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Mannose 6-phosphate receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Mannose 6-phosphate receptor domain [ 50910]
Superfamily:   Mannose 6-phosphate receptor domain [ 50911]
Families:   Mannose 6-phosphate receptor domain [ 50912] (2)


Superfamily statistics
Genomes (482) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,924 4,679 7
Proteins 2,307 2,665 5


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000001782 Least Informative Direct
Biological Process (BP) biosynthetic process 0.3993 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5159 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001899 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.03739 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000007022 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0009072 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000113 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.03529 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.007584 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08209 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6376 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01339 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9515 Moderately Informative Inherited
Biological Process (BP) organ development 0.8781 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.0001035 Informative Direct
Biological Process (BP) protein transport 0.00002158 Informative Direct
Biological Process (BP) protein catabolic process 0.000000944 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000136 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.05541 Informative Inherited
Biological Process (BP) protein glycosylation 0.000002971 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.000000001119 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.0000000000233 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.000976 Highly Informative Direct
Molecular Function (MF) binding 0.00487 Least Informative Inherited
Molecular Function (MF) monosaccharide binding 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000000000174 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0005248 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.07896 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000000002315 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0000000002342 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0007454 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.4898 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1618 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.000000003561 Informative Direct
Cellular Component (CC) endosome 0.00000758 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0008494 Informative Direct
Cellular Component (CC) late endosome 0.0001549 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.000001523 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000001581Least InformativeDirect
Biological processProtein transport0.00005181Moderately InformativeDirect
Biological processAutophagy4.711e-16Highly InformativeDirect
Cellular componentMembrane0.000004552Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus3.244e-16Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000002673Moderately InformativeDirect
Cellular componentEndosome0.000002881Moderately InformativeDirect
Cellular componentLysosome0.000000000000006951InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.1329Least InformativeInherited
Molecular functionLectin0InformativeDirect
Post-translational modificationReceptor0.00000299Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009011 SSF50911 Protein matches
Abstract

Mannose-6-phosphate receptors (MPRs) are transmembrane proteins involved in the transport of lysosomal enzymes from the Golgi complex and the cell surface to lysosomes [PubMed1376319]. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to MPRs in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment, where the low pH mediates dissociation of the complex. There are two distinct MPRs that function in the recognition of mannose-6-phosphate-containing proteins: the cation-dependent MPR (CD-MPR) and the cation-independent MPR (CI-MPR). The CI-MPR is also known as the insulin-like growth factor II receptor, a multi-functional protein implicated in tumour suppression.

The crystal structure of the N-terminal, extracytoplasmic, receptor-binding domain of bovine CD-MPR (excluding the signal sequence) [PubMed11786557] reveals structural similarity to the fifteen homologous, repeating domains comprising the extracellular region of human CI-MPR [PubMed11867533]. The structure consists of a partly opened, nine-stranded, beta-barrel.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mannose 6-phosphate receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Mannose 6-phosphate receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]