SUPERFAMILY 1.75 HMM library and genome assignments server


Quinoprotein alcohol dehydrogenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   8-bladed beta-propeller [ 50997] (3)
Superfamily:   Quinoprotein alcohol dehydrogenase-like [ 50998]
Families:   Quinoprotein alcohol dehydrogenase-like [ 50999] (3)


Superfamily statistics
Genomes (2,189) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 17,113 24,466 9
Proteins 15,870 22,610 9


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.84230.1529Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.69270.4134Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.70120.3859Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.93290.9598Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.80260.6103Least InformativeInherited
Biological Process (BP)regulation of cellular process0.029961Least InformativeInherited
Biological Process (BP)single-organism cellular process0.21980.9474Least InformativeInherited
Biological Process (BP)developmental process0.35541Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.32840.8039Least InformativeInherited
Biological Process (BP)response to stimulus0.74461Least InformativeInherited
Biological Process (BP)RNA metabolic process0.021113.928e-05Moderately InformativeInherited
Biological Process (BP)signal transduction0.037910.001389Moderately InformativeInherited
Biological Process (BP)organelle organization0.43740.6025Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.023341Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.087020.005578Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.15981Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.067741.412e-05Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.11950.00418Moderately InformativeInherited
Biological Process (BP)response to organic substance0.26810.1516Moderately InformativeInherited
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.0026831.354e-05InformativeInherited
Biological Process (BP)cell death0.020070.003102InformativeInherited
Biological Process (BP)intracellular signal transduction3.295e-050.08861InformativeInherited
Biological Process (BP)cell projection organization0.00099880.4522InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0026550.7943InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.010950.7163InformativeInherited
Biological Process (BP)organelle assembly0.00075850.01155InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway7.249e-050Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress0.00025950Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein9.241e-050Highly InformativeDirect
Biological Process (BP)RNA phosphodiester bond hydrolysis, endonucleolytic1.04e-050.0005637Highly InformativeDirect
Biological Process (BP)intrinsic apoptotic signaling pathway0.018813.162e-06Highly InformativeInherited
Biological Process (BP)cellular component assembly involved in morphogenesis0.00017830.01238Highly InformativeInherited
Biological Process (BP)cell projection assembly0.00065780.002165Highly InformativeInherited
Biological Process (BP)cell part morphogenesis0.00014150.1742Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.87381Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.15740.0566Moderately InformativeInherited
Molecular Function (MF)nuclease activity0.00054311.026e-07InformativeDirect
Molecular Function (MF)endoribonuclease activity4.766e-060.0001024Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.74241Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.4670.002895Least InformativeInherited
Cellular Component (CC)membrane0.57471Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0015493.367e-08Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.0068792.411e-09Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.082110.0006656Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.00010433.334e-13InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.4134 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9474 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.8039 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3859 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.9598 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6103 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1529 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3481 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) RNA metabolic process 3.928e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.412e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.005578 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6025 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.00418 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.001389 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4343 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9267 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9794 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1381 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9808 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9973 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.09806 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.7141 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.06616 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.6303 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1516 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.4131 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4663 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0.0005976 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0.0004106 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 1.354e-05 Informative Direct
Biological Process (BP) intracellular signal transduction 0.08861 Informative Inherited
Biological Process (BP) cell death 0.003102 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1566 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7943 Informative Inherited
Biological Process (BP) cell projection organization 0.4522 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7163 Informative Inherited
Biological Process (BP) organelle assembly 0.01155 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.7201 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.9312 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.8838 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.9755 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2827 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.02671 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.14 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.1774 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.009715 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.323 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.1104 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.07328 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.06267 Informative Inherited
Biological Process (BP) ossification 0.0001351 Highly Informative Direct
Biological Process (BP) protein phosphorylation 2.124e-05 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) RNA phosphodiester bond hydrolysis, endonucleolytic 0.0005637 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 3.162e-06 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.02532 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.1742 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.01238 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.002165 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.7859 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.002131 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.0108 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001158 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.04743 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001512 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.1155 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0566 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 1.026e-07 Informative Direct
Molecular Function (MF) kinase activity 0.03515 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01417 Informative Inherited
Molecular Function (MF) endoribonuclease activity 0.0001024 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0008792 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.002895 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1234 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.08266 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 3.367e-08 Moderately Informative Direct
Cellular Component (CC) endomembrane system 2.411e-09 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0006656 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.0986 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.6077 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.01792 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.0002116 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 3.334e-13 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 2.927e-05 Informative Direct
Cellular Component (CC) integral to membrane 0.2558 Informative Inherited
Cellular Component (CC) spindle 0.000117 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 3.482e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 2.94e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1.049e-06Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor1.147e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0136Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02876Least InformativeInherited
Worm Phenotype (WP)developmental timing variant0.3949Least InformativeInherited
Worm Phenotype (WP)larval development variant0.6469Least InformativeInherited
Worm Phenotype (WP)growth variant0.9682Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.05863Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1991Moderately InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.0001013InformativeDirect
Worm Phenotype (WP)activity level variant0.001129InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.09966InformativeInherited
Worm Phenotype (WP)fat content increased0.0005572Highly InformativeDirect
Worm Phenotype (WP)early larval arrest0.0007819Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1.273e-09Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups2.075e-05Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors2.164e-12Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters2.783e-06InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease4.53e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway5.071e-10InformativeDirect
Biological processTranslation regulation0.0009924InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentNucleus1.231e-07Least InformativeDirect
Cellular componentMembrane3.42e-07Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum8.615e-10Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentPeriplasm7.703e-06InformativeDirect
Coding sequence diversityAlternative splicing9.526e-05Least InformativeDirect
DomainRepeat3.106e-16Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainWD repeat0InformativeDirect
Molecular functionCalcium8.82e-06Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.005219Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase4.203e-13InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationADP-ribosylation6.837e-06InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism4.884e-15Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011047 SSF50998 Protein matches
Abstract

Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase, type II includes soluble quinohaemoprotein with a C-terminal containing haem C, and type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain [PubMed11761326]. These quinoproteins contain an 8-bladed beta-propeller motif, which is present in the N-terminal domain of quinoprotein alcohol dehydrogenase, ethanol dehydrogenase, and the heavy chain (alpha subunit) of methanol dehydrogenase [PubMed11714714, PubMed12686116, PubMed12686102].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Quinoprotein alcohol dehydrogenase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Quinoprotein alcohol dehydrogenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]