi-organism cellular process0.0022060.00000008167Highly InformativeInherited
Biological Process (BP)neuromuscular process0.0015640.00002736Highly InformativeInherited
Biological Process (BP)regulation of cell adhesion00.04178Highly InformativeInherited
Biological Process (BP)cell wall polysaccharide metabolic process0.00058340.009269Highly InformativeInherited
Biological Process (BP)positive regulation of growth00.01553Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process11Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.0000000000000063590.7654Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.0043350.0000000000003905Highly InformativeInherited
Biological Process (BP)energy reserve metabolic process0.0023250Highly InformativeInherited
Biological Process (BP)striated muscle contraction0.0020850.03272Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups0.000000010090InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)receptor activity0.00000011780.4906InformativeInherited
Molecular Function (MF)UDP-glycosyltransferase activity0.00010821Highly InformativeInherited
Molecular Function (MF)transferase activity, transferring hexosyl groups0.027150.008211Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle0.00015380.0001282Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.000046290.00000000001277Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane0.081640.02439Moderately InformativeInherited
Cellular Component (CC)plasma membrane part0.68840.963Moderately InformativeInherited
Cellular Component (CC)extracellular space0.00015240.00000000724InformativeDirect
Cellular Component (CC)external encapsulating structure0.00000000055540InformativeDirect
Cellular Component (CC)intrinsic component of plasma membrane0.053090.0005113InformativeInherited
Cellular Component (CC)lytic vacuole0.0074440.000006396InformativeInherited
Cellular Component (CC)anchored component of membrane0.0000000000018540Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00006293 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) defense response 0.0003761 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00002384 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000000008063 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1539 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.001912 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8784 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.05477 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.007603 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.07544 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1481 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.532 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.01991 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3708 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2328 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0007344 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0.000007218 Informative Direct
Biological Process (BP) response to light stimulus 0.00001267 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0000000000008941 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000001946 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0004121 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.0000005618 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00004725 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001464 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0002391 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.000000002429 Informative Direct
Biological Process (BP) regulation of response to wounding 0.0005905 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0.000000000001219 Informative Direct
Biological Process (BP) regulation of secretion 0.03623 Informative Inherited
Biological Process (BP) regulation of protein localization 0.01408 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.6899 Informative Inherited
Biological Process (BP) sexual reproduction 0.9828 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.05958 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.9724 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1432 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) protein transport 0.3551 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.03309 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01369 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.008291 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.1391 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.002388 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2727 Informative Inherited
Biological Process (BP) regulation of defense response 0.01312 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) tube development 0.8768 Informative Inherited
Biological Process (BP) regulation of growth 0.003132 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) lipid catabolic process 0.005095 Informative Inherited
Biological Process (BP) lipid localization 0.008852 Informative Inherited
Biological Process (BP) secondary metabolic process 0.6134 Informative Inherited
Biological Process (BP) anion transport 0.9794 Informative Inherited
Biological Process (BP) organic acid transport 0.1493 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) secretion by cell 0.02836 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.1934 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.9627 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) muscle system process 0.7652 Informative Inherited
Biological Process (BP) leukocyte activation 0.1074 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.0000000007452 Highly Informative Direct
Biological Process (BP) galactose metabolic process 0.0009632 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 0.0000004001 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.000000003604 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0.0000000000003905 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0 Highly Informative Direct
Biological Process (BP) ensheathment of neurons 0.0001449 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0 Highly Informative Direct
Biological Process (BP) response to UV 0.00000000000005349 Highly Informative Direct
Biological Process (BP) response to virus 0.00000000004506 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.000002538 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0.00008469 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.00001732 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.000001904 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.000109 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0002444 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00001045 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.00000007358 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00001853 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0000000128 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.00000008167 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.00003083 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000000000007041 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.00000000002731 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.0003263 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00002736 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000007105 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.0003377 Highly Informative Direct
Biological Process (BP) membrane fusion 0.000001813 Highly Informative Direct
Biological Process (BP) connective tissue development 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000000003068 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0 Highly Informative Direct
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.00000000002144 Highly Informative Direct
Biological Process (BP) positive regulation of response to wounding 0.000000004765 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.6906 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.3892 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.009097 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.9715 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.0227 Highly Informative Inherited
Biological Process (BP) negative regulation of protein phosphorylation 0.001175 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.04178 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.01441 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.5942 Highly Informative Inherited
Biological Process (BP) cell wall polysaccharide metabolic process 0.009269 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.002754 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.002338 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.01553 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.003894 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.008285 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.7654 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.0433 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1607 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.4724 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.03272 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.00001709 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.7222 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.00009054 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) receptor binding 0.9017 Informative Inherited
Molecular Function (MF) receptor activity 0.4906 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.00000004076 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001816 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.008211 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0001914 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0001282 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000001277 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.02439 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.9506 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.963 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.000006396 Informative Direct
Cellular Component (CC) extracellular space 0.00000000724 Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0005113 Informative Direct
Cellular Component (CC) vacuolar part 0.0001443 Informative Direct
Cellular Component (CC) cell surface 0.001547 Informative Inherited
Cellular Component (CC) side of membrane 0.2959 Informative Inherited
Cellular Component (CC) plasma membrane region 0.1464 Informative Inherited
Cellular Component (CC) cell junction 1 Informative Inherited
Cellular Component (CC) brush border 0.0004596 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0002741 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0005434 Highly Informative Direct
Cellular Component (CC) anchored component of membrane 0 Highly Informative Direct
Cellular Component (CC) symplast 0.00008726 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.092 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.00000000000005295InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.000000001012Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0.000000009899Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.0000003619Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.05303InformativeInherited
Disease Ontology (DO)sphingolipidosis0.000000002963Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.0009376Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7594Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.0009215Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.001231Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.007883Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01657Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.02884Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.03406Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1035Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1112Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.3836Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.8317Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.0004799InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0.004718InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.006038InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.006929InformativeInherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.01412InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.03416InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.04007InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0.1016InformativeInherited
Phenotypic Abnormality (PA)Angiokeratoma0.00000007559Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion0.000005762Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex0.00001235Highly InformativeDirect
Phenotypic Abnormality (PA)Opacification of the corneal stroma0.0001422Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.0002533Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomegaly0.000302Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature of the conjunctiva0.0005069Highly InformativeDirect
Phenotypic Abnormality (PA)Hearing impairment0.0006749Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the abdominal wall musculature0.0007953Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.2276Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.04469Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.05931Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.07477Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1108Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1131Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.138Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4066Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.000009603Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.00005522Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.003771Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.05509Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2535Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.000337InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0006612InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.001705InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.008942InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.09646InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1117InformativeInherited
Mammalian Phenotype (MP)abnormal gait0.00000009437Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycosaminoglycan level0.0000001957Highly InformativeDirect
Mammalian Phenotype (MP)decreased vertical activity0.00005013Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.00006536Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.0001641Highly InformativeDirect
Mammalian Phenotype (MP)impaired hearing0.001476Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0665Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2956Least InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.000004242InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.03921InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0002063Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.02576Least InformativeInherited
Plant ANatomical entity (PAN)root system0.5269Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.0000007076InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle0.00007238Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.00000000000005589Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004678Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.001561Least InformativeInherited
Drugbank ATC_code (DB)drugs used in diabetes0.000002588Moderately InformativeDirect
Drugbank ATC_code (DB)alpha glucosidase inhibitors0.00000000000009233InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell cycle0.000003081Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processInflammatory response0.0000005909InformativeDirect
Biological processVirulence0.000549InformativeDirect
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processFertilization0.000001802Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole0.00000002198InformativeDirect
Cellular componentCell wall0.000007418Highly InformativeDirect
DiseaseGlycogen storage disease0.000000000694InformativeDirect
DiseaseDental caries0.0000000000002708Highly InformativeDirect
DiseaseMucopolysaccharidosis0.00000002501Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0000001383InformativeDirect
DomainEGF-like domain0.000006808InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin0.00004532InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationAntimicrobial0.0000008744InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0.000000000000004007Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.0001896Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)cellulose metabolism0InformativeDirect
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)cellulose degradation0Highly InformativeDirect
UniPathway (UP)glycogen degradation0.00000001671Highly InformativeDirect
UniPathway (UP)N-glycan degradation0.0007999Highly InformativeDirect
UniPathway (UP)sphingolipid metabolism0.001902Highly InformativeInherited
UniPathway (UP)trehalose metabolism1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]