SUPERFAMILY 1.75 HMM library and genome assignments server


(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,313) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 75,086 171,485 385
Proteins 73,351 168,976 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.92941Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0021561Least InformativeInherited
Biological Process (BP)response to stimulus0.081431Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0002421Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.8758Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.77471Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis9.812e-060.01531Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.75561Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)developmental process2.834e-060.3236Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus1.081e-086.141e-13Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus2.041e-072.985e-06Moderately InformativeDirect
Biological Process (BP)multi-organism process6.653e-135.286e-09Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus7.87e-074.252e-06Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process8.53e-090Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound6.985e-060.0002044Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization3.927e-060.2092Moderately InformativeInherited
Biological Process (BP)tissue development7.253e-070.08184Moderately InformativeInherited
Biological Process (BP)regulation of localization6.089e-060.04032Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.018981Moderately InformativeInherited
Biological Process (BP)organ development0.0011010.03189Moderately InformativeInherited
Biological Process (BP)system process10.856Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process3.391e-070.003994Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0021160.0001142Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.0018831Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.99670.1552Moderately InformativeInherited
Biological Process (BP)regulation of developmental process5.022e-070.06578Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.37174.794e-06Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.067891Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00InformativeDirect
Biological Process (BP)membrane lipid metabolic process2.349e-050InformativeDirect
Biological Process (BP)defense response1.099e-071.992e-07InformativeDirect
Biological Process (BP)response to oxidative stress1.426e-063.711e-09InformativeDirect
Biological Process (BP)response to light stimulus3.468e-134.937e-09InformativeDirect
Biological Process (BP)response to wounding1.806e-092.354e-10InformativeDirect
Biological Process (BP)carbohydrate catabolic process9.533e-130InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis7.185e-059.245e-07InformativeDirect
Biological Process (BP)response to cytokine stimulus2.729e-120InformativeDirect
Biological Process (BP)regulation of growth2.365e-108.699e-06InformativeDirect
Biological Process (BP)regulation of locomotion2.098e-126.311e-08InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process6.773e-120InformativeDirect
Biological Process (BP)positive regulation of developmental process3.222e-111.09e-06InformativeDirect
Biological Process (BP)regulation of cellular component movement7.462e-135.203e-09InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process1.482e-060InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process0.00066364.008e-15InformativeDirect
Biological Process (BP)positive regulation of cellular component organization2.597e-130.1351InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis6.238e-130.04754InformativeInherited
Biological Process (BP)regulation of cell proliferation2.497e-071InformativeInherited
Biological Process (BP)lipid catabolic process0.34092.468e-06InformativeInherited
Biological Process (BP)biological adhesion0.00020920.7701InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus6.539e-120.001393InformativeInherited
Biological Process (BP)response to other organism0.0069710.004347InformativeInherited
Biological Process (BP)muscle system process0.0065550.3906InformativeInherited
Biological Process (BP)polysaccharide catabolic process2.851e-120Highly InformativeDirect
Biological Process (BP)skeletal system development00Highly InformativeDirect
Biological Process (BP)aminoglycan biosynthetic process08.188e-08Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process6.516e-091.727e-10Highly InformativeDirect
Biological Process (BP)glycosphingolipid metabolic process0.00020460Highly InformativeDirect
Biological Process (BP)inflammatory response2.091e-100Highly InformativeDirect
Biological Process (BP)lysosome organization1.339e-060Highly InformativeDirect
Biological Process (BP)response to UV9.68e-081.5e-13Highly InformativeDirect
Biological Process (BP)response to virus4.893e-107.341e-12Highly InformativeDirect
Biological Process (BP)response to toxic substance01.822e-09Highly InformativeDirect
Biological Process (BP)glycoside metabolic process0.0001080Highly InformativeDirect
Biological Process (BP)negative regulation of cell growth00Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process4.729e-070Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism0.00042557.429e-12Highly InformativeDirect
Biological Process (BP)multi-organism cellular process0.00012083.868e-13Highly InformativeDirect
Biological Process (BP)external encapsulating structure organization0.00010050Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis00Highly InformativeDirect
Biological Process (BP)positive regulation of growth00.0001675Highly InformativeDirect
Biological Process (BP)positive regulation of epithelial cell proliferation04.007e-07Highly InformativeDirect
Biological Process (BP)neuromuscular process0.00032151.077e-06Highly InformativeDirect
Biological Process (BP)connective tissue development2.312e-130Highly InformativeDirect
Biological Process (BP)cellular response to abiotic stimulus00Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus2.359e-104.589e-09Highly InformativeDirect
Biological Process (BP)amino sugar metabolic process0.010851.39e-11Highly InformativeInherited
Biological Process (BP)regulation of cell adhesion00.001075Highly InformativeInherited
Biological Process (BP)cellular glucan metabolic process0.018610.002024Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration00.765Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process11Highly InformativeInherited
Biological Process (BP)striated muscle contraction0.00082120.004837Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups1.691e-090InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)receptor activity7.324e-100.0399InformativeInherited
Molecular Function (MF)transferase activity, transferring hexosyl groups1.042e-110Highly InformativeDirect
Molecular Function (MF)UDP-glycosyltransferase activity2.671e-140.9336Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.97710.002905Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)extracellular region00Moderately InformativeDirect
Cellular Component (CC)vesicle9.363e-094.064e-08Moderately InformativeDirect
Cellular Component (CC)plasma membrane10.8348Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.01170.0002845Moderately InformativeInherited
Cellular Component (CC)vacuole00InformativeDirect
Cellular Component (CC)cell surface1.238e-062.486e-10InformativeDirect
Cellular Component (CC)external encapsulating structure3.115e-100InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.036643.584e-06InformativeInherited
Cellular Component (CC)cell wall5.227e-121.507e-07Highly InformativeDirect
Cellular Component (CC)lysosome02.684e-09Highly InformativeDirect
Cellular Component (CC)anchored to membrane1.084e-130Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.01531 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.3236 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8758 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 6.141e-13 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 2.985e-06 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0001142 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.0002262 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 4.794e-06 Moderately Informative Direct
Biological Process (BP) multi-organism process 5.286e-09 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 4.252e-06 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0002044 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.003994 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2092 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3443 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.08184 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.09167 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3505 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04032 Moderately Informative Inherited
Biological Process (BP) system process 0.856 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1552 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1095 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.9828 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.06161 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.9975 Moderately Informative Inherited
Biological Process (BP) organ development 0.03189 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.06578 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.002667 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6961 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.6808 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0001125 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.0008772 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) defense response 1.992e-07 Informative Direct
Biological Process (BP) response to oxidative stress 3.711e-09 Informative Direct
Biological Process (BP) response to light stimulus 4.937e-09 Informative Direct
Biological Process (BP) response to wounding 2.354e-10 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 1.981e-08 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 7.427e-11 Informative Direct
Biological Process (BP) lipid catabolic process 2.468e-06 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0002282 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 9.245e-07 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000847 Informative Direct
Biological Process (BP) regulation of protein localization 7.832e-05 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of growth 8.699e-06 Informative Direct
Biological Process (BP) regulation of locomotion 6.311e-08 Informative Direct
Biological Process (BP) regulation of kinase activity 3.907e-09 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) multi-organism reproductive process 3.475e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 5.544e-05 Informative Direct
Biological Process (BP) regulation of secretion 0.0001169 Informative Direct
Biological Process (BP) positive regulation of transport 0.0006935 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.09e-06 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0005331 Informative Direct
Biological Process (BP) regulation of cellular component movement 5.203e-09 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 4.008e-15 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.1351 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.04754 Informative Inherited
Biological Process (BP) protein transport 0.02679 Informative Inherited
Biological Process (BP) secretion 0.01249 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03639 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) biological adhesion 0.7701 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9939 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.001393 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.04046 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2372 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2251 Informative Inherited
Biological Process (BP) cell activation 0.03962 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) regulation of response to stress 0.04997 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.5917 Informative Inherited
Biological Process (BP) sexual reproduction 0.423 Informative Inherited
Biological Process (BP) tube development 0.04855 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.06039 Informative Inherited
Biological Process (BP) anion transport 0.4854 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.6264 Informative Inherited
Biological Process (BP) organic acid transport 0.05028 Informative Inherited
Biological Process (BP) positive regulation of phosphorus metabolic process 0.03091 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2992 Informative Inherited
Biological Process (BP) response to other organism 0.004347 Informative Inherited
Biological Process (BP) response to external stimulus 0.8413 Informative Inherited
Biological Process (BP) single-organism behavior 0.4129 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5614 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.6972 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.1685 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) muscle system process 0.3906 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 3.631e-12 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 8.188e-08 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 1.39e-11 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 1.727e-10 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0 Highly Informative Direct
Biological Process (BP) digestion 0.0001901 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0 Highly Informative Direct
Biological Process (BP) response to UV 1.5e-13 Highly Informative Direct
Biological Process (BP) response to virus 7.341e-12 Highly Informative Direct
Biological Process (BP) response to toxic substance 1.822e-09 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0002049 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0 Highly Informative Direct
Biological Process (BP) lung development 1.931e-08 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000145 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 1.867e-06 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 2.23e-07 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 1.31e-09 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 4.862e-08 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0004098 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 1.275e-09 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 7.429e-12 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 3.868e-13 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0001675 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 4.007e-07 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 4.651e-12 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 4.172e-06 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.0003345 Highly Informative Direct
Biological Process (BP) neuromuscular process 1.077e-06 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 7.463e-10 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 6.387e-11 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 1.625e-08 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 9.842e-10 Highly Informative Direct
Biological Process (BP) connective tissue development 0 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0.0004699 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 4.589e-09 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.6444 Highly Informative Inherited
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.001277 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.001075 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.2251 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.2943 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.1369 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.003014 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.765 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.00343 Highly Informative Inherited
Biological Process (BP) adult behavior 0.03576 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.2649 Highly Informative Inherited
Biological Process (BP) cellular glucan metabolic process 0.002024 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.004837 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.05007 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.5736 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 6.72e-06 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) receptor binding 0.4009 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.4114 Informative Inherited
Molecular Function (MF) receptor activity 0.0399 Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 3.278e-10 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.9336 Highly Informative Inherited
Molecular Function (MF) amino acid transmembrane transporter activity 0.002676 Highly Informative Inherited
Molecular Function (MF) glycosaminoglycan binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.002905 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1.866e-09 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0002845 Moderately Informative Direct
Cellular Component (CC) vesicle 4.064e-08 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.8348 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 1.113e-06 Informative Direct
Cellular Component (CC) vacuole 0 Informative Direct
Cellular Component (CC) cell surface 2.486e-10 Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 3.584e-06 Informative Direct
Cellular Component (CC) cell junction 0.4235 Informative Inherited
Cellular Component (CC) cell wall 1.507e-07 Highly Informative Direct
Cellular Component (CC) lysosome 2.684e-09 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 3.76e-14 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 4.342e-06 Highly Informative Direct
Cellular Component (CC) anchored to membrane 0 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 0.0007366 Highly Informative Direct
Cellular Component (CC) membrane raft 1.894e-13 Highly Informative Direct
Cellular Component (CC) symplast 1.588e-06 Highly Informative Direct
Cellular Component (CC) cell-cell junction 0.03062 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase5.295e-14InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase1.012e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase9.899e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism3.315e-07Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.03048InformativeInherited
Disease Ontology (DO)sphingolipidosis8.551e-11Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen5.408e-06Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.0202Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.03985Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.04012Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.09391Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system1.78e-05Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.0006738Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.001449Moderately InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.003935Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.102Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1099Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.4391Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the skeleton0.4933Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the eye0.4988Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.617Moderately InformativeInherited
Phenotypic Abnormality (PA)Malformation of the heart and great vessels0.9784Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.0002035InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spleen0.0007417InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the myocardium0.0009991InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0.001186InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.007249InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.03083InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.08002InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting bones of the axial skeleton0.09416InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.7659InformativeInherited
Phenotypic Abnormality (PA)Angiokeratoma8.378e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion5.132e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Cherry red spot of the macula1.023e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex4.389e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Opacification of the corneal stroma0.0001066Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.000292Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomegaly0.0003331Highly InformativeDirect
Phenotypic Abnormality (PA)Developmental regression0.0003756Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature of the conjunctiva0.0006072Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the abdominal wall musculature0.000731Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.2842Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.04804Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.09713Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1733Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.532Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype8.423e-06Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype4.856e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.001406Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.003422Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.04096Moderately InformativeInherited
Mammalian Phenotype (MP)behavior/neurological phenotype0.1598Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology4.335e-06InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology1.509e-05InformativeDirect
Mammalian Phenotype (MP)abnormal hindbrain morphology0.00836InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.01844InformativeInherited
Mammalian Phenotype (MP)abnormal motor capabilities/coordination/movement0.09898InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.133InformativeInherited
Mammalian Phenotype (MP)abnormal glycosaminoglycan level1.929e-07Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis3.899e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal impulse conducting system conduction0.0008994Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hearing physiology0.005808Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0665Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2956Least InformativeInherited
Worm Phenotype (WP)transgene expression reduced4.242e-06InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.03921InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0002063Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0.9699Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)vascular leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit6.513e-07InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle7.379e-05Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase4.366e-14Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004156Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alpha glucosidase inhibitors2.03e-09InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell cycle8.358e-07Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processGlycogen metabolism0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processXylan degradation0Highly InformativeDirect
Biological processSphingolipid metabolism1.231e-09Highly InformativeDirect
Biological processFertilization5.604e-07Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole1.392e-07InformativeDirect
Cellular componentCell wall0.0008974Highly InformativeDirect
DiseaseGlycogen storage disease1.242e-09InformativeDirect
DiseaseDental caries4.667e-13Highly InformativeDirect
DiseaseMucopolysaccharidosis3.889e-08Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor9.777e-08Moderately InformativeDirect
DomainEGF-like domain0.0006466InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin5.606e-05InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationAntimicrobial0.006737InformativeInherited
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond8.556e-10Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism4.459e-16Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis7.653e-05Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)cellulose metabolism0InformativeDirect
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)cellulose degradation0Highly InformativeDirect
UniPathway (UP)N-glycan metabolism7.221e-11Highly InformativeDirect
UniPathway (UP)glycogen degradation1.93e-08Highly InformativeDirect
UniPathway (UP)sphingolipid metabolism0.0009697Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]