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Carbonic anhydrase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Carbonic anhydrase [ 51068]
Superfamily:   Carbonic anhydrase [ 51069]
Families:   Carbonic anhydrase [ 51070]


Superfamily statistics
Genomes (748) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,947 6,122 72
Proteins 3,851 6,067 72


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.000034580.0000001012Least InformativeDirect
Biological Process (BP)regulation of cellular process0.077781Least InformativeInherited
Biological Process (BP)single-organism cellular process0.96181Least InformativeInherited
Biological Process (BP)response to stimulus0.0016680.7453Least InformativeInherited
Biological Process (BP)regulation of biological quality0.000110.0003958Moderately InformativeDirect
Biological Process (BP)organic substance transport0.00011790.00004561Moderately InformativeDirect
Biological Process (BP)regulation of localization0.0000032330.008154Moderately InformativeInherited
Biological Process (BP)signal transduction0.0090890.6945Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00037360.8325Moderately InformativeInherited
Biological Process (BP)ion transport0.018230.0636Moderately InformativeInherited
Biological Process (BP)regulation of ion transport0.000000000013390.0000001532InformativeDirect
Biological Process (BP)cation homeostasis0.00000000000019940InformativeDirect
Biological Process (BP)positive regulation of transport0.000065290.001304InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.59071InformativeInherited
Biological Process (BP)anion transport0.042230.0005211InformativeInherited
Biological Process (BP)gas transport0.0000000053340Highly InformativeDirect
Biological Process (BP)one-carbon compound transport0.00000000057720Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process0.000000027240.0000001377Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.0000000014450.0000003901Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation homeostasis00Highly InformativeDirect
Biological Process (BP)regulation of peptide transport0.000020380.00002433Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis0.000000049490.0000009126Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway0.0000008130.001118Highly InformativeInherited
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity00InformativeDirect
Cellular Component (CC)membrane0.0025390.04221Least InformativeInherited
Cellular Component (CC)plasma membrane0.0026020.0002939Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.15710.04592Moderately InformativeInherited
Cellular Component (CC)intrinsic to plasma membrane0.06640.1188InformativeInherited
Cellular Component (CC)anchored to membrane0.0000030130.000001991Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0000001012 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.7453 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.6675 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0.0003958 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.00004561 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.008154 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.6945 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8325 Moderately Informative Inherited
Biological Process (BP) ion transport 0.0636 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4927 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.6206 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2894 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5837 Moderately Informative Inherited
Biological Process (BP) organ development 0.4767 Moderately Informative Inherited
Biological Process (BP) anion transport 0.0005211 Informative Direct
Biological Process (BP) dephosphorylation 0.0000516 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000001532 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.001304 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.002569 Informative Inherited
Biological Process (BP) protein dephosphorylation 0.0000003285 Highly Informative Direct
Biological Process (BP) gas transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0000001377 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0000003901 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.00002433 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000009126 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.001118 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.01366 Moderately Informative Inherited
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.0002764 Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0000003521 Highly Informative Direct
Cellular Component (CC) membrane 0.04221 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.0002939 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0000000002224 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.04592 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0.0008185 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.1188 Informative Inherited
Cellular Component (CC) anchored to membrane 0.000001991 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0000167 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.4594Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004856Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0000002434InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.5263Least InformativeInherited
Mammalian Phenotype (MP)abnormal pH regulation0.00001568Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001734Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000001378InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.00001142Moderately InformativeDirect
Biological processVirus entry into host cell0.0000000643InformativeDirect
Cellular componentMembrane0.1363Least InformativeInherited
Cellular componentSecreted0.00000000001136Moderately InformativeDirect
Cellular componentGPI-anchor0.000003728InformativeDirect
Cellular componentExtracellular matrix0.00001579InformativeDirect
Cellular componentPeriplasm0.00007391InformativeDirect
Cellular componentViral envelope protein0.0000000008041Highly InformativeDirect
Developmental stageLate protein0.000000003727Least InformativeDirect
DiseaseDisease mutation0.00008362Least InformativeDirect
DomainSignal3.091e-16Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0.0009842Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.00000007973InformativeDirect
Post-translational modificationGlycoprotein0.0000000603Least InformativeDirect
Post-translational modificationDisulfide bond0.000000903Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001148 SSF51069 Protein matches
Abstract

Synonym(s): Carbonic dehydratase, Carbonic anhydrase

Carbonate dehydratase (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. Eight enzymatic and evolutionary related forms of carbonic anhydrase are currently known to exist in vertebrates: three cytosolic isozymes (CA-I, CA-II and CA-III); two membrane-bound forms (CA-IV and CA-VII); a mitochondrial form (CA-V); a secreted salivary form (CA-VI); and a yet uncharacterised isozyme.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Carbonic anhydrase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Carbonic anhydrase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]