SUPERFAMILY 1.75 HMM library and genome assignments server


Oncogene products superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Oncogene products [ 50903]
Superfamily:   Oncogene products [ 50904]
Families:   Oncogene products [ 50905] (2)


Superfamily statistics
Genomes (47) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 134 168 4
Proteins 134 166 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process9.66e-050.0006853Least InformativeDirect
Biological Process (BP)developmental process3.823e-050.000349Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0028980.01109Least InformativeInherited
Biological Process (BP)single-organism cellular process0.15350.273Least InformativeInherited
Biological Process (BP)cell differentiation1.532e-059.547e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process3.39e-058.2e-05Moderately InformativeDirect
Biological Process (BP)regulation of developmental process1.633e-064.465e-06Moderately InformativeDirect
Biological Process (BP)negative regulation of developmental process4.94e-099.906e-09InformativeDirect
Biological Process (BP)negative regulation of cell differentiation1.695e-091.886e-09Highly InformativeDirect
Biological Process (BP)stem cell development1.084e-113.868e-11Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.002390.003343Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0023260.0007162Least InformativeInherited
Cellular Component (CC)cell cortex1.662e-086.144e-09InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0006853 Least Informative Direct
Biological Process (BP) developmental process 0.000349 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.01109 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.273 Least Informative Inherited
Biological Process (BP) cell differentiation 9.547e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 8.2e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 4.465e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of developmental process 9.906e-09 Informative Direct
Biological Process (BP) negative regulation of cell differentiation 1.886e-09 Highly Informative Direct
Biological Process (BP) stem cell development 3.868e-11 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0007162 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.003343 Least Informative Inherited
Cellular Component (CC) cell cortex 6.144e-09 Informative Direct

Document: GO annotation of SCOP domains

InterPro annotation
Cross references IPR004832 SSF50904 Protein matches
Abstract Two related oncogenes, TCL-1 and MTCP-1 , are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28 [PubMed9520380].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Oncogene products domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Oncogene products superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Internal database links ]