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alpha-D-mannose-specific plant lectins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Prism II [ 51109]
Superfamily:   alpha-D-mannose-specific plant lectins [ 51110]
Families:   alpha-D-mannose-specific plant lectins [ 51111] (3)


Superfamily statistics
Genomes (226) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,716 5,879 13
Proteins 6,998 5,421 12


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.4347 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.03876 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2971 Least Informative Inherited
Biological Process (BP) multi-organism process 0.007951 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.00876 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001349 Moderately Informative Inherited
Biological Process (BP) defense response 0.0009169 Informative Direct
Biological Process (BP) phosphorylation 0.00001059 Informative Direct
Biological Process (BP) protein phosphorylation 0.00004162 Highly Informative Direct
Molecular Function (MF) binding 0.0000000000003282 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0473 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0.000000002889Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.000000005473Least InformativeDirect
DomainEGF-like domain0InformativeDirect
Molecular functionNucleotide-binding0.00000000002973Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001480 SSF51110 Protein matches
Abstract Members of this domain are plant lectins. Curculin is a sweet-tasting and taste-modifying protein from the fruits of Curculigo latifolia (Lumbah). The three mannose-binding sites are devoid of mannose-binding activity [PubMed9132060]. Other members of this domain are mannose specific and have diverse functions. The lectin of the saffron crocus (Crocus sativus) (Saffron) specifically interacts with a yeast mannan and is a major corm protein specifically expressed in this organ [PubMed10691656].

The actin-binding and vesicle-associated protein comitin exhibits a mannose-specific lectin activity and may have a role in cell motility. It binds to vesicle membranes via mannose residues and, by way of its interaction with actin, links these membranes to the cytoskeleton.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha-D-mannose-specific plant lectins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the alpha-D-mannose-specific plant lectins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]