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cAMP-binding domain-like superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Regulation |
| Detailed category | Signal transduction |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR000595 SSF51206 Protein matches |
| Abstract | Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [ 14638413,
10550204, 1710853]. The best studied of these proteins is the prokaryotic catabolite gene activator (also
known as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three alpha-helices and
a distinctive eight-stranded, antiparallel beta-barrel structure. There are six invariant amino acids in this domain,
three of which are glycine residues that are thought to be essential for maintenance of the structural integrity of
the beta-barrel. cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic
nucleotide-binding domain. The cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain,
which contains both copies of the domain. The cGPK's are single chain enzymes that include the two copies of the domain
in their N-terminal section. Vertebrate cyclic nucleotide-gated ion-channels also contain this domain. Two such
cations channels have been fully characterised, one is found in rod cells where it plays a role in visual signal
transduction. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 16 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a cAMP-binding domain-like domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 16 hidden Markov models representing the cAMP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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