SUPERFAMILY 1.75 HMM library and genome assignments server


Hemopexin-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   4-bladed beta-propeller [ 50922]
Superfamily:   Hemopexin-like domain [ 50923]
Families:   Hemopexin-like domain [ 50924] (5)


Superfamily statistics
Genomes (185) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,371 2,778 11
Proteins 2,243 2,567 10


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0026270Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0067343.563e-06Least InformativeInherited
Biological Process (BP)multicellular organismal metabolic process2.465e-110Highly InformativeDirect
Molecular Function (MF)hydrolase activity4.899e-050Least InformativeDirect
Molecular Function (MF)peptidase activity1.251e-080InformativeDirect
Molecular Function (MF)metallopeptidase activity2.099e-130Highly InformativeDirect
Molecular Function (MF)endopeptidase activity0.33429.609e-07Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 9.275e-07 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 3.563e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 4.756e-07 Least Informative Direct
Biological Process (BP) localization 0.2647 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001146 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1321 Least Informative Inherited
Biological Process (BP) immune system process 0.0002174 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0001169 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 4.372e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.02601 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.0308 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.009985 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.002375 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02128 Moderately Informative Inherited
Biological Process (BP) organ development 0.007765 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9971 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.03491 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9412 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.9026 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01033 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8012 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.005572 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01845 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01782 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0141 Moderately Informative Inherited
Biological Process (BP) tissue development 0.07583 Moderately Informative Inherited
Biological Process (BP) proteolysis 2.617e-09 Informative Direct
Biological Process (BP) cellular component movement 0.0003985 Informative Direct
Biological Process (BP) response to wounding 0.0001948 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0005175 Informative Direct
Biological Process (BP) biological adhesion 0.0002891 Informative Direct
Biological Process (BP) regulation of defense response 7.074e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0003977 Informative Direct
Biological Process (BP) locomotion 3.843e-07 Informative Direct
Biological Process (BP) regulation of locomotion 8.154e-09 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0001915 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0007093 Informative Direct
Biological Process (BP) regulation of cellular component movement 3.426e-10 Informative Direct
Biological Process (BP) localization of cell 3.665e-10 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.09905 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4233 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.003645 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.006685 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.7119 Informative Inherited
Biological Process (BP) embryonic organ development 0.06694 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.01995 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.001722 Informative Inherited
Biological Process (BP) response to lipid 0.0115 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2182 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.002629 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.1102 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.9492 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.004335 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2642 Informative Inherited
Biological Process (BP) tube development 0.03153 Informative Inherited
Biological Process (BP) reproductive system development 0.982 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02511 Informative Inherited
Biological Process (BP) organ morphogenesis 0.001176 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.04512 Informative Inherited
Biological Process (BP) epithelium development 0.9424 Informative Inherited
Biological Process (BP) skeletal system development 7.318e-15 Highly Informative Direct
Biological Process (BP) ossification 3.057e-13 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.297e-06 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0007122 Highly Informative Direct
Biological Process (BP) protein processing 2.176e-10 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 2.161e-05 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.0001037 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 9.323e-07 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0005034 Highly Informative Direct
Biological Process (BP) response to amino acid stimulus 1.095e-06 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 2.074e-06 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 2.186e-08 Highly Informative Direct
Biological Process (BP) respiratory system development 4.503e-06 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.02037 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1318 Highly Informative Inherited
Biological Process (BP) gonad development 0.02818 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.3804 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.7288 Least Informative Inherited
Molecular Function (MF) cation binding 1.172e-12 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.02441 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0002365 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) endopeptidase activity 9.609e-07 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1473 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0001267 Informative Direct
Cellular Component (CC) extracellular matrix 3.594e-11 Informative Direct
Cellular Component (CC) neuron projection 0.01002 Informative Inherited
Cellular Component (CC) dendrite 7.887e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Gelatinase B6.093e-06Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A6.093e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.03846Least InformativeInherited
Disease Ontology (DO)organ system cancer0.04612Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4175Least InformativeInherited
Disease Ontology (DO)mouth disease3.629e-05Moderately InformativeDirect
Disease Ontology (DO)lung disease0.000187Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.0008728Moderately InformativeDirect
Disease Ontology (DO)artery disease0.0018Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.00793Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.008344Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.009244Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.02472Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system cancer0.03423Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.08064Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.08814Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1272Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1933Moderately InformativeInherited
Disease Ontology (DO)Kawasaki disease1.824e-07InformativeDirect
Disease Ontology (DO)chondrosarcoma2.86e-07InformativeDirect
Disease Ontology (DO)myopia1.323e-06InformativeDirect
Disease Ontology (DO)female reproductive system disease1.762e-06InformativeDirect
Disease Ontology (DO)prostate cancer5.656e-06InformativeDirect
Disease Ontology (DO)atherosclerosis1.971e-05InformativeDirect
Disease Ontology (DO)integumentary system cancer0.0001275InformativeDirect
Disease Ontology (DO)arthritis0.000187InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.0002495InformativeDirect
Disease Ontology (DO)myeloma0.0003332InformativeDirect
Disease Ontology (DO)endometrial cancer0.0003375InformativeDirect
Disease Ontology (DO)meningioma0.0004594InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0006281InformativeDirect
Disease Ontology (DO)multiple sclerosis0.000983InformativeDirect
Disease Ontology (DO)rheumatic disease0.001655InformativeInherited
Disease Ontology (DO)collagen disease0.008881InformativeInherited
Disease Ontology (DO)heart disease0.01552InformativeInherited
Disease Ontology (DO)urinary system cancer0.02777InformativeInherited
Disease Ontology (DO)malignant glioma0.05234InformativeInherited
Disease Ontology (DO)esophageal disease0.0686InformativeInherited
Disease Ontology (DO)abdominal aortic aneurysm3.276e-06Highly InformativeDirect
Disease Ontology (DO)adult astrocytic tumour3.311e-06Highly InformativeDirect
Disease Ontology (DO)ovary epithelial cancer5.535e-05Highly InformativeDirect
Disease Ontology (DO)bronchiectasis0.0001144Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2159Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.02156Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.02497Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.0007524InformativeDirect
Phenotypic Abnormality (PA)Limitation of joint mobility0.0003833Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the femur0.01039Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.07515Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1275Least InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.03475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1657Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.2308Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3133Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0005801InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0009316InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0009697InformativeDirect
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.006272InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.01286InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.02185InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02488InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.0263InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.06652InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1394InformativeInherited
Mammalian Phenotype (MP)overexpanded pulmonary alveoli0.000107Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.0001889Highly InformativeDirect
Mammalian Phenotype (MP)decreased angiogenesis0.0002145Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.0003676Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0008102Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0008155Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.004334Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.09329Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.5796Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant1.214e-05Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant5.838e-06InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7615Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8065Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.9083Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.1951Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9989Moderately InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.0001142InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage1.067e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage1.827e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis1.285e-12InformativeDirect
Cellular componentMembrane0.5376Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor9.806e-07InformativeDirect
Coding sequence diversityPolymorphism0.0008013Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage8.332e-09InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000585 SSF50923 Protein matches
Abstract

Hemopexin is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation [PubMed12042069]. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. Hemopexin-like domains have been found in two other types of proteins, vitronectin [PubMed9572850], a cell adhesion and spreading factor found in plasma and tissues, and matrixins MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15 and MMP-16, members of the matrix metalloproteinase family that cleave extracellular matrix constituents [PubMed14619953]. These zinc endopeptidases, which belong to MEROPS peptidase subfamily M10A, have a single hemopexin-like domain in their C-terminal section. It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hemopexin-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Hemopexin-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]