SUPERFAMILY 1.75 HMM library and genome assignments server

Glycosyl hydrolase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Glycosyl hydrolase domain [ 51010]
Superfamily:   Glycosyl hydrolase domain [ 51011] (5)
Families:   alpha-Amylases, C-terminal beta-sheet domain [ 51012] (22)
  Composite domain of glycosyl hydrolase families 5, 30, 39 and 51 [ 89388] (4)
  Putative alpha-L-fucosidase C-terminal domain [ 101928]
  Putative glucosidase YicI, domain 3 [ 117298]
  Beta-galactosidase LacA, domain 2 [ 117301]


Superfamily statistics
Genomes (2,558) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 18,343 76,891 154
Proteins 18,084 76,521 152


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000001218 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0001367 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000169 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0002311 Moderately Informative Direct
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.9823 Moderately Informative Inherited
Biological Process (BP) ion transport 0.8664 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1519 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.2951 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9386 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.000000000000007248 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.000000000009357 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0.0000000947 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.0000004797 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00001762 Informative Direct
Biological Process (BP) nitrogen compound transport 0.2235 Informative Inherited
Biological Process (BP) organ morphogenesis 0.4199 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) lipid catabolic process 0.00805 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.7831 Informative Inherited
Biological Process (BP) organic acid transport 0.01205 Informative Inherited
Biological Process (BP) anion transport 0.1718 Informative Inherited
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0.00000000007081 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.00000003444 Highly Informative Direct
Biological Process (BP) digestion 0.000007958 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00001807 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.0000736 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.0008286 Highly Informative Direct
Biological Process (BP) skeletal system development 0.02338 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.001379 Highly Informative Inherited
Biological Process (BP) glycosphingolipid metabolic process 0.01911 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.2543 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.000000000000448 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.0113 Informative Inherited
Molecular Function (MF) amino acid transmembrane transporter activity 0.00001664 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.00005338 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.02767 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4922 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.0009849 Moderately Informative Direct
Cellular Component (CC) vesicle 0.07909 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.2723 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0.00001105 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0002759 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0003526 Informative Direct
Cellular Component (CC) plastid 0.0005411 Informative Direct
Cellular Component (CC) lytic vacuole 0.0006205 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.0004805InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.00000000005571Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.000001116Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.0001201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.0001208Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.1061InformativeInherited
Disease Ontology (DO)sphingolipidosis0.000003276Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.02317Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.08113Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1633Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.0004668Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the mouth0.02532Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.09949Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1601Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the myocardium0.0000007481InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the mitral valve0.0003709InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the aortic valve0.0004411InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.0004895InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0.0005839InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lip0.02292InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pyramidal motor function0.02804InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.2352InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower lip0.0001569Highly InformativeDirect
Phenotypic Abnormality (PA)Sensory neuropathy0.0001733Highly InformativeDirect
Phenotypic Abnormality (PA)Paralysis due to lesions of the principle motor tracts0.0003008Highly InformativeDirect
Phenotypic Abnormality (PA)Developmental regression0.000413Highly InformativeDirect
Phenotypic Abnormality (PA)Edema0.0007621Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.04099Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4206Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.008665Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.02082Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1352Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.002328InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.02554InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.0355InformativeInherited
Mammalian Phenotype (MP)abnormal heart left ventricle size0.000002487Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.0000418Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.00017Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gait0.0002653Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.0007431Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.0003122Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)drugs used in diabetes0.000000113Moderately InformativeDirect
Drugbank ATC_code (DB)alpha glucosidase inhibitors0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processGlycogen biosynthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0.000000000001392Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
DiseaseGlycogen storage disease0.00000000007229InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0.0006702InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationSulfation0.0004541InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)glycan degradation1InformativeInherited
UniPathway (UP)glycogen biosynthesis0Highly InformativeDirect
UniPathway (UP)L-arabinan degradation0.000000000009948Highly InformativeDirect
UniPathway (UP)glycogen degradation0.000004783Highly InformativeDirect
UniPathway (UP)sphingolipid metabolism0.0007882Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 55 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycosyl hydrolase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 55 hidden Markov models representing the Glycosyl hydrolase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]