SUPERFAMILY 1.75 HMM library and genome assignments server


Hemopexin-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   4-bladed beta-propeller [ 50922]
Superfamily:   Hemopexin-like domain [ 50923]
Families:   Hemopexin-like domain [ 50924] (5)


Superfamily statistics
Genomes (163) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,162 2,326 11
Proteins 2,048 2,145 10


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0026190Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0065852.017e-05Least InformativeInherited
Biological Process (BP)collagen metabolic process2.066e-110Highly InformativeDirect
Biological Process (BP)multicellular organismal catabolic process7.299e-120Highly InformativeDirect
Molecular Function (MF)hydrolase activity5.04e-050Least InformativeDirect
Molecular Function (MF)peptidase activity1.235e-080InformativeDirect
Molecular Function (MF)metallopeptidase activity1.645e-130Highly InformativeDirect
Molecular Function (MF)endopeptidase activity0.34431.097e-05Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 5.388e-08 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 5.387e-10 Least Informative Direct
Biological Process (BP) single-organism metabolic process 2.017e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.026e-05 Least Informative Direct
Biological Process (BP) localization 0.1706 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01284 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1447 Least Informative Inherited
Biological Process (BP) response to endogenous stimulus 1.342e-05 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0008618 Moderately Informative Direct
Biological Process (BP) organ development 0.0001529 Moderately Informative Direct
Biological Process (BP) immune system process 0.001364 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.007106 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01595 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.05718 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.005679 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.3676 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.08378 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.00881 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9202 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01957 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.1066 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9252 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.8911 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.07452 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9709 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6387 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.005555 Moderately Informative Inherited
Biological Process (BP) reproduction 0.004689 Moderately Informative Inherited
Biological Process (BP) tissue development 0.07854 Moderately Informative Inherited
Biological Process (BP) proteolysis 6.565e-08 Informative Direct
Biological Process (BP) cellular component movement 0.0002253 Informative Direct
Biological Process (BP) response to wounding 0.0002182 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0005164 Informative Direct
Biological Process (BP) regulation of defense response 3.242e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0001823 Informative Direct
Biological Process (BP) locomotion 1.3e-06 Informative Direct
Biological Process (BP) regulation of locomotion 1.429e-07 Informative Direct
Biological Process (BP) regulation of cellular component movement 4.502e-09 Informative Direct
Biological Process (BP) localization of cell 6.283e-10 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.1179 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.449 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.003606 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.006649 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.008613 Informative Inherited
Biological Process (BP) regulation of immune response 0.002643 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02476 Informative Inherited
Biological Process (BP) organ morphogenesis 0.001535 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1247 Informative Inherited
Biological Process (BP) embryonic organ development 0.02286 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.01922 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.00168 Informative Inherited
Biological Process (BP) response to lipid 0.0116 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.1559 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.002579 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.9423 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.002494 Informative Inherited
Biological Process (BP) reproductive structure development 0.5193 Informative Inherited
Biological Process (BP) single organism reproductive process 0.005988 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.001727 Informative Inherited
Biological Process (BP) epithelium development 0.2556 Informative Inherited
Biological Process (BP) response to acid 1.916e-07 Highly Informative Direct
Biological Process (BP) skeletal system development 1.032e-11 Highly Informative Direct
Biological Process (BP) ossification 5.078e-14 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.065e-06 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0008472 Highly Informative Direct
Biological Process (BP) cell proliferation 1.223e-06 Highly Informative Direct
Biological Process (BP) protein processing 1.007e-10 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 9.039e-06 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) lung development 5.347e-06 Highly Informative Direct
Biological Process (BP) collagen metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 6.286e-07 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0002694 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 1.352e-06 Highly Informative Direct
Biological Process (BP) epithelial tube morphogenesis 0.7419 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.01772 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.8242 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.02851 Highly Informative Inherited
Biological Process (BP) gonad development 0.005073 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.1019 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.8969 Least Informative Inherited
Molecular Function (MF) cation binding 6.331e-10 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.01638 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0001439 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0.005668 Informative Inherited
Molecular Function (MF) endopeptidase activity 1.097e-05 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0924 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 8.63e-12 Informative Direct
Cellular Component (CC) neuron projection 0.005308 Informative Inherited
Cellular Component (CC) dendrite 3.722e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Gelatinase B6.093e-06Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A6.093e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06128Least InformativeInherited
Disease Ontology (DO)immune system disease0.06862Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5589Least InformativeInherited
Disease Ontology (DO)lung disease0.0007319Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.001709Moderately InformativeInherited
Disease Ontology (DO)artery disease0.005088Moderately InformativeInherited
Disease Ontology (DO)skin disease0.007582Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.0122Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.02007Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.02343Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.02615Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.08052Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.09172Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.09628Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.1639Moderately InformativeInherited
Disease Ontology (DO)Kawasaki disease1.344e-07InformativeDirect
Disease Ontology (DO)myopia7.127e-07InformativeDirect
Disease Ontology (DO)prostate cancer3.83e-06InformativeDirect
Disease Ontology (DO)female reproductive system disease1.361e-05InformativeDirect
Disease Ontology (DO)integumentary system cancer8.092e-05InformativeDirect
Disease Ontology (DO)arthritis0.0001141InformativeDirect
Disease Ontology (DO)myeloma0.0002342InformativeDirect
Disease Ontology (DO)meningioma0.000347InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0005409InformativeDirect
Disease Ontology (DO)renal carcinoma0.001276InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.001732InformativeInherited
Disease Ontology (DO)connective tissue cancer0.001783InformativeInherited
Disease Ontology (DO)rheumatic disease0.004194InformativeInherited
Disease Ontology (DO)retinal disease0.01549InformativeInherited
Disease Ontology (DO)cardiomyopathy0.02365InformativeInherited
Disease Ontology (DO)malignant glioma0.039InformativeInherited
Disease Ontology (DO)esophageal disease0.05214InformativeInherited
Disease Ontology (DO)connective tissue disease0.271InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9057InformativeInherited
Disease Ontology (DO)chondrosarcoma1.513e-07Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm2.661e-06Highly InformativeDirect
Disease Ontology (DO)adult astrocytic tumour3.111e-06Highly InformativeDirect
Disease Ontology (DO)bronchiectasis3.854e-05Highly InformativeDirect
Disease Ontology (DO)Lyme disease0.0003319Highly InformativeDirect
Disease Ontology (DO)ovary epithelial cancer0.0003711Highly InformativeDirect
Disease Ontology (DO)lichen disease0.0003862Highly InformativeDirect
Disease Ontology (DO)glaucoma0.0008747Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.2383Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.02238Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.02574Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.0007459InformativeDirect
Phenotypic Abnormality (PA)Abnormality of joint mobility0.01144InformativeInherited
Phenotypic Abnormality (PA)Limitation of joint mobility0.0003847Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the femur0.01096Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.07539Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1238Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.001966Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.03253Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.03747Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1695Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.2308Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3694Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.711Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0006027InformativeDirect
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.006489InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.01266InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02285InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.02616InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.03367InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.06713InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1366InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to bacterial infection1.782e-05Highly InformativeDirect
Mammalian Phenotype (MP)overexpanded pulmonary alveoli0.0001134Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.000344Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0007419Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0008364Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.004391Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.09498Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.4147Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant1.214e-05Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant5.838e-06InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7618Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8027Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.9053Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.1937Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9971Moderately InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.0001014InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage1.062e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage1.809e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis1.31e-12InformativeDirect
Cellular componentMembrane0.5465Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor9.157e-07InformativeDirect
Coding sequence diversityPolymorphism0.0009223Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage9.035e-09InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000585 SSF50923 Protein matches
Abstract

Hemopexin is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation [PubMed12042069]. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. Hemopexin-like domains have been found in two other types of proteins, vitronectin [PubMed9572850], a cell adhesion and spreading factor found in plasma and tissues, and matrixins MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15 and MMP-16, members of the matrix metalloproteinase family that cleave extracellular matrix constituents [PubMed14619953]. These zinc endopeptidases, which belong to MEROPS peptidase subfamily M10A, have a single hemopexin-like domain in their C-terminal section. It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hemopexin-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Hemopexin-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]