SUPERFAMILY 1.75 HMM library and genome assignments server

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Lipocalins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Lipocalins [ 50813]
Superfamily:   Lipocalins [ 50814] (9)
Families:   Retinol binding protein-like [ 50815] (21)
  Fatty acid binding protein-like [ 50847] (17)
  Thrombin inhibitor [ 50872]
  Hypothetical protein YodA [ 101863]
  Hypothetical protein YwiB [ 101866]
  Phenolic acid decarboxylase (PAD) [ 141469]
  Dinoflagellate luciferase repeat [ 141472]
  Rv2717c-like [ 141475] (2)
  All1756-like [ 159230]


Superfamily statistics
Genomes (1,869) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,508 32,024 119
Proteins 7,230 31,663 118


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00.000002097Least InformativeDirect
Biological Process (BP)developmental process0.000000000042660.0008431Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00000000000055940Least InformativeDirect
Biological Process (BP)response to stimulus0.0000000000018970.00000133Least InformativeDirect
Biological Process (BP)biosynthetic process0.91780.9262Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.013330.07991Least InformativeInherited
Biological Process (BP)single-organism cellular process0.83671Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0033720.4768Least InformativeInherited
Biological Process (BP)localization0.10.5966Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000023010.0000001682Moderately InformativeDirect
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.0000000040060.0000005667Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.0000000000076680.00000000000003459Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000003930.00000004943Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00000015230.0001418Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0000026150.00007184Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.00000062240.00000006081Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.74740.8821Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.91961Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0030910.000009639Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0098250.01707Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0056220.004946Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.77821Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0075170.02272Moderately InformativeInherited
Biological Process (BP)tissue development0.0010330.01024Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0026690.001095Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)nervous system development0.00096450.05589Moderately InformativeInherited
Biological Process (BP)ion transport0.59780.7996Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.43411Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.84141Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.95970.8234Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.23650.5258Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)signal transduction0.62140.9747Moderately InformativeInherited
Biological Process (BP)organ development0.021360.01628Moderately InformativeInherited
Biological Process (BP)organelle organization0.46651Moderately InformativeInherited
Biological Process (BP)organic substance transport0.034120.01417Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0066570.02305Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.048420.008295Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.0000098290.00000001109InformativeDirect
Biological Process (BP)negative regulation of immune system process0.00000000019880.00000000000003296InformativeDirect
Biological Process (BP)response to oxidative stress0.0000000020440.000000000000005594InformativeDirect
Biological Process (BP)mitochondrion organization0.0000068280.00003194InformativeDirect
Biological Process (BP)central nervous system development0.000000000029530.000000003872InformativeDirect
Biological Process (BP)response to wounding0.00000000032770.000000001024InformativeDirect
Biological Process (BP)response to hormone stimulus0.0001180.00001669InformativeDirect
Biological Process (BP)response to organonitrogen compound0.0006370.0005788InformativeDirect
Biological Process (BP)negative regulation of cell communication0.0000094760.000006703InformativeDirect
Biological Process (BP)lipid localization0.0000000000000063980.00000000000008636InformativeDirect
Biological Process (BP)regulation of lipid metabolic process00InformativeDirect
Biological Process (BP)hexose metabolic process0.0000000000000016880InformativeDirect
Biological Process (BP)negative regulation of signaling0.0000067980.00000845InformativeDirect
Biological Process (BP)cell projection organization0.00000000079620.00005485InformativeDirect
Biological Process (BP)regulation of defense response0.0000000000000063980.000003902InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00000030270.0000000003086InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00026350.00001612InformativeDirect
Biological Process (BP)regulation of protein localization0.000058640.000001796InformativeDirect
Biological Process (BP)response to lipid0.00000066020.0000001405InformativeDirect
Biological Process (BP)growth0.000000093660.000005925InformativeDirect
Biological Process (BP)regulation of locomotion0.000000060980.000000009079InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00000000056590.000000004935InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.000000013110.000000002661InformativeDirect
Biological Process (BP)single-organism behavior00.0000000000002192InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.0002690.0001411InformativeDirect
Biological Process (BP)negative regulation of transport00InformativeDirect
Biological Process (BP)negative regulation of cellular component organization0.00000011470.000000005584InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process0.000012250.0000000004824InformativeDirect
Biological Process (BP)regulation of cellular component movement0.00000000054240.0000000004901InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.000006990.000006379InformativeDirect
Biological Process (BP)cellular response to nitrogen compound0.000020530.0003853InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.64890.9832InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.63630.668InformativeInherited
Biological Process (BP)regulation of secretion0.42720.6839InformativeInherited
Biological Process (BP)cellular component morphogenesis0.020140.4165InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.095670.5719InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0011120.003448InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds0.000038240.001613InformativeInherited
Biological Process (BP)regulation of hormone levels0.0067450.00004175InformativeInherited
Biological Process (BP)generation of neurons0.24560.5929InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.014680.002781InformativeInherited
Biological Process (BP)anion transport0.071590.0558InformativeInherited
Biological Process (BP)organic acid transport0.0079190.002148InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.83520.9946InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.60860.656InformativeInherited
Biological Process (BP)response to light stimulus0.0075120.01142InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.00000010340.003107InformativeInherited
Biological Process (BP)retinoid metabolic process00Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process0.0000000000013150.00000000005418Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process00Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.0000000032380.0001076Highly InformativeDirect
Biological Process (BP)aging0.0000000000067990Highly InformativeDirect
Biological Process (BP)circadian rhythm00Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.00000000014870.000000000006563Highly InformativeDirect
Biological Process (BP)aerobic respiration0.00000000023150.0000000002223Highly InformativeDirect
Biological Process (BP)detection of light stimulus0.000068010.000007922Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process0.0000000054420.0000000006272Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.00000046640.00000001858Highly InformativeDirect
Biological Process (BP)regulation of lipid storage0.0000000013940.0000000001034Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport0.0000019930.000003487Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion00.0000000000001162Highly InformativeDirect
Biological Process (BP)neuron projection development0.00000000000004210.0000006957Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular transport0.0000000036750.000000001659Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.00000085550.0000003749Highly InformativeDirect
Biological Process (BP)carbohydrate homeostasis0.0000014370.000007794Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process0.0000000059040.000000005472Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.0000000032540.00000000002308Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion0.00000000000024340Highly InformativeDirect
Biological Process (BP)wound healing0.00001080.0006681Highly InformativeDirect
Biological Process (BP)response to drug0.000000004830.000000002406Highly InformativeDirect
Biological Process (BP)regulation of circadian rhythm0.00000000000088810.0000000007047Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus0.00010910.00004623Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.00000010590.0000000003988Highly InformativeDirect
Biological Process (BP)negative regulation of carbohydrate metabolic process0.00000015280.000000001143Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport00Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.00000020220.0000003737Highly InformativeDirect
Biological Process (BP)developmental growth0.00000000027840.0000000006653Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000000000014310Highly InformativeDirect
Biological Process (BP)response to axon injury0.000000000013480Highly InformativeDirect
Biological Process (BP)regulation of behavior0.00053270.0007374Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process0.000050520.000000007337Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.0001020.0000103Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.00000000019050.000000000003332Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement0.0000000000001180Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade0.00000000000057220.000000003403Highly InformativeDirect
Biological Process (BP)regulation of peptide transport0.000081280.0002052Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.0000000070930.000000001865Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process00Highly InformativeDirect
Biological Process (BP)cellular response to peptide0.000001820.00004857Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte migration00Highly InformativeDirect
Biological Process (BP)cell part morphogenesis0.0015690.02927Highly InformativeInherited
Biological Process (BP)negative regulation of secretion0.033280.06968Highly InformativeInherited
Biological Process (BP)locomotory behavior0.91860.8715Highly InformativeInherited
Molecular Function (MF)binding00.00000000009884Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transporter activity0.000022190.0001023Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.000000000002410.0000000000002554Moderately InformativeDirect
Molecular Function (MF)anion binding0.0000010420.0001078Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.039630.5107Moderately InformativeInherited
Molecular Function (MF)lipid binding00InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)carboxylic acid binding00InformativeDirect
Molecular Function (MF)receptor activity0.0030770.2745InformativeInherited
Molecular Function (MF)molecular transducer activity0.0061660.328InformativeInherited
Molecular Function (MF)kinase activity0.010980.2972InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0013120.1906InformativeInherited
Molecular Function (MF)lipid transporter activity0.000000000000048190.000000000000001562Highly InformativeDirect
Molecular Function (MF)steroid binding0.000000000000002620Highly InformativeDirect
Molecular Function (MF)odorant binding0.00000000000019090Highly InformativeDirect
Molecular Function (MF)isoprenoid binding0.0000012130Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding00Highly InformativeDirect
Molecular Function (MF)alcohol binding00Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.00011750.04597Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.00043960.00224Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.013010.3903Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum00Moderately InformativeDirect
Cellular Component (CC)cytosol0.0000011180.00000002058Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex0.0000010490.0000008325Moderately InformativeDirect
Cellular Component (CC)cell projection0.000000016110.0000261Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)vesicle0.0094350.001186Moderately InformativeInherited
Cellular Component (CC)extracellular space0.00000000031330InformativeDirect
Cellular Component (CC)cytosolic ribosome0.000000000000069170InformativeDirect
Cellular Component (CC)neuron projection0.000087650.0006534InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle0.000063620.0000004197InformativeDirect
Cellular Component (CC)dendrite00.0000000000001122Highly InformativeDirect
Cellular Component (CC)cell body00Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm0.0000000000013550.000000000005177Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000002097 Least Informative Direct
Biological Process (BP) developmental process 0.0008431 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000133 Least Informative Direct
Biological Process (BP) biosynthetic process 0.9262 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.07991 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4768 Least Informative Inherited
Biological Process (BP) localization 0.5966 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000001682 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0000005667 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.00000000000003459 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000004943 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001418 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00007184 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000009639 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000006081 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.8821 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01707 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.004946 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02272 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01024 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001095 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.05589 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7996 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.9273 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8234 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.5258 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9747 Moderately Informative Inherited
Biological Process (BP) organ development 0.01628 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01417 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02305 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.008295 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.00000001109 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.00000000000003296 Informative Direct
Biological Process (BP) response to oxidative stress 0.000000000000005594 Informative Direct
Biological Process (BP) mitochondrion organization 0.00003194 Informative Direct
Biological Process (BP) central nervous system development 0.000000003872 Informative Direct
Biological Process (BP) response to wounding 0.000000001024 Informative Direct
Biological Process (BP) response to hormone stimulus 0.00001669 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0005788 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000006703 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00004175 Informative Direct
Biological Process (BP) lipid localization 0.00000000000008636 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00000845 Informative Direct
Biological Process (BP) cell projection organization 0.00005485 Informative Direct
Biological Process (BP) regulation of defense response 0.000003902 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0000000003086 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.00001612 Informative Direct
Biological Process (BP) regulation of protein localization 0.000001796 Informative Direct
Biological Process (BP) response to lipid 0.0000001405 Informative Direct
Biological Process (BP) growth 0.000005925 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000009079 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000000004935 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000002661 Informative Direct
Biological Process (BP) single-organism behavior 0.0000000000002192 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001411 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000000005584 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0000000004824 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0000000004901 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000006379 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0003853 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.9832 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.668 Informative Inherited
Biological Process (BP) regulation of secretion 0.6839 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.4165 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.5719 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.003448 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.001613 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.002781 Informative Inherited
Biological Process (BP) generation of neurons 0.5929 Informative Inherited
Biological Process (BP) anion transport 0.0558 Informative Inherited
Biological Process (BP) organic acid transport 0.002148 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.003209 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9946 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.656 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.001509 Informative Inherited
Biological Process (BP) response to light stimulus 0.01142 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.003107 Informative Inherited
Biological Process (BP) retinoid metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.00000000005418 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001076 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) circadian rhythm 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000000000006563 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.0000000002223 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.000007922 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0000000006272 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000001858 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.0000000001034 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.00002044 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.000003487 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0000000000001162 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0000006957 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.000000001659 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0000003749 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.000007794 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.000000005472 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.00000000002308 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) wound healing 0.0006681 Highly Informative Direct
Biological Process (BP) response to drug 0.000000002406 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0000000007047 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.00004623 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0000000003988 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.000000001143 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0000003737 Highly Informative Direct
Biological Process (BP) developmental growth 0.0000000006653 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0007374 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.000000007337 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0000103 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000000000003332 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.000000003403 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0002052 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.000000001865 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.00004857 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.02927 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.06968 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.8715 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000009884 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0001023 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.0000000000002554 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001078 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.5796 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.5107 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0000009359 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0003506 Informative Direct
Molecular Function (MF) protein dimerization activity 0.001293 Informative Inherited
Molecular Function (MF) receptor activity 0.2745 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.328 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.002072 Informative Inherited
Molecular Function (MF) kinase activity 0.2972 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1906 Informative Inherited
Molecular Function (MF) lipid transporter activity 0.000000000000001562 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 0.000000004241 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.000002258 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0002196 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.04597 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00224 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3903 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) cytosol 0.00000002058 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.0000008325 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000261 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.001186 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cytosolic ribosome 0 Informative Direct
Cellular Component (CC) neuron projection 0.0006534 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000004197 Informative Direct
Cellular Component (CC) dendrite 0.0000000000001122 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000000000005177 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.00000000000004383Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.2413Least InformativeInherited
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0000004287Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06147Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.0000001309InformativeDirect
Worm Phenotype (WP)fat content increased0.00000000001068Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.4472Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.834Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.4811Moderately InformativeInherited
Xenopus ANatomical entity (XAN)foregut0.0006087Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01599Least InformativeInherited
Enzyme Commission (EC)Isomerases0.0000000000005393Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors0.00000003526Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.5087Moderately InformativeInherited
Biological processSensory transduction0.000000134InformativeDirect
Biological processInnate immunity0.000001054InformativeDirect
Biological processFatty acid metabolism0.00003567InformativeDirect
Biological processLipid biosynthesis0.01621InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processAcute phase4.711e-16Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00001654Moderately InformativeDirect
Cellular componentGolgi apparatus0.00007669Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionLipid-binding0InformativeDirect
Molecular functionChromophore0.00000003888InformativeDirect
Molecular functionZinc transport0.000000002856Highly InformativeDirect
Post-translational modificationProtease inhibitor0.000003945InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationAcetylation0.0002906Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011038 SSF50814 Protein matches
Abstract

Calycins form a large protein superfamily that share similar beta-barrel structures. Calycins can be divided into families that include lipocalins, fatty acid binding proteins, triabin, and thrombin inhibitor [PubMed11058743]. Of these families, the lipocalin family is the largest and functionally the most diverse. Lipocalins are extracellular proteins that share several common recognition properties such as ligand binding, receptor binding and the formation of complexes with other macromolecules. Lipocalins include the retinol binding protein, lipocalin allergen, aphrodisin (a sex hormone), alpha-2U-globulin, prostaglandin D synthase, beta-lactoglobulin, bilin-binding protein, and the nitrophorins [PubMed12432930, PubMed11058763, PubMed11058769, PubMed11058756].

This entry represents calycin as well as some other proteins that share a similar calycin beta-barrel structure, including two bacterial hypothetical proteins YodA from Escherichia coli and YwiB from bacillus subtilis. Part of the YodA hypothetical protein has a calycin-like structure [PubMed12909634].

Please be aware that some of the protein hits may be false positives.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 69 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipocalins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 69 hidden Markov models representing the Lipocalins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]