SUPERFAMILY 1.75 HMM library and genome assignments server


Hemopexin-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   4-bladed beta-propeller [ 50922]
Superfamily:   Hemopexin-like domain [ 50923]
Families:   Hemopexin-like domain [ 50924] (5)


Superfamily statistics
Genomes (176) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,207 0 11
Proteins 2,089 0 10


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0024440Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0058185.959e-07Least InformativeInherited
Biological Process (BP)multicellular organismal metabolic process2.343e-110Highly InformativeDirect
Molecular Function (MF)hydrolase activity4.223e-050Least InformativeDirect
Molecular Function (MF)peptidase activity1.137e-080InformativeDirect
Molecular Function (MF)metallopeptidase activity1.523e-130Highly InformativeDirect
Molecular Function (MF)endopeptidase activity0.34242.174e-06Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 5.959e-07 Least Informative Direct
Biological Process (BP) developmental process 1.933e-14 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 9.852e-08 Least Informative Direct
Biological Process (BP) protein metabolic process 3.437e-06 Least Informative Direct
Biological Process (BP) localization 0.1976 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002474 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2127 Least Informative Inherited
Biological Process (BP) organ development 2.044e-05 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 2.155e-05 Moderately Informative Direct
Biological Process (BP) immune system process 0.0001227 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0002474 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0267 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02216 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.07089 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.008357 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.415 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03248 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.02722 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9802 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02536 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.812 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6932 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01626 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01037 Moderately Informative Inherited
Biological Process (BP) reproduction 0.009364 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2842 Moderately Informative Inherited
Biological Process (BP) cellular component disassembly 0 Informative Direct
Biological Process (BP) localization of cell 1.969e-10 Informative Direct
Biological Process (BP) regulation of cellular component movement 6.973e-09 Informative Direct
Biological Process (BP) proteolysis 2.015e-08 Informative Direct
Biological Process (BP) locomotion 1.872e-07 Informative Direct
Biological Process (BP) regulation of locomotion 1.932e-07 Informative Direct
Biological Process (BP) organ morphogenesis 9.228e-05 Informative Direct
Biological Process (BP) cellular component movement 0.0002259 Informative Direct
Biological Process (BP) response to wounding 0.0003701 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0003762 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00057 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.04268 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.003768 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.006758 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4578 Informative Inherited
Biological Process (BP) regulation of immune response 0.004638 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.007839 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.04282 Informative Inherited
Biological Process (BP) embryonic organ development 0.03047 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.04926 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.001832 Informative Inherited
Biological Process (BP) response to lipid 0.01187 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.01836 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.1902 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.002629 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.09222 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.9511 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.0036 Informative Inherited
Biological Process (BP) regulation of response to stress 0.01255 Informative Inherited
Biological Process (BP) tube development 0.01318 Informative Inherited
Biological Process (BP) reproductive system development 0.9229 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01943 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.014 Informative Inherited
Biological Process (BP) epithelium development 0.3686 Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) skeletal system development 0 Highly Informative Direct
Biological Process (BP) ossification 1.012e-13 Highly Informative Direct
Biological Process (BP) protein processing 1.478e-10 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 1.745e-08 Highly Informative Direct
Biological Process (BP) response to acid 4.305e-07 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 7.653e-07 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 1.681e-06 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.687e-06 Highly Informative Direct
Biological Process (BP) respiratory system development 2.556e-06 Highly Informative Direct
Biological Process (BP) ovulation cycle process 1.759e-05 Highly Informative Direct
Biological Process (BP) respiratory tube development 3.44e-05 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0003846 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0007294 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.02176 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.9866 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.03964 Highly Informative Inherited
Biological Process (BP) gonad development 0.01442 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.2562 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.686 Least Informative Inherited
Molecular Function (MF) cation binding 3.319e-13 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.02025 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0001822 Informative Direct
Molecular Function (MF) transition metal ion binding 0.0006717 Informative Direct
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 2.174e-06 Highly Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.12 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 1.894e-11 Informative Direct
Cellular Component (CC) neuron projection 0.007608 Informative Inherited
Cellular Component (CC) dendrite 5.723e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Gelatinase B6.093e-06Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A6.093e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0607Least InformativeInherited
Disease Ontology (DO)immune system disease0.06868Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5485Least InformativeInherited
Disease Ontology (DO)lung disease0.0007303Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.00173Moderately InformativeInherited
Disease Ontology (DO)artery disease0.005061Moderately InformativeInherited
Disease Ontology (DO)skin disease0.007525Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.01212Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.02006Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.02329Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.02596Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.0799Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.09269Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.09568Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.1626Moderately InformativeInherited
Disease Ontology (DO)Kawasaki disease1.343e-07InformativeDirect
Disease Ontology (DO)myopia7.117e-07InformativeDirect
Disease Ontology (DO)prostate cancer3.831e-06InformativeDirect
Disease Ontology (DO)female reproductive system disease1.362e-05InformativeDirect
Disease Ontology (DO)integumentary system cancer8.099e-05InformativeDirect
Disease Ontology (DO)arthritis0.0001139InformativeDirect
Disease Ontology (DO)myeloma0.0002339InformativeDirect
Disease Ontology (DO)meningioma0.0003467InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0005408InformativeDirect
Disease Ontology (DO)renal carcinoma0.001273InformativeInherited
Disease Ontology (DO)primary bacterial infectious disease0.00173InformativeInherited
Disease Ontology (DO)connective tissue cancer0.001779InformativeInherited
Disease Ontology (DO)rheumatic disease0.00418InformativeInherited
Disease Ontology (DO)retinal disease0.01541InformativeInherited
Disease Ontology (DO)cardiomyopathy0.02351InformativeInherited
Disease Ontology (DO)malignant glioma0.03872InformativeInherited
Disease Ontology (DO)esophageal disease0.0519InformativeInherited
Disease Ontology (DO)connective tissue disease0.2688InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.8993InformativeInherited
Disease Ontology (DO)chondrosarcoma1.511e-07Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm2.659e-06Highly InformativeDirect
Disease Ontology (DO)adult astrocytic tumour3.115e-06Highly InformativeDirect
Disease Ontology (DO)bronchiectasis3.867e-05Highly InformativeDirect
Disease Ontology (DO)Lyme disease0.0003312Highly InformativeDirect
Disease Ontology (DO)ovary epithelial cancer0.0003707Highly InformativeDirect
Disease Ontology (DO)lichen disease0.0003864Highly InformativeDirect
Disease Ontology (DO)glaucoma0.0008745Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2187Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.02221Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.0256Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.0007413InformativeDirect
Phenotypic Abnormality (PA)Limitation of joint mobility0.0003844Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the femur0.01094Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.07542Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1281Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.002018Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.03363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1629Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.2326Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3126Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7126Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0006009InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.000922InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0009547InformativeDirect
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.006486InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.01264InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.02164InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02495InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.02669InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.06796InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1409InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.0001936Highly InformativeDirect
Mammalian Phenotype (MP)decreased angiogenesis0.0002103Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.0003464Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0007559Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0008306Highly InformativeDirect
Mammalian Phenotype (MP)abnormal maxilla morphology0.004416Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.01958Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.09381Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.579Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant1.214e-05Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant5.838e-06InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7618Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8056Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.9073Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.1941Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9979Moderately InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.000104InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage1.064e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage1.822e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAngiogenesis1.301e-12InformativeDirect
Cellular componentMembrane0.5334Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor9.937e-07InformativeDirect
Coding sequence diversityPolymorphism0.000802Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage8.5e-09InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000585 SSF50923 Protein matches
Abstract

Hemopexin is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation [PubMed12042069]. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. Hemopexin-like domains have been found in two other types of proteins, vitronectin [PubMed9572850], a cell adhesion and spreading factor found in plasma and tissues, and matrixins MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15 and MMP-16, members of the matrix metalloproteinase family that cleave extracellular matrix constituents [PubMed14619953]. These zinc endopeptidases, which belong to MEROPS peptidase subfamily M10A, have a single hemopexin-like domain in their C-terminal section. It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hemopexin-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Hemopexin-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]