SUPERFAMILY 1.75 HMM library and genome assignments server


PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (913) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 73,136 80,177 146
Proteins 65,156 71,522 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00025330Least InformativeDirect
Biological Process (BP)developmental process2.31e-050Least InformativeDirect
Biological Process (BP)single-organism cellular process2.666e-070Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis1.639e-050Least InformativeDirect
Biological Process (BP)response to stimulus0.016170Least InformativeInherited
Biological Process (BP)localization0.11890Least InformativeInherited
Biological Process (BP)regulation of cellular process0.012028.705e-08Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.76261Least InformativeInherited
Biological Process (BP)protein metabolic process0.40521Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.56131Least InformativeInherited
Biological Process (BP)macromolecule localization0.00023570.000204Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00064490Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.60470.7454Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00066790.6725Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.79380.919Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.13660Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.089040.08357Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.12550.115Moderately InformativeInherited
Biological Process (BP)response to organic substance0.35590.002648Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.48120Moderately InformativeInherited
Biological Process (BP)cellular localization0.0075171.091e-14Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.92940.005919Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0012160Moderately InformativeInherited
Biological Process (BP)cell differentiation5.142e-061Moderately InformativeInherited
Biological Process (BP)system process0.058050.0001434Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.10580.0004992Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.49171Moderately InformativeInherited
Biological Process (BP)organelle organization0.54126.232e-08Moderately InformativeInherited
Biological Process (BP)regulation of localization0.017561.95e-05Moderately InformativeInherited
Biological Process (BP)nervous system development0.02161.47e-07Moderately InformativeInherited
Biological Process (BP)signal transduction0.060090Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.03860.0104Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.049231.439e-14Moderately InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process0.00032640InformativeDirect
Biological Process (BP)response to organonitrogen compound0.00043521.841e-07InformativeDirect
Biological Process (BP)cellular membrane organization0.00036842.052e-05InformativeDirect
Biological Process (BP)cell projection organization0.00010690InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus0.00087910.000133InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00046070InformativeDirect
Biological Process (BP)cellular response to nitrogen compound2.324e-053.44e-07InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.0028090.01593InformativeInherited
Biological Process (BP)response to hormone stimulus0.0025550.2721InformativeInherited
Biological Process (BP)regulation of organelle organization0.14191.087e-13InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.032090InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.017950InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.16930InformativeInherited
Biological Process (BP)positive regulation of developmental process0.059940.3729InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.15170InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.0323.77e-15InformativeInherited
Biological Process (BP)cytoskeleton organization0.02190InformativeInherited
Biological Process (BP)actin filament-based process0.0094260InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0027130InformativeInherited
Biological Process (BP)phosphorylation0.0023160.03285InformativeInherited
Biological Process (BP)protein phosphorylation5.095e-050Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway1.239e-061.922e-12Highly InformativeDirect
Biological Process (BP)positive regulation of Ras GTPase activity6.474e-073.393e-09Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization1.691e-051.365e-05Highly InformativeDirect
Biological Process (BP)cell junction organization1.585e-064.41e-10Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.00041880.0006155Highly InformativeDirect
Biological Process (BP)response to peptide hormone stimulus5.528e-060Highly InformativeDirect
Biological Process (BP)neural precursor cell proliferation2.709e-081.172e-05Highly InformativeDirect
Biological Process (BP)stem cell proliferation2.329e-087.124e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular response to insulin stimulus1.295e-060.00018Highly InformativeDirect
Biological Process (BP)cellular response to peptide4.691e-070Highly InformativeDirect
Biological Process (BP)regulation of glucose import1.198e-080.01075Highly InformativeInherited
Biological Process (BP)glial cell differentiation5.594e-050.8188Highly InformativeInherited
Biological Process (BP)regulation of membrane potential8.671e-051Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell differentiation0.00014211Highly InformativeInherited
Biological Process (BP)regulation of organ morphogenesis8.948e-051Highly InformativeInherited
Molecular Function (MF)binding0.00017270Least InformativeDirect
Molecular Function (MF)transferase activity0.37940.9711Least InformativeInherited
Molecular Function (MF)anion binding0.016660Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0049455.866e-09Moderately InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.00033023.308e-12InformativeDirect
Molecular Function (MF)lipid binding0.0033520InformativeInherited
Molecular Function (MF)kinase activity0.0016755.551e-14InformativeInherited
Molecular Function (MF)protein kinase activity5.756e-055.667e-10Highly InformativeDirect
Molecular Function (MF)phosphatidylinositol binding5.818e-099.201e-11Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.47411Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0027270Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.74853.128e-05Least InformativeInherited
Cellular Component (CC)membrane0.03080Least InformativeInherited
Cellular Component (CC)cell projection0.00012020Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.0052810Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.009690Moderately InformativeInherited
Cellular Component (CC)cell cortex3.382e-060InformativeDirect
Cellular Component (CC)cell leading edge1.185e-050InformativeDirect
Cellular Component (CC)actin cytoskeleton0.20481.071e-13InformativeInherited
Cellular Component (CC)apical plasma membrane5.062e-058.591e-11Highly InformativeDirect
Cellular Component (CC)extrinsic to plasma membrane8.579e-052.39e-10Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton1.905e-051.737e-11Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 8.705e-08 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 1.793e-08 Moderately Informative Direct
Biological Process (BP) system process 0.0001434 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 1.439e-14 Moderately Informative Direct
Biological Process (BP) organelle organization 6.232e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 1.47e-07 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.447e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.95e-05 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000204 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0004992 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cellular localization 1.091e-14 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7454 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.919 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.3783 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.02158 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.07683 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3142 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.002648 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.08357 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.115 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.005919 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6725 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2652 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.0104 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 5.567e-10 Informative Direct
Biological Process (BP) cellular component movement 2.462e-14 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) synaptic transmission 1.078e-05 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) response to wounding 0.0001248 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.841e-07 Informative Direct
Biological Process (BP) protein transport 0.0005767 Informative Direct
Biological Process (BP) cellular membrane organization 2.052e-05 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) dephosphorylation 0.0001348 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) biological adhesion 8.81e-08 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.748e-05 Informative Direct
Biological Process (BP) regulation of organelle organization 1.087e-13 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 2.437e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 1.459e-13 Informative Direct
Biological Process (BP) generation of neurons 0.0002261 Informative Direct
Biological Process (BP) positive regulation of transport 9.76e-06 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 7.632e-08 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 6.546e-12 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0 Informative Direct
Biological Process (BP) localization of cell 4.43e-12 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) regulation of cell development 7.537e-14 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.000133 Informative Direct
Biological Process (BP) regulation of anatomical structure size 3.77e-15 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 3.44e-07 Informative Direct
Biological Process (BP) regulation of ion transport 0.7829 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.23 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.01593 Informative Inherited
Biological Process (BP) apoptotic process 0.02325 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.7987 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5496 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4408 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 1 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.01813 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.2721 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.5232 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6913 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.6904 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.9636 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.922 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.3326 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.9163 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4544 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6743 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2768 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1366 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.01269 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.9774 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.002188 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) growth 0.1882 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.07307 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) defense response 0.1007 Informative Inherited
Biological Process (BP) immune response 0.6554 Informative Inherited
Biological Process (BP) immune effector process 0.192 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) lipid localization 0.9435 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3729 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.04526 Informative Inherited
Biological Process (BP) central nervous system development 0.697 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.4113 Informative Inherited
Biological Process (BP) phosphorylation 0.03285 Informative Inherited
Biological Process (BP) organelle localization 0.006762 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) secretion by cell 0.03933 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.3729 Informative Inherited
Biological Process (BP) regulation of system process 0.7891 Informative Inherited
Biological Process (BP) regulation of growth 0.03382 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.09414 Informative Inherited
Biological Process (BP) muscle structure development 0.9421 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.07128 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4495 Informative Inherited
Biological Process (BP) epithelium development 0.7098 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.006539 Informative Inherited
Biological Process (BP) sexual reproduction 0.0227 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5922 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.08551 Informative Inherited
Biological Process (BP) pigment metabolic process 0.07683 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) leukocyte activation 0.7948 Informative Inherited
Biological Process (BP) response to nutrient levels 0.08688 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 1.966e-10 Highly Informative Direct
Biological Process (BP) phagocytosis 2.029e-08 Highly Informative Direct
Biological Process (BP) chemotaxis 8.591e-13 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000176 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 1.362e-10 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.922e-12 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) hemostasis 6.176e-12 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 9.137e-08 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000437 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0002034 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 2.616e-06 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 1.105e-06 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 2.8e-11 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0009244 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.752e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 5.298e-09 Highly Informative Direct
Biological Process (BP) adult behavior 0.0005491 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 3.393e-09 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1.365e-05 Highly Informative Direct
Biological Process (BP) cell junction organization 4.41e-10 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0002469 Highly Informative Direct
Biological Process (BP) wound healing 6.192e-07 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 2.524e-07 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 8.214e-07 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0006155 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0001164 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0003089 Highly Informative Direct
Biological Process (BP) positive regulation of growth 1.342e-06 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 1.76e-08 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 5.062e-05 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 2.414e-05 Highly Informative Direct
Biological Process (BP) coagulation 1.508e-05 Highly Informative Direct
Biological Process (BP) leukocyte migration 2.235e-05 Highly Informative Direct
Biological Process (BP) maintenance of location 7.162e-05 Highly Informative Direct
Biological Process (BP) cell division 0.0001234 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 1.172e-05 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) stem cell proliferation 7.124e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.00018 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 4.335e-10 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 4.295e-05 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.01075 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.154 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.9347 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.8516 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1192 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.04788 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.1661 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.1109 Highly Informative Inherited
Biological Process (BP) cell growth 0.7229 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 1 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.004821 Highly Informative Inherited
Biological Process (BP) placenta development 0.9004 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.6359 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.03839 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.002421 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) hair follicle development 0.5465 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.01133 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.0166 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) lipid modification 0.009355 Highly Informative Inherited
Biological Process (BP) circadian rhythm 1 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.4306 Highly Informative Inherited
Biological Process (BP) regulation of behavior 1 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.4571 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.001748 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9721 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.6092 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.5367 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.8987 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.244 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.9779 Highly Informative Inherited
Biological Process (BP) innate immune response 0.001001 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.8188 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.1269 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.4581 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.003209 Highly Informative Inherited
Biological Process (BP) exocytosis 0.01412 Highly Informative Inherited
Biological Process (BP) signal release 0.3011 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.02676 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2497 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.06374 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.9416 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.9269 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.1883 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) axon development 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.008835 Highly Informative Inherited
Biological Process (BP) fertilization 0.1015 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.04339 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.003239 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.001763 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein import 0.2029 Highly Informative Inherited
Biological Process (BP) nuclear import 0.01224 Highly Informative Inherited
Biological Process (BP) meiosis 1 Highly Informative Inherited
Biological Process (BP) mitosis 0.9845 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 1 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.07529 Highly Informative Inherited
Biological Process (BP) B cell activation 0.7272 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.299 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.2374 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.8331 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) membrane fusion 1 Highly Informative Inherited
Biological Process (BP) autophagy 0.1621 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.03927 Highly Informative Inherited
Biological Process (BP) organelle fusion 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.9711 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 5.866e-09 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1.02e-13 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.0006768 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) kinase activity 5.551e-14 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 3.308e-12 Informative Direct
Molecular Function (MF) enzyme binding 1.086e-12 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) amide binding 1 Informative Inherited
Molecular Function (MF) actin binding 6.389e-05 Highly Informative Direct
Molecular Function (MF) protein kinase activity 5.667e-10 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 7.109e-06 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 2.523e-05 Highly Informative Direct
Molecular Function (MF) steroid binding 6.426e-05 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 5.938e-07 Highly Informative Direct
Molecular Function (MF) lipase activity 1.409e-14 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) protein complex binding 2.602e-06 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 9.201e-11 Highly Informative Direct
Molecular Function (MF) alcohol binding 7.956e-11 Highly Informative Direct
Molecular Function (MF) carbohydrate derivative transporter activity 0.03474 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.9623 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.1272 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 3.128e-05 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 1.095e-08 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 1.485e-12 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) endosome 5.406e-09 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 1.071e-13 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.0005246 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.5884 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.03305 Informative Inherited
Cellular Component (CC) vacuolar part 0.2943 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 8.591e-11 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 2.39e-10 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 9.864e-06 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0.0002809 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 1.737e-11 Highly Informative Direct
Cellular Component (CC) cell projection membrane 5.254e-05 Highly Informative Direct
Cellular Component (CC) cell division site part 0 Highly Informative Direct
Cellular Component (CC) cell body 3.149e-13 Highly Informative Direct
Cellular Component (CC) pore complex 0.0001967 Highly Informative Direct
Cellular Component (CC) cilium part 0.02281 Highly Informative Inherited
Cellular Component (CC) centrosome 1 Highly Informative Inherited
Cellular Component (CC) spindle 1 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.9376 Highly Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0.2541 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.6331 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.8307 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.1044 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.8083 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.902 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.2653 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.03626 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase4.532e-08InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula1.873e-14Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C3.652e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscle tissue disease0.7838InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.9183Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.7124InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.06976Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.05624Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1697Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5018Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.8807Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1066Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1495Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5238Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.789Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)ectopic neuron0.001961InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.07565InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.4471InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology8.939e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell development0.0001659Highly InformativeDirect
Mammalian Phenotype (MP)ectopic cortical neuron0.000956Highly InformativeDirect
Mammalian Phenotype (MP)abnormal placenta labyrinth morphology0.6491Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.8786Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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