|
GO term |
FDR (all) |
IC level |
SDFO level |
Annotation (direct or inherited) |
| Biological Process (BP) |
ER overload response |
5.27e-05 |
2.699 |
-- |
DIRECT |
| Biological Process (BP) |
rRNA metabolic process |
0.0001389 |
1.796 |
-- |
DIRECT |
| Biological Process (BP) |
phosphorylation |
0.0001253 |
1.398 |
-- |
DIRECT |
| Biological Process (BP) |
negative regulation of translation |
0.0001613 |
2.699 |
-- |
DIRECT |
| Biological Process (BP) |
calcium-mediated signaling |
3.654e-05 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
cellular response to unfolded protein |
0 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
cellular response to topologically incorrect protein |
0 |
2.222 |
-- |
DIRECT |
| Biological Process (BP) |
cilium assembly |
0.0004196 |
2.699 |
-- |
DIRECT |
| Biological Process (BP) |
cilium organization |
0.0001726 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
cilium morphogenesis |
0.0001256 |
2.398 |
-- |
DIRECT |
| Biological Process (BP) |
cellular developmental process |
1 |
0.9666 |
-- |
INHERITED FROM: cilium morphogenesis || cilium assembly |
| Biological Process (BP) |
cell surface receptor signaling pathway |
1 |
1.237 |
-- |
INHERITED FROM: insulin-like growth factor receptor signaling pathway |
| Biological Process (BP) |
cellular component organization |
1 |
0.6819 |
-- |
INHERITED FROM: cilium organization || cilium morphogenesis || cilium assembly |
| Biological Process (BP) |
cell morphogenesis |
0.645 |
1.658 |
-- |
INHERITED FROM: cilium assembly || cilium morphogenesis |
| Biological Process (BP) |
cell part morphogenesis |
0.226 |
1.796 |
-- |
INHERITED FROM: cilium assembly || cilium morphogenesis |
| Biological Process (BP) |
cell projection morphogenesis |
0.2117 |
1.854 |
-- |
INHERITED FROM: cilium assembly || cilium morphogenesis |
| Biological Process (BP) |
anatomical structure development |
1 |
0.7212 |
-- |
INHERITED FROM: cilium assembly || pancreas development || cilium morphogenesis |
| Biological Process (BP) |
cellular component assembly |
0.2011 |
1.076 |
-- |
INHERITED FROM: cilium assembly |
| Biological Process (BP) |
cellular process |
1 |
0.1415 |
-- |
INHERITED FROM: cellular response to topologically incorrect protein || rRNA metabolic process || protein phosphorylation || phosphorylation || cilium organization || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || ER-nucleus signaling pathway || insulin-like growth factor receptor signaling pathway || calcium-mediated signaling || cilium assembly || response to endoplasmic reticulum stress || cellular response to stress || cellular response to unfolded protein || cellular response to sterol depletion || cilium morphogenesis || ER overload response |
| Biological Process (BP) |
cellular response to stimulus |
0.02651 |
0.7645 |
-- |
INHERITED FROM: response to endoplasmic reticulum stress || cellular response to unfolded protein || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || insulin-like growth factor receptor signaling pathway || cellular response to sterol depletion || calcium-mediated signaling || ER-nucleus signaling pathway || ER overload response || cellular response to stress || cellular response to topologically incorrect protein |
| Biological Process (BP) |
response to stress |
0.1227 |
0.8125 |
-- |
INHERITED FROM: response to endoplasmic reticulum stress || cellular response to unfolded protein || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || ER overload response || cellular response to stress || cellular response to sterol depletion || response to topologically incorrect protein || cellular response to topologically incorrect protein || response to sterol depletion |
| Biological Process (BP) |
cellular response to organic substance |
0.003776 |
1.208 |
-- |
INHERITED FROM: cellular response to unfolded protein || activation of signaling protein activity involved in unfolded protein response || cellular response to topologically incorrect protein |
| Biological Process (BP) |
response to chemical stimulus |
0.1761 |
0.8861 |
-- |
INHERITED FROM: cellular response to unfolded protein || activation of signaling protein activity involved in unfolded protein response || response to topologically incorrect protein || cellular response to topologically incorrect protein |
| Biological Process (BP) |
response to unfolded protein |
0.01794 |
2.398 |
-- |
INHERITED FROM: cellular response to unfolded protein || activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
cell communication |
0.009516 |
0.8477 |
-- |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || insulin-like growth factor receptor signaling pathway || calcium-mediated signaling || ER-nucleus signaling pathway || ER overload response |
| Biological Process (BP) |
signaling |
0.005137 |
0.8416 |
-- |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || ER-nucleus signaling pathway || insulin-like growth factor receptor signaling pathway || ER overload response || calcium-mediated signaling |
| Biological Process (BP) |
single organism signaling |
0.002679 |
0.8601 |
-- |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || ER-nucleus signaling pathway || insulin-like growth factor receptor signaling pathway || ER overload response || calcium-mediated signaling |
| Biological Process (BP) |
positive regulation of macromolecule metabolic process |
0.2692 |
1.301 |
-- |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of cellular metabolic process |
0.3038 |
1.208 |
-- |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of biological process |
1 |
0.8182 |
-- |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
regulation of transcription, DNA-dependent |
1 |
1.237 |
-- |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
positive regulation of biosynthetic process |
1 |
1.495 |
-- |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
positive regulation of transcription, DNA-dependent |
0.9357 |
1.745 |
-- |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
positive regulation of nucleobase-containing compound metabolic process |
1 |
1.585 |
-- |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
positive regulation of transcription from RNA polymerase II promoter |
0.4315 |
2.398 |
-- |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
regulation of RNA metabolic process |
1 |
1.131 |
-- |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
positive regulation of RNA metabolic process |
0.9704 |
1.658 |
-- |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
regulation of RNA biosynthetic process |
1 |
1.167 |
-- |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
regulation of biological process |
1 |
0.4486 |
-- |
INHERITED FROM: positive regulation of nuclease activity || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || ER-nucleus signaling pathway || insulin-like growth factor receptor signaling pathway || calcium-mediated signaling || negative regulation of translation || regulation of translation || regulation of nuclease activity || ER overload response |
| Biological Process (BP) |
biological regulation |
1 |
0.4202 |
-- |
INHERITED FROM: positive regulation of nuclease activity || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || ER-nucleus signaling pathway || insulin-like growth factor receptor signaling pathway || calcium-mediated signaling || negative regulation of translation || regulation of translation || regulation of nuclease activity || ER overload response |
| Biological Process (BP) |
regulation of nucleobase-containing compound metabolic process |
0.8255 |
1.027 |
-- |
INHERITED FROM: regulation of nuclease activity || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || positive regulation of nuclease activity |
| Biological Process (BP) |
regulation of catalytic activity |
0.069 |
1.155 |
-- |
INHERITED FROM: regulation of nuclease activity || activation of signaling protein activity involved in unfolded protein response || positive regulation of nuclease activity |
| Biological Process (BP) |
multicellular organismal development |
1 |
0.7496 |
-- |
INHERITED FROM: pancreas development |
| Biological Process (BP) |
system development |
1 |
0.8069 |
-- |
INHERITED FROM: pancreas development |
| Biological Process (BP) |
second-messenger-mediated signaling |
0.001846 |
2.398 |
-- |
INHERITED FROM: calcium-mediated signaling |
| Biological Process (BP) |
regulation of macromolecule metabolic process |
0.9621 |
0.7959 |
-- |
INHERITED FROM: negative regulation of translation || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || regulation of nuclease activity || regulation of translation || positive regulation of nuclease activity |
| Biological Process (BP) |
regulation of primary metabolic process |
0.9283 |
0.7852 |
-- |
INHERITED FROM: negative regulation of translation || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || regulation of nuclease activity || regulation of translation || positive regulation of nuclease activity |
| Biological Process (BP) |
regulation of macromolecule biosynthetic process |
0.9912 |
1.066 |
-- |
INHERITED FROM: negative regulation of translation || SREBP signaling pathway || regulation of translation |
| Biological Process (BP) |
regulation of cellular biosynthetic process |
1 |
1.009 |
-- |
INHERITED FROM: negative regulation of translation || SREBP signaling pathway || regulation of translation |
| Biological Process (BP) |
regulation of cellular macromolecule biosynthetic process |
0.958 |
1.119 |
-- |
INHERITED FROM: negative regulation of translation || SREBP signaling pathway || regulation of translation |
| Biological Process (BP) |
regulation of cellular protein metabolic process |
0.009397 |
1.252 |
-- |
INHERITED FROM: negative regulation of translation || regulation of translation || activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
negative regulation of macromolecule biosynthetic process |
0.3392 |
1.854 |
-- |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
negative regulation of macromolecule metabolic process |
0.6728 |
1.301 |
-- |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
negative regulation of cellular biosynthetic process |
0.3828 |
1.658 |
-- |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
negative regulation of cellular protein metabolic process |
0.1577 |
1.62 |
-- |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
negative regulation of biological process |
1 |
0.8665 |
-- |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
metabolic process |
0.9872 |
0.2411 |
-- |
INHERITED FROM: rRNA metabolic process || protein phosphorylation || phosphorylation |
| Biological Process (BP) |
cellular metabolic process |
1 |
0.2708 |
-- |
INHERITED FROM: rRNA metabolic process || protein phosphorylation || phosphorylation |
| Biological Process (BP) |
organic substance metabolic process |
0.5331 |
0.2676 |
-- |
INHERITED FROM: rRNA metabolic process || protein phosphorylation |
| Biological Process (BP) |
nucleobase-containing compound metabolic process |
0.479 |
0.7305 |
-- |
INHERITED FROM: rRNA metabolic process |
| Biological Process (BP) |
cellular nitrogen compound metabolic process |
0.8877 |
0.585 |
-- |
INHERITED FROM: rRNA metabolic process |
| Biological Process (BP) |
ncRNA metabolic process |
0.02353 |
1.444 |
-- |
INHERITED FROM: rRNA metabolic process |
| Biological Process (BP) |
nucleic acid metabolic process |
0.08205 |
0.9066 |
-- |
INHERITED FROM: rRNA metabolic process |
| Biological Process (BP) |
biological_process |
0.1138 |
0 |
-- |
INHERITED FROM: response to sterol depletion || protein phosphorylation || cilium organization || ER-nucleus signaling pathway || insulin-like growth factor receptor signaling pathway || cellular response to unfolded protein || ribonucleoprotein complex biogenesis || regulation of translation || positive regulation of nuclease activity || ossification || cellular response to topologically incorrect protein || rRNA metabolic process || phosphorylation || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || pancreas development || calcium-mediated signaling || cilium assembly || response to endoplasmic reticulum stress || cellular response to stress || response to topologically incorrect protein || negative regulation of translation || cellular response to sterol depletion || cilium morphogenesis || regulation of nuclease activity || ER overload response |
| Biological Process (BP) |
positive regulation of molecular function |
0.02595 |
1.222 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response || positive regulation of nuclease activity |
| Biological Process (BP) |
positive regulation of hydrolase activity |
0.005786 |
1.62 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response || positive regulation of nuclease activity |
| Biological Process (BP) |
positive regulation of protein phosphorylation |
0.06561 |
1.745 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
regulation of phosphate metabolic process |
0.3067 |
1.284 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
endoplasmic reticulum unfolded protein response |
0.00994 |
2.699 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
regulation of protein modification process |
1 |
1.377 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of protein modification process |
0.005666 |
1.585 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of cellular protein metabolic process |
0.005085 |
1.585 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of kinase activity |
0.00722 |
1.854 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
regulation of phosphorylation |
0.1376 |
1.469 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of phosphorylation |
0.01561 |
1.745 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
regulation of protein kinase activity |
0.1051 |
1.62 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of protein kinase activity |
0.01188 |
1.854 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of phosphate metabolic process |
0.03439 |
1.699 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
regulation of phosphorus metabolic process |
0.3123 |
1.252 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
regulation of transferase activity |
0.2827 |
1.62 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of transferase activity |
0.09046 |
1.854 |
-- |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
response to biotic stimulus |
0.8195 |
1.377 |
-- |
INHERITED FROM: ER overload response |
| Biological Process (BP) |
phosphorus metabolic process |
0.09941 |
0.8013 |
-- |
INHERITED FROM: protein phosphorylation || phosphorylation |
| Biological Process (BP) |
macromolecule metabolic process |
0.1008 |
0.4634 |
-- |
INHERITED FROM: protein phosphorylation || rRNA metabolic process |
| Biological Process (BP) |
primary metabolic process |
0.4624 |
0.2976 |
-- |
INHERITED FROM: protein phosphorylation || rRNA metabolic process |
| Biological Process (BP) |
protein modification process |
0.08937 |
0.9066 |
-- |
INHERITED FROM: protein phosphorylation |
| Biological Process (BP) |
macromolecule modification |
0.3874 |
0.8416 |
-- |
INHERITED FROM: protein phosphorylation |
| Biological Process (BP) |
cellular protein metabolic process |
0.2091 |
0.6778 |
-- |
INHERITED FROM: protein phosphorylation |
| Biological Process (BP) |
single-organism process |
1 |
0.3316 |
-- |
INHERITED FROM: ossification || cellular response to topologically incorrect protein || cilium organization || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || pancreas development || ER-nucleus signaling pathway || insulin-like growth factor receptor signaling pathway || calcium-mediated signaling || cilium assembly || response to endoplasmic reticulum stress || cellular response to stress || cellular response to unfolded protein || cellular response to sterol depletion || cilium morphogenesis || ER overload response |
| Biological Process (BP) |
single-multicellular organism process |
1 |
0.6383 |
-- |
INHERITED FROM: ossification || pancreas development |
| Biological Process (BP) |
single-organism cellular process |
0.9723 |
0.3915 |
Least Informative |
INHERITED FROM: insulin-like growth factor receptor signaling pathway || calcium-mediated signaling || cilium assembly || response to endoplasmic reticulum stress || cellular response to stress || cellular response to topologically incorrect protein || cellular response to unfolded protein || cilium organization || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || cellular response to sterol depletion || cilium morphogenesis || ER-nucleus signaling pathway || ER overload response |
| Biological Process (BP) |
regulation of cellular process |
1 |
0.5317 |
Least Informative |
INHERITED FROM: insulin-like growth factor receptor signaling pathway || calcium-mediated signaling || positive regulation of nuclease activity || negative regulation of translation || regulation of translation || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || regulation of nuclease activity || ER-nucleus signaling pathway || ER overload response |
| Biological Process (BP) |
cellular component organization or biogenesis |
0.755 |
0.6536 |
Least Informative |
INHERITED FROM: cilium organization || cilium morphogenesis || cilium assembly || ribonucleoprotein complex biogenesis |
| Biological Process (BP) |
developmental process |
1 |
0.6904 |
Least Informative |
INHERITED FROM: cilium assembly || pancreas development || cilium morphogenesis |
| Biological Process (BP) |
response to stimulus |
0.8538 |
0.5498 |
Least Informative |
INHERITED FROM: cellular response to unfolded protein || insulin-like growth factor receptor signaling pathway || calcium-mediated signaling || response to sterol depletion || response to endoplasmic reticulum stress || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || cellular response to sterol depletion || ER-nucleus signaling pathway || ER overload response || cellular response to stress || response to topologically incorrect protein || cellular response to topologically incorrect protein |
| Biological Process (BP) |
regulation of metabolic process |
1 |
0.6946 |
Least Informative |
INHERITED FROM: negative regulation of translation || regulation of translation || positive regulation of nuclease activity || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || regulation of nuclease activity |
| Biological Process (BP) |
cellular aromatic compound metabolic process |
0.7488 |
0.6271 |
Least Informative |
INHERITED FROM: rRNA metabolic process |
| Biological Process (BP) |
nitrogen compound metabolic process |
1 |
0.5171 |
Least Informative |
INHERITED FROM: rRNA metabolic process |
| Biological Process (BP) |
heterocycle metabolic process |
0.7717 |
0.6308 |
Least Informative |
INHERITED FROM: rRNA metabolic process |
| Biological Process (BP) |
organic cyclic compound metabolic process |
0.949 |
0.5817 |
Least Informative |
INHERITED FROM: rRNA metabolic process |
| Biological Process (BP) |
cellular macromolecule metabolic process |
0.05062 |
0.4976 |
Least Informative |
INHERITED FROM: protein phosphorylation || rRNA metabolic process |
| Biological Process (BP) |
protein metabolic process |
0.1798 |
0.6383 |
Least Informative |
INHERITED FROM: protein phosphorylation |
| Biological Process (BP) |
multicellular organismal process |
1 |
0.6091 |
Least Informative |
INHERITED FROM: ossification || pancreas development |
| Biological Process (BP) |
cellular response to stress |
4.529e-05 |
1.086 |
Moderately Informative |
DIRECT |
| Biological Process (BP) |
anatomical structure morphogenesis |
1 |
1.036 |
Moderately Informative |
INHERITED FROM: cilium morphogenesis || cilium assembly |
| Biological Process (BP) |
single-organism developmental process |
1 |
0.7645 |
Moderately Informative |
INHERITED FROM: cilium assembly || pancreas development || cilium morphogenesis |
| Biological Process (BP) |
cellular component biogenesis |
0.007421 |
0.983 |
Moderately Informative |
INHERITED FROM: cilium assembly || ribonucleoprotein complex biogenesis |
| Biological Process (BP) |
cellular response to chemical stimulus |
0.01091 |
1.097 |
Moderately Informative |
INHERITED FROM: cellular response to unfolded protein || activation of signaling protein activity involved in unfolded protein response || cellular response to topologically incorrect protein |
| Biological Process (BP) |
response to organic substance |
0.08773 |
1.018 |
Moderately Informative |
INHERITED FROM: cellular response to unfolded protein || activation of signaling protein activity involved in unfolded protein response || response to topologically incorrect protein || cellular response to topologically incorrect protein |
| Biological Process (BP) |
regulation of nitrogen compound metabolic process |
0.8663 |
0.9914 |
Moderately Informative |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || regulation of nuclease activity || positive regulation of nuclease activity |
| Biological Process (BP) |
signal transduction |
0.001746 |
0.9914 |
Moderately Informative |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || ER-nucleus signaling pathway || insulin-like growth factor receptor signaling pathway || ER overload response || calcium-mediated signaling |
| Biological Process (BP) |
positive regulation of metabolic process |
0.3974 |
1.167 |
Moderately Informative |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of cellular process |
0.9498 |
0.9066 |
Moderately Informative |
INHERITED FROM: SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
regulation of molecular function |
0.2432 |
1.056 |
Moderately Informative |
INHERITED FROM: regulation of nuclease activity || activation of signaling protein activity involved in unfolded protein response || positive regulation of nuclease activity |
| Biological Process (BP) |
organ development |
1 |
0.9355 |
Moderately Informative |
INHERITED FROM: pancreas development |
| Biological Process (BP) |
regulation of biosynthetic process |
1 |
0.9914 |
Moderately Informative |
INHERITED FROM: negative regulation of translation || SREBP signaling pathway || regulation of translation |
| Biological Process (BP) |
regulation of gene expression |
0.9537 |
0.9914 |
Moderately Informative |
INHERITED FROM: negative regulation of translation || SREBP signaling pathway || regulation of translation |
| Biological Process (BP) |
regulation of protein metabolic process |
0.03823 |
1.119 |
Moderately Informative |
INHERITED FROM: negative regulation of translation || activation of signaling protein activity involved in unfolded protein response || regulation of translation |
| Biological Process (BP) |
regulation of cellular metabolic process |
0.9555 |
0.7905 |
Moderately Informative |
INHERITED FROM: negative regulation of translation || regulation of translation || positive regulation of nuclease activity || SREBP signaling pathway || activation of signaling protein activity involved in unfolded protein response || regulation of nuclease activity |
| Biological Process (BP) |
negative regulation of metabolic process |
0.7735 |
1.222 |
Moderately Informative |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
negative regulation of cellular process |
1 |
0.9355 |
Moderately Informative |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
RNA metabolic process |
0.03118 |
1.086 |
Moderately Informative |
INHERITED FROM: rRNA metabolic process |
| Biological Process (BP) |
phosphate-containing compound metabolic process |
0.0743 |
0.8182 |
Moderately Informative |
INHERITED FROM: protein phosphorylation || phosphorylation |
| Biological Process (BP) |
cellular protein modification process |
0.4768 |
0.9066 |
Moderately Informative |
INHERITED FROM: protein phosphorylation |
| Biological Process (BP) |
protein phosphorylation |
1.506e-05 |
1.585 |
Informative |
DIRECT |
| Biological Process (BP) |
ribonucleoprotein complex biogenesis |
0.0002073 |
1.658 |
Informative |
DIRECT |
| Biological Process (BP) |
enzyme linked receptor protein signaling pathway |
0.1289 |
1.658 |
Informative |
INHERITED FROM: insulin-like growth factor receptor signaling pathway |
| Biological Process (BP) |
cellular component morphogenesis |
0.8136 |
1.495 |
Informative |
INHERITED FROM: cilium assembly || cilium morphogenesis |
| Biological Process (BP) |
cell projection organization |
0.4678 |
1.553 |
Informative |
INHERITED FROM: cilium assembly || cilium organization || cilium morphogenesis |
| Biological Process (BP) |
anatomical structure formation involved in morphogenesis |
0.4664 |
1.444 |
Informative |
INHERITED FROM: cilium assembly |
| Biological Process (BP) |
regulation of transcription from RNA polymerase II promoter |
0.8139 |
1.745 |
Informative |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
positive regulation of macromolecule biosynthetic process |
0.937 |
1.585 |
Informative |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
positive regulation of gene expression |
0.9968 |
1.699 |
Informative |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
positive regulation of cellular biosynthetic process |
1 |
1.495 |
Informative |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
positive regulation of nitrogen compound metabolic process |
1 |
1.523 |
Informative |
INHERITED FROM: SREBP signaling pathway |
| Biological Process (BP) |
intracellular signal transduction |
0.7963 |
1.398 |
Informative |
INHERITED FROM: calcium-mediated signaling |
| Biological Process (BP) |
posttranscriptional regulation of gene expression |
0.01144 |
1.745 |
Informative |
INHERITED FROM: negative regulation of translation || regulation of translation |
| Biological Process (BP) |
negative regulation of biosynthetic process |
0.3982 |
1.62 |
Informative |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
negative regulation of cellular metabolic process |
0.7275 |
1.301 |
Informative |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
negative regulation of protein metabolic process |
0.2323 |
1.523 |
Informative |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
positive regulation of catalytic activity |
0.005029 |
1.337 |
Informative |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response || positive regulation of nuclease activity |
| Biological Process (BP) |
regulation of hydrolase activity |
0.01363 |
1.42 |
Informative |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response || regulation of nuclease activity || positive regulation of nuclease activity |
| Biological Process (BP) |
regulation of protein phosphorylation |
0.2963 |
1.495 |
Informative |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of phosphorus metabolic process |
0.03439 |
1.658 |
Informative |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
regulation of kinase activity |
0.0982 |
1.62 |
Informative |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
positive regulation of protein metabolic process |
0.01297 |
1.469 |
Informative |
INHERITED FROM: activation of signaling protein activity involved in unfolded protein response |
| Biological Process (BP) |
ossification |
6.38e-05 |
2.222 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
regulation of translation |
0.0006461 |
2.097 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
ER-nucleus signaling pathway |
0 |
2.222 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
response to endoplasmic reticulum stress |
1.896e-14 |
1.921 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
response to topologically incorrect protein |
0 |
2.097 |
Highly Informative |
DIRECT |
| Biological Process (BP) |
transmembrane receptor protein tyrosine kinase signaling pathway |
0.01921 |
1.796 |
Highly Informative |
INHERITED FROM: insulin-like growth factor receptor signaling pathway |
| Biological Process (BP) |
cellular component assembly involved in morphogenesis |
0.02464 |
1.921 |
Highly Informative |
INHERITED FROM: cilium assembly |
| Biological Process (BP) |
cell projection assembly |
0.00753 |
2 |
Highly Informative |
INHERITED FROM: cilium assembly |
| Biological Process (BP) |
negative regulation of cellular macromolecule biosynthetic process |
0.3012 |
2 |
Highly Informative |
INHERITED FROM: negative regulation of translation |
| Biological Process (BP) |
cellular response to biotic stimulus |
0.00903 |
2.097 |
Highly Informative |
INHERITED FROM: ER overload response |
| Molecular Function (MF) |
protein serine/threonine kinase activity |
0.0007067 |
2.377 |
-- |
DIRECT |
| Molecular Function (MF) |
catalytic activity |
1 |
0.2686 |
-- |
INHERITED FROM: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as accepto || oxidoreductase activity, acting on CH-OH group of donors || endoribonuclease activity || protein serine/threonine kinase activity || nuclease activity |
| Molecular Function (MF) |
molecular_function |
0.1987 |
0 |
-- |
INHERITED FROM: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as accepto || endoribonuclease activity || nuclease activity || oxidoreductase activity, acting on CH-OH group of donors || protein serine/threonine kinase activity |
| Molecular Function (MF) |
endonuclease activity |
0.001378 |
1.9 |
-- |
INHERITED FROM: endoribonuclease activity |
| Molecular Function (MF) |
ribonuclease activity |
0.002463 |
1.775 |
-- |
INHERITED FROM: endoribonuclease activity |
| Molecular Function (MF) |
transferase activity |
0.9115 |
0.7491 |
Least Informative |
INHERITED FROM: protein serine/threonine kinase activity |
| Molecular Function (MF) |
hydrolase activity |
1 |
0.6657 |
Least Informative |
INHERITED FROM: endoribonuclease activity || nuclease activity |
| Molecular Function (MF) |
oxidoreductase activity |
0.3384 |
0.9883 |
Moderately Informative |
INHERITED FROM: oxidoreductase activity, acting on CH-OH group of donors || oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as accepto |
| Molecular Function (MF) |
transferase activity, transferring phosphorus-containing groups |
0.07047 |
1.134 |
Moderately Informative |
INHERITED FROM: protein serine/threonine kinase activity |
| Molecular Function (MF) |
hydrolase activity, acting on ester bonds |
0.1121 |
1.122 |
Moderately Informative |
INHERITED FROM: nuclease activity || endoribonuclease activity |
| Molecular Function (MF) |
nuclease activity |
2.201e-06 |
1.565 |
Informative |
DIRECT |
| Molecular Function (MF) |
oxidoreductase activity, acting on CH-OH group of donors |
0.0002433 |
1.724 |
Informative |
DIRECT |
| Molecular Function (MF) |
kinase activity |
0.01825 |
1.474 |
Informative |
INHERITED FROM: protein serine/threonine kinase activity |
| Molecular Function (MF) |
phosphotransferase activity, alcohol group as acceptor |
0.007048 |
1.599 |
Informative |
INHERITED FROM: protein serine/threonine kinase activity |
| Molecular Function (MF) |
endoribonuclease activity |
0.0004453 |
2.076 |
Highly Informative |
DIRECT |
| Molecular Function (MF) |
protein kinase activity |
0.001172 |
1.98 |
Highly Informative |
INHERITED FROM: protein serine/threonine kinase activity |
| Cellular Component (CC) |
integral to endoplasmic reticulum membrane |
4.7e-07 |
2.241 |
-- |
DIRECT |
| Cellular Component (CC) |
preribosome |
5.414e-05 |
2.241 |
-- |
DIRECT |
| Cellular Component (CC) |
intrinsic to organelle membrane |
5.391e-05 |
1.763 |
-- |
DIRECT |
| Cellular Component (CC) |
nuclear outer membrane-endoplasmic reticulum membrane network |
1.363e-11 |
1.365 |
-- |
DIRECT |
| Cellular Component (CC) |
endoplasmic reticulum part |
2.892e-10 |
1.365 |
-- |
DIRECT |
| Cellular Component (CC) |
ER membrane protein complex |
1.731e-10 |
2.542 |
-- |
DIRECT |
| Cellular Component (CC) |
Cul4-RING ubiquitin ligase complex |
0.0006006 |
2.542 |
-- |
DIRECT |
| Cellular Component (CC) |
organelle part |
0.05929 |
0.3713 |
-- |
INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || ER membrane protein complex || organelle membrane || intrinsic to organelle membrane || integral to endoplasmic reticulum membrane || endoplasmic reticulum membrane |
| Cellular Component (CC) |
intracellular organelle |
1 |
0.1875 |
-- |
INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || ER membrane protein complex || endoplasmic reticulum || intrinsic to organelle membrane || integral to endoplasmic reticulum membrane || endoplasmic reticulum membrane |
| Cellular Component (CC) |
organelle |
1 |
0.1836 |
-- |
INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || ER membrane protein complex || endoplasmic reticulum || organelle membrane || intrinsic to organelle membrane || integral to endoplasmic reticulum membrane || endoplasmic reticulum membrane |
| Cellular Component (CC) |
membrane-bounded organelle |
1 |
0.2912 |
-- |
INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || ER membrane protein complex || endoplasmic reticulum || organelle membrane || intrinsic to organelle membrane || integral to endoplasmic reticulum membrane || endoplasmic reticulum membrane |
| Cellular Component (CC) |
cell |
1 |
0.08068 |
-- |
INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || small-subunit processome || nuclear outer membrane-endoplasmic reticulum membrane network || ubiquitin ligase complex || intrinsic to organelle membrane || integral to endoplasmic reticulum membrane || endoplasmic reticulum membrane || Cul4B-RING ubiquitin ligase complex || preribosome || ER membrane protein complex || endoplasmic reticulum || Cul4-RING ubiquitin ligase complex || endomembrane system || cullin-RING ubiquitin ligase complex |
| Cellular Component (CC) |
cell part |
1 |
0.08068 |
-- |
INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || small-subunit processome || nuclear outer membrane-endoplasmic reticulum membrane network || ubiquitin ligase complex || intrinsic to organelle membrane || integral to endoplasmic reticulum membrane || endoplasmic reticulum membrane || Cul4B-RING ubiquitin ligase complex || preribosome || ER membrane protein complex || endoplasmic reticulum || Cul4-RING ubiquitin ligase complex || endomembrane system || cullin-RING ubiquitin ligase complex |
| Cellular Component (CC) |
cellular_component |
0.4928 |
0 |
-- |
INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || small-subunit processome || nuclear outer membrane-endoplasmic reticulum membrane network || ubiquitin ligase complex || intrinsic to organelle membrane || integral to endoplasmic reticulum membrane || endoplasmic reticulum membrane || Cul4B-RING ubiquitin ligase complex || preribosome || ER membrane protein complex || endoplasmic reticulum || organelle membrane || Cul4-RING ubiquitin ligase complex || endomembrane system || cullin-RING ubiquitin ligase complex |
| Cellular Component (CC) |
cytoplasm |
1 |
0.2515 |
-- |
INHERITED FROM: endoplasmic reticulum part || integral to endoplasmic reticulum membrane || ER membrane protein complex || endoplasmic reticulum || endoplasmic reticulum membrane |
| Cellular Component (CC) |
intracellular |
1 |
0.1266 |
-- |
INHERITED FROM: Cul4B-RING ubiquitin ligase complex || endoplasmic reticulum part || integral to organelle membrane || small-subunit processome || preribosome || ER membrane protein complex || endoplasmic reticulum || ubiquitin ligase complex || intrinsic to organelle membrane || Cul4-RING ubiquitin ligase complex || integral to endoplasmic reticulum membrane || cullin-RING ubiquitin ligase complex || endoplasmic reticulum membrane |
| Cellular Component (CC) |
intracellular part |
1 |
0.1266 |
-- |
INHERITED FROM: Cul4B-RING ubiquitin ligase complex || endoplasmic reticulum part || integral to organelle membrane || small-subunit processome || preribosome || ER membrane protein complex || endoplasmic reticulum || ubiquitin ligase complex || intrinsic to organelle membrane || Cul4-RING ubiquitin ligase complex || integral to endoplasmic reticulum membrane || cullin-RING ubiquitin ligase complex || endoplasmic reticulum membrane |
| Cellular Component (CC) |
macromolecular complex |
0.09191 |
0.4276 |
-- |
INHERITED FROM: Cul4B-RING ubiquitin ligase complex || small-subunit processome || preribosome || ER membrane protein complex || ubiquitin ligase complex || Cul4-RING ubiquitin ligase complex || cullin-RING ubiquitin ligase complex |
| Cellular Component (CC) |
membrane part |
0.562 |
0.6842 |
-- |
INHERITED FROM: intrinsic to organelle membrane || integral to organelle membrane || integral to endoplasmic reticulum membrane || ER membrane protein complex || nuclear outer membrane-endoplasmic reticulum membrane network || endoplasmic reticulum membrane |
| Cellular Component (CC) |
intracellular membrane-bounded organelle |
1 |
0.2961 |
Least Informative |
INHERITED FROM: endoplasmic reticulum part || ER membrane protein complex || endoplasmic reticulum || integral to endoplasmic reticulum membrane || endoplasmic reticulum membrane |
| Cellular Component (CC) |
intracellular organelle part |
0.03025 |
0.3893 |
Least Informative |
INHERITED FROM: endoplasmic reticulum part || integral to organelle membrane || ER membrane protein complex || intrinsic to organelle membrane || integral to endoplasmic reticulum membrane || endoplasmic reticulum membrane |
| Cellular Component (CC) |
cytoplasmic part |
1 |
0.2605 |
Least Informative |
INHERITED FROM: endoplasmic reticulum part || integral to endoplasmic reticulum membrane || ER membrane protein complex || endoplasmic reticulum || endoplasmic reticulum membrane |
| Cellular Component (CC) |
protein complex |
0.2364 |
0.5639 |
Least Informative |
INHERITED FROM: Cul4B-RING ubiquitin ligase complex || ER membrane protein complex || ubiquitin ligase complex || Cul4-RING ubiquitin ligase complex || cullin-RING ubiquitin ligase complex |
| Cellular Component (CC) |
membrane |
1 |
0.5731 |
Least Informative |
INHERITED FROM: intrinsic to organelle membrane || integral to organelle membrane || integral to endoplasmic reticulum membrane || ER membrane protein complex || nuclear outer membrane-endoplasmic reticulum membrane network || organelle membrane || endoplasmic reticulum membrane |
| Cellular Component (CC) |
endoplasmic reticulum |
2.499e-08 |
1.127 |
Moderately Informative |
DIRECT |
| Cellular Component (CC) |
endomembrane system |
4.797e-06 |
1.11 |
Moderately Informative |
DIRECT |
| Cellular Component (CC) |
organelle membrane |
0.0007443 |
0.8514 |
Moderately Informative |
DIRECT |
| Cellular Component (CC) |
ribonucleoprotein complex |
0.07009 |
0.9505 |
Moderately Informative |
INHERITED FROM: small-subunit processome || preribosome |
| Cellular Component (CC) |
intrinsic to membrane |
0.956 |
1.18 |
Moderately Informative |
INHERITED FROM: intrinsic to organelle membrane || integral to endoplasmic reticulum membrane || integral to organelle membrane || ER membrane protein complex |
| Cellular Component (CC) |
ubiquitin ligase complex |
0.0006361 |
1.638 |
Informative |
DIRECT |
| Cellular Component (CC) |
endoplasmic reticulum membrane |
6.549e-12 |
1.462 |
Informative |
DIRECT |
| Cellular Component (CC) |
integral to membrane |
0.6932 |
1.286 |
Informative |
INHERITED FROM: integral to endoplasmic reticulum membrane || integral to organelle membrane || ER membrane protein complex |
| Cellular Component (CC) |
integral to organelle membrane |
2.361e-05 |
1.94 |
Highly Informative |
DIRECT |
| Cellular Component (CC) |
cullin-RING ubiquitin ligase complex |
0.00011 |
1.763 |
Highly Informative |
DIRECT |
| Cellular Component (CC) |
intrinsic to endoplasmic reticulum membrane |
0.01876 |
2.241 |
Highly Informative |
INHERITED FROM: integral to endoplasmic reticulum membrane || ER membrane protein complex |
0
11761326
