SUPERFAMILY 1.75 HMM library and genome assignments server


(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,948) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 86,346 171,485 385
Proteins 84,502 168,976 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.13411Least InformativeInherited
Biological Process (BP)response to stimulus0.69021Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0039241Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.21121Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0001170.7234Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)developmental process0.0025931Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)macromolecule catabolic process00Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus9.282e-065.428e-06Moderately InformativeDirect
Biological Process (BP)multi-organism process6.032e-100.0003154Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00015450Moderately InformativeDirect
Biological Process (BP)regulation of developmental process8.304e-051Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00043371Moderately InformativeInherited
Biological Process (BP)tissue development1.973e-061Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00070860.9762Moderately InformativeInherited
Biological Process (BP)organ development0.0013151Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.21351Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process3.289e-050.7433Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00073480.07025Moderately InformativeInherited
Biological Process (BP)response to organic substance0.01070.1451Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus1.314e-050.007943Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.044911Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.8734Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.93810.1106Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.015324.374e-08Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.020731Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00022820.1577Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00InformativeDirect
Biological Process (BP)defense response1.776e-080.0007957InformativeDirect
Biological Process (BP)response to oxidative stress8.203e-061.852e-06InformativeDirect
Biological Process (BP)response to light stimulus4.988e-116.87e-06InformativeDirect
Biological Process (BP)response to wounding1.048e-081.416e-06InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)response to cytokine stimulus1.832e-110InformativeDirect
Biological Process (BP)regulation of locomotion6.682e-100.0002283InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process3.885e-130InformativeDirect
Biological Process (BP)regulation of cellular component movement1.987e-107.781e-05InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.00017460InformativeDirect
Biological Process (BP)positive regulation of cellular component organization3.981e-100.8392InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis1.703e-100.4813InformativeInherited
Biological Process (BP)positive regulation of cell proliferation2.635e-080.6863InformativeInherited
Biological Process (BP)lipid catabolic process0.8050.00455InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.0047020InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis9.511e-050.009919InformativeInherited
Biological Process (BP)positive regulation of developmental process8.782e-090.004432InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus2.281e-090.002261InformativeInherited
Biological Process (BP)regulation of growth4.58e-090.002414InformativeInherited
Biological Process (BP)cell death0.60441InformativeInherited
Biological Process (BP)polysaccharide catabolic process00Highly InformativeDirect
Biological Process (BP)skeletal system development00Highly InformativeDirect
Biological Process (BP)regulation of cell growth2.696e-131.525e-09Highly InformativeDirect
Biological Process (BP)aminoglycan biosynthetic process01.878e-08Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process1.932e-056.724e-09Highly InformativeDirect
Biological Process (BP)inflammatory response3.198e-090Highly InformativeDirect
Biological Process (BP)lysosome organization4.635e-060Highly InformativeDirect
Biological Process (BP)response to UV5.247e-087.325e-14Highly InformativeDirect
Biological Process (BP)response to virus4.907e-097.521e-12Highly InformativeDirect
Biological Process (BP)response to toxic substance3.152e-158.916e-07Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process2.779e-090Highly InformativeDirect
Biological Process (BP)external encapsulating structure organization0.00013990Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis00Highly InformativeDirect
Biological Process (BP)negative regulation of growth1.235e-133.441e-13Highly InformativeDirect
Biological Process (BP)positive regulation of epithelial cell proliferation02.784e-05Highly InformativeDirect
Biological Process (BP)connective tissue development1.471e-130Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus1.425e-102.575e-09Highly InformativeDirect
Biological Process (BP)cellular response to radiation6.503e-140Highly InformativeDirect
Biological Process (BP)amino sugar metabolic process0.016630Highly InformativeInherited
Biological Process (BP)neuromuscular process0.0010351.353e-05Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.0040935.794e-13Highly InformativeInherited
Biological Process (BP)regulation of cell adhesion00.02652Highly InformativeInherited
Biological Process (BP)positive regulation of growth00.005903Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process11Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration6.167e-150.7707Highly InformativeInherited
Biological Process (BP)striated muscle contraction0.0019410.02043Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups3.42e-090InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)receptor activity6.892e-080.5233InformativeInherited
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds1.788e-100Highly InformativeDirect
Molecular Function (MF)UDP-glycosyltransferase activity9.704e-051Highly InformativeInherited
Molecular Function (MF)transferase activity, transferring hexosyl groups0.027340.009044Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle2.658e-050.000765Moderately InformativeDirect
Cellular Component (CC)extracellular region part2.422e-062.503e-12Moderately InformativeDirect
Cellular Component (CC)plasma membrane part0.43990.6254Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.026070.009035Moderately InformativeInherited
Cellular Component (CC)cell surface0.00052657.644e-05InformativeDirect
Cellular Component (CC)external encapsulating structure1.193e-090InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.017978.204e-05InformativeInherited
Cellular Component (CC)lytic vacuole0.0018962.626e-06InformativeInherited
Cellular Component (CC)cell wall3.682e-129.247e-09Highly InformativeDirect
Cellular Component (CC)lysosome1.373e-153.207e-07Highly InformativeDirect
Cellular Component (CC)anchored to membrane6.653e-140Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7234 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 5.428e-06 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0003154 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 4.374e-08 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.7433 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.8548 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9762 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.01394 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.8734 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.9139 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8183 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.007943 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07025 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1451 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.3406 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.1106 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.2431 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1577 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0003998 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) defense response 0.0007957 Informative Direct
Biological Process (BP) response to oxidative stress 1.852e-06 Informative Direct
Biological Process (BP) response to light stimulus 6.87e-06 Informative Direct
Biological Process (BP) response to wounding 1.416e-06 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 9.853e-05 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 9.345e-12 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0002283 Informative Direct
Biological Process (BP) regulation of kinase activity 2.031e-05 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 7.781e-05 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.05283 Informative Inherited
Biological Process (BP) regulation of secretion 0.01331 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.8392 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.4813 Informative Inherited
Biological Process (BP) protein transport 0.304 Informative Inherited
Biological Process (BP) secretion by cell 0.02255 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5745 Informative Inherited
Biological Process (BP) membrane organization 0.28 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.06732 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.03182 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.003732 Informative Inherited
Biological Process (BP) regulation of defense response 0.02346 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.6863 Informative Inherited
Biological Process (BP) lipid catabolic process 0.00455 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.009919 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.004432 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.002261 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.04436 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) cell activation 0.3367 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.001125 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.0392 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.8035 Informative Inherited
Biological Process (BP) regulation of growth 0.002414 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5654 Informative Inherited
Biological Process (BP) lipid localization 0.006809 Informative Inherited
Biological Process (BP) secondary metabolic process 0.2731 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 1 Informative Inherited
Biological Process (BP) anion transport 0.9258 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9763 Informative Inherited
Biological Process (BP) organic acid transport 0.1523 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.4032 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.9109 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.8178 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.002097 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) regulation of cell growth 1.525e-09 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 3.572e-10 Highly Informative Direct
Biological Process (BP) galactose metabolic process 0.0004106 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 1.878e-08 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 6.724e-09 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 5.794e-13 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 5.586e-15 Highly Informative Direct
Biological Process (BP) response to UV 7.325e-14 Highly Informative Direct
Biological Process (BP) response to virus 7.521e-12 Highly Informative Direct
Biological Process (BP) response to toxic substance 8.916e-07 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 4.757e-05 Highly Informative Direct
Biological Process (BP) pentose metabolic process 2.915e-06 Highly Informative Direct
Biological Process (BP) lung development 1.282e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0002553 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0001929 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 1.48e-05 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 1.732e-05 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.206e-05 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0004437 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 1.746e-08 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 6.182e-08 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) negative regulation of growth 3.441e-13 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 2.784e-05 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 4.905e-09 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 1.044e-05 Highly Informative Direct
Biological Process (BP) neuromuscular process 1.353e-05 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 4.71e-07 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 1.411e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 3.188e-06 Highly Informative Direct
Biological Process (BP) interaction with host 1.171e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 8.676e-10 Highly Informative Direct
Biological Process (BP) connective tissue development 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 2.575e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.7097 Highly Informative Inherited
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.004656 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.02652 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.2003 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.293 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.4818 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.005903 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.009913 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.008881 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.7707 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.02414 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1485 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.5324 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.02043 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 6.222e-05 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.9325 Informative Inherited
Molecular Function (MF) receptor activity 0.5233 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 3.048e-08 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.000179 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.009044 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 7.519e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000765 Moderately Informative Direct
Cellular Component (CC) extracellular region part 2.503e-12 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.6254 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.009035 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 2.626e-06 Informative Direct
Cellular Component (CC) extracellular space 1.65e-08 Informative Direct
Cellular Component (CC) cell surface 7.644e-05 Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 8.204e-05 Informative Direct
Cellular Component (CC) vacuolar part 0.0001757 Informative Direct
Cellular Component (CC) cell-cell junction 0.421 Informative Inherited
Cellular Component (CC) cell wall 9.247e-09 Highly Informative Direct
Cellular Component (CC) lysosome 3.207e-07 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 8.991e-13 Highly Informative Direct
Cellular Component (CC) microvillus 5.336e-11 Highly Informative Direct
Cellular Component (CC) brush border 0.0004658 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0001843 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0003858 Highly Informative Direct
Cellular Component (CC) anchored to membrane 0 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 0.0003631 Highly Informative Direct
Cellular Component (CC) membrane raft 6.707e-10 Highly Informative Direct
Cellular Component (CC) symplast 0.0001025 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.1726 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase5.295e-14InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase1.012e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase9.899e-09Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism8.161e-07Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.05086InformativeInherited
Disease Ontology (DO)sphingolipidosis3.677e-09Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.0009711Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.1122Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.0009167Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.005312Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.02412Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.03063Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.04349Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.04993Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1663Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.8694Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.0003846InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0.004782InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.02438InformativeInherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.04326InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.09971InformativeInherited
Phenotypic Abnormality (PA)Angiokeratoma7.527e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex1.698e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion3.549e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomegaly0.0001685Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature of the conjunctiva0.0005235Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the abdominal wall musculature0.0006747Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.04331Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.07332Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1036Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2022Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5427Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype8.607e-06Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype5.751e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.002973Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.003412Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01858Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.04765Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4382Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology6.417e-06InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology1.783e-05InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0005814InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.00545InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.008412InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1106InformativeInherited
Mammalian Phenotype (MP)abnormal gait7.776e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycosaminoglycan level1.555e-07Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis6.464e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal impulse conducting system conduction0.0009149Highly InformativeDirect
Mammalian Phenotype (MP)impaired hearing0.001477Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0665Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2956Least InformativeInherited
Worm Phenotype (WP)transgene expression reduced4.242e-06InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.03921InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0002063Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.02576Least InformativeInherited
Plant ANatomical entity (PAN)root system0.5269Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit7.076e-07InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle7.238e-05Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase5.089e-14Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004475Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell cycle1.954e-06Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processFertilization1.283e-06Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole1.408e-08InformativeDirect
Cellular componentCell wall0.0002336Highly InformativeDirect
DiseaseGlycogen storage disease7.829e-10InformativeDirect
DiseaseDental caries3.057e-13Highly InformativeDirect
DiseaseMucopolysaccharidosis2.805e-08Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor7.253e-08InformativeDirect
DomainEGF-like domain0.0001427InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin1.866e-05InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationAntimicrobial0.008169InformativeInherited
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond3.311e-13Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)cellulose metabolism8.255e-09InformativeDirect
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)cellulose degradation3.914e-09Highly InformativeDirect
UniPathway (UP)N-glycan metabolism0.1421Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]