SUPERFAMILY 1.75 HMM library and genome assignments server


Carbonic anhydrase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Carbonic anhydrase [ 51068]
Superfamily:   Carbonic anhydrase [ 51069]
Families:   Carbonic anhydrase [ 51070]


Superfamily statistics
Genomes (703) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,406 4,157 72
Proteins 3,336 4,112 72


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.0021390.01754Least InformativeInherited
Biological Process (BP)regulation of cellular process0.27841Least InformativeInherited
Biological Process (BP)single-organism cellular process0.77531Least InformativeInherited
Biological Process (BP)response to stimulus0.00041590.4911Least InformativeInherited
Biological Process (BP)organic substance transport0.00018050.0005021Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.01011Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0003940.1333Moderately InformativeInherited
Biological Process (BP)homeostatic process4.627e-070.001757Moderately InformativeInherited
Biological Process (BP)ion transport0.0017510.0003638Moderately InformativeInherited
Biological Process (BP)signal transduction0.0028020.5785Moderately InformativeInherited
Biological Process (BP)regulation of ion transport8.652e-084.588e-05InformativeDirect
Biological Process (BP)positive regulation of transport4.621e-070.0005659InformativeDirect
Biological Process (BP)cation homeostasis9.066e-101.188e-06InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.1630.2386InformativeInherited
Biological Process (BP)anion transport0.044680.0005504InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway3.736e-070.0006949Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transport2.233e-109.546e-08Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH7.824e-123.249e-10Highly InformativeDirect
Biological Process (BP)regulation of peptide transport1.327e-118.252e-08Highly InformativeDirect
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity00InformativeDirect
Cellular Component (CC)membrane0.00045640.01119Least InformativeInherited
Cellular Component (CC)plasma membrane part0.010240.001284Moderately InformativeInherited
Cellular Component (CC)intrinsic to membrane0.15040.04903Moderately InformativeInherited
Cellular Component (CC)intrinsic to plasma membrane0.066260.1143InformativeInherited
Cellular Component (CC)anchored to membrane2.199e-061.883e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4911 Least Informative Inherited
Biological Process (BP) localization 0.01754 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.0003638 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0005021 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1333 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.001757 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5785 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.568 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.6823 Moderately Informative Inherited
Biological Process (BP) anion transport 0.0005504 Informative Direct
Biological Process (BP) dephosphorylation 0.0001854 Informative Direct
Biological Process (BP) regulation of ion transport 4.588e-05 Informative Direct
Biological Process (BP) positive regulation of transport 0.0005659 Informative Direct
Biological Process (BP) cation homeostasis 1.188e-06 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.2386 Informative Inherited
Biological Process (BP) protein dephosphorylation 2.206e-06 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.0006949 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 9.546e-08 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 3.249e-10 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 8.252e-08 Highly Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.007861 Moderately Informative Inherited
Molecular Function (MF) phosphatase activity 2.499e-05 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 1.686e-07 Highly Informative Direct
Cellular Component (CC) membrane 0.01119 Least Informative Inherited
Cellular Component (CC) extracellular region part 2.614e-10 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.001284 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.04903 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0.0005877 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.1143 Informative Inherited
Cellular Component (CC) anchored to membrane 1.883e-06 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 1.062e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.4594Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004856Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase2.434e-07InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.5177Least InformativeInherited
Mammalian Phenotype (MP)abnormal pH regulation1.636e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001094Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase8.087e-09InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction6.649e-06Moderately InformativeDirect
Biological processVirus entry into host cell3.623e-08InformativeDirect
Cellular componentMembrane0.0519Least InformativeInherited
Cellular componentSecreted8.677e-13Moderately InformativeDirect
Cellular componentGPI-anchor3.491e-06InformativeDirect
Cellular componentExtracellular matrix1.693e-05InformativeDirect
Cellular componentPeriplasm4.456e-05InformativeDirect
Cellular componentViral envelope protein4.647e-10Highly InformativeDirect
Developmental stageLate protein2.348e-09Least InformativeDirect
DomainSignal9.847e-13Least InformativeDirect
DomainTransmembrane0.8211Least InformativeInherited
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0.0004298Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtein phosphatase4.979e-08InformativeDirect
Post-translational modificationGlycoprotein9.686e-06Least InformativeDirect
Post-translational modificationDisulfide bond6.4e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001148 SSF51069 Protein matches
Abstract

Synonym(s): Carbonic dehydratase, Carbonic anhydrase

Carbonate dehydratase (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. Eight enzymatic and evolutionary related forms of carbonic anhydrase are currently known to exist in vertebrates: three cytosolic isozymes (CA-I, CA-II and CA-III); two membrane-bound forms (CA-IV and CA-VII); a mitochondrial form (CA-V); a secreted salivary form (CA-VI); and a yet uncharacterised isozyme.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Carbonic anhydrase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Carbonic anhydrase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]