SUPERFAMILY 1.75 HMM library and genome assignments server


Epsilon subunit of F1F0-ATP synthase N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Epsilon subunit of F1F0-ATP synthase N-terminal domain [ 51343]
Superfamily:   Epsilon subunit of F1F0-ATP synthase N-terminal domain [ 51344]
Families:   Epsilon subunit of F1F0-ATP synthase N-terminal domain [ 51345]


Superfamily statistics
Genomes (2,803) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,182 17,908 3
Proteins 3,182 17,908 3


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.4672 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.007663 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.002551 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.004102 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.005661 Least Informative Inherited
Biological Process (BP) localization 0.001859 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.001627 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.002274 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 3.806e-07 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 2.044e-06 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 3.144e-05 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 8.252e-05 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0001021 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0001133 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0001215 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001801 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0002378 Moderately Informative Direct
Biological Process (BP) ion transport 0.0004015 Moderately Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 2.123e-11 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 2.302e-11 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 3.858e-11 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 1.151e-07 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 1.8e-07 Informative Direct
Biological Process (BP) transmembrane transport 2.503e-07 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0005191 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.02878 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.005453 Informative Inherited
Biological Process (BP) hydrogen transport 4.075e-14 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 6.65e-14 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 3.465e-12 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 4.406e-12 Highly Informative Direct
Biological Process (BP) ATP metabolic process 4.124e-09 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 0.0003908 Highly Informative Direct
Molecular Function (MF) hydrolase activity 5.415e-05 Least Informative Direct
Molecular Function (MF) transporter activity 2.44e-09 Moderately Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 1.334e-11 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 2.457e-09 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 6.576e-07 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.001199 Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 3.548e-08 Highly Informative Direct
Cellular Component (CC) protein complex 6.428e-09 Least Informative Direct
Cellular Component (CC) membrane 2.544e-07 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 9.628e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.05703 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.008069 Least Informative Inherited
Cellular Component (CC) mitochondrial part 2.429e-12 Moderately Informative Direct
Cellular Component (CC) organelle envelope 8.431e-12 Moderately Informative Direct
Cellular Component (CC) organelle membrane 2.202e-08 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 8.586e-10 Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 4.269e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane0.0008636InformativeDirect
Cellular componentCF(1)0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001469 SSF51344 Protein matches
Abstract

This family represents subunits called delta (in mitochondrial ATPase) or epsilon (in bacteria or chloroplast ATPase). The interaction site of subunit C of the F0 complex with the delta or epsilon subunit of the F1 complex may be important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit) [PubMed12887009]. In bacterial species, the delta subunit is the equivalent of the Oligomycin sensitive subunit (OSCP, ) in metazoans. The C-terminal domain of the epsilon subunit appears to act as an inhibitor of ATPase activity [PubMed16707672].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Epsilon subunit of F1F0-ATP synthase N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Epsilon subunit of F1F0-ATP synthase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]