SUPERFAMILY 1.75 HMM library and genome assignments server

Lipocalins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Lipocalins [ 50813]
Superfamily:   Lipocalins [ 50814] (9)
Families:   Retinol binding protein-like [ 50815] (21)
  Fatty acid binding protein-like [ 50847] (17)
  Thrombin inhibitor [ 50872]
  Hypothetical protein YodA [ 101863]
  Hypothetical protein YwiB [ 101866]
  Phenolic acid decarboxylase (PAD) [ 141469]
  Dinoflagellate luciferase repeat [ 141472]
  Rv2717c-like [ 141475] (2)
  All1756-like [ 159230]


Superfamily statistics
Genomes (1,870) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,532 32,024 119
Proteins 7,253 31,663 118


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00.0000003748Least InformativeDirect
Biological Process (BP)developmental process0.000000000045580.0008311Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0000017820.000000004449Least InformativeDirect
Biological Process (BP)response to stimulus0.0000000000015630.000001322Least InformativeDirect
Biological Process (BP)positive regulation of biological process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.89650.8979Least InformativeInherited
Biological Process (BP)localization0.13350.6586Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0037750.5466Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.025950.1239Least InformativeInherited
Biological Process (BP)single-organism cellular process0.047370.3975Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00002210.0000001921Moderately InformativeDirect
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.0000000049850.000000003453Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.000000000096490.0000000000005867Moderately InformativeDirect
Biological Process (BP)regulation of localization0.0000052220.00000007146Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00016160.00001624Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000000092080.00001718Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.00000050480.00001956Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.00000069370.00000007123Moderately InformativeDirect
Biological Process (BP)response to organic substance0.80641Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0082060.02319Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.91881Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization0.26720.8953Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0053320.0000008832Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.26730.565Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.98040.9173Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.016590.02625Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.94311Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.00090640.001183Moderately InformativeInherited
Biological Process (BP)tissue development0.00020190.002183Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)nervous system development0.0012590.0639Moderately InformativeInherited
Biological Process (BP)organic substance transport0.024990.01071Moderately InformativeInherited
Biological Process (BP)ion transport0.89621Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.002760.001234Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.99961Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0047070.02187Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.76341Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.11880.04646Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.7590.8825Moderately InformativeInherited
Biological Process (BP)signal transduction0.68750.9884Moderately InformativeInherited
Biological Process (BP)organ development0.017410.01275Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.023470.02031Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.000025540.00000002949InformativeDirect
Biological Process (BP)negative regulation of immune system process0.000000048760.00000000003806InformativeDirect
Biological Process (BP)response to oxidative stress0.000000002130.000000000000007248InformativeDirect
Biological Process (BP)mitochondrion organization0.0000076250.00003353InformativeDirect
Biological Process (BP)central nervous system development0.000000000043210.000000005169InformativeDirect
Biological Process (BP)response to organonitrogen compound0.00057670.0005638InformativeDirect
Biological Process (BP)negative regulation of cell communication0.00000000000082730.000000000003984InformativeDirect
Biological Process (BP)lipid localization0.000000000000012480.00000000000011InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.0000096110.0000002007InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.000046530.00001265InformativeDirect
Biological Process (BP)regulation of lipid metabolic process00InformativeDirect
Biological Process (BP)hexose metabolic process00InformativeDirect
Biological Process (BP)negative regulation of signaling0.0000000000006710.000000000007184InformativeDirect
Biological Process (BP)cell projection organization0.000000034340.00006758InformativeDirect
Biological Process (BP)regulation of defense response0.0000000000000063590.000002593InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.0000016460.00000002776InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00025560.00001469InformativeDirect
Biological Process (BP)regulation of protein localization0.000056310.000001989InformativeDirect
Biological Process (BP)response to lipid0.0000006350.0000001462InformativeDirect
Biological Process (BP)growth0.000000088180.000005601InformativeDirect
Biological Process (BP)regulation of locomotion0.000000061210.000000009334InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0000000019830.000000005955InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.000000019860.000000004371InformativeDirect
Biological Process (BP)single-organism behavior0.0000000094240.000004665InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.0000000071510.00000000418InformativeDirect
Biological Process (BP)multicellular organismal homeostasis0.00000073550.00000008843InformativeDirect
Biological Process (BP)negative regulation of transport00InformativeDirect
Biological Process (BP)negative regulation of cellular component organization0.00000039660.00000005379InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.000017160.00004824InformativeDirect
Biological Process (BP)regulation of cellular component movement0.0000000011450.0000000005766InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.0000024960.000001962InformativeDirect
Biological Process (BP)cellular response to nitrogen compound0.000018970.0003812InformativeDirect
Biological Process (BP)regulation of response to wounding00.000000000000264InformativeDirect
Biological Process (BP)cellular response to hormone stimulus0.0056850.006909InformativeInherited
Biological Process (BP)cellular component morphogenesis0.016140.3179InformativeInherited
Biological Process (BP)regulation of secretion0.45160.6822InformativeInherited
Biological Process (BP)positive regulation of intracellular signal transduction0.00011880.007173InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.086940.7853InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00044010.001427InformativeInherited
Biological Process (BP)regulation of hormone levels0.0030910.00001574InformativeInherited
Biological Process (BP)alcohol metabolic process0.0011850.01438InformativeInherited
Biological Process (BP)generation of neurons0.25040.5973InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.015440.003012InformativeInherited
Biological Process (BP)anion transport0.076890.06305InformativeInherited
Biological Process (BP)organic acid transport0.014290.002218InformativeInherited
Biological Process (BP)response to light stimulus0.0074850.01179InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.63430.672InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.00000010610.003185InformativeInherited
Biological Process (BP)retinoid metabolic process00Highly InformativeDirect
Biological Process (BP)negative regulation of cytokine production0.000000000017670Highly InformativeDirect
Biological Process (BP)glucose metabolic process00Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process0.0000000000011570.00000000005305Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process00Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.0000000033480.0001096Highly InformativeDirect
Biological Process (BP)aging0.0000000000052710Highly InformativeDirect
Biological Process (BP)circadian rhythm00Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.00000000027950.00000000004812Highly InformativeDirect
Biological Process (BP)aerobic respiration0.00000000023880.0000000002254Highly InformativeDirect
Biological Process (BP)detection of light stimulus0.000049160.00000747Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process0.0000000061090.000000002259Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.00000040130.0000000496Highly InformativeDirect
Biological Process (BP)regulation of lipid storage0.0000000011760.00000000008382Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport0.0000020330.000003608Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.0000000000000032510.000000000000147Highly InformativeDirect
Biological Process (BP)neuron projection development0.00000000000006350.0000007834Highly InformativeDirect
Biological Process (BP)negative regulation of defense response0.000009610.0000001193Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.000000084090.0000000002308Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular transport0.000000023630.000000005669Highly InformativeDirect
Biological Process (BP)negative regulation of homeostatic process0.000000070410.00000000473Highly InformativeDirect
Biological Process (BP)carbohydrate homeostasis0.00000014270.0000006029Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process0.0000000058990.000000005796Highly InformativeDirect
Biological Process (BP)primary alcohol metabolic process0.00000057530.000000001034Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.0000000033770.00000000002342Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion0.00000000000036180Highly InformativeDirect
Biological Process (BP)wound healing0.000062330.0008968Highly InformativeDirect
Biological Process (BP)response to drug0.0000000017470.000000001476Highly InformativeDirect
Biological Process (BP)regulation of circadian rhythm0.00000000000086070.0000000006731Highly InformativeDirect
Biological Process (BP)response to peptide hormone0.000097750.00004555Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.0000000036490.00000000005926Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport00Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.00000051540.0000008004Highly InformativeDirect
Biological Process (BP)developmental growth0.00000000031540.0000000006922Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000000000009640Highly InformativeDirect
Biological Process (BP)response to axon injury0.00000000007890Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process0.000046470.000000006977Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.000084390.00000948Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement0.00000000000030450Highly InformativeDirect
Biological Process (BP)mitochondrion morphogenesis00Highly InformativeDirect
Biological Process (BP)regulation of peptide transport0.00012110.0009222Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.000000004920.000000001202Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process00Highly InformativeDirect
Biological Process (BP)cellular response to peptide0.0000016350.00004722Highly InformativeDirect
Biological Process (BP)negative regulation of response to wounding0.00000068340.00000000003452Highly InformativeDirect
Biological Process (BP)negative regulation of secretion by cell0.0000015580.0000001769Highly InformativeDirect
Biological Process (BP)regulation of protein targeting00Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte migration00Highly InformativeDirect
Biological Process (BP)locomotory behavior0.41080.4485Highly InformativeInherited
Molecular Function (MF)binding00.00000000009597Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transporter activity0.000024460.000109Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.0000000000025870.0000000000002701Moderately InformativeDirect
Molecular Function (MF)small molecule binding00Moderately InformativeDirect
Molecular Function (MF)anion binding0.0000010630.0001071Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.04180.518Moderately InformativeInherited
Molecular Function (MF)lipid binding00InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)carboxylic acid binding00InformativeDirect
Molecular Function (MF)molecular transducer activity0.0061630.3005InformativeInherited
Molecular Function (MF)kinase activity0.011310.3013InformativeInherited
Molecular Function (MF)receptor activity0.0030590.2493InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0014410.1956InformativeInherited
Molecular Function (MF)lipid transporter activity0.000000000000050310.000000000000002376Highly InformativeDirect
Molecular Function (MF)steroid binding00Highly InformativeDirect
Molecular Function (MF)odorant binding0.00000000000020560Highly InformativeDirect
Molecular Function (MF)isoprenoid binding0.0000020030Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding00Highly InformativeDirect
Molecular Function (MF)alcohol binding00Highly InformativeDirect
Molecular Function (MF)transmembrane signaling receptor activity0.00018550.01695Highly InformativeInherited
Molecular Function (MF)protein kinase activity0.00012210.04708Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.04670.3017Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0012760.004082Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum00Moderately InformativeDirect
Cellular Component (CC)cytosol0.00000057740.0000000112Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex0.0000011090.0000008749Moderately InformativeDirect
Cellular Component (CC)cell projection0.000000021880.00004098Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)vesicle0.010630.001379Moderately InformativeInherited
Cellular Component (CC)extracellular space0.0000000003470InformativeDirect
Cellular Component (CC)cytosolic ribosome0.000000000000072340InformativeDirect
Cellular Component (CC)neuron projection0.000065530.0004073InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.000079720.0000006678InformativeDirect
Cellular Component (CC)dendrite0.000000037510.0000007724Highly InformativeDirect
Cellular Component (CC)cell body00Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm0.0000000000010820.00000000000394Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0000003748 Least Informative Direct
Biological Process (BP) developmental process 0.0008311 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000000004449 Least Informative Direct
Biological Process (BP) response to stimulus 0.000001322 Least Informative Direct
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) localization 0.6586 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5466 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1239 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3975 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8979 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000001921 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000000003453 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0000000000005867 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000007146 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00001624 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00001718 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00001956 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000008832 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000007123 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02319 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.8953 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.565 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9173 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.898 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02625 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02031 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.001183 Moderately Informative Inherited
Biological Process (BP) tissue development 0.002183 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.0639 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01071 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001234 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02187 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.04646 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8825 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9884 Moderately Informative Inherited
Biological Process (BP) organ development 0.01275 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.00000002949 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.00000000003806 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.0006613 Informative Direct
Biological Process (BP) response to oxidative stress 0.000000000000007248 Informative Direct
Biological Process (BP) mitochondrion organization 0.00003353 Informative Direct
Biological Process (BP) central nervous system development 0.000000005169 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0005638 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000000000003984 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00001574 Informative Direct
Biological Process (BP) lipid localization 0.00000000000011 Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0000002007 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.00001265 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000000000007184 Informative Direct
Biological Process (BP) cell projection organization 0.00006758 Informative Direct
Biological Process (BP) regulation of defense response 0.000002593 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00000002776 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.00001469 Informative Direct
Biological Process (BP) regulation of protein localization 0.000001989 Informative Direct
Biological Process (BP) response to lipid 0.0000001462 Informative Direct
Biological Process (BP) growth 0.000005601 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000009334 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000000005955 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000004371 Informative Direct
Biological Process (BP) single-organism behavior 0.000004665 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00000000418 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00000008843 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000005379 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00004824 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0000000005766 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000001962 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0003812 Informative Direct
Biological Process (BP) regulation of response to wounding 0.000000000000264 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.006909 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3179 Informative Inherited
Biological Process (BP) regulation of secretion 0.6822 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.007173 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.7853 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.001427 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.01438 Informative Inherited
Biological Process (BP) generation of neurons 0.5973 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.003012 Informative Inherited
Biological Process (BP) anion transport 0.06305 Informative Inherited
Biological Process (BP) organic acid transport 0.002218 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1503 Informative Inherited
Biological Process (BP) negative regulation of protein processing 0.05726 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.4982 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.001642 Informative Inherited
Biological Process (BP) response to light stimulus 0.01179 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.672 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.003185 Informative Inherited
Biological Process (BP) retinoid metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.00000000005305 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001096 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) circadian rhythm 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00000000004812 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.0000000002254 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.00000747 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000000002259 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0000000496 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.00000000008382 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.00002274 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000003608 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000000000147 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0000007834 Highly Informative Direct
Biological Process (BP) negative regulation of defense response 0.0000001193 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0000000002308 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.000000005669 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00000000473 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0000006029 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.000000005796 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.000000001034 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.00000000002342 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) wound healing 0.0008968 Highly Informative Direct
Biological Process (BP) response to drug 0.000000001476 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0000000006731 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00004555 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.00000000005926 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0000008004 Highly Informative Direct
Biological Process (BP) developmental growth 0.0000000006922 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.000000006977 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.00000948 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) mitochondrion morphogenesis 0 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0009222 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.000000001202 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00004722 Highly Informative Direct
Biological Process (BP) negative regulation of response to wounding 0.00000000003452 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0000001769 Highly Informative Direct
Biological Process (BP) regulation of protein targeting 0 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.4485 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000009597 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.000109 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.0000000000002701 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001071 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.3692 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.518 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0000005534 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0003588 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.002143 Informative Inherited
Molecular Function (MF) protein complex binding 0.002142 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.3005 Informative Inherited
Molecular Function (MF) kinase activity 0.3013 Informative Inherited
Molecular Function (MF) receptor activity 0.2493 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1956 Informative Inherited
Molecular Function (MF) lipid transporter activity 0.000000000000002376 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 0.000000004404 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.01695 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.04708 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.3017 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.004082 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0000000112 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.0000008749 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00004098 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.001379 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cytosolic ribosome 0 Informative Direct
Cellular Component (CC) neuron projection 0.0004073 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000006678 Informative Direct
Cellular Component (CC) dendrite 0.0000007724 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00000000000394 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.00000000000004383Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.2413Least InformativeInherited
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0000004287Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06147Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.0000001309InformativeDirect
Worm Phenotype (WP)fat content increased0.00000000001068Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.4472Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.834Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.4811Moderately InformativeInherited
Xenopus ANatomical entity (XAN)foregut0.0006087Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01599Least InformativeInherited
Enzyme Commission (EC)Isomerases0.0000000000005393Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors0.00000003526Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.5087Moderately InformativeInherited
Biological processSensory transduction0.000000134InformativeDirect
Biological processInnate immunity0.000001054InformativeDirect
Biological processFatty acid metabolism0.00003567InformativeDirect
Biological processLipid biosynthesis0.01621InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processAcute phase4.711e-16Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00001654Moderately InformativeDirect
Cellular componentGolgi apparatus0.00007669Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionLipid-binding0InformativeDirect
Molecular functionChromophore0.00000003888InformativeDirect
Molecular functionZinc transport0.000000002856Highly InformativeDirect
Post-translational modificationProtease inhibitor0.000003945InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationAcetylation0.0002906Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011038 SSF50814 Protein matches
Abstract

Calycins form a large protein superfamily that share similar beta-barrel structures. Calycins can be divided into families that include lipocalins, fatty acid binding proteins, triabin, and thrombin inhibitor [PubMed11058743]. Of these families, the lipocalin family is the largest and functionally the most diverse. Lipocalins are extracellular proteins that share several common recognition properties such as ligand binding, receptor binding and the formation of complexes with other macromolecules. Lipocalins include the retinol binding protein, lipocalin allergen, aphrodisin (a sex hormone), alpha-2U-globulin, prostaglandin D synthase, beta-lactoglobulin, bilin-binding protein, and the nitrophorins [PubMed12432930, PubMed11058763, PubMed11058769, PubMed11058756].

This entry represents calycin as well as some other proteins that share a similar calycin beta-barrel structure, including two bacterial hypothetical proteins YodA from Escherichia coli and YwiB from bacillus subtilis. Part of the YodA hypothetical protein has a calycin-like structure [PubMed12909634].

Please be aware that some of the protein hits may be false positives.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 69 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipocalins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 69 hidden Markov models representing the Lipocalins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]