SUPERFAMILY 1.75 HMM library and genome assignments server


(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,988) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 93,858 323,608 385
Proteins 91,506 319,943 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.15631Least InformativeInherited
Biological Process (BP)response to stimulus0.75071Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0063461Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.26661Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00010440.6814Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)developmental process0.003441Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus1.369e-051.093e-05Moderately InformativeDirect
Biological Process (BP)multi-organism process5.367e-104.639e-05Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.0001270Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00010491Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00041731Moderately InformativeInherited
Biological Process (BP)tissue development2.586e-061Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0012131Moderately InformativeInherited
Biological Process (BP)organ development0.0018451Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.24931Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process7.21e-060.5411Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00077230.07065Moderately InformativeInherited
Biological Process (BP)response to organic substance0.01280.1149Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus1.847e-050.004933Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.016581Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.9686Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.94610.1278Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.0092965.752e-08Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.027941Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00026340.1842Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00InformativeDirect
Biological Process (BP)response to oxidative stress7.742e-064.927e-06InformativeDirect
Biological Process (BP)response to light stimulus6.958e-119.646e-06InformativeDirect
Biological Process (BP)response to wounding6.278e-092.01e-06InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)response to cytokine stimulus2.838e-110InformativeDirect
Biological Process (BP)regulation of locomotion6.934e-100.000322InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process5.015e-130InformativeDirect
Biological Process (BP)regulation of cellular component movement1.918e-100.0001133InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process9.943e-050InformativeDirect
Biological Process (BP)positive regulation of cellular component organization4.565e-100.9053InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis1.566e-100.6078InformativeInherited
Biological Process (BP)regulation of cell proliferation2.291e-051InformativeInherited
Biological Process (BP)lipid catabolic process0.82310.007456InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.0056290InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis5.813e-050.01337InformativeInherited
Biological Process (BP)positive regulation of developmental process9e-090.006303InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus2.735e-090.004069InformativeInherited
Biological Process (BP)regulation of growth2.077e-080.003497InformativeInherited
Biological Process (BP)response to other organism0.0028990.02779InformativeInherited
Biological Process (BP)defense response3.081e-080.001628InformativeInherited
Biological Process (BP)muscle system process0.015420.7572InformativeInherited
Biological Process (BP)polysaccharide catabolic process00Highly InformativeDirect
Biological Process (BP)skeletal system development00Highly InformativeDirect
Biological Process (BP)aminoglycan biosynthetic process02.56e-08Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process2.041e-053.613e-09Highly InformativeDirect
Biological Process (BP)inflammatory response1.816e-090Highly InformativeDirect
Biological Process (BP)lysosome organization4.265e-060Highly InformativeDirect
Biological Process (BP)response to UV2.864e-082.79e-14Highly InformativeDirect
Biological Process (BP)response to virus5.516e-098.59e-12Highly InformativeDirect
Biological Process (BP)response to toxic substance9.449e-151.686e-06Highly InformativeDirect
Biological Process (BP)negative regulation of cell growth00Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process1.572e-090Highly InformativeDirect
Biological Process (BP)external encapsulating structure organization0.00011430Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis00Highly InformativeDirect
Biological Process (BP)positive regulation of epithelial cell proliferation02.704e-05Highly InformativeDirect
Biological Process (BP)connective tissue development1.504e-130Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus1.524e-102.099e-09Highly InformativeDirect
Biological Process (BP)cellular response to radiation3.324e-140Highly InformativeDirect
Biological Process (BP)amino sugar metabolic process0.0036080Highly InformativeInherited
Biological Process (BP)neuromuscular process0.0015432.697e-05Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.004464.735e-13Highly InformativeInherited
Biological Process (BP)regulation of cell adhesion00.0336Highly InformativeInherited
Biological Process (BP)positive regulation of growth00.00536Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process11Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration3.256e-150.7708Highly InformativeInherited
Biological Process (BP)striated muscle contraction0.0020590.0285Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups8.169e-090InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)receptor activity1.076e-070.5466InformativeInherited
Molecular Function (MF)UDP-glycosyltransferase activity0.00010061Highly InformativeInherited
Molecular Function (MF)transferase activity, transferring hexosyl groups0.029030.005146Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle0.00034710.0001256Moderately InformativeDirect
Cellular Component (CC)extracellular region part3.631e-056.642e-12Moderately InformativeDirect
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.030570.008153Moderately InformativeInherited
Cellular Component (CC)extracellular space0.00014247.604e-09InformativeDirect
Cellular Component (CC)external encapsulating structure2.977e-090InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.018410.0001427InformativeInherited
Cellular Component (CC)lytic vacuole0.0066213.167e-06InformativeInherited
Cellular Component (CC)lysosome1.454e-152.993e-07Highly InformativeDirect
Cellular Component (CC)anchored to membrane7.127e-140Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6814 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.093e-05 Moderately Informative Direct
Biological Process (BP) multi-organism process 4.639e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 5.752e-08 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.5411 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9086 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.01694 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9686 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.9389 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8294 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.004933 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07065 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1149 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.3582 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.1278 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.3299 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1842 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0006246 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 4.927e-06 Informative Direct
Biological Process (BP) response to light stimulus 9.646e-06 Informative Direct
Biological Process (BP) response to wounding 2.01e-06 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0001101 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 8.439e-13 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 7.531e-05 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.000322 Informative Direct
Biological Process (BP) regulation of kinase activity 2.083e-05 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001133 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.08477 Informative Inherited
Biological Process (BP) regulation of secretion 0.02269 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9053 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.6078 Informative Inherited
Biological Process (BP) protein transport 0.3301 Informative Inherited
Biological Process (BP) secretion by cell 0.02506 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5802 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.9594 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.07036 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.04689 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.004699 Informative Inherited
Biological Process (BP) regulation of defense response 0.03075 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) lipid catabolic process 0.007456 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01337 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.006303 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.004069 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.04961 Informative Inherited
Biological Process (BP) leukocyte activation 0.1034 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.04725 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.8472 Informative Inherited
Biological Process (BP) tube development 0.4513 Informative Inherited
Biological Process (BP) regulation of growth 0.003497 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5953 Informative Inherited
Biological Process (BP) lipid localization 0.007674 Informative Inherited
Biological Process (BP) secondary metabolic process 0.2759 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 1 Informative Inherited
Biological Process (BP) anion transport 0.9396 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9893 Informative Inherited
Biological Process (BP) organic acid transport 0.1442 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.9326 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.4112 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to other organism 0.02779 Informative Inherited
Biological Process (BP) single-organism behavior 0.9733 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) defense response 0.001628 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.002317 Informative Inherited
Biological Process (BP) muscle system process 0.7572 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 6.056e-10 Highly Informative Direct
Biological Process (BP) galactose metabolic process 0.0003688 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 2.56e-08 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 3.613e-09 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 4.735e-13 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0 Highly Informative Direct
Biological Process (BP) response to UV 2.79e-14 Highly Informative Direct
Biological Process (BP) response to virus 8.59e-12 Highly Informative Direct
Biological Process (BP) response to toxic substance 1.686e-06 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 8.281e-05 Highly Informative Direct
Biological Process (BP) pentose metabolic process 2.888e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 1.77e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0002578 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0003929 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 1.931e-05 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 9.788e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 1.104e-06 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.487e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0009319 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 7.423e-08 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) sulfur compound catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 2.179e-08 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 8.633e-08 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 2.704e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 4.912e-12 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 7.638e-12 Highly Informative Direct
Biological Process (BP) neuromuscular process 2.697e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 3.653e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0 Highly Informative Direct
Biological Process (BP) membrane fusion 1.454e-06 Highly Informative Direct
Biological Process (BP) connective tissue development 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 2.099e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.5529 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.6977 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.0336 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.1912 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.3575 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.5376 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.002317 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.00536 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.007955 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.7708 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.03053 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1553 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.5279 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.0285 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 8.155e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.8856 Informative Inherited
Molecular Function (MF) receptor activity 0.5466 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 3.15e-08 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001697 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.005146 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0001565 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0001256 Moderately Informative Direct
Cellular Component (CC) extracellular region part 6.642e-12 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.008153 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 3.167e-06 Informative Direct
Cellular Component (CC) extracellular space 7.604e-09 Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.0001427 Informative Direct
Cellular Component (CC) vacuolar part 0.0001782 Informative Direct
Cellular Component (CC) cell surface 0.00139 Informative Inherited
Cellular Component (CC) cell-cell junction 0.4424 Informative Inherited
Cellular Component (CC) lysosome 2.993e-07 Highly Informative Direct
Cellular Component (CC) brush border 0.0004506 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0002219 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0005016 Highly Informative Direct
Cellular Component (CC) anchored to membrane 0 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 0.0003556 Highly Informative Direct
Cellular Component (CC) membrane raft 9.786e-10 Highly Informative Direct
Cellular Component (CC) symplast 8.289e-05 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.1361 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase5.295e-14InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase1.012e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase9.899e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism3.562e-07Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.05316InformativeInherited
Disease Ontology (DO)sphingolipidosis2.958e-09Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.000946Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7595Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.0009291Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.001241Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.007916Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01663Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.02923Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.03417Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1036Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1113Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.3836Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.8317Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.0004844InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0.004685InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.00606InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.006962InformativeInherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.01418InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.03474InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.04016InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0.1018InformativeInherited
Phenotypic Abnormality (PA)Angiokeratoma7.713e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion5.86e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex1.254e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Opacification of the corneal stroma0.0001442Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.0002562Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomegaly0.0003054Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature of the conjunctiva0.000512Highly InformativeDirect
Phenotypic Abnormality (PA)Hearing impairment0.0006814Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the abdominal wall musculature0.000804Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.2278Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.04376Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.05532Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.07308Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1071Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1121Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1611Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3996Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype9.307e-06Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype5.638e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.003146Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.00341Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.05423Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2491Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology6.984e-06InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0005961InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.001774InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.008659InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.09567InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1077InformativeInherited
Mammalian Phenotype (MP)abnormal gait8.238e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycosaminoglycan level1.971e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased vertical activity4.28e-05Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis6.497e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.0001538Highly InformativeDirect
Mammalian Phenotype (MP)impaired hearing0.001514Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0665Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2956Least InformativeInherited
Worm Phenotype (WP)transgene expression reduced4.242e-06InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.03921InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0002063Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.02576Least InformativeInherited
Plant ANatomical entity (PAN)root system0.5269Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit7.076e-07InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle7.238e-05Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase5.916e-14Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004742Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell cycle4.738e-06Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processInflammatory response5.174e-07InformativeDirect
Biological processVirulence0.0005471InformativeDirect
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processFertilization1.807e-06Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole2.212e-08InformativeDirect
Cellular componentCell wall7.529e-06Highly InformativeDirect
DiseaseGlycogen storage disease7.062e-10InformativeDirect
DiseaseDental caries2.757e-13Highly InformativeDirect
DiseaseMucopolysaccharidosis2.551e-08Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor1.35e-07InformativeDirect
DomainEGF-like domain7.048e-06InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin2.952e-05InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationAntimicrobial8.975e-07InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond2.505e-14Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)cellulose metabolism4.899e-11InformativeDirect
UniPathway (UP)cellulose degradation6.213e-16Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]