SUPERFAMILY 1.75 HMM library and genome assignments server


Lipocalins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Lipocalins [ 50813]
Superfamily:   Lipocalins [ 50814] (9)
Families:   Retinol binding protein-like [ 50815] (21)
  Fatty acid binding protein-like [ 50847] (17)
  Thrombin inhibitor [ 50872]
  Hypothetical protein YodA [ 101863]
  Hypothetical protein YwiB [ 101866]
  Phenolic acid decarboxylase (PAD) [ 141469]
  Dinoflagellate luciferase repeat [ 141472]
  Rv2717c-like [ 141475] (2)
  All1756-like [ 159230]


Superfamily statistics
Genomes (1,870) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,510 32,024 119
Proteins 7,232 31,663 118


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process01.443e-06Least InformativeDirect
Biological Process (BP)developmental process3.456e-110.0006718Least InformativeDirect
Biological Process (BP)single-organism metabolic process1.306e-130Least InformativeDirect
Biological Process (BP)response to stimulus8.354e-136.415e-07Least InformativeDirect
Biological Process (BP)biosynthetic process0.90430.9138Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.013420.07664Least InformativeInherited
Biological Process (BP)single-organism cellular process0.84941Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0026530.4292Least InformativeInherited
Biological Process (BP)localization0.091080.5545Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process2.245e-051.719e-07Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process3.144e-094.073e-07Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process4.185e-122.125e-14Moderately InformativeDirect
Biological Process (BP)regulation of localization3.061e-064.224e-08Moderately InformativeDirect
Biological Process (BP)homeostatic process0.00066380.0007757Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process1.286e-077.744e-05Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process2.124e-066.594e-05Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound5.682e-075.043e-08Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.74760.8648Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.91591Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0027228.98e-06Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0097980.01621Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.0011396.938e-05Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.97661Moderately InformativeInherited
Biological Process (BP)response to organic substance0.77061Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.007560.02141Moderately InformativeInherited
Biological Process (BP)tissue development0.0010560.01014Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0026080.0009578Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)nervous system development0.00089310.05377Moderately InformativeInherited
Biological Process (BP)ion transport0.59850.8057Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.40411Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.8151Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.96150.8224Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.260.5606Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)signal transduction0.63920.9632Moderately InformativeInherited
Biological Process (BP)organ development0.020340.0161Moderately InformativeInherited
Biological Process (BP)organelle organization0.47231Moderately InformativeInherited
Biological Process (BP)organic substance transport0.035720.01529Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.006770.02088Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.043920.007394Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production1.289e-051.224e-08InformativeDirect
Biological Process (BP)response to oxidative stress2.196e-093.77e-15InformativeDirect
Biological Process (BP)mitochondrion organization6.397e-062.883e-05InformativeDirect
Biological Process (BP)central nervous system development1.98e-113.22e-09InformativeDirect
Biological Process (BP)response to wounding4.394e-101.231e-09InformativeDirect
Biological Process (BP)response to hormone stimulus0.0001351.817e-05InformativeDirect
Biological Process (BP)response to organonitrogen compound0.00068580.0006229InformativeDirect
Biological Process (BP)negative regulation of cell communication8.047e-066.233e-06InformativeDirect
Biological Process (BP)lipid localization6.509e-157.054e-14InformativeDirect
Biological Process (BP)regulation of lipid metabolic process00InformativeDirect
Biological Process (BP)hexose metabolic process00InformativeDirect
Biological Process (BP)negative regulation of signaling5.573e-067.7e-06InformativeDirect
Biological Process (BP)cell projection organization7.327e-104.84e-05InformativeDirect
Biological Process (BP)regulation of defense response3.321e-154.35e-06InformativeDirect
Biological Process (BP)regulation of response to external stimulus3.01e-072.491e-10InformativeDirect
Biological Process (BP)regulation of intracellular transport0.000241.688e-05InformativeDirect
Biological Process (BP)response to lipid5.205e-071.257e-07InformativeDirect
Biological Process (BP)growth6.031e-083.878e-06InformativeDirect
Biological Process (BP)regulation of locomotion5.994e-089.788e-09InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis1.193e-081.848e-09InformativeDirect
Biological Process (BP)single-organism behavior01.211e-13InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.00021560.00013InformativeDirect
Biological Process (BP)negative regulation of transport00InformativeDirect
Biological Process (BP)negative regulation of cellular component organization8.797e-085.222e-09InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process1.595e-057.57e-10InformativeDirect
Biological Process (BP)regulation of cellular component movement5.217e-104.137e-10InformativeDirect
Biological Process (BP)regulation of establishment of protein localization03.77e-15InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process6.44e-066.219e-06InformativeDirect
Biological Process (BP)cellular response to nitrogen compound1.962e-050.0003855InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.64010.9736InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.6250.6603InformativeInherited
Biological Process (BP)regulation of secretion0.36810.6531InformativeInherited
Biological Process (BP)cellular component morphogenesis0.019780.4239InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.10270.5717InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00093050.003182InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds4.003e-050.001652InformativeInherited
Biological Process (BP)regulation of hormone levels0.0080194.631e-05InformativeInherited
Biological Process (BP)generation of neurons0.24630.588InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.015250.002763InformativeInherited
Biological Process (BP)anion transport0.068260.05296InformativeInherited
Biological Process (BP)organic acid transport0.0082660.002071InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.83511InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.60660.642InformativeInherited
Biological Process (BP)response to light stimulus0.007140.01049InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway9.961e-080.002831InformativeInherited
Biological Process (BP)retinoid metabolic process00Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process1.183e-102.971e-14Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process1.083e-124.537e-11Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process00Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway2.908e-099.725e-05Highly InformativeDirect
Biological Process (BP)aging7.583e-120Highly InformativeDirect
Biological Process (BP)circadian rhythm00Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation2.087e-108.53e-12Highly InformativeDirect
Biological Process (BP)aerobic respiration2.028e-101.948e-10Highly InformativeDirect
Biological Process (BP)detection of light stimulus7.02e-058.219e-06Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process6.527e-095.779e-10Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process2.499e-079.574e-09Highly InformativeDirect
Biological Process (BP)regulation of lipid storage1.825e-091.116e-10Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport1.944e-063.256e-06Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion08.018e-14Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular transport4.178e-091.876e-09Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport8.19e-074.392e-07Highly InformativeDirect
Biological Process (BP)carbohydrate homeostasis8.767e-076.025e-06Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process1.028e-087.654e-09Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process3.121e-092.063e-11Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion3.448e-130Highly InformativeDirect
Biological Process (BP)wound healing8.454e-060.000584Highly InformativeDirect
Biological Process (BP)response to drug5.014e-092.276e-09Highly InformativeDirect
Biological Process (BP)regulation of circadian rhythm1.041e-126.326e-10Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus9.889e-054.315e-05Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process1.502e-075.198e-10Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport00Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion3.197e-082.754e-07Highly InformativeDirect
Biological Process (BP)developmental growth3.561e-107.893e-10Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation1.522e-120Highly InformativeDirect
Biological Process (BP)response to axon injury1.41e-110Highly InformativeDirect
Biological Process (BP)regulation of behavior0.00051560.0007328Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process5.454e-055.332e-09Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.00011451.103e-05Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process2.116e-103.658e-12Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement1.665e-130Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade2.7e-133.233e-09Highly InformativeDirect
Biological Process (BP)axon development03.366e-09Highly InformativeDirect
Biological Process (BP)regulation of peptide transport1.248e-050.0001481Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus1.389e-083.061e-09Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process00Highly InformativeDirect
Biological Process (BP)cellular response to peptide1.768e-064.866e-05Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte migration00Highly InformativeDirect
Biological Process (BP)negative regulation of secretion0.048590.07681Highly InformativeInherited
Biological Process (BP)locomotory behavior0.92270.8523Highly InformativeInherited
Molecular Function (MF)binding02.784e-11Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transporter activity2.13e-050.0001012Moderately InformativeDirect
Molecular Function (MF)isomerase activity1.439e-121.525e-13Moderately InformativeDirect
Molecular Function (MF)anion binding1.582e-060.0001278Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.035820.4951Moderately InformativeInherited
Molecular Function (MF)lipid binding00InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)carboxylic acid binding00InformativeDirect
Molecular Function (MF)receptor activity0.0029120.2677InformativeInherited
Molecular Function (MF)molecular transducer activity0.0058740.3194InformativeInherited
Molecular Function (MF)kinase activity0.0098320.2878InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0012080.1854InformativeInherited
Molecular Function (MF)lipid transporter activity4.548e-141.563e-15Highly InformativeDirect
Molecular Function (MF)steroid binding3.919e-150Highly InformativeDirect
Molecular Function (MF)odorant binding2.637e-130Highly InformativeDirect
Molecular Function (MF)isoprenoid binding1.307e-060Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding00Highly InformativeDirect
Molecular Function (MF)alcohol binding00Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.00011140.04457Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.00040790.001662Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.013440.3797Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum00Moderately InformativeDirect
Cellular Component (CC)cytosol9.28e-071.705e-08Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex9.976e-077.194e-07Moderately InformativeDirect
Cellular Component (CC)cell projection1.006e-081.553e-05Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)vesicle0.009240.001034Moderately InformativeInherited
Cellular Component (CC)extracellular space3.109e-100InformativeDirect
Cellular Component (CC)cytosolic ribosome6.127e-140InformativeDirect
Cellular Component (CC)neuron projection5.786e-050.0005885InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle6.341e-053.755e-07InformativeDirect
Cellular Component (CC)dendrite06.804e-14Highly InformativeDirect
Cellular Component (CC)cell body00Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm1.255e-123.7e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1.443e-06 Least Informative Direct
Biological Process (BP) developmental process 0.0006718 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 6.415e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 0.9138 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.07664 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4292 Least Informative Inherited
Biological Process (BP) localization 0.5545 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1.719e-07 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 6.938e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 4.073e-07 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 2.125e-14 Moderately Informative Direct
Biological Process (BP) regulation of localization 4.224e-08 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0009578 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.0007757 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 7.744e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 6.594e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 8.98e-06 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 5.043e-08 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.8648 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01621 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02141 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01014 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.05377 Moderately Informative Inherited
Biological Process (BP) ion transport 0.8057 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.9304 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8224 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.5606 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9632 Moderately Informative Inherited
Biological Process (BP) organ development 0.0161 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01529 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02088 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.007394 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 1.224e-08 Informative Direct
Biological Process (BP) response to oxidative stress 3.77e-15 Informative Direct
Biological Process (BP) mitochondrion organization 2.883e-05 Informative Direct
Biological Process (BP) central nervous system development 3.22e-09 Informative Direct
Biological Process (BP) response to wounding 1.231e-09 Informative Direct
Biological Process (BP) response to hormone stimulus 1.817e-05 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0006229 Informative Direct
Biological Process (BP) negative regulation of cell communication 6.233e-06 Informative Direct
Biological Process (BP) regulation of hormone levels 4.631e-05 Informative Direct
Biological Process (BP) lipid localization 7.054e-14 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 7.7e-06 Informative Direct
Biological Process (BP) cell projection organization 4.84e-05 Informative Direct
Biological Process (BP) regulation of defense response 4.35e-06 Informative Direct
Biological Process (BP) regulation of response to external stimulus 2.491e-10 Informative Direct
Biological Process (BP) regulation of intracellular transport 1.688e-05 Informative Direct
Biological Process (BP) response to lipid 1.257e-07 Informative Direct
Biological Process (BP) growth 3.878e-06 Informative Direct
Biological Process (BP) regulation of locomotion 9.788e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.848e-09 Informative Direct
Biological Process (BP) single-organism behavior 1.211e-13 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00013 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 5.222e-09 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 7.57e-10 Informative Direct
Biological Process (BP) regulation of cellular component movement 4.137e-10 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 3.77e-15 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 6.219e-06 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0003855 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.9736 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.6603 Informative Inherited
Biological Process (BP) regulation of secretion 0.6531 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.4239 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.5717 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.003182 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.001652 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.002763 Informative Inherited
Biological Process (BP) generation of neurons 0.588 Informative Inherited
Biological Process (BP) anion transport 0.05296 Informative Inherited
Biological Process (BP) organic acid transport 0.002071 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.002862 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.642 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.00138 Informative Inherited
Biological Process (BP) response to light stimulus 0.01049 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.002831 Informative Inherited
Biological Process (BP) retinoid metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 2.971e-14 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 4.537e-11 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 9.725e-05 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) circadian rhythm 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 8.53e-12 Highly Informative Direct
Biological Process (BP) aerobic respiration 1.948e-10 Highly Informative Direct
Biological Process (BP) detection of light stimulus 8.219e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 5.779e-10 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 9.574e-09 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 1.116e-10 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 1.919e-05 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 3.256e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 8.018e-14 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 1.876e-09 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 4.392e-07 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 6.025e-06 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 7.654e-09 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 2.063e-11 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) wound healing 0.000584 Highly Informative Direct
Biological Process (BP) response to drug 2.276e-09 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 6.326e-10 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 4.315e-05 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 5.198e-10 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 2.754e-07 Highly Informative Direct
Biological Process (BP) developmental growth 7.893e-10 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0007328 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 5.332e-09 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 1.103e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.658e-12 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 3.233e-09 Highly Informative Direct
Biological Process (BP) axon development 3.366e-09 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0001481 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 3.061e-09 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 4.866e-05 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.07681 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.8523 Highly Informative Inherited
Molecular Function (MF) binding 2.784e-11 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0001012 Moderately Informative Direct
Molecular Function (MF) isomerase activity 1.525e-13 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001278 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.5664 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.4951 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 7.798e-07 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0003344 Informative Direct
Molecular Function (MF) protein dimerization activity 0.001159 Informative Inherited
Molecular Function (MF) receptor activity 0.2677 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.3194 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.001957 Informative Inherited
Molecular Function (MF) kinase activity 0.2878 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1854 Informative Inherited
Molecular Function (MF) lipid transporter activity 1.563e-15 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 2.864e-09 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.892e-06 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0002189 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.04457 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.001662 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3797 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) cytosol 1.705e-08 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 7.194e-07 Moderately Informative Direct
Cellular Component (CC) cell projection 1.553e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.001034 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cytosolic ribosome 0 Informative Direct
Cellular Component (CC) neuron projection 0.0005885 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 3.755e-07 Informative Direct
Cellular Component (CC) dendrite 6.804e-14 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 3.7e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases4.383e-14Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.2689Least InformativeInherited
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level6.202e-07Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06147Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant1.309e-07InformativeDirect
Worm Phenotype (WP)fat content increased1.068e-11Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.4464Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8309Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.4766Moderately InformativeInherited
Xenopus ANatomical entity (XAN)foregut0.0006095Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01587Least InformativeInherited
Enzyme Commission (EC)Isomerases5.46e-13Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors3.579e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.509Moderately InformativeInherited
Biological processSensory transduction1.26e-07InformativeDirect
Biological processInnate immunity1.063e-06InformativeDirect
Biological processFatty acid metabolism3.633e-05InformativeDirect
Biological processLipid biosynthesis0.01633InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processAcute phase4.713e-16Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.499e-05Moderately InformativeDirect
Cellular componentGolgi apparatus7.382e-05Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionLipid-binding0InformativeDirect
Molecular functionChromophore3.936e-08InformativeDirect
Molecular functionZinc transport2.878e-09Highly InformativeDirect
Post-translational modificationProtease inhibitor3.956e-06InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationAcetylation0.0002883Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011038 SSF50814 Protein matches
Abstract

Calycins form a large protein superfamily that share similar beta-barrel structures. Calycins can be divided into families that include lipocalins, fatty acid binding proteins, triabin, and thrombin inhibitor [PubMed11058743]. Of these families, the lipocalin family is the largest and functionally the most diverse. Lipocalins are extracellular proteins that share several common recognition properties such as ligand binding, receptor binding and the formation of complexes with other macromolecules. Lipocalins include the retinol binding protein, lipocalin allergen, aphrodisin (a sex hormone), alpha-2U-globulin, prostaglandin D synthase, beta-lactoglobulin, bilin-binding protein, and the nitrophorins [PubMed12432930, PubMed11058763, PubMed11058769, PubMed11058756].

This entry represents calycin as well as some other proteins that share a similar calycin beta-barrel structure, including two bacterial hypothetical proteins YodA from Escherichia coli and YwiB from bacillus subtilis. Part of the YodA hypothetical protein has a calycin-like structure [PubMed12909634].

Please be aware that some of the protein hits may be false positives.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 69 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipocalins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 69 hidden Markov models representing the Lipocalins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]