SUPERFAMILY 1.75 HMM library and genome assignments server

Carbonic anhydrase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Carbonic anhydrase [ 51068]
Superfamily:   Carbonic anhydrase [ 51069]
Families:   Carbonic anhydrase [ 51070]


Superfamily statistics
Genomes (749) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,959 6,122 72
Proteins 3,862 6,067 72


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.000050830.0000001791Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.0035741Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.0016410.7519Least InformativeInherited
Biological Process (BP)regulation of cellular process0.087891Least InformativeInherited
Biological Process (BP)regulation of biological quality0.000096990.0003433Moderately InformativeDirect
Biological Process (BP)organic substance transport0.000082030.00002882Moderately InformativeDirect
Biological Process (BP)regulation of localization0.0000036750.009247Moderately InformativeInherited
Biological Process (BP)signal transduction0.0078940.704Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00070720.9273Moderately InformativeInherited
Biological Process (BP)ion transport0.076880.22Moderately InformativeInherited
Biological Process (BP)regulation of ion transport0.000000000015620.000000203InformativeDirect
Biological Process (BP)cation homeostasis0.00000000000011710InformativeDirect
Biological Process (BP)positive regulation of transport0.000058690.0017InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.55461InformativeInherited
Biological Process (BP)anion transport0.020410.0002609InformativeInherited
Biological Process (BP)gas transport0.000000011610Highly InformativeDirect
Biological Process (BP)one-carbon compound transport0.0000000012250Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process0.000000038730.000001379Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.00000000019780.000000001295Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation homeostasis00Highly InformativeDirect
Biological Process (BP)regulation of peptide transport0.000026590.00007022Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis0.000000023410.0000001809Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway0.00000081770.001137Highly InformativeInherited
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity00InformativeDirect
Cellular Component (CC)membrane0.0025490.04225Least InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.17050.04337Moderately InformativeInherited
Cellular Component (CC)plasma membrane part0.018210.004358Moderately InformativeInherited
Cellular Component (CC)intrinsic component of plasma membrane0.058370.09552InformativeInherited
Cellular Component (CC)anchored component of membrane0.0000083530.0000003331Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0000001791 Least Informative Direct
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.7519 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.6724 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0.0003433 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.00002882 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.009247 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.704 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4955 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9273 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.6898 Moderately Informative Inherited
Biological Process (BP) ion transport 0.22 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2901 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6006 Moderately Informative Inherited
Biological Process (BP) organ development 0.4511 Moderately Informative Inherited
Biological Process (BP) anion transport 0.0002609 Informative Direct
Biological Process (BP) dephosphorylation 0.00005564 Informative Direct
Biological Process (BP) regulation of ion transport 0.000000203 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.0017 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.002568 Informative Inherited
Biological Process (BP) protein dephosphorylation 0.0000003277 Highly Informative Direct
Biological Process (BP) gas transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.000001379 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.000000001295 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.00007022 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000001809 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.001137 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.01455 Moderately Informative Inherited
Molecular Function (MF) phosphatase activity 0.00005289 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0000003748 Highly Informative Direct
Cellular Component (CC) membrane 0.04225 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.0000000002278 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.04337 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.004358 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0.0007299 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.09552 Informative Inherited
Cellular Component (CC) anchored component of membrane 0.0000003331 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.00001027 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.4594Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004856Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0000002434InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.5263Least InformativeInherited
Mammalian Phenotype (MP)abnormal pH regulation0.00001568Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001734Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000001378InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.004603Least InformativeInherited
Drugbank ATC_code (DB)cardiovascular system0.06759Least InformativeInherited
Drugbank ATC_code (DB)other antiepileptics0InformativeDirect
Drugbank ATC_code (DB)zonisamide0Highly InformativeDirect
Drugbank ATC_code (DB)carbonic anhydrase inhibitors0.00000000000007626Highly InformativeDirect
Drugbank ATC_code (DB)low-ceiling diuretics, thiazides0.0000000006295Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.00001142Moderately InformativeDirect
Biological processVirus entry into host cell0.0000000643InformativeDirect
Cellular componentMembrane0.1363Least InformativeInherited
Cellular componentSecreted0.00000000001136Moderately InformativeDirect
Cellular componentGPI-anchor0.000003728InformativeDirect
Cellular componentExtracellular matrix0.00001579InformativeDirect
Cellular componentPeriplasm0.00007391InformativeDirect
Cellular componentViral envelope protein0.0000000008041Highly InformativeDirect
Developmental stageLate protein0.000000003727Least InformativeDirect
DiseaseDisease mutation0.00008362Least InformativeDirect
DomainSignal3.091e-16Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0.0009842Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.00000007973InformativeDirect
Post-translational modificationGlycoprotein0.0000000603Least InformativeDirect
Post-translational modificationDisulfide bond0.000000903Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001148 SSF51069 Protein matches
Abstract

Synonym(s): Carbonic dehydratase, Carbonic anhydrase

Carbonate dehydratase (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. Eight enzymatic and evolutionary related forms of carbonic anhydrase are currently known to exist in vertebrates: three cytosolic isozymes (CA-I, CA-II and CA-III); two membrane-bound forms (CA-IV and CA-VII); a mitochondrial form (CA-V); a secreted salivary form (CA-VI); and a yet uncharacterised isozyme.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Carbonic anhydrase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Carbonic anhydrase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]