SUPERFAMILY 1.75 HMM library and genome assignments server

Epsilon subunit of F1F0-ATP synthase N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Epsilon subunit of F1F0-ATP synthase N-terminal domain [ 51343]
Superfamily:   Epsilon subunit of F1F0-ATP synthase N-terminal domain [ 51344]
Families:   Epsilon subunit of F1F0-ATP synthase N-terminal domain [ 51345]


Superfamily statistics
Genomes (2,811) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,202 17,908 3
Proteins 3,202 17,908 3


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.02563 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.005881 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.003075 Least Informative Inherited
Biological Process (BP) localization 0.001412 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.001695 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5784 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.001145 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.001902 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000003405 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000001681 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00002802 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.00008415 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0001176 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0001299 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0001398 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001652 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0002668 Moderately Informative Direct
Biological Process (BP) ion transport 0.001401 Moderately Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.0000000000162 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00000000001695 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.0000000000266 Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.00000000003144 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0000001321 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0000001919 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0004198 Informative Direct
Biological Process (BP) ion transmembrane transport 0.002833 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.03659 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.007052 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.00000000000003903 Highly Informative Direct
Biological Process (BP) hydrogen ion transmembrane transport 0.00007165 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00003272 Least Informative Direct
Molecular Function (MF) transporter activity 0.000000001136 Moderately Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0000000000001282 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.000000001258 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.0000005738 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.001203 Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0.00000003738 Highly Informative Direct
Cellular Component (CC) protein complex 0.000000001858 Least Informative Direct
Cellular Component (CC) membrane 0.000000009995 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000009876 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.04936 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.009923 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.000000000002648 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000000000009067 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.00000000082 Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 0.000003999 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane0.000842InformativeDirect
Cellular componentCF(1)0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001469 SSF51344 Protein matches
Abstract

This family represents subunits called delta (in mitochondrial ATPase) or epsilon (in bacteria or chloroplast ATPase). The interaction site of subunit C of the F0 complex with the delta or epsilon subunit of the F1 complex may be important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit) [PubMed12887009]. In bacterial species, the delta subunit is the equivalent of the Oligomycin sensitive subunit (OSCP, ) in metazoans. The C-terminal domain of the epsilon subunit appears to act as an inhibitor of ATPase activity [PubMed16707672].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Epsilon subunit of F1F0-ATP synthase N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Epsilon subunit of F1F0-ATP synthase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]