SUPERFAMILY 1.75 HMM library and genome assignments server


Mannose 6-phosphate receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Mannose 6-phosphate receptor domain [ 50910]
Superfamily:   Mannose 6-phosphate receptor domain [ 50911]
Families:   Mannose 6-phosphate receptor domain [ 50912] (2)


Superfamily statistics
Genomes (473) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,775 0 7
Proteins 2,249 0 5


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 4.198e-06 Least Informative Direct
Biological Process (BP) biosynthetic process 0.4233 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5173 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.002656 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.04856 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 9.343e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 1.257e-07 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.03853 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001098 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.008871 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08108 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6513 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01402 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9558 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.9031 Moderately Informative Inherited
Biological Process (BP) proteolysis 9.044e-05 Informative Direct
Biological Process (BP) protein transport 2.68e-05 Informative Direct
Biological Process (BP) protein catabolic process 8.262e-07 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 1.377e-06 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.05535 Informative Inherited
Biological Process (BP) protein glycosylation 3.074e-06 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 1.446e-09 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 2.908e-11 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0008967 Highly Informative Direct
Molecular Function (MF) binding 0.02093 Least Informative Inherited
Molecular Function (MF) monosaccharide binding 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1.316e-10 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000432 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.08481 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 2.184e-09 Moderately Informative Direct
Cellular Component (CC) endomembrane system 3.682e-08 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0007582 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.5083 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.172 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 9.315e-11 Informative Direct
Cellular Component (CC) endosome 6.913e-06 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0009099 Informative Direct
Cellular Component (CC) trans-Golgi network 1.449e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1.577e-06Least InformativeDirect
Biological processProtein transport5.227e-05Moderately InformativeDirect
Biological processAutophagy4.701e-16Highly InformativeDirect
Cellular componentMembrane4.319e-06Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus3.235e-16Moderately InformativeDirect
Cellular componentCytoplasmic vesicle2.595e-07Moderately InformativeDirect
Cellular componentEndosome2.779e-06Moderately InformativeDirect
Cellular componentLysosome6.919e-15InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.1317Least InformativeInherited
Molecular functionLectin0InformativeDirect
Post-translational modificationReceptor3.035e-06Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009011 SSF50911 Protein matches
Abstract

Mannose-6-phosphate receptors (MPRs) are transmembrane proteins involved in the transport of lysosomal enzymes from the Golgi complex and the cell surface to lysosomes [PubMed1376319]. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to MPRs in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment, where the low pH mediates dissociation of the complex. There are two distinct MPRs that function in the recognition of mannose-6-phosphate-containing proteins: the cation-dependent MPR (CD-MPR) and the cation-independent MPR (CI-MPR). The CI-MPR is also known as the insulin-like growth factor II receptor, a multi-functional protein implicated in tumour suppression.

The crystal structure of the N-terminal, extracytoplasmic, receptor-binding domain of bovine CD-MPR (excluding the signal sequence) [PubMed11786557] reveals structural similarity to the fifteen homologous, repeating domains comprising the extracellular region of human CI-MPR [PubMed11867533]. The structure consists of a partly opened, nine-stranded, beta-barrel.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mannose 6-phosphate receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Mannose 6-phosphate receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]