SUPERFAMILY 1.75 HMM library and genome assignments server


Hemopexin-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   4-bladed beta-propeller [ 50922]
Superfamily:   Hemopexin-like domain [ 50923]
Families:   Hemopexin-like domain [ 50924] (5)


Superfamily statistics
Genomes (185) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,371 2,778 11
Proteins 2,243 2,567 10


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0025830Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0061082.838e-06Least InformativeInherited
Biological Process (BP)multicellular organismal metabolic process2.442e-110Highly InformativeDirect
Molecular Function (MF)hydrolase activity4.503e-050Least InformativeDirect
Molecular Function (MF)peptidase activity1.207e-080InformativeDirect
Molecular Function (MF)metallopeptidase activity1.62e-130Highly InformativeDirect
Molecular Function (MF)endopeptidase activity0.3431.018e-06Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.103e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 2.838e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 3.627e-07 Least Informative Direct
Biological Process (BP) localization 0.2501 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001244 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1141 Least Informative Inherited
Biological Process (BP) immune system process 0.0001983 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.000112 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.02601 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02778 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.009559 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.002301 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01151 Moderately Informative Inherited
Biological Process (BP) organ development 0.007657 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.03206 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9356 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.145 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8957 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.00984 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.803 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.005139 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01801 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01505 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01327 Moderately Informative Inherited
Biological Process (BP) tissue development 0.07634 Moderately Informative Inherited
Biological Process (BP) proteolysis 2.365e-09 Informative Direct
Biological Process (BP) cellular component movement 0.0004103 Informative Direct
Biological Process (BP) response to wounding 0.0002057 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0005298 Informative Direct
Biological Process (BP) biological adhesion 0.00027 Informative Direct
Biological Process (BP) regulation of defense response 6.274e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0003663 Informative Direct
Biological Process (BP) locomotion 3.371e-07 Informative Direct
Biological Process (BP) regulation of locomotion 8.412e-09 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0001963 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0007406 Informative Direct
Biological Process (BP) regulation of cellular component movement 3.493e-10 Informative Direct
Biological Process (BP) localization of cell 3.078e-10 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.09847 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4165 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.003768 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.006713 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.7157 Informative Inherited
Biological Process (BP) embryonic organ development 0.06651 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.02056 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.001774 Informative Inherited
Biological Process (BP) response to lipid 0.0115 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2084 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.002651 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.9495 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.004208 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2642 Informative Inherited
Biological Process (BP) tube development 0.03211 Informative Inherited
Biological Process (BP) reproductive system development 0.9806 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02577 Informative Inherited
Biological Process (BP) organ morphogenesis 0.001209 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.0427 Informative Inherited
Biological Process (BP) epithelium development 0.9423 Informative Inherited
Biological Process (BP) response to acid 4.276e-07 Highly Informative Direct
Biological Process (BP) skeletal system development 9.182e-15 Highly Informative Direct
Biological Process (BP) ossification 3.176e-13 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.211e-06 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0007118 Highly Informative Direct
Biological Process (BP) protein processing 1.939e-10 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 2.191e-05 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.0001044 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 8.88e-07 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0004758 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 1.976e-06 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 2.178e-08 Highly Informative Direct
Biological Process (BP) respiratory system development 4.841e-06 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.02148 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1352 Highly Informative Inherited
Biological Process (BP) gonad development 0.02796 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.3795 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.6852 Least Informative Inherited
Molecular Function (MF) cation binding 6.081e-13 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.02299 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0002154 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0.0006325 Informative Direct
Molecular Function (MF) endopeptidase activity 1.018e-06 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1366 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0001266 Informative Direct
Cellular Component (CC) extracellular matrix 3.244e-11 Informative Direct
Cellular Component (CC) neuron projection 0.008996 Informative Inherited
Cellular Component (CC) dendrite 7.187e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Gelatinase B6.093e-06Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A6.093e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06131Least InformativeInherited
Disease Ontology (DO)immune system disease0.07554Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4544Least InformativeInherited
Disease Ontology (DO)bone disease0.0005825Moderately InformativeDirect
Disease Ontology (DO)lung disease0.0007248Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.001896Moderately InformativeInherited
Disease Ontology (DO)artery disease0.005061Moderately InformativeInherited
Disease Ontology (DO)skin disease0.007709Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.01214Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.02239Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system cancer0.02378Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.02566Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.08071Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.09665Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1276Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.1617Moderately InformativeInherited
Disease Ontology (DO)Kawasaki disease1.235e-07InformativeDirect
Disease Ontology (DO)myopia7.338e-07InformativeDirect
Disease Ontology (DO)prostate cancer3.5e-06InformativeDirect
Disease Ontology (DO)female reproductive system disease1.367e-05InformativeDirect
Disease Ontology (DO)integumentary system cancer8.621e-05InformativeDirect
Disease Ontology (DO)arthritis0.0001114InformativeDirect
Disease Ontology (DO)myeloma0.0002373InformativeDirect
Disease Ontology (DO)meningioma0.0003714InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0004994InformativeDirect
Disease Ontology (DO)collagen disease0.0005602InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.001617InformativeInherited
Disease Ontology (DO)connective tissue cancer0.001851InformativeInherited
Disease Ontology (DO)kidney cancer0.002357InformativeInherited
Disease Ontology (DO)rheumatic disease0.004423InformativeInherited
Disease Ontology (DO)retinal disease0.01548InformativeInherited
Disease Ontology (DO)cardiomyopathy0.02387InformativeInherited
Disease Ontology (DO)malignant glioma0.03987InformativeInherited
Disease Ontology (DO)esophageal disease0.05252InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.911InformativeInherited
Disease Ontology (DO)chondrosarcoma1.743e-07Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm2.726e-06Highly InformativeDirect
Disease Ontology (DO)adult astrocytic tumour3.084e-06Highly InformativeDirect
Disease Ontology (DO)bronchiectasis3.949e-05Highly InformativeDirect
Disease Ontology (DO)Lyme disease0.0003603Highly InformativeDirect
Disease Ontology (DO)ovary epithelial cancer0.0003889Highly InformativeDirect
Disease Ontology (DO)lichen disease0.0004182Highly InformativeDirect
Disease Ontology (DO)glaucoma0.0008918Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.218Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.02166Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.0252Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.0007088InformativeDirect
Phenotypic Abnormality (PA)Limitation of joint mobility0.0003848Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the femur0.01055Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0747Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1275Least InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.03414Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1639Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.2312Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.312Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7131Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.000588InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0009208InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0009622InformativeDirect
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.006344InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.01258InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.02139InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02542InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.02657InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.06704InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1409InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.000185Highly InformativeDirect
Mammalian Phenotype (MP)decreased angiogenesis0.0002068Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.0003558Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0007419Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.000819Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.004352Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.01941Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.09322Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.5795Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant1.214e-05Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant5.838e-06InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7616Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8058Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.9073Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.1949Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9982Moderately InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.000109InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage1.062e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage1.819e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis1.285e-12InformativeDirect
Cellular componentMembrane0.5376Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor9.806e-07InformativeDirect
Coding sequence diversityPolymorphism0.0008013Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage8.332e-09InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000585 SSF50923 Protein matches
Abstract

Hemopexin is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation [PubMed12042069]. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. Hemopexin-like domains have been found in two other types of proteins, vitronectin [PubMed9572850], a cell adhesion and spreading factor found in plasma and tissues, and matrixins MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15 and MMP-16, members of the matrix metalloproteinase family that cleave extracellular matrix constituents [PubMed14619953]. These zinc endopeptidases, which belong to MEROPS peptidase subfamily M10A, have a single hemopexin-like domain in their C-terminal section. It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hemopexin-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Hemopexin-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]