SUPERFAMILY 1.75 HMM library and genome assignments server


PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (904) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 69,534 80,177 146
Proteins 62,090 71,522 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.00000038270Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.000018340Least InformativeDirect
Biological Process (BP)developmental process0.000028880Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00031450Least InformativeDirect
Biological Process (BP)response to stimulus0.018480Least InformativeInherited
Biological Process (BP)localization0.1320Least InformativeInherited
Biological Process (BP)regulation of cellular process0.014510.0000004893Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.77821Least InformativeInherited
Biological Process (BP)protein metabolic process0.42281Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.5791Least InformativeInherited
Biological Process (BP)macromolecule localization0.00023320.0001322Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00062790.000001698Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00073120Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.61240.7906Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00067580.5871Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.79560.8496Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.13480Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.090030.0718Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.1180.1024Moderately InformativeInherited
Biological Process (BP)response to organic substance0.34660.002162Moderately InformativeInherited
Biological Process (BP)cellular localization0.0075330.000000000000007281Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.93390.005419Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0012430Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0000051581Moderately InformativeInherited
Biological Process (BP)system process0.058360.00008081Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.11310.000557Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.50161Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.49360Moderately InformativeInherited
Biological Process (BP)organelle organization0.54090.00000002737Moderately InformativeInherited
Biological Process (BP)regulation of localization0.018190.00003483Moderately InformativeInherited
Biological Process (BP)nervous system development0.0220.00000009865Moderately InformativeInherited
Biological Process (BP)signal transduction0.060140Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.042650.01114Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.052950.00000000000001253Moderately InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.000024250.0000002064InformativeDirect
Biological Process (BP)cell projection organization0.00010190InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process0.00032120InformativeDirect
Biological Process (BP)cellular membrane organization0.00033690.00001346InformativeDirect
Biological Process (BP)response to organonitrogen compound0.00047140.0000001373InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00049260InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.00093260.0007278InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.0029380.01203InformativeInherited
Biological Process (BP)response to hormone stimulus0.0023350.1733InformativeInherited
Biological Process (BP)regulation of organelle organization0.13960.0000000000003826InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.01810InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.16820InformativeInherited
Biological Process (BP)transmission of nerve impulse0.0010880.00000000999InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.034080InformativeInherited
Biological Process (BP)positive regulation of developmental process0.063670.4696InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.1540InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.033020.00000000000003424InformativeInherited
Biological Process (BP)actin filament-based process0.0092770InformativeInherited
Biological Process (BP)cytoskeleton organization0.021960InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0026190InformativeInherited
Biological Process (BP)phosphorylation0.002340.02981InformativeInherited
Biological Process (BP)stem cell proliferation0.0000000250.00007425Highly InformativeDirect
Biological Process (BP)neural precursor cell proliferation0.00000002910.00001222Highly InformativeDirect
Biological Process (BP)cellular response to peptide0.00000051060Highly InformativeDirect
Biological Process (BP)positive regulation of Ras GTPase activity0.0000006480.000000006119Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus0.0000013430.0001842Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.0000013530.00000000002097Highly InformativeDirect
Biological Process (BP)cell junction organization0.0000016370.000000001061Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus0.0000060340Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization0.000017530.00001544Highly InformativeDirect
Biological Process (BP)protein phosphorylation0.000057570Highly InformativeDirect
Biological Process (BP)plasma membrane organization0.00010350.0000671Highly InformativeDirect
Biological Process (BP)regulation of glucose import0.000000012920.01035Highly InformativeInherited
Biological Process (BP)glial cell differentiation0.000061170.7035Highly InformativeInherited
Biological Process (BP)regulation of membrane potential0.000087251Highly InformativeInherited
Biological Process (BP)regulation of protein complex assembly0.00043630.001674Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.0093780.05089Highly InformativeInherited
Biological Process (BP)regulation of organ morphogenesis0.000089151Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation0.00014481Highly InformativeInherited
Molecular Function (MF)binding0.00023530Least InformativeDirect
Molecular Function (MF)anion binding0.017240Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0052740.000000003698Moderately InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.00035790.000000000003319InformativeDirect
Molecular Function (MF)lipid binding0.0033790InformativeInherited
Molecular Function (MF)kinase activity0.0017870.00000000000003172InformativeInherited
Molecular Function (MF)phosphatidylinositol binding0.0000000057470.000000000096Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.000063390.0000000005244Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.47651Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0027140Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.73360.00001567Least InformativeInherited
Cellular Component (CC)membrane0.021390Least InformativeInherited
Cellular Component (CC)cell projection0.00013570Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.0052210Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.0054230Moderately InformativeInherited
Cellular Component (CC)cell cortex0.0000041280InformativeDirect
Cellular Component (CC)cell leading edge0.000013370InformativeDirect
Cellular Component (CC)actin cytoskeleton0.2060.0000000000001531InformativeInherited
Cellular Component (CC)cortical cytoskeleton0.000019740.00000000002129Highly InformativeDirect
Cellular Component (CC)apical plasma membrane0.0000510.0000000001273Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane0.00008630.000000000266Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000004893 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.0001322 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.000001698 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000000000007281 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00003483 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00000009865 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00000000000001253 Moderately Informative Direct
Biological Process (BP) system process 0.00008081 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000008564 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000557 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000002737 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) immune system process 0.00000001181 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7906 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8496 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.01964 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.06631 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.2935 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.002162 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0718 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1024 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.005419 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5871 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.235 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01114 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.0000002064 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) cellular membrane organization 0.00001346 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0000001373 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0007278 Informative Direct
Biological Process (BP) transmission of nerve impulse 0.00000000999 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00004816 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000000003424 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000000001005 Informative Direct
Biological Process (BP) positive regulation of transport 0.000007741 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000000000003826 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) cellular component movement 0.00000000000003424 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000000000007918 Informative Direct
Biological Process (BP) regulation of cell development 0.0000000000001259 Informative Direct
Biological Process (BP) localization of cell 0.000000000006922 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0000000004635 Informative Direct
Biological Process (BP) biological adhesion 0.0000001551 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000005402 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000009634 Informative Direct
Biological Process (BP) response to wounding 0.00009488 Informative Direct
Biological Process (BP) dephosphorylation 0.0001691 Informative Direct
Biological Process (BP) generation of neurons 0.0004035 Informative Direct
Biological Process (BP) protein transport 0.0005904 Informative Direct
Biological Process (BP) regulation of ion transport 0.8092 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.1983 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.01203 Informative Inherited
Biological Process (BP) programmed cell death 0.06813 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.7539 Informative Inherited
Biological Process (BP) organ morphogenesis 0.6028 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4025 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.001431 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.01835 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1733 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.5216 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.7924 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.6494 Informative Inherited
Biological Process (BP) cell-cell signaling 0.4066 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.9023 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.9444 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.347 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.8938 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4343 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6434 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1209 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2431 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9809 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.001886 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) growth 0.02884 Informative Inherited
Biological Process (BP) response to nutrient levels 0.08523 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.0764 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) defense response 0.08781 Informative Inherited
Biological Process (BP) immune response 0.6166 Informative Inherited
Biological Process (BP) immune effector process 0.1831 Informative Inherited
Biological Process (BP) secondary metabolic process 0.9922 Informative Inherited
Biological Process (BP) lipid localization 0.9542 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4696 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.04683 Informative Inherited
Biological Process (BP) central nervous system development 0.7362 Informative Inherited
Biological Process (BP) phosphorylation 0.02981 Informative Inherited
Biological Process (BP) organelle localization 0.006049 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) secretion by cell 0.03694 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.3964 Informative Inherited
Biological Process (BP) regulation of system process 0.7956 Informative Inherited
Biological Process (BP) regulation of growth 0.03185 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.08249 Informative Inherited
Biological Process (BP) muscle structure development 0.9798 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.06558 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3971 Informative Inherited
Biological Process (BP) epithelium development 0.7169 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.008463 Informative Inherited
Biological Process (BP) sexual reproduction 0.02757 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6286 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.08333 Informative Inherited
Biological Process (BP) pigment metabolic process 0.07059 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) leukocyte activation 0.8518 Informative Inherited
Biological Process (BP) stem cell proliferation 0.00007425 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.00001222 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 0.000000006119 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.0001842 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000000002097 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000000001061 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.00001544 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.0000671 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0000007196 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0000001918 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0001479 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00000007452 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000000000000001922 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000000000009139 Highly Informative Direct
Biological Process (BP) hemostasis 0.000000000003648 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0.00000000000634 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000006663 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.0000000003035 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000004258 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00000001165 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000001713 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0.00000003594 Highly Informative Direct
Biological Process (BP) wound healing 0.0000005603 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.000002256 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.000003599 Highly Informative Direct
Biological Process (BP) coagulation 0.00001096 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.00001937 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0.00002594 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.00002653 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00003261 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.00004331 Highly Informative Direct
Biological Process (BP) response to ethanol 0.00004363 Highly Informative Direct
Biological Process (BP) cell division 0.00009596 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0001094 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0002193 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0002446 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0003302 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0003896 Highly Informative Direct
Biological Process (BP) adult behavior 0.0005366 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0008121 Highly Informative Direct
Biological Process (BP) innate immune response 0.0009478 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.01035 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.1459 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.9141 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1642 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.9204 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.04096 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.1494 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.1236 Highly Informative Inherited
Biological Process (BP) cell growth 0.7171 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.00452 Highly Informative Inherited
Biological Process (BP) placenta development 0.8987 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.6082 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.03524 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.001674 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) tissue homeostasis 0.01171 Highly Informative Inherited
Biological Process (BP) hair follicle development 0.5414 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.006729 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02898 Highly Informative Inherited
Biological Process (BP) lipid modification 0.009618 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.3752 Highly Informative Inherited
Biological Process (BP) circadian rhythm 1 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.455 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.001643 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9578 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.5324 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.8628 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.2155 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.9716 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.7035 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.05089 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.2158 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.00381 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.003156 Highly Informative Inherited
Biological Process (BP) exocytosis 0.01339 Highly Informative Inherited
Biological Process (BP) signal release 0.3015 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.4516 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.03022 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3098 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0632 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.9322 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.9177 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.194 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) axon development 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.009134 Highly Informative Inherited
Biological Process (BP) fertilization 0.09461 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.05033 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.004294 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.001766 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) nuclear import 0.01259 Highly Informative Inherited
Biological Process (BP) protein import 0.2067 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) mitosis 0.9038 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.07762 Highly Informative Inherited
Biological Process (BP) B cell activation 0.6652 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.3146 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.2662 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.733 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) cellular membrane fusion 1 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.03541 Highly Informative Inherited
Biological Process (BP) autophagy 0.1324 Highly Informative Inherited
Biological Process (BP) organelle fusion 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000003698 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.00000000000005658 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000000003319 Informative Direct
Molecular Function (MF) kinase activity 0.00000000000003172 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000000005059 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.0006521 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) amide binding 1 Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.000000000096 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0000000005244 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0.00000000000001332 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00000000007296 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0000006133 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00000185 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.000005591 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.0000229 Highly Informative Direct
Molecular Function (MF) steroid binding 0.00006981 Highly Informative Direct
Molecular Function (MF) actin binding 0.0001056 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.03515 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.9658 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.1249 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001567 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytosol 0.000000001615 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000000000006168 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) endosome 0.000000005113 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000000001531 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.0006333 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.6078 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.04722 Informative Inherited
Cellular Component (CC) vacuolar part 0.2991 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.00000000002129 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0000000001273 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 0.000000000266 Highly Informative Direct
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000000000009197 Highly Informative Direct
Cellular Component (CC) cell body 0.0000000000005054 Highly Informative Direct
Cellular Component (CC) internal side of plasma membrane 0.000000008135 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.0000001986 Highly Informative Direct
Cellular Component (CC) coated pit 0.000000766 Highly Informative Direct
Cellular Component (CC) contractile ring 0.00001276 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.00002771 Highly Informative Direct
Cellular Component (CC) leading edge membrane 0.00002785 Highly Informative Direct
Cellular Component (CC) actin filament 0.00009839 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.0002377 Highly Informative Direct
Cellular Component (CC) pore complex 0.0005211 Highly Informative Direct
Cellular Component (CC) cilium part 0.02256 Highly Informative Inherited
Cellular Component (CC) microvillus 0.01079 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.9322 Highly Informative Inherited
Cellular Component (CC) centrosome 1 Highly Informative Inherited
Cellular Component (CC) spindle 1 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.2548 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0.001261 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.5686 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.7628 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.09242 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.7691 Highly Informative Inherited
Cellular Component (CC) Golgi membrane 1 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.2572 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.9053 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) apical junction complex 0.1042 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.03478 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000004532InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0.00000000000001873Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.000003652Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)musculoskeletal system disease1Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.8094InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.9173Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.7983Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.7166InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.06933Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.06078Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.8647Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1457Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.7724Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.002003InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.4506InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology0.000008691Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell development0.0001664Highly InformativeDirect
Mammalian Phenotype (MP)ectopic cortical neuron0.0009597Highly InformativeDirect
Mammalian Phenotype (MP)abnormal placenta labyrinth morphology0.6486Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.8751Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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