SUPERFAMILY 1.75 HMM library and genome assignments server


Lipocalins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Lipocalins [ 50813]
Superfamily:   Lipocalins [ 50814] (9)
Families:   Retinol binding protein-like [ 50815] (21)
  Fatty acid binding protein-like [ 50847] (17)
  Thrombin inhibitor [ 50872]
  Hypothetical protein YodA [ 101863]
  Hypothetical protein YwiB [ 101866]
  Phenolic acid decarboxylase (PAD) [ 141469]
  Dinoflagellate luciferase repeat [ 141472]
  Rv2717c-like [ 141475] (2)
  All1756-like [ 159230]


Superfamily statistics
Genomes (1,869) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,508 32,024 119
Proteins 7,230 31,663 118


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process02.097e-06Least InformativeDirect
Biological Process (BP)developmental process4.266e-110.0008431Least InformativeDirect
Biological Process (BP)single-organism metabolic process5.594e-130Least InformativeDirect
Biological Process (BP)response to stimulus1.897e-121.33e-06Least InformativeDirect
Biological Process (BP)biosynthetic process0.91780.9262Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.013330.07991Least InformativeInherited
Biological Process (BP)single-organism cellular process0.83671Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0033720.4768Least InformativeInherited
Biological Process (BP)localization0.10.5966Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process2.301e-051.682e-07Moderately InformativeDirect
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process4.006e-095.667e-07Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process7.668e-123.459e-14Moderately InformativeDirect
Biological Process (BP)regulation of localization3.93e-064.943e-08Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process1.523e-070.0001418Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process2.615e-067.184e-05Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound6.224e-076.081e-08Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.74740.8821Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.91961Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0030919.639e-06Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0098250.01707Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0056220.004946Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.77821Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.0075170.02272Moderately InformativeInherited
Biological Process (BP)tissue development0.0010330.01024Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0026690.001095Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)nervous system development0.00096450.05589Moderately InformativeInherited
Biological Process (BP)ion transport0.59780.7996Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.43411Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.84141Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.95970.8234Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.23650.5258Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)signal transduction0.62140.9747Moderately InformativeInherited
Biological Process (BP)organ development0.021360.01628Moderately InformativeInherited
Biological Process (BP)organelle organization0.46651Moderately InformativeInherited
Biological Process (BP)organic substance transport0.034120.01417Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0066570.02305Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.048420.008295Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production9.829e-061.109e-08InformativeDirect
Biological Process (BP)negative regulation of immune system process1.988e-103.296e-14InformativeDirect
Biological Process (BP)response to oxidative stress2.044e-095.594e-15InformativeDirect
Biological Process (BP)mitochondrion organization6.828e-063.194e-05InformativeDirect
Biological Process (BP)central nervous system development2.953e-113.872e-09InformativeDirect
Biological Process (BP)response to wounding3.277e-101.024e-09InformativeDirect
Biological Process (BP)response to hormone stimulus0.0001181.669e-05InformativeDirect
Biological Process (BP)response to organonitrogen compound0.0006370.0005788InformativeDirect
Biological Process (BP)negative regulation of cell communication9.476e-066.703e-06InformativeDirect
Biological Process (BP)lipid localization6.398e-158.636e-14InformativeDirect
Biological Process (BP)regulation of lipid metabolic process00InformativeDirect
Biological Process (BP)hexose metabolic process1.688e-150InformativeDirect
Biological Process (BP)negative regulation of signaling6.798e-068.45e-06InformativeDirect
Biological Process (BP)cell projection organization7.962e-105.485e-05InformativeDirect
Biological Process (BP)regulation of defense response6.398e-153.902e-06InformativeDirect
Biological Process (BP)regulation of response to external stimulus3.027e-073.086e-10InformativeDirect
Biological Process (BP)regulation of intracellular transport0.00026351.612e-05InformativeDirect
Biological Process (BP)regulation of protein localization5.864e-051.796e-06InformativeDirect
Biological Process (BP)response to lipid6.602e-071.405e-07InformativeDirect
Biological Process (BP)growth9.366e-085.925e-06InformativeDirect
Biological Process (BP)regulation of locomotion6.098e-089.079e-09InformativeDirect
Biological Process (BP)regulation of cell proliferation5.659e-104.935e-09InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis1.311e-082.661e-09InformativeDirect
Biological Process (BP)single-organism behavior02.192e-13InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.0002690.0001411InformativeDirect
Biological Process (BP)negative regulation of transport00InformativeDirect
Biological Process (BP)negative regulation of cellular component organization1.147e-075.584e-09InformativeDirect
Biological Process (BP)negative regulation of protein metabolic process1.225e-054.824e-10InformativeDirect
Biological Process (BP)regulation of cellular component movement5.424e-104.901e-10InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process6.99e-066.379e-06InformativeDirect
Biological Process (BP)cellular response to nitrogen compound2.053e-050.0003853InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.64890.9832InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.63630.668InformativeInherited
Biological Process (BP)regulation of secretion0.42720.6839InformativeInherited
Biological Process (BP)cellular component morphogenesis0.020140.4165InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.095670.5719InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0011120.003448InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds3.824e-050.001613InformativeInherited
Biological Process (BP)regulation of hormone levels0.0067454.175e-05InformativeInherited
Biological Process (BP)generation of neurons0.24560.5929InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.014680.002781InformativeInherited
Biological Process (BP)anion transport0.071590.0558InformativeInherited
Biological Process (BP)organic acid transport0.0079190.002148InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.83520.9946InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.60860.656InformativeInherited
Biological Process (BP)response to light stimulus0.0075120.01142InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway1.034e-070.003107InformativeInherited
Biological Process (BP)retinoid metabolic process00Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process1.315e-125.418e-11Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process00Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway3.238e-090.0001076Highly InformativeDirect
Biological Process (BP)aging6.799e-120Highly InformativeDirect
Biological Process (BP)circadian rhythm00Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation1.487e-106.563e-12Highly InformativeDirect
Biological Process (BP)aerobic respiration2.315e-102.223e-10Highly InformativeDirect
Biological Process (BP)detection of light stimulus6.801e-057.922e-06Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process5.442e-096.272e-10Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process4.664e-071.858e-08Highly InformativeDirect
Biological Process (BP)regulation of lipid storage1.394e-091.034e-10Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport1.993e-063.487e-06Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion01.162e-13Highly InformativeDirect
Biological Process (BP)neuron projection development4.21e-146.957e-07Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular transport3.675e-091.659e-09Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport8.555e-073.749e-07Highly InformativeDirect
Biological Process (BP)carbohydrate homeostasis1.437e-067.794e-06Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid metabolic process5.904e-095.472e-09Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process3.254e-092.308e-11Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion2.434e-130Highly InformativeDirect
Biological Process (BP)wound healing1.08e-050.0006681Highly InformativeDirect
Biological Process (BP)response to drug4.83e-092.406e-09Highly InformativeDirect
Biological Process (BP)regulation of circadian rhythm8.881e-137.047e-10Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus0.00010914.623e-05Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process1.059e-073.988e-10Highly InformativeDirect
Biological Process (BP)negative regulation of carbohydrate metabolic process1.528e-071.143e-09Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport00Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion2.022e-073.737e-07Highly InformativeDirect
Biological Process (BP)developmental growth2.784e-106.653e-10Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation1.431e-120Highly InformativeDirect
Biological Process (BP)response to axon injury1.348e-110Highly InformativeDirect
Biological Process (BP)regulation of behavior0.00053270.0007374Highly InformativeDirect
Biological Process (BP)negative regulation of lipid biosynthetic process5.052e-057.337e-09Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.0001021.03e-05Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process1.905e-103.332e-12Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement1.18e-130Highly InformativeDirect
Biological Process (BP)regulation of protein kinase B signaling cascade5.722e-133.403e-09Highly InformativeDirect
Biological Process (BP)regulation of peptide transport8.128e-050.0002052Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus7.093e-091.865e-09Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process00Highly InformativeDirect
Biological Process (BP)cellular response to peptide1.82e-064.857e-05Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte migration00Highly InformativeDirect
Biological Process (BP)cell part morphogenesis0.0015690.02927Highly InformativeInherited
Biological Process (BP)negative regulation of secretion0.033280.06968Highly InformativeInherited
Biological Process (BP)locomotory behavior0.91860.8715Highly InformativeInherited
Molecular Function (MF)binding09.884e-11Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transporter activity2.219e-050.0001023Moderately InformativeDirect
Molecular Function (MF)isomerase activity2.41e-122.554e-13Moderately InformativeDirect
Molecular Function (MF)anion binding1.042e-060.0001078Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.039630.5107Moderately InformativeInherited
Molecular Function (MF)lipid binding00InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)carboxylic acid binding00InformativeDirect
Molecular Function (MF)receptor activity0.0030770.2745InformativeInherited
Molecular Function (MF)molecular transducer activity0.0061660.328InformativeInherited
Molecular Function (MF)kinase activity0.010980.2972InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0013120.1906InformativeInherited
Molecular Function (MF)lipid transporter activity4.819e-141.562e-15Highly InformativeDirect
Molecular Function (MF)steroid binding2.62e-150Highly InformativeDirect
Molecular Function (MF)odorant binding1.909e-130Highly InformativeDirect
Molecular Function (MF)isoprenoid binding1.213e-060Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding00Highly InformativeDirect
Molecular Function (MF)alcohol binding00Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.00011750.04597Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.00043960.00224Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.013010.3903Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum00Moderately InformativeDirect
Cellular Component (CC)cytosol1.118e-062.058e-08Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex1.049e-068.325e-07Moderately InformativeDirect
Cellular Component (CC)cell projection1.611e-082.61e-05Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)vesicle0.0094350.001186Moderately InformativeInherited
Cellular Component (CC)extracellular space3.133e-100InformativeDirect
Cellular Component (CC)cytosolic ribosome6.917e-140InformativeDirect
Cellular Component (CC)neuron projection8.765e-050.0006534InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle6.362e-054.197e-07InformativeDirect
Cellular Component (CC)dendrite01.122e-13Highly InformativeDirect
Cellular Component (CC)cell body00Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm1.355e-125.177e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 2.097e-06 Least Informative Direct
Biological Process (BP) developmental process 0.0008431 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.33e-06 Least Informative Direct
Biological Process (BP) biosynthetic process 0.9262 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.07991 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4768 Least Informative Inherited
Biological Process (BP) localization 0.5966 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1.682e-07 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 5.667e-07 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 3.459e-14 Moderately Informative Direct
Biological Process (BP) regulation of localization 4.943e-08 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001418 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 7.184e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 9.639e-06 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 6.081e-08 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.8821 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01707 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.004946 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.02272 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01024 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001095 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.05589 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7996 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.9273 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8234 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.5258 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9747 Moderately Informative Inherited
Biological Process (BP) organ development 0.01628 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01417 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02305 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.008295 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 1.109e-08 Informative Direct
Biological Process (BP) negative regulation of immune system process 3.296e-14 Informative Direct
Biological Process (BP) response to oxidative stress 5.594e-15 Informative Direct
Biological Process (BP) mitochondrion organization 3.194e-05 Informative Direct
Biological Process (BP) central nervous system development 3.872e-09 Informative Direct
Biological Process (BP) response to wounding 1.024e-09 Informative Direct
Biological Process (BP) response to hormone stimulus 1.669e-05 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0005788 Informative Direct
Biological Process (BP) negative regulation of cell communication 6.703e-06 Informative Direct
Biological Process (BP) regulation of hormone levels 4.175e-05 Informative Direct
Biological Process (BP) lipid localization 8.636e-14 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 8.45e-06 Informative Direct
Biological Process (BP) cell projection organization 5.485e-05 Informative Direct
Biological Process (BP) regulation of defense response 3.902e-06 Informative Direct
Biological Process (BP) regulation of response to external stimulus 3.086e-10 Informative Direct
Biological Process (BP) regulation of intracellular transport 1.612e-05 Informative Direct
Biological Process (BP) regulation of protein localization 1.796e-06 Informative Direct
Biological Process (BP) response to lipid 1.405e-07 Informative Direct
Biological Process (BP) growth 5.925e-06 Informative Direct
Biological Process (BP) regulation of locomotion 9.079e-09 Informative Direct
Biological Process (BP) regulation of cell proliferation 4.935e-09 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.661e-09 Informative Direct
Biological Process (BP) single-organism behavior 2.192e-13 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001411 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 5.584e-09 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 4.824e-10 Informative Direct
Biological Process (BP) regulation of cellular component movement 4.901e-10 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 6.379e-06 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0003853 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.9832 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.668 Informative Inherited
Biological Process (BP) regulation of secretion 0.6839 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.4165 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.5719 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.003448 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.001613 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.002781 Informative Inherited
Biological Process (BP) generation of neurons 0.5929 Informative Inherited
Biological Process (BP) anion transport 0.0558 Informative Inherited
Biological Process (BP) organic acid transport 0.002148 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.003209 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9946 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.656 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.001509 Informative Inherited
Biological Process (BP) response to light stimulus 0.01142 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.003107 Informative Inherited
Biological Process (BP) retinoid metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 5.418e-11 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001076 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) circadian rhythm 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 6.563e-12 Highly Informative Direct
Biological Process (BP) aerobic respiration 2.223e-10 Highly Informative Direct
Biological Process (BP) detection of light stimulus 7.922e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 6.272e-10 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1.858e-08 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 1.034e-10 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 2.044e-05 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 3.487e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 1.162e-13 Highly Informative Direct
Biological Process (BP) neuron projection development 6.957e-07 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 1.659e-09 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 3.749e-07 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 7.794e-06 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 5.472e-09 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 2.308e-11 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) wound healing 0.0006681 Highly Informative Direct
Biological Process (BP) response to drug 2.406e-09 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 7.047e-10 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 4.623e-05 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 3.988e-10 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 1.143e-09 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 3.737e-07 Highly Informative Direct
Biological Process (BP) developmental growth 6.653e-10 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0007374 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 7.337e-09 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 1.03e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 3.332e-12 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 3.403e-09 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0002052 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 1.865e-09 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 4.857e-05 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte migration 0 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.02927 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.06968 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.8715 Highly Informative Inherited
Molecular Function (MF) binding 9.884e-11 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0001023 Moderately Informative Direct
Molecular Function (MF) isomerase activity 2.554e-13 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001078 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.5796 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.5107 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 9.359e-07 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0003506 Informative Direct
Molecular Function (MF) protein dimerization activity 0.001293 Informative Inherited
Molecular Function (MF) receptor activity 0.2745 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.328 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.002072 Informative Inherited
Molecular Function (MF) kinase activity 0.2972 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1906 Informative Inherited
Molecular Function (MF) lipid transporter activity 1.562e-15 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 4.241e-09 Highly Informative Direct
Molecular Function (MF) protein complex binding 2.258e-06 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0002196 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.04597 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00224 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3903 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) cytosol 2.058e-08 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 8.325e-07 Moderately Informative Direct
Cellular Component (CC) cell projection 2.61e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.001186 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cytosolic ribosome 0 Informative Direct
Cellular Component (CC) neuron projection 0.0006534 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 4.197e-07 Informative Direct
Cellular Component (CC) dendrite 1.122e-13 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 5.177e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases4.383e-14Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.2413Least InformativeInherited
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level4.287e-07Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.06147Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant1.309e-07InformativeDirect
Worm Phenotype (WP)fat content increased1.068e-11Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.4472Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.834Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.4811Moderately InformativeInherited
Xenopus ANatomical entity (XAN)foregut0.0006087Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01599Least InformativeInherited
Enzyme Commission (EC)Isomerases5.393e-13Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors3.526e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.5087Moderately InformativeInherited
Biological processSensory transduction1.34e-07InformativeDirect
Biological processInnate immunity1.054e-06InformativeDirect
Biological processFatty acid metabolism3.567e-05InformativeDirect
Biological processLipid biosynthesis0.01621InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processAcute phase4.711e-16Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum1.654e-05Moderately InformativeDirect
Cellular componentGolgi apparatus7.669e-05Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionLipid-binding0InformativeDirect
Molecular functionChromophore3.888e-08InformativeDirect
Molecular functionZinc transport2.856e-09Highly InformativeDirect
Post-translational modificationProtease inhibitor3.945e-06InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationAcetylation0.0002906Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011038 SSF50814 Protein matches
Abstract

Calycins form a large protein superfamily that share similar beta-barrel structures. Calycins can be divided into families that include lipocalins, fatty acid binding proteins, triabin, and thrombin inhibitor [PubMed11058743]. Of these families, the lipocalin family is the largest and functionally the most diverse. Lipocalins are extracellular proteins that share several common recognition properties such as ligand binding, receptor binding and the formation of complexes with other macromolecules. Lipocalins include the retinol binding protein, lipocalin allergen, aphrodisin (a sex hormone), alpha-2U-globulin, prostaglandin D synthase, beta-lactoglobulin, bilin-binding protein, and the nitrophorins [PubMed12432930, PubMed11058763, PubMed11058769, PubMed11058756].

This entry represents calycin as well as some other proteins that share a similar calycin beta-barrel structure, including two bacterial hypothetical proteins YodA from Escherichia coli and YwiB from bacillus subtilis. Part of the YodA hypothetical protein has a calycin-like structure [PubMed12909634].

Please be aware that some of the protein hits may be false positives.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 69 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipocalins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 69 hidden Markov models representing the Lipocalins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]