SUPERFAMILY 1.75 HMM library and genome assignments server


Lipocalins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Lipocalins [ 50813]
Superfamily:   Lipocalins [ 50814] (9)
Families:   Retinol binding protein-like [ 50815] (21)
  Fatty acid binding protein-like [ 50847] (17)
  Thrombin inhibitor [ 50872]
  Hypothetical protein YodA [ 101863]
  Hypothetical protein YwiB [ 101866]
  Phenolic acid decarboxylase (PAD) [ 141469]
  Dinoflagellate luciferase repeat [ 141472]
  Rv2717c-like [ 141475] (2)
  All1756-like [ 159230]


Superfamily statistics
Genomes (1,827) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 6,872 14,411 119
Proteins 6,650 14,118 118


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process01.764e-06Least InformativeDirect
Biological Process (BP)developmental process4.389e-110.0009166Least InformativeDirect
Biological Process (BP)single-organism metabolic process1.604e-130Least InformativeDirect
Biological Process (BP)response to stimulus2.126e-134.628e-07Least InformativeDirect
Biological Process (BP)biosynthetic process0.89770.9133Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.024420.1028Least InformativeInherited
Biological Process (BP)single-organism cellular process0.79391Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0016890.3445Least InformativeInherited
Biological Process (BP)localization0.081570.4961Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process2.577e-051.906e-07Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process1.841e-091.745e-07Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process4.597e-122.112e-14Moderately InformativeDirect
Biological Process (BP)regulation of localization1.508e-061.724e-08Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)single-organism developmental process1.886e-070.0002768Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process1.755e-075.359e-05Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process1.096e-063.956e-05Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound2.33e-072.446e-08Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.72150.8275Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.95561Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0023647.855e-06Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.011130.01277Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.0012997.653e-05Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.81241Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.014370.02937Moderately InformativeInherited
Biological Process (BP)tissue development0.0015230.0137Moderately InformativeInherited
Biological Process (BP)homeostatic process0.00051580.001215Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0029220.0007171Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)nervous system development0.00047070.03681Moderately InformativeInherited
Biological Process (BP)ion transport0.6080.7973Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.38510.987Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.80951Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.96970.822Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.25680.542Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)signal transduction0.66740.9656Moderately InformativeInherited
Biological Process (BP)organ development0.020010.01628Moderately InformativeInherited
Biological Process (BP)organelle organization0.46661Moderately InformativeInherited
Biological Process (BP)organic substance transport0.035080.01584Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0058180.01835Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.045170.00777Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production8.07e-061.12e-08InformativeDirect
Biological Process (BP)response to oxidative stress2.409e-091.431e-14InformativeDirect
Biological Process (BP)mitochondrion organization4.627e-062.607e-05InformativeDirect
Biological Process (BP)central nervous system development8.789e-121.448e-09InformativeDirect
Biological Process (BP)response to wounding6.712e-107.016e-10InformativeDirect
Biological Process (BP)response to hormone stimulus0.0002043.325e-05InformativeDirect
Biological Process (BP)response to organonitrogen compound0.00052520.000346InformativeDirect
Biological Process (BP)negative regulation of cell communication8.151e-064.679e-06InformativeDirect
Biological Process (BP)lipid localization6.167e-156.686e-14InformativeDirect
Biological Process (BP)regulation of lipid metabolic process00InformativeDirect
Biological Process (BP)hexose metabolic process1.61e-150InformativeDirect
Biological Process (BP)negative regulation of signaling6.483e-065.923e-06InformativeDirect
Biological Process (BP)cell projection organization5.938e-103.245e-05InformativeDirect
Biological Process (BP)regulation of defense response1.61e-155.77e-06InformativeDirect
Biological Process (BP)regulation of response to external stimulus2.918e-072.968e-10InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00040522.576e-05InformativeDirect
Biological Process (BP)response to lipid1.345e-074.431e-08InformativeDirect
Biological Process (BP)growth2.738e-103.55e-07InformativeDirect
Biological Process (BP)regulation of locomotion6.861e-087.456e-09InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis1.744e-089.986e-10InformativeDirect
Biological Process (BP)single-organism behavior04.755e-14InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.00021750.0001068InformativeDirect
Biological Process (BP)negative regulation of cellular component organization1.866e-075.38e-09InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process1.462e-054.794e-10InformativeDirect
Biological Process (BP)regulation of cellular component movement7.763e-103.186e-10InformativeDirect
Biological Process (BP)regulation of establishment of protein localization00InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process5.074e-064.487e-06InformativeDirect
Biological Process (BP)cellular response to nitrogen compound1.867e-050.0003592InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.5740.9251InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.58450.6561InformativeInherited
Biological Process (BP)regulation of secretion0.33650.6602InformativeInherited
Biological Process (BP)cellular component morphogenesis0.01710.3667InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.09410.5457InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0011580.003049InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds3.65e-050.001585InformativeInherited
Biological Process (BP)regulation of hormone levels0.010184.561e-05InformativeInherited
Biological Process (BP)generation of neurons0.23760.6105InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.014930.002796InformativeInherited
Biological Process (BP)anion transport0.075170.05237InformativeInherited
Biological Process (BP)organic acid transport0.0097570.002249InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.83790.9936InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.60670.6366InformativeInherited
Biological Process (BP)response to light stimulus0.0066020.009879InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway1.024e-070.002689InformativeInherited
Biological Process (BP)retinoid metabolic process00Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process1.2e-102.78e-14Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process1.121e-123.469e-11Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway3.808e-090.0001065Highly InformativeDirect
Biological Process (BP)aging5.469e-120Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation2.988e-101.326e-11Highly InformativeDirect
Biological Process (BP)aerobic respiration2.476e-102.038e-10Highly InformativeDirect
Biological Process (BP)detection of light stimulus8.813e-059.299e-06Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process2.713e-094.239e-10Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process1.806e-077.551e-09Highly InformativeDirect
Biological Process (BP)regulation of lipid storage2.324e-091.377e-10Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport2.201e-063.22e-06Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion05.078e-14Highly InformativeDirect
Biological Process (BP)neuron projection development3.76e-144.212e-07Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular transport4.367e-092.772e-09Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport8.453e-076.633e-07Highly InformativeDirect
Biological Process (BP)carbohydrate homeostasis5.741e-071.87e-05Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process9.991e-098.459e-09Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process3.669e-092.294e-11Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion3.85e-130Highly InformativeDirect
Biological Process (BP)wound healing8.868e-060.0005173Highly InformativeDirect
Biological Process (BP)response to drug4.293e-091.603e-09Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus6.674e-052.146e-05Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process2.068e-078.13e-10Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport00Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion1.899e-082.46e-07Highly InformativeDirect
Biological Process (BP)developmental growth4.943e-103.651e-10Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation2.302e-120Highly InformativeDirect
Biological Process (BP)response to axon injury1.607e-110Highly InformativeDirect
Biological Process (BP)regulation of inflammatory response8.599e-092.118e-12Highly InformativeDirect
Biological Process (BP)regulation of behavior0.00062270.0008509Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process4.149e-055.783e-09Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.00023992.012e-05Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process2.695e-104.252e-12Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement1.761e-130Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase B signaling cascade1.207e-143.757e-12Highly InformativeDirect
Biological Process (BP)regulation of peptide transport9.75e-060.0001501Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus1.175e-083.1e-09Highly InformativeDirect
Biological Process (BP)fatty acid derivative metabolic process00Highly InformativeDirect
Biological Process (BP)cellular response to peptide2.723e-066.163e-05Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte migration00Highly InformativeDirect
Biological Process (BP)cell part morphogenesis0.0011480.02295Highly InformativeInherited
Biological Process (BP)negative regulation of secretion0.057590.08593Highly InformativeInherited
Biological Process (BP)locomotory behavior0.90470.878Highly InformativeInherited
Molecular Function (MF)binding03.737e-12Least InformativeDirect
Molecular Function (MF)transporter activity1.855e-057.18e-05Moderately InformativeDirect
Molecular Function (MF)isomerase activity1.448e-121.188e-13Moderately InformativeDirect
Molecular Function (MF)anion binding1.257e-060.0001398Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.033070.4837Moderately InformativeInherited
Molecular Function (MF)lipid binding00InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)carboxylic acid binding00InformativeDirect
Molecular Function (MF)receptor activity0.0021640.2553InformativeInherited
Molecular Function (MF)molecular transducer activity0.0045670.3116InformativeInherited
Molecular Function (MF)kinase activity0.0089760.2797InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0011280.1801InformativeInherited
Molecular Function (MF)lipid transporter activity5.859e-141.555e-15Highly InformativeDirect
Molecular Function (MF)steroid binding7.543e-150Highly InformativeDirect
Molecular Function (MF)odorant binding4.386e-130Highly InformativeDirect
Molecular Function (MF)isoprenoid binding1.72e-060Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding00Highly InformativeDirect
Molecular Function (MF)alcohol binding00Highly InformativeDirect
Molecular Function (MF)protein kinase activity9.899e-050.04224Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.0005330.0007991Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0052590.1652Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.88830.9419Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum00Moderately InformativeDirect
Cellular Component (CC)cytosol1.006e-062.015e-08Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex1.532e-067.039e-07Moderately InformativeDirect
Cellular Component (CC)cell projection1.426e-081.064e-05Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space3.236e-061.481e-12InformativeDirect
Cellular Component (CC)cytosolic ribosome5.565e-140InformativeDirect
Cellular Component (CC)neuron projection5.51e-050.0006571InformativeDirect
Cellular Component (CC)dendrite03.964e-14Highly InformativeDirect
Cellular Component (CC)cell body00Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm1.552e-122.412e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1.764e-06 Least Informative Direct
Biological Process (BP) developmental process 0.0009166 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 4.628e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 0.9133 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.1028 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3445 Least Informative Inherited
Biological Process (BP) localization 0.4961 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1.906e-07 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 7.653e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.745e-07 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 2.112e-14 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.724e-08 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0007171 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0002768 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 5.359e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 3.956e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 7.855e-06 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.446e-08 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.8275 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01277 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02937 Moderately Informative Inherited
Biological Process (BP) tissue development 0.0137 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.001215 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03681 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7973 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.987 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.822 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.542 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9656 Moderately Informative Inherited
Biological Process (BP) organ development 0.01628 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01584 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01835 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.00777 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 1.12e-08 Informative Direct
Biological Process (BP) response to oxidative stress 1.431e-14 Informative Direct
Biological Process (BP) mitochondrion organization 2.607e-05 Informative Direct
Biological Process (BP) central nervous system development 1.448e-09 Informative Direct
Biological Process (BP) response to wounding 7.016e-10 Informative Direct
Biological Process (BP) response to hormone stimulus 3.325e-05 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.000346 Informative Direct
Biological Process (BP) negative regulation of cell communication 4.679e-06 Informative Direct
Biological Process (BP) regulation of hormone levels 4.561e-05 Informative Direct
Biological Process (BP) lipid localization 6.686e-14 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 5.923e-06 Informative Direct
Biological Process (BP) cell projection organization 3.245e-05 Informative Direct
Biological Process (BP) regulation of defense response 5.77e-06 Informative Direct
Biological Process (BP) regulation of response to external stimulus 2.968e-10 Informative Direct
Biological Process (BP) regulation of intracellular transport 2.576e-05 Informative Direct
Biological Process (BP) response to lipid 4.431e-08 Informative Direct
Biological Process (BP) growth 3.55e-07 Informative Direct
Biological Process (BP) regulation of locomotion 7.456e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 9.986e-10 Informative Direct
Biological Process (BP) single-organism behavior 4.755e-14 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001068 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 5.38e-09 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 4.794e-10 Informative Direct
Biological Process (BP) regulation of cellular component movement 3.186e-10 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 4.487e-06 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0003592 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.9251 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.6561 Informative Inherited
Biological Process (BP) regulation of secretion 0.6602 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3667 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.5457 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.003049 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.001585 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.002796 Informative Inherited
Biological Process (BP) generation of neurons 0.6105 Informative Inherited
Biological Process (BP) anion transport 0.05237 Informative Inherited
Biological Process (BP) organic acid transport 0.002249 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.00931 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9936 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6366 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.006432 Informative Inherited
Biological Process (BP) response to light stimulus 0.009879 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.002689 Informative Inherited
Biological Process (BP) retinoid metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 2.78e-14 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 3.469e-11 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001065 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 1.326e-11 Highly Informative Direct
Biological Process (BP) aerobic respiration 2.038e-10 Highly Informative Direct
Biological Process (BP) detection of light stimulus 9.299e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 4.239e-10 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 7.551e-09 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 1.377e-10 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.000172 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 3.22e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 5.078e-14 Highly Informative Direct
Biological Process (BP) neuron projection development 4.212e-07 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 2.772e-09 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 6.633e-07 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 1.87e-05 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 8.459e-09 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 2.294e-11 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) wound healing 0.0005173 Highly Informative Direct
Biological Process (BP) response to drug 1.603e-09 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 2.146e-05 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 8.13e-10 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 2.46e-07 Highly Informative Direct
Biological Process (BP) developmental growth 3.651e-10 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 2.118e-12 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0008509 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 5.783e-09 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 2.012e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 4.252e-12 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 3.757e-12 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0001501 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 3.1e-09 Highly Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 6.163e-05 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.02295 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.08593 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.878 Highly Informative Inherited
Molecular Function (MF) binding 3.737e-12 Least Informative Direct
Molecular Function (MF) transporter activity 7.18e-05 Moderately Informative Direct
Molecular Function (MF) isomerase activity 1.188e-13 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001398 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.4837 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 9.462e-07 Informative Direct
Molecular Function (MF) protein dimerization activity 0.001005 Informative Inherited
Molecular Function (MF) receptor activity 0.2553 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.3116 Informative Inherited
Molecular Function (MF) kinase activity 0.2797 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1801 Informative Inherited
Molecular Function (MF) lipid transporter activity 1.555e-15 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 2.832e-09 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.527e-06 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.000223 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.04224 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0007991 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.1652 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9419 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) cytosol 2.015e-08 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 7.039e-07 Moderately Informative Direct
Cellular Component (CC) cell projection 1.064e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0842 Moderately Informative Inherited
Cellular Component (CC) extracellular space 1.481e-12 Informative Direct
Cellular Component (CC) cytosolic ribosome 0 Informative Direct
Cellular Component (CC) neuron projection 0.0006571 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0003086 Informative Direct
Cellular Component (CC) dendrite 3.964e-14 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.412e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases4.383e-14Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.297Least InformativeInherited
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level6.559e-07Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06147Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant1.309e-07InformativeDirect
Worm Phenotype (WP)fat content increased1.068e-11Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01669Least InformativeInherited
Enzyme Commission (EC)Isomerases6.218e-13Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors3.598e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.5008Moderately InformativeInherited
Biological processSensory transduction1.15e-07InformativeDirect
Biological processInnate immunity8.957e-07InformativeDirect
Biological processFatty acid metabolism3.683e-05InformativeDirect
Biological processLipid biosynthesis0.01595InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processAcute phase4.701e-16Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.176e-05Moderately InformativeDirect
Cellular componentGolgi apparatus7.055e-05Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionLipid-binding0InformativeDirect
Molecular functionChromophore3.776e-08InformativeDirect
Molecular functionZinc transport2.911e-09Highly InformativeDirect
Post-translational modificationProtease inhibitor3.587e-06InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationAcetylation0.0002795Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011038 SSF50814 Protein matches
Abstract

Calycins form a large protein superfamily that share similar beta-barrel structures. Calycins can be divided into families that include lipocalins, fatty acid binding proteins, triabin, and thrombin inhibitor [PubMed11058743]. Of these families, the lipocalin family is the largest and functionally the most diverse. Lipocalins are extracellular proteins that share several common recognition properties such as ligand binding, receptor binding and the formation of complexes with other macromolecules. Lipocalins include the retinol binding protein, lipocalin allergen, aphrodisin (a sex hormone), alpha-2U-globulin, prostaglandin D synthase, beta-lactoglobulin, bilin-binding protein, and the nitrophorins [PubMed12432930, PubMed11058763, PubMed11058769, PubMed11058756].

This entry represents calycin as well as some other proteins that share a similar calycin beta-barrel structure, including two bacterial hypothetical proteins YodA from Escherichia coli and YwiB from bacillus subtilis. Part of the YodA hypothetical protein has a calycin-like structure [PubMed12909634].

Please be aware that some of the protein hits may be false positives.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 69 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipocalins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 69 hidden Markov models representing the Lipocalins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]