SUPERFAMILY 1.75 HMM library and genome assignments server


Glycosyl hydrolase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Glycosyl hydrolase domain [ 51010]
Superfamily:   Glycosyl hydrolase domain [ 51011] (5)
Families:   alpha-Amylases, C-terminal beta-sheet domain [ 51012] (22)
  Composite domain of glycosyl hydrolase families 5, 30, 39 and 51 [ 89388] (4)
  Putative alpha-L-fucosidase C-terminal domain [ 101928]
  Putative glucosidase YicI, domain 3 [ 117298]
  Beta-galactosidase LacA, domain 2 [ 117301]


Superfamily statistics
Genomes (2,557) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 18,314 76,891 154
Proteins 18,055 76,521 152


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 0.0002299 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1534 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.3287 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.2702 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7663 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 4.935e-08 Informative Direct
Biological Process (BP) membrane lipid metabolic process 4.872e-07 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0001756 Informative Direct
Biological Process (BP) organ morphogenesis 0.4155 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.9237 Informative Inherited
Biological Process (BP) lipid catabolic process 0.01073 Informative Inherited
Biological Process (BP) anion transport 0.157 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.219 Informative Inherited
Biological Process (BP) organic acid transport 0.01183 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) lysosome organization 7.107e-11 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 3.445e-08 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 3.047e-07 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 5.702e-06 Highly Informative Direct
Biological Process (BP) digestion 7.928e-06 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 1.952e-05 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.0003103 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.0003574 Highly Informative Direct
Biological Process (BP) skeletal system development 0.02285 Highly Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0.01924 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.00136 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.2482 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 3.821e-12 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.01052 Informative Inherited
Molecular Function (MF) amino acid transmembrane transporter activity 1.643e-05 Highly Informative Direct
Molecular Function (MF) calcium ion binding 4.993e-05 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.03708 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4639 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.0009463 Moderately Informative Direct
Cellular Component (CC) vesicle 0.07278 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.5992 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 1.3e-05 Informative Direct
Cellular Component (CC) external encapsulating structure 8.156e-05 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0002254 Informative Direct
Cellular Component (CC) lytic vacuole 0.000484 Informative Direct
Cellular Component (CC) plastid 0.0005366 Informative Direct
Cellular Component (CC) lysosome 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.0004805InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase5.571e-11Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase1.116e-06Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.0001201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.000121Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.106InformativeInherited
Disease Ontology (DO)sphingolipidosis3.276e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.02312Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.08121Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1634Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.0004708Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the mouth0.02537Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1602Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the myocardium7.622e-07InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the mitral valve0.0003742InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the aortic valve0.0004448InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.0004941InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0.0005806InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lip0.02261InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pyramidal motor function0.02787InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.2362InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower lip0.0001591Highly InformativeDirect
Phenotypic Abnormality (PA)Sensory neuropathy0.0001758Highly InformativeDirect
Phenotypic Abnormality (PA)Paralysis due to lesions of the principle motor tracts0.0003042Highly InformativeDirect
Phenotypic Abnormality (PA)Developmental regression0.0004166Highly InformativeDirect
Phenotypic Abnormality (PA)Edema0.0007693Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.03976Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4502Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.008286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.02055Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.131Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.002208InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.02639InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.0347InformativeInherited
Mammalian Phenotype (MP)abnormal heart left ventricle size2.494e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature3.926e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0001685Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gait0.000248Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.0007387Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.0003163Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processSphingolipid metabolism1.254e-12Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
DiseaseGlycogen storage disease7.237e-11InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0.0005406InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationSulfation0.0004474InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)L-arabinan degradation4.569e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 55 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycosyl hydrolase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 55 hidden Markov models representing the Glycosyl hydrolase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]