SUPERFAMILY 1.75 HMM library and genome assignments server


Glycosyl hydrolase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Glycosyl hydrolase domain [ 51010]
Superfamily:   Glycosyl hydrolase domain [ 51011] (5)
Families:   alpha-Amylases, C-terminal beta-sheet domain [ 51012] (22)
  Composite domain of glycosyl hydrolase families 5, 30, 39 and 51 [ 89388] (4)
  Putative alpha-L-fucosidase C-terminal domain [ 101928]
  Putative glucosidase YicI, domain 3 [ 117298]
  Beta-galactosidase LacA, domain 2 [ 117301]


Superfamily statistics
Genomes (1,978) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 14,933 37,559 154
Proteins 14,717 37,264 152


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.6277 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.4814 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7954 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 1.044e-06 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 5.234e-06 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 2.822e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6875 Moderately Informative Inherited
Biological Process (BP) organ development 0.5452 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5005 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.003883 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.03772 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9358 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6802 Moderately Informative Inherited
Biological Process (BP) ion transport 0.2995 Moderately Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) lipid catabolic process 1.968e-10 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 8.121e-06 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0005869 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0006126 Informative Direct
Biological Process (BP) organ morphogenesis 0.05904 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.06158 Informative Inherited
Biological Process (BP) anion transport 0.03993 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.07658 Informative Inherited
Biological Process (BP) organic acid transport 0.00268 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) glycoside metabolic process 0 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) lysosome organization 6.857e-12 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 3.295e-10 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 3.071e-08 Highly Informative Direct
Biological Process (BP) digestion 1.686e-06 Highly Informative Direct
Biological Process (BP) limb morphogenesis 5.056e-05 Highly Informative Direct
Biological Process (BP) amino acid transport 0.0003449 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0.0006704 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.0008898 Highly Informative Direct
Biological Process (BP) skeletal system development 0.003558 Highly Informative Inherited
Biological Process (BP) cellular glucan metabolic process 0.03632 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.7557 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.05393 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 8.136e-07 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.001953 Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 3.779e-08 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 3.547e-06 Highly Informative Direct
Molecular Function (MF) calcium ion binding 4.345e-06 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01347 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6307 Least Informative Inherited
Cellular Component (CC) extracellular region 1.488e-12 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0003989 Moderately Informative Direct
Cellular Component (CC) vacuole 1.062e-14 Informative Direct
Cellular Component (CC) external encapsulating structure 1.153e-05 Informative Direct
Cellular Component (CC) cell surface 7.229e-05 Informative Direct
Cellular Component (CC) plastid 7.393e-05 Informative Direct
Cellular Component (CC) extracellular space 0.000325 Informative Direct
Cellular Component (CC) lysosome 0 Highly Informative Direct
Cellular Component (CC) cell wall 1.027e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.0004805InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase5.571e-11Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase1.116e-06Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.0001201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.0003983Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.1024InformativeInherited
Disease Ontology (DO)sphingolipidosis5.295e-06Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.0996Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1615Least InformativeInherited
Phenotypic Abnormality (PA)Malformation of the heart and great vessels0.0003986Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0.0005802Moderately InformativeDirect
Phenotypic Abnormality (PA)Cognitive impairment0.01976Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.03316Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1558Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the myocardium7.852e-07InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the mitral valve0.000356InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the aortic valve0.0003994InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.0005224InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.003736InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pyramidal motor function0.02678InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lip0.03113InformativeInherited
Phenotypic Abnormality (PA)Sensory neuropathy0.0001496Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lower lip0.0001906Highly InformativeDirect
Phenotypic Abnormality (PA)Paralysis due to lesions of the principle motor tracts0.0003107Highly InformativeDirect
Phenotypic Abnormality (PA)Developmental regression0.000675Highly InformativeDirect
Phenotypic Abnormality (PA)Edema0.0007701Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.01975Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5253Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.003585Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01135Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.07783Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.001081InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.02331InformativeInherited
Mammalian Phenotype (MP)abnormal heart left ventricle size7.262e-07Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.0003705Highly InformativeDirect
Mammalian Phenotype (MP)abnormal impulse conducting system conduction0.002305Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.0004741Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alpha glucosidase inhibitors4.63e-11InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processGlycogen metabolism0Highly InformativeDirect
Biological processSphingolipid metabolism4.767e-13Highly InformativeDirect
Biological processXylan degradation2.03e-06Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
DiseaseGlycogen storage disease6.894e-11InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0.0009147InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationSulfation0.0004581InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation1InformativeInherited
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)L-arabinan degradation1.403e-11Highly InformativeDirect
UniPathway (UP)glycogen degradation8.802e-06Highly InformativeDirect
UniPathway (UP)sphingolipid metabolism0.0005055Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 55 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycosyl hydrolase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 55 hidden Markov models representing the Glycosyl hydrolase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]