SUPERFAMILY 1.75 HMM library and genome assignments server

Oncogene products superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Oncogene products [ 50903]
Superfamily:   Oncogene products [ 50904]
Families:   Oncogene products [ 50905] (2)


Superfamily statistics
Genomes (47) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 134 168 4
Proteins 134 166 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.000081920.0005326Least InformativeDirect
Biological Process (BP)developmental process0.000038320.0003482Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0031740.01161Least InformativeInherited
Biological Process (BP)single-organism cellular process0.43040.4565Least InformativeInherited
Biological Process (BP)cell differentiation0.000016230.0001011Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000047070.00009784Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0000016420.000004521Moderately InformativeDirect
Biological Process (BP)negative regulation of developmental process0.0000000073510.00000001575InformativeDirect
Biological Process (BP)negative regulation of cell differentiation0.0000000023820.000000003217Highly InformativeDirect
Biological Process (BP)stem cell development0.000000000010740.00000000003664Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0020820.002813Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0022470.000728Least InformativeInherited
Cellular Component (CC)cell cortex0.000000016430.000000006008InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0005326 Least Informative Direct
Biological Process (BP) developmental process 0.0003482 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.01161 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4565 Least Informative Inherited
Biological Process (BP) cell differentiation 0.0001011 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00009784 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000004521 Moderately Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00000001575 Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.000000003217 Highly Informative Direct
Biological Process (BP) stem cell development 0.00000000003664 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000728 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.002813 Least Informative Inherited
Cellular Component (CC) cell cortex 0.000000006008 Informative Direct

Document: GO annotation of SCOP domains

InterPro annotation
Cross references IPR004832 SSF50904 Protein matches
Abstract Two related oncogenes, TCL-1 and MTCP-1 , are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28 [PubMed9520380].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Oncogene products domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Oncogene products superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Internal database links ]