SUPERFAMILY 1.75 HMM library and genome assignments server


Hemopexin-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   4-bladed beta-propeller [ 50922]
Superfamily:   Hemopexin-like domain [ 50923]
Families:   Hemopexin-like domain [ 50924] (5)


Superfamily statistics
Genomes (185) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,371 2,778 11
Proteins 2,243 2,567 10


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0026430Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0067763.288e-06Least InformativeInherited
Biological Process (BP)multicellular organismal metabolic process2.466e-110Highly InformativeDirect
Molecular Function (MF)hydrolase activity4.871e-050Least InformativeDirect
Molecular Function (MF)peptidase activity1.272e-080InformativeDirect
Molecular Function (MF)metallopeptidase activity2.082e-130Highly InformativeDirect
Molecular Function (MF)endopeptidase activity0.33879.44e-07Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 9.729e-07 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 3.288e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 5.428e-07 Least Informative Direct
Biological Process (BP) localization 0.2721 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001188 Least Informative Inherited
Biological Process (BP) response to stimulus 0.09253 Least Informative Inherited
Biological Process (BP) immune system process 0.0002182 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0001802 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.04764 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.01567 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01544 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01336 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.003118 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.5822 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.001169 Moderately Informative Inherited
Biological Process (BP) organ development 0.00776 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.03797 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9884 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.9114 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01145 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8424 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.006198 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0193 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0143 Moderately Informative Inherited
Biological Process (BP) tissue development 0.07693 Moderately Informative Inherited
Biological Process (BP) proteolysis 2.926e-09 Informative Direct
Biological Process (BP) cellular component movement 0.0003836 Informative Direct
Biological Process (BP) response to wounding 0.0003419 Informative Direct
Biological Process (BP) organ morphogenesis 1.808e-05 Informative Direct
Biological Process (BP) biological adhesion 0.0002895 Informative Direct
Biological Process (BP) regulation of defense response 7.906e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0003917 Informative Direct
Biological Process (BP) locomotion 3.77e-07 Informative Direct
Biological Process (BP) regulation of locomotion 1.101e-08 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0001918 Informative Direct
Biological Process (BP) regulation of cellular component movement 3.181e-10 Informative Direct
Biological Process (BP) localization of cell 4.244e-10 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.09906 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001137 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.428 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.00115 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.002962 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.004177 Informative Inherited
Biological Process (BP) regulation of immune response 0.008024 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.7078 Informative Inherited
Biological Process (BP) embryonic organ development 0.06638 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.01988 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.001687 Informative Inherited
Biological Process (BP) response to lipid 0.01198 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.2266 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.002579 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.9498 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.004513 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.001629 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2716 Informative Inherited
Biological Process (BP) tube development 0.03135 Informative Inherited
Biological Process (BP) reproductive system development 0.9823 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02584 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.04417 Informative Inherited
Biological Process (BP) epithelium development 0.9462 Informative Inherited
Biological Process (BP) skeletal system development 9.148e-15 Highly Informative Direct
Biological Process (BP) ossification 2.959e-13 Highly Informative Direct
Biological Process (BP) response to hypoxia 2.253e-06 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0007348 Highly Informative Direct
Biological Process (BP) protein processing 2.459e-10 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 1.67e-05 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) respiratory tube development 0.0001019 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 9.683e-07 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0005405 Highly Informative Direct
Biological Process (BP) response to amino acid stimulus 2.218e-06 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 2.156e-06 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 2.314e-08 Highly Informative Direct
Biological Process (BP) respiratory system development 4.511e-06 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.01937 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2358 Highly Informative Inherited
Biological Process (BP) gonad development 0.02808 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.3793 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.7618 Least Informative Inherited
Molecular Function (MF) cation binding 1.442e-12 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.02542 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0002527 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) endopeptidase activity 9.44e-07 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1587 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0001299 Informative Direct
Cellular Component (CC) extracellular matrix 4.034e-11 Informative Direct
Cellular Component (CC) neuron projection 0.01135 Informative Inherited
Cellular Component (CC) dendrite 8.959e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Gelatinase B6.093e-06Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A6.093e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.03967Least InformativeInherited
Disease Ontology (DO)organ system cancer0.04732Least InformativeInherited
Disease Ontology (DO)nervous system disease0.3819Least InformativeInherited
Disease Ontology (DO)obstructive lung disease1.927e-05Moderately InformativeDirect
Disease Ontology (DO)mouth disease3.563e-05Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.0008861Moderately InformativeDirect
Disease Ontology (DO)artery disease0.001797Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.007069Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.008317Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.009345Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.02479Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.08014Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.08861Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1038Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1352Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1409Moderately InformativeInherited
Disease Ontology (DO)Kawasaki disease1.827e-07InformativeDirect
Disease Ontology (DO)female reproductive system disease1.775e-06InformativeDirect
Disease Ontology (DO)prostate cancer5.689e-06InformativeDirect
Disease Ontology (DO)atherosclerosis1.979e-05InformativeDirect
Disease Ontology (DO)integumentary system cancer0.000126InformativeDirect
Disease Ontology (DO)arthritis0.0001895InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.0002493InformativeDirect
Disease Ontology (DO)myeloma0.0003272InformativeDirect
Disease Ontology (DO)endometrial cancer0.0003362InformativeDirect
Disease Ontology (DO)meningioma0.0004582InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0006258InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0009824InformativeDirect
Disease Ontology (DO)rheumatic disease0.001625InformativeInherited
Disease Ontology (DO)connective tissue cancer0.001942InformativeInherited
Disease Ontology (DO)collagen disease0.008769InformativeInherited
Disease Ontology (DO)heart disease0.01554InformativeInherited
Disease Ontology (DO)urinary system cancer0.02767InformativeInherited
Disease Ontology (DO)eye disease0.03402InformativeInherited
Disease Ontology (DO)malignant glioma0.05467InformativeInherited
Disease Ontology (DO)esophageal disease0.07027InformativeInherited
Disease Ontology (DO)abdominal aortic aneurysm3.279e-06Highly InformativeDirect
Disease Ontology (DO)adult astrocytic tumour3.294e-06Highly InformativeDirect
Disease Ontology (DO)ovary epithelial cancer5.542e-05Highly InformativeDirect
Disease Ontology (DO)bronchiectasis0.000112Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2159Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.02147Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.02473Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.0007459InformativeDirect
Phenotypic Abnormality (PA)Limitation of joint mobility0.0003796Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the femur0.01035Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.07672Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1317Least InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.03587Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.03929Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1674Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.238Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3163Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7147Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0006138InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0009885InformativeDirect
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.006928InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.01262InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.02223InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02714InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.02748InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.06904InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1464InformativeInherited
Mammalian Phenotype (MP)overexpanded pulmonary alveoli0.0001079Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.0001801Highly InformativeDirect
Mammalian Phenotype (MP)decreased angiogenesis0.0002164Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.000353Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.000765Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0009375Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.004618Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.09613Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.589Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant1.214e-05Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant5.838e-06InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7613Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8064Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.909Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.1956Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9995Moderately InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.0001141InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage1.06e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage1.816e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis1.485e-12InformativeDirect
Biological processCell adhesion5.08e-08InformativeDirect
Cellular componentMembrane0.5413Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor9.796e-07InformativeDirect
Coding sequence diversityPolymorphism0.0006745Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage8.172e-09InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000585 SSF50923 Protein matches
Abstract

Hemopexin is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation [PubMed12042069]. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. Hemopexin-like domains have been found in two other types of proteins, vitronectin [PubMed9572850], a cell adhesion and spreading factor found in plasma and tissues, and matrixins MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15 and MMP-16, members of the matrix metalloproteinase family that cleave extracellular matrix constituents [PubMed14619953]. These zinc endopeptidases, which belong to MEROPS peptidase subfamily M10A, have a single hemopexin-like domain in their C-terminal section. It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hemopexin-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Hemopexin-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]