SUPERFAMILY 1.75 HMM library and genome assignments server

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(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,989) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 93,899 323,608 385
Proteins 91,546 319,943 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.1551Least InformativeInherited
Biological Process (BP)response to stimulus0.75611Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0064671Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.26371Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00010560.6883Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)developmental process0.0034011Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.00001530.00001469Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000000058320.00005129Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00012310Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00010561Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00040961Moderately InformativeInherited
Biological Process (BP)tissue development0.0000025241Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0012541Moderately InformativeInherited
Biological Process (BP)organ development0.001861Moderately InformativeInherited
Biological Process (BP)system process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.25511Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0000073530.5463Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00078360.07657Moderately InformativeInherited
Biological Process (BP)response to organic substance0.012950.1232Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.000019150.005715Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.01721Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.9694Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.9460.1322Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.0090370.00000005189Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.027741Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00026770.1902Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00InformativeDirect
Biological Process (BP)response to oxidative stress0.0000072290.000005151InformativeDirect
Biological Process (BP)response to light stimulus0.00000000007340.00001018InformativeDirect
Biological Process (BP)response to wounding0.0000000059340.000002103InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)response to cytokine stimulus0.000000000028660InformativeDirect
Biological Process (BP)regulation of locomotion0.00000000076320.0003363InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.00000000000072060InformativeDirect
Biological Process (BP)regulation of cellular component movement0.00000000021310.0001189InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000097510InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.00000000048250.9036InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.00000000016630.6057InformativeInherited
Biological Process (BP)regulation of cell proliferation0.000023051InformativeInherited
Biological Process (BP)lipid catabolic process0.82230.007247InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.0056430InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.000058250.01333InformativeInherited
Biological Process (BP)positive regulation of developmental process0.0000000090470.005994InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.0000000028420.004203InformativeInherited
Biological Process (BP)regulation of growth0.00000002090.003532InformativeInherited
Biological Process (BP)response to other organism0.0030930.02922InformativeInherited
Biological Process (BP)defense response0.000000033460.001728InformativeInherited
Biological Process (BP)muscle system process0.015470.7675InformativeInherited
Biological Process (BP)polysaccharide catabolic process00Highly InformativeDirect
Biological Process (BP)skeletal system development00Highly InformativeDirect
Biological Process (BP)aminoglycan biosynthetic process00.0000000249Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process0.000020470.000000003889Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000000017280Highly InformativeDirect
Biological Process (BP)lysosome organization0.0000042770Highly InformativeDirect
Biological Process (BP)response to UV0.000000031350.00000000000002782Highly InformativeDirect
Biological Process (BP)response to virus0.0000000039050.000000000007026Highly InformativeDirect
Biological Process (BP)response to toxic substance0.000000000000012510.000001838Highly InformativeDirect
Biological Process (BP)negative regulation of cell growth00Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process0.0000000013390Highly InformativeDirect
Biological Process (BP)external encapsulating structure organization0.00011410Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis00Highly InformativeDirect
Biological Process (BP)positive regulation of epithelial cell proliferation00.00002736Highly InformativeDirect
Biological Process (BP)connective tissue development0.00000000000015590Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus0.00000000016680.000000002819Highly InformativeDirect
Biological Process (BP)cellular response to radiation0.000000000000030380Highly InformativeDirect
Biological Process (BP)amino sugar metabolic process0.0036230Highly InformativeInherited
Biological Process (BP)neuromuscular process0.0015460.00002658Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.004460.0000000000004161Highly InformativeInherited
Biological Process (BP)regulation of cell adhesion00.03458Highly InformativeInherited
Biological Process (BP)positive regulation of growth00.005524Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process11Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.0000000000000048450.7724Highly InformativeInherited
Biological Process (BP)striated muscle contraction0.0020640.03236Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups0.000000008230InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)receptor activity0.00000010560.5482InformativeInherited
Molecular Function (MF)UDP-glycosyltransferase activity0.00010051Highly InformativeInherited
Molecular Function (MF)transferase activity, transferring hexosyl groups0.029020.00521Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle0.00035230.0001367Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.000037460.000000000007395Moderately InformativeDirect
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.030690.008279Moderately InformativeInherited
Cellular Component (CC)extracellular space0.00014420.000000007687InformativeDirect
Cellular Component (CC)external encapsulating structure0.0000000030050InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.018480.0001446InformativeInherited
Cellular Component (CC)lytic vacuole0.0066250.000003134InformativeInherited
Cellular Component (CC)lysosome0.0000000000000014540.0000003027Highly InformativeDirect
Cellular Component (CC)anchored to membrane0.000000000000071440Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6883 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00001469 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00005129 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00000005189 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5463 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9234 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.01744 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9694 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.9564 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8553 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.005715 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07657 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1232 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.3816 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.1322 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1902 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.0006268 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0.000005151 Informative Direct
Biological Process (BP) response to light stimulus 0.00001018 Informative Direct
Biological Process (BP) response to wounding 0.000002103 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0001198 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0000000000008669 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00007624 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0003363 Informative Direct
Biological Process (BP) regulation of kinase activity 0.00002311 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001189 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.08657 Informative Inherited
Biological Process (BP) regulation of secretion 0.02363 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9036 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.6057 Informative Inherited
Biological Process (BP) protein transport 0.3366 Informative Inherited
Biological Process (BP) secretion by cell 0.0258 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5859 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.9613 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.04586 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.005531 Informative Inherited
Biological Process (BP) regulation of defense response 0.03107 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.06968 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) lipid catabolic process 0.007247 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01333 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.005994 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.004203 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.05059 Informative Inherited
Biological Process (BP) leukocyte activation 0.1046 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.05603 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.8456 Informative Inherited
Biological Process (BP) tube development 0.4467 Informative Inherited
Biological Process (BP) regulation of growth 0.003532 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5949 Informative Inherited
Biological Process (BP) lipid localization 0.007738 Informative Inherited
Biological Process (BP) secondary metabolic process 0.2683 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 1 Informative Inherited
Biological Process (BP) anion transport 0.943 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9893 Informative Inherited
Biological Process (BP) organic acid transport 0.145 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.9506 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.4432 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to other organism 0.02922 Informative Inherited
Biological Process (BP) single-organism behavior 0.9875 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) defense response 0.001728 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.002343 Informative Inherited
Biological Process (BP) muscle system process 0.7675 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) myeloid leukocyte activation 0.0000000006143 Highly Informative Direct
Biological Process (BP) galactose metabolic process 0.0003693 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 0.0000000249 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.000000003889 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0.0000000000004161 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0 Highly Informative Direct
Biological Process (BP) response to UV 0.00000000000002782 Highly Informative Direct
Biological Process (BP) response to virus 0.000000000007026 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.000001838 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0.00008334 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.00000289 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.000001751 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0002608 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0003237 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00003791 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00001008 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.000001147 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00001608 Highly Informative Direct
Biological Process (BP) negative regulation of phosphorylation 0.0007303 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.00000007483 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) sulfur compound catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.00000002225 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.00000008783 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.00002736 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000000000004911 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.000000000007771 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00002658 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000003995 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0 Highly Informative Direct
Biological Process (BP) membrane fusion 0.000001511 Highly Informative Direct
Biological Process (BP) connective tissue development 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000000002819 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.5572 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.7025 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.03458 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.1831 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.3614 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.5392 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.002177 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.005524 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.008014 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.7724 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.03801 Highly Informative Inherited
Biological Process (BP) adult behavior 0.156 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.4864 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.03236 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.0000825 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.8883 Informative Inherited
Molecular Function (MF) receptor activity 0.5482 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.0000000332 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001759 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.00521 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0001574 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0001367 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.000000000007395 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.008279 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.000003134 Informative Direct
Cellular Component (CC) extracellular space 0.000000007687 Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.0001446 Informative Direct
Cellular Component (CC) vacuolar part 0.0001803 Informative Direct
Cellular Component (CC) cell surface 0.001369 Informative Inherited
Cellular Component (CC) cell junction 1 Informative Inherited
Cellular Component (CC) lysosome 0.0000003027 Highly Informative Direct
Cellular Component (CC) brush border 0.0004526 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0002584 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.0005062 Highly Informative Direct
Cellular Component (CC) anchored to membrane 0 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 0.0003573 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0000000009967 Highly Informative Direct
Cellular Component (CC) symplast 0.00008447 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.1302 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.00000000000005295InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.000000001012Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0.000000009899Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.0000003562Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.05316InformativeInherited
Disease Ontology (DO)sphingolipidosis0.000000002958Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.000946Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7595Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.0009291Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.001241Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.007916Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.01663Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.02923Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.03417Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1036Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1113Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.3836Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.8317Moderately InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.0004844InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0.004685InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.00606InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.006962InformativeInherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.01418InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.03474InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.04016InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0.1018InformativeInherited
Phenotypic Abnormality (PA)Angiokeratoma0.00000007713Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion0.00000586Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex0.00001254Highly InformativeDirect
Phenotypic Abnormality (PA)Opacification of the corneal stroma0.0001442Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.0002562Highly InformativeDirect
Phenotypic Abnormality (PA)Cardiomegaly0.0003054Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature of the conjunctiva0.000512Highly InformativeDirect
Phenotypic Abnormality (PA)Hearing impairment0.0006814Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the abdominal wall musculature0.000804Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.2278Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.04376Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.05532Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.07308Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1071Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1121Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1611Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3996Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.000009307Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.00005638Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.003146Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.00341Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.05423Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2491Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.000006984InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0005961InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.001774InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.008659InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.09567InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1077InformativeInherited
Mammalian Phenotype (MP)abnormal gait0.00000008238Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycosaminoglycan level0.0000001971Highly InformativeDirect
Mammalian Phenotype (MP)decreased vertical activity0.0000428Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.00006497Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.0001538Highly InformativeDirect
Mammalian Phenotype (MP)impaired hearing0.001514Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0665Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2956Least InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.000004242InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.03921InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0002063Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0.02576Least InformativeInherited
Plant ANatomical entity (PAN)root system0.5269Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)leaf1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.0000007076InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)radicle0.00007238Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0.00000000000005916Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004742Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell cycle0.000004738Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processInflammatory response0.0000005174InformativeDirect
Biological processVirulence0.0005471InformativeDirect
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processFertilization0.000001807Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole0.00000002212InformativeDirect
Cellular componentCell wall0.000007529Highly InformativeDirect
DiseaseGlycogen storage disease0.0000000007062InformativeDirect
DiseaseDental caries0.0000000000002757Highly InformativeDirect
DiseaseMucopolysaccharidosis0.00000002551Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.000000135InformativeDirect
DomainEGF-like domain0.000007048InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin0.00002952InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationAntimicrobial0.0000008975InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00000000000002505Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)cellulose metabolism0.00000000004899InformativeDirect
UniPathway (UP)cellulose degradation6.213e-16Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]