SUPERFAMILY 1.75 HMM library and genome assignments server


Carbonic anhydrase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Carbonic anhydrase [ 51068]
Superfamily:   Carbonic anhydrase [ 51069]
Families:   Carbonic anhydrase [ 51070]


Superfamily statistics
Genomes (748) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,947 6,122 72
Proteins 3,851 6,067 72


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization7.466e-056.595e-06Least InformativeDirect
Biological Process (BP)regulation of cellular process0.055041Least InformativeInherited
Biological Process (BP)single-organism cellular process0.96541Least InformativeInherited
Biological Process (BP)response to stimulus0.00085050.5965Least InformativeInherited
Biological Process (BP)homeostatic process3.743e-102.584e-10Moderately InformativeDirect
Biological Process (BP)organic substance transport1.613e-052.891e-07Moderately InformativeDirect
Biological Process (BP)regulation of localization1.731e-060.01405Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0002110.7309Moderately InformativeInherited
Biological Process (BP)ion transport0.018280.06585Moderately InformativeInherited
Biological Process (BP)signal transduction0.0095810.6209Moderately InformativeInherited
Biological Process (BP)regulation of ion transport6.792e-128.122e-08InformativeDirect
Biological Process (BP)positive regulation of transport5.632e-050.0008943InformativeDirect
Biological Process (BP)cellular cation homeostasis11InformativeInherited
Biological Process (BP)anion transport0.041110.000491InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway5.129e-070.0008215Highly InformativeDirect
Biological Process (BP)gas transport4.838e-090Highly InformativeDirect
Biological Process (BP)one-carbon compound transport6.021e-100Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process2.843e-089.849e-08Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport1.6e-092.559e-07Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH1.328e-114.077e-10Highly InformativeDirect
Biological Process (BP)regulation of peptide transport5.904e-061.942e-05Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis2.894e-085.131e-07Highly InformativeDirect
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity00InformativeDirect
Cellular Component (CC)membrane0.0014340.02773Least InformativeInherited
Cellular Component (CC)plasma membrane0.0023530.0001185Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.16080.05029Moderately InformativeInherited
Cellular Component (CC)intrinsic to plasma membrane0.065030.1205InformativeInherited
Cellular Component (CC)anchored to membrane2.735e-062.056e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 6.595e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5965 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.5516 Least Informative Inherited
Biological Process (BP) homeostatic process 2.584e-10 Moderately Informative Direct
Biological Process (BP) organic substance transport 2.891e-07 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.01405 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7309 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.6209 Moderately Informative Inherited
Biological Process (BP) ion transport 0.06585 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4269 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.5428 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2451 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5022 Moderately Informative Inherited
Biological Process (BP) organ development 0.4752 Moderately Informative Inherited
Biological Process (BP) anion transport 0.000491 Informative Direct
Biological Process (BP) dephosphorylation 3.101e-05 Informative Direct
Biological Process (BP) regulation of ion transport 8.122e-08 Informative Direct
Biological Process (BP) positive regulation of transport 0.0008943 Informative Direct
Biological Process (BP) cellular cation homeostasis 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.001919 Informative Inherited
Biological Process (BP) protein dephosphorylation 2.156e-07 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.0008215 Highly Informative Direct
Biological Process (BP) gas transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 9.849e-08 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 2.559e-07 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 4.077e-10 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 1.942e-05 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 5.131e-07 Highly Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.009607 Moderately Informative Inherited
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.0001735 Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 2.338e-07 Highly Informative Direct
Cellular Component (CC) membrane 0.02773 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.0001185 Moderately Informative Direct
Cellular Component (CC) extracellular region part 1.085e-10 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.05029 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0.0006862 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.1205 Informative Inherited
Cellular Component (CC) anchored to membrane 2.056e-06 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 1.253e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.4594Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004856Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase2.434e-07InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.5227Least InformativeInherited
Mammalian Phenotype (MP)abnormal pH regulation1.569e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001744Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase1.397e-08InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction1.14e-05Moderately InformativeDirect
Biological processVirus entry into host cell6.326e-08InformativeDirect
Cellular componentMembrane0.1347Least InformativeInherited
Cellular componentSecreted1.15e-11Moderately InformativeDirect
Cellular componentGPI-anchor3.738e-06InformativeDirect
Cellular componentExtracellular matrix1.581e-05InformativeDirect
Cellular componentPeriplasm7.268e-05InformativeDirect
Cellular componentViral envelope protein8.154e-10Highly InformativeDirect
Developmental stageLate protein3.75e-09Least InformativeDirect
DomainSignal3.104e-16Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0.0009205Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtein phosphatase8.019e-08InformativeDirect
Post-translational modificationGlycoprotein5.633e-08Least InformativeDirect
Post-translational modificationDisulfide bond9.128e-07Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001148 SSF51069 Protein matches
Abstract

Synonym(s): Carbonic dehydratase, Carbonic anhydrase

Carbonate dehydratase (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. Eight enzymatic and evolutionary related forms of carbonic anhydrase are currently known to exist in vertebrates: three cytosolic isozymes (CA-I, CA-II and CA-III); two membrane-bound forms (CA-IV and CA-VII); a mitochondrial form (CA-V); a secreted salivary form (CA-VI); and a yet uncharacterised isozyme.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Carbonic anhydrase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Carbonic anhydrase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]