SUPERFAMILY 1.75 HMM library and genome assignments server

  Home > SCOP hierarchy > Lipocalins superfamily


Lipocalins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Lipocalins [ 50813]
Superfamily:   Lipocalins [ 50814] (9)
Families:   Retinol binding protein-like [ 50815] (21)
  Fatty acid binding protein-like [ 50847] (17)
  Thrombin inhibitor [ 50872]
  Hypothetical protein YodA [ 101863]
  Hypothetical protein YwiB [ 101866]
  Phenolic acid decarboxylase (PAD) [ 141469]
  Dinoflagellate luciferase repeat [ 141472]
  Rv2717c-like [ 141475] (2)
  All1756-like [ 159230]

 Superfamily statistics
Genomes (1,406) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 6,093 14,411 119
Proteins 5,908 14,118 118

 Functional annotation
General category Processes_IC
Detailed category Transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process1.34e-141.316e-05Least InformativeDirect
Biological Process (BP)single-organism metabolic process2.224e-130Least InformativeDirect
Biological Process (BP)response to stimulus8.69e-138.928e-07Least InformativeDirect
Biological Process (BP)biosynthetic process0.8810.889Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.002580.4169Least InformativeInherited
Biological Process (BP)developmental process2.066e-100.002244Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.039190.2765Least InformativeInherited
Biological Process (BP)single-organism cellular process0.61531Least InformativeInherited
Biological Process (BP)localization0.096120.4962Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process1.74e-051.762e-08Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.00087139.484e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process4.349e-105.029e-08Moderately InformativeDirect
Biological Process (BP)regulation of cell communication3.887e-089.442e-06Moderately InformativeDirect
Biological Process (BP)regulation of signaling1.926e-068.604e-06Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process1.803e-115.953e-14Moderately InformativeDirect
Biological Process (BP)regulation of localization6.315e-081.09e-09Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00014812.94e-05Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process4.939e-088.378e-05Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus4.133e-103.477e-09Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process5.791e-088.929e-06Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound9.87e-087.212e-09Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.53170.6342Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0049543.414e-05Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00041020.002448Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.00094430.01023Moderately InformativeInherited
Biological Process (BP)single-organism developmental process8.112e-080.00198Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.71841Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.010090.02141Moderately InformativeInherited
Biological Process (BP)tissue development0.00030090.01463Moderately InformativeInherited
Biological Process (BP)homeostatic process0.0046290.02068Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0011350.0004098Moderately InformativeInherited
Biological Process (BP)nervous system development0.001620.0744Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)ion transport0.71130.8554Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process2.602e-050.1689Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.33070.894Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.78291Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)signal transduction0.74621Moderately InformativeInherited
Biological Process (BP)organ development0.030090.05272Moderately InformativeInherited
Biological Process (BP)organelle organization0.59681Moderately InformativeInherited
Biological Process (BP)organic substance transport0.061270.03843Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.013480.05104Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.21490.2934Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production1.448e-058.369e-09InformativeDirect
Biological Process (BP)lipid transport2.195e-142.258e-14InformativeDirect
Biological Process (BP)response to oxidative stress5.032e-102.076e-15InformativeDirect
Biological Process (BP)mitochondrion organization7.835e-063.463e-05InformativeDirect
Biological Process (BP)central nervous system development2.485e-102.868e-08InformativeDirect
Biological Process (BP)response to wounding3.119e-105.349e-10InformativeDirect
Biological Process (BP)response to hormone stimulus0.00028626.656e-05InformativeDirect
Biological Process (BP)response to organic nitrogen0.00050330.0002605InformativeDirect
Biological Process (BP)negative regulation of cell communication3.484e-073.082e-07InformativeDirect
Biological Process (BP)regulation of lipid metabolic process00InformativeDirect
Biological Process (BP)hexose metabolic process6.09e-150InformativeDirect
Biological Process (BP)negative regulation of signaling2.354e-074.178e-07InformativeDirect
Biological Process (BP)cell projection organization6.378e-105.34e-05InformativeDirect
Biological Process (BP)negative regulation of cellular metabolic process4.079e-123.174e-09InformativeDirect
Biological Process (BP)regulation of response to external stimulus1.52e-061.767e-09InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00011778.232e-06InformativeDirect
Biological Process (BP)regulation of protein localization2.641e-052.128e-06InformativeDirect
Biological Process (BP)cellular component morphogenesis1.911e-146.499e-09InformativeDirect
Biological Process (BP)response to lipid1.367e-074.269e-08InformativeDirect
Biological Process (BP)growth8.762e-083.663e-06InformativeDirect
Biological Process (BP)regulation of locomotion1.002e-084.631e-10InformativeDirect
Biological Process (BP)regulation of cell proliferation2.702e-106.045e-09InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis2.48e-101.114e-10InformativeDirect
Biological Process (BP)single-organism behavior06.291e-14InformativeDirect
Biological Process (BP)negative regulation of response to stimulus1.683e-057.815e-06InformativeDirect
Biological Process (BP)multicellular organismal homeostasis6.242e-075.789e-08InformativeDirect
Biological Process (BP)negative regulation of cellular component organization4.338e-132.153e-11InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process9.087e-074.255e-11InformativeDirect
Biological Process (BP)regulation of cellular component movement2.47e-107.651e-11InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process6.828e-064.676e-06InformativeDirect
Biological Process (BP)cellular response to nitrogen compound2.364e-050.0002653InformativeDirect
Biological Process (BP)regulation of reproductive process1.335e-057.041e-05InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.53440.8665InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.55440.5269InformativeInherited
Biological Process (BP)regulation of secretion0.46350.7428InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.086360.4462InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0040720.006919InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds0.00031620.005516InformativeInherited
Biological Process (BP)regulation of hormone levels0.007793.981e-05InformativeInherited
Biological Process (BP)regulation of response to stress0.049070.01775InformativeInherited
Biological Process (BP)generation of neurons0.18640.5495InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.013670.004395InformativeInherited
Biological Process (BP)anion transport0.16440.1241InformativeInherited
Biological Process (BP)organic acid transport0.022310.01099InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.58440.8212InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.78850.763InformativeInherited
Biological Process (BP)response to external stimulus0.029150.2212InformativeInherited
Biological Process (BP)response to light stimulus0.0092740.01424InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway1.701e-070.004398InformativeInherited
Biological Process (BP)retinoid metabolic process00Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process8.2e-110Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process3.75e-124.009e-11Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway7.826e-090.0002262Highly InformativeDirect
Biological Process (BP)axonogenesis06.737e-09Highly InformativeDirect
Biological Process (BP)aging6.383e-120Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation3.82e-102.204e-11Highly InformativeDirect
Biological Process (BP)aerobic respiration4.246e-102.115e-10Highly InformativeDirect
Biological Process (BP)detection of visible light2.64e-074.138e-08Highly InformativeDirect
Biological Process (BP)negative regulation of signal transduction7.479e-050.0004131Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process7.142e-071.23e-08Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process4.848e-081.204e-09Highly InformativeDirect
Biological Process (BP)regulation of lipid storage6.488e-106.115e-11Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport1.497e-053.581e-05Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion07.145e-14Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular transport1.741e-081.194e-08Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport4.121e-071.213e-06Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process3.793e-093.993e-09Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion2.237e-130Highly InformativeDirect
Biological Process (BP)wound healing4.291e-060.0004464Highly InformativeDirect
Biological Process (BP)response to drug4.649e-092.06e-09Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process1.494e-062.169e-09Highly InformativeDirect
Biological Process (BP)icosanoid biosynthetic process00Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport00Highly InformativeDirect
Biological Process (BP)developmental growth8.289e-111.291e-10Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation5.809e-120Highly InformativeDirect
Biological Process (BP)response to axon injury4.54e-110Highly InformativeDirect
Biological Process (BP)regulation of inflammatory response4.545e-082.866e-11Highly InformativeDirect
Biological Process (BP)regulation of behavior0.00045610.0005485Highly InformativeDirect
Biological Process (BP)regulation of insulin secretion1.483e-141.247e-11Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process6.742e-061.144e-09Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.00072233.947e-05Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process6.158e-108.743e-12Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement9.727e-140Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase B signaling cascade6.09e-155.068e-12Highly InformativeDirect
Biological Process (BP)cellular response to peptide hormone stimulus9.851e-050.0008744Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus4.064e-087.295e-09Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte migration00Highly InformativeDirect
Biological Process (BP)negative regulation of secretion0.055630.09406Highly InformativeInherited
Biological Process (BP)locomotory behavior0.90580.9203Highly InformativeInherited
Biological Process (BP)response to insulin stimulus0.0044730.008217Highly InformativeInherited
Molecular Function (MF)binding04.571e-12Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transporter activity2.192e-057.594e-05Moderately InformativeDirect
Molecular Function (MF)isomerase activity4.196e-111.586e-12Moderately InformativeDirect
Molecular Function (MF)anion binding9.702e-060.0003515Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding0.33980.6225Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.047650.4907Moderately InformativeInherited
Molecular Function (MF)lipid binding00InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)carboxylic acid binding00InformativeDirect
Molecular Function (MF)receptor activity0.0029180.2966InformativeInherited
Molecular Function (MF)molecular transducer activity0.0069520.3729InformativeInherited
Molecular Function (MF)kinase activity0.012890.2718InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0020240.1727InformativeInherited
Molecular Function (MF)lipid transporter activity5.688e-143.07e-15Highly InformativeDirect
Molecular Function (MF)steroid binding6.715e-160Highly InformativeDirect
Molecular Function (MF)odorant binding1.015e-120Highly InformativeDirect
Molecular Function (MF)isoprenoid binding5.843e-060Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding00Highly InformativeDirect
Molecular Function (MF)alcohol binding00Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.00022350.06907Highly InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0170.4789Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0042030.0122Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.13891Least InformativeInherited
Cellular Component (CC)extracellular region00Moderately InformativeDirect
Cellular Component (CC)endoplasmic reticulum00Moderately InformativeDirect
Cellular Component (CC)cytosol6.094e-061.135e-07Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex1.433e-062.269e-06Moderately InformativeDirect
Cellular Component (CC)cell projection4.776e-091.763e-05Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)Golgi apparatus1.331e-050.0003009InformativeDirect
Cellular Component (CC)cytosolic ribosome1.785e-130InformativeDirect
Cellular Component (CC)neuron part5.027e-142.624e-08InformativeDirect
Cellular Component (CC)dendrite02.635e-13Highly InformativeDirect
Cellular Component (CC)cell body00Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm2.842e-135.755e-13Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1.316e-05 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 8.928e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 0.889 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4169 Least Informative Inherited
Biological Process (BP) developmental process 0.002244 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.2765 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.4962 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1.762e-08 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 9.484e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 5.029e-08 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 9.442e-06 Moderately Informative Direct
Biological Process (BP) regulation of signaling 8.604e-06 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 5.953e-14 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.09e-09 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0004098 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 2.94e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 8.378e-05 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 3.477e-09 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 8.929e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 3.414e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 7.212e-09 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.6342 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.002448 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01023 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.00198 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02141 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01463 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.02068 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.0744 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.8554 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.1689 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.894 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.05272 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.03843 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.05104 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.2934 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 8.369e-09 Informative Direct
Biological Process (BP) lipid transport 2.258e-14 Informative Direct
Biological Process (BP) response to oxidative stress 2.076e-15 Informative Direct
Biological Process (BP) mitochondrion organization 3.463e-05 Informative Direct
Biological Process (BP) central nervous system development 2.868e-08 Informative Direct
Biological Process (BP) response to wounding 5.349e-10 Informative Direct
Biological Process (BP) response to hormone stimulus 6.656e-05 Informative Direct
Biological Process (BP) response to organic nitrogen 0.0002605 Informative Direct
Biological Process (BP) negative regulation of cell communication 3.082e-07 Informative Direct
Biological Process (BP) regulation of hormone levels 3.981e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 4.178e-07 Informative Direct
Biological Process (BP) cell projection organization 5.34e-05 Informative Direct
Biological Process (BP) negative regulation of cellular metabolic process 3.174e-09 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.767e-09 Informative Direct
Biological Process (BP) regulation of intracellular transport 8.232e-06 Informative Direct
Biological Process (BP) regulation of protein localization 2.128e-06 Informative Direct
Biological Process (BP) cellular component morphogenesis 6.499e-09 Informative Direct
Biological Process (BP) response to lipid 4.269e-08 Informative Direct
Biological Process (BP) growth 3.663e-06 Informative Direct
Biological Process (BP) regulation of locomotion 4.631e-10 Informative Direct
Biological Process (BP) regulation of cell proliferation 6.045e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.114e-10 Informative Direct
Biological Process (BP) single-organism behavior 6.291e-14 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 7.815e-06 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 5.789e-08 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 2.153e-11 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 4.255e-11 Informative Direct
Biological Process (BP) regulation of cellular component movement 7.651e-11 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 4.676e-06 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0002653 Informative Direct
Biological Process (BP) regulation of reproductive process 7.041e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.8665 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.5269 Informative Inherited
Biological Process (BP) regulation of secretion 0.7428 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.4462 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.4636 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.006919 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.005516 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.004395 Informative Inherited
Biological Process (BP) regulation of response to stress 0.01775 Informative Inherited
Biological Process (BP) generation of neurons 0.5495 Informative Inherited
Biological Process (BP) anion transport 0.1241 Informative Inherited
Biological Process (BP) organic acid transport 0.01099 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.8212 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.763 Informative Inherited
Biological Process (BP) response to external stimulus 0.2212 Informative Inherited
Biological Process (BP) response to light stimulus 0.01424 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.004398 Informative Inherited
Biological Process (BP) retinoid metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 4.009e-11 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0002262 Highly Informative Direct
Biological Process (BP) axonogenesis 6.737e-09 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 2.204e-11 Highly Informative Direct
Biological Process (BP) aerobic respiration 2.115e-10 Highly Informative Direct
Biological Process (BP) detection of visible light 4.138e-08 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.0004131 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.23e-08 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1.204e-09 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 6.115e-11 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 3.581e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 7.145e-14 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 1.194e-08 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 1.213e-06 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 3.993e-09 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) wound healing 0.0004464 Highly Informative Direct
Biological Process (BP) response to drug 2.06e-09 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 2.169e-09 Highly Informative Direct
Biological Process (BP) icosanoid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0007506 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0 Highly Informative Direct
Biological Process (BP) developmental growth 1.291e-10 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 2.866e-11 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0005485 Highly Informative Direct
Biological Process (BP) regulation of insulin secretion 1.247e-11 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 1.144e-09 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 3.947e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 8.743e-12 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 5.068e-12 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 0.0008744 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 7.295e-09 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.09406 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.9203 Highly Informative Inherited
Biological Process (BP) response to insulin stimulus 0.008217 Highly Informative Inherited
Molecular Function (MF) binding 4.571e-12 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 7.594e-05 Moderately Informative Direct
Molecular Function (MF) isomerase activity 1.586e-12 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0003515 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.6225 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.4907 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.002039 Informative Inherited
Molecular Function (MF) receptor activity 0.2966 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.3729 Informative Inherited
Molecular Function (MF) kinase activity 0.2718 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1727 Informative Inherited
Molecular Function (MF) lipid transporter activity 3.07e-15 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 6.786e-09 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.786e-06 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0006643 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.06907 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.4789 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0122 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) cytosol 1.135e-07 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 2.269e-06 Moderately Informative Direct
Cellular Component (CC) cell projection 1.763e-05 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0003009 Informative Direct
Cellular Component (CC) cytosolic ribosome 0 Informative Direct
Cellular Component (CC) neuron part 2.624e-08 Informative Direct
Cellular Component (CC) dendrite 2.635e-13 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 5.755e-13 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases4.383e-14Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.338Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.1564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid level0.7591Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1629InformativeInherited
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level5.449e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased liver triglyceride level0.0004797Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06147Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant1.309e-07InformativeDirect
Worm Phenotype (WP)fat content increased1.068e-11Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01526Least InformativeInherited
Enzyme Commission (EC)Isomerases7.54e-13Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors3.906e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)vitamins0.002013Least InformativeInherited
Drugbank ATC_code (DB)dermatologicals6.686e-05Moderately InformativeDirect
Drugbank ATC_code (DB)respiratory system0.0003499Moderately InformativeDirect
Drugbank ATC_code (DB)other ophthalmologicals1Moderately InformativeInherited
Drugbank ATC_code (DB)vitamin a, plain1.145e-07InformativeDirect
Drugbank ATC_code (DB)retinol1.145e-07InformativeDirect
Drugbank ATC_code (DB)retinol1.145e-07InformativeDirect
Drugbank ATC_code (DB)retinol1.145e-07InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.4965Moderately InformativeInherited
Biological processSensory transduction1.201e-07InformativeDirect
Biological processInnate immunity4.763e-07InformativeDirect
Biological processFatty acid metabolism3.616e-05InformativeDirect
Biological processLipid biosynthesis0.01579InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processAcute phase4.622e-16Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.025e-05Moderately InformativeDirect
Cellular componentGolgi apparatus5.8e-05Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionLipid-binding0InformativeDirect
Molecular functionChromophore3.744e-08InformativeDirect
Molecular functionZinc transport3.014e-09Highly InformativeDirect
Post-translational modificationProtease inhibitor2.505e-06InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationAcetylation8.404e-06Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011038 SSF50814 Protein matches
Abstract

Calycins form a large protein superfamily that share similar beta-barrel structures. Calycins can be divided into families that include lipocalins, fatty acid binding proteins, triabin, and thrombin inhibitor [PubMed11058743]. Of these families, the lipocalin family is the largest and functionally the most diverse. Lipocalins are extracellular proteins that share several common recognition properties such as ligand binding, receptor binding and the formation of complexes with other macromolecules. Lipocalins include the retinol binding protein, lipocalin allergen, aphrodisin (a sex hormone), alpha-2U-globulin, prostaglandin D synthase, beta-lactoglobulin, bilin-binding protein, and the nitrophorins [PubMed12432930, PubMed11058763, PubMed11058769, PubMed11058756].

This entry represents calycin as well as some other proteins that share a similar calycin beta-barrel structure, including two bacterial hypothetical proteins YodA from Escherichia coli and YwiB from bacillus subtilis. Part of the YodA hypothetical protein has a calycin-like structure [PubMed12909634].

Please be aware that some of the protein hits may be false positives.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 69 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipocalins domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 69 hidden Markov models representing the Lipocalins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.