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Epsilon subunit of F1F0-ATP synthase N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Epsilon subunit of F1F0-ATP synthase N-terminal domain [ 51343]
Superfamily:   Epsilon subunit of F1F0-ATP synthase N-terminal domain [ 51344]
Families:   Epsilon subunit of F1F0-ATP synthase N-terminal domain [ 51345]


Superfamily statistics
Genomes (2,810) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,198 17,908 3
Proteins 3,198 17,908 3


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.3947 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.005409 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.001739 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.00284 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.004134 Least Informative Inherited
Biological Process (BP) localization 0.001157 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.001132 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.00155 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000002484 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000001307 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00002198 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.00008925 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0001037 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0001132 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001182 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000122 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0002379 Moderately Informative Direct
Biological Process (BP) ion transport 0.0003964 Moderately Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.0000000000165 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00000000001707 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00000000002683 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000007811 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0000001167 Informative Direct
Biological Process (BP) transmembrane transport 0.0000001655 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.000584 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.02797 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.004825 Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) hydrogen transport 0.00000000000004112 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.00000000000004112 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 0.000000000002458 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0000000000027 Highly Informative Direct
Biological Process (BP) ATP metabolic process 0.000000002429 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0000323 Least Informative Direct
Molecular Function (MF) transporter activity 0.00000000112 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000000002381 Moderately Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.000000000007051 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.000000001264 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.0000005724 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.001149 Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0.00000003563 Highly Informative Direct
Cellular Component (CC) protein complex 0.000000002073 Least Informative Direct
Cellular Component (CC) membrane 0.000000009295 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000001519 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.05419 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.008768 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.000000000002365 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000000000008288 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.00000004116 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.0000000008885 Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 0.000004141 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane0.0008482InformativeDirect
Cellular componentCF(1)0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001469 SSF51344 Protein matches
Abstract

This family represents subunits called delta (in mitochondrial ATPase) or epsilon (in bacteria or chloroplast ATPase). The interaction site of subunit C of the F0 complex with the delta or epsilon subunit of the F1 complex may be important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit) [PubMed12887009]. In bacterial species, the delta subunit is the equivalent of the Oligomycin sensitive subunit (OSCP, ) in metazoans. The C-terminal domain of the epsilon subunit appears to act as an inhibitor of ATPase activity [PubMed16707672].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Epsilon subunit of F1F0-ATP synthase N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Epsilon subunit of F1F0-ATP synthase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]