SUPERFAMILY 1.75 HMM library and genome assignments server

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Trypsin-like serine proteases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Trypsin-like serine proteases [ 50493]
Superfamily:   Trypsin-like serine proteases [ 50494] (4)
Families:   Prokaryotic proteases [ 50495] (15)
  Eukaryotic proteases [ 50514] (47)
  Viral proteases [ 50596] (4)
  Viral cysteine protease of trypsin fold [ 50603] (3)


Superfamily statistics
Genomes (3,094) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 35,715 140,817 291
Proteins 33,498 137,135 291


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0000014030.05535Least InformativeInherited
Biological Process (BP)response to stimulus0.650.0000000004374Least InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.030660.01387Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.13230.006193Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)reproduction0.0079580.2263Moderately InformativeInherited
Biological Process (BP)multi-organism process0.10580Moderately InformativeInherited
Biological Process (BP)system process0.10830.03293Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.2150.7056Moderately InformativeInherited
Biological Process (BP)immune system process0.004010.0002808Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.012250Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)defense response0.00015440InformativeDirect
Biological Process (BP)immune response0.00060060.0000004249InformativeDirect
Biological Process (BP)response to wounding0.00000035480.0002612InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.0004770.00002554InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.31InformativeInherited
Biological Process (BP)single-organism behavior0.78991InformativeInherited
Biological Process (BP)multi-multicellular organism process0.08830.000001848InformativeInherited
Biological Process (BP)multicellular organismal reproductive process10.3071InformativeInherited
Biological Process (BP)immune effector process0.15190.0000001719InformativeInherited
Biological Process (BP)positive regulation of immune system process0.37620.009605InformativeInherited
Biological Process (BP)regulation of immune response0.77880InformativeInherited
Biological Process (BP)blood circulation0.00000053590.001016InformativeInherited
Biological Process (BP)cellular component disassembly0.0000000048720.0000000000002071Highly InformativeDirect
Biological Process (BP)multicellular organismal metabolic process0.0000000010180.00001743Highly InformativeDirect
Biological Process (BP)regulation of coagulation0.000011460Highly InformativeDirect
Biological Process (BP)regulation of wound healing0.00032640.0000000006088Highly InformativeDirect
Biological Process (BP)regulation of hemostasis0.0000066810Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.0073870.4492Highly InformativeInherited
Biological Process (BP)extracellular matrix organization10.000000000004246Highly InformativeInherited
Biological Process (BP)learning or memory0.054870.09393Highly InformativeInherited
Biological Process (BP)humoral immune response0.95690.0000000002352Highly InformativeInherited
Biological Process (BP)innate immune response0.7651Highly InformativeInherited
Biological Process (BP)protein activation cascade0.035440Highly InformativeInherited
Biological Process (BP)inflammatory response0.023091Highly InformativeInherited
Biological Process (BP)regulation of blood pressure0.00000022880.05056Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.58191Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)anion binding0.85351Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000052510.01196InformativeInherited
Molecular Function (MF)sulfur compound binding0.000033550.01007InformativeInherited
Molecular Function (MF)endopeptidase activity0.00000001650Highly InformativeDirect
Molecular Function (MF)heparin binding0.0000031730.0005805Highly InformativeDirect
Molecular Function (MF)serine hydrolase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part0.0000000000000028240Moderately InformativeDirect
Cellular Component (CC)vesicle0.036410.000007436Moderately InformativeInherited
Cellular Component (CC)extracellular space0.000044280.00000000002869InformativeDirect
Cellular Component (CC)secretory granule0.000020690.0000000003503InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000004374 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.05535 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0.0002808 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00002214 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001002 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00001209 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.006193 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.6228 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8573 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.5916 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2263 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.03127 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01387 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) system process 0.03293 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.7056 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.0000001719 Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune effector process 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) immune response 0.0000004249 Informative Direct
Biological Process (BP) response to wounding 0.0002612 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0000049 Informative Direct
Biological Process (BP) negative regulation of cell communication 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of defense response 0.0003502 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00002554 Informative Direct
Biological Process (BP) regulation of intracellular transport 0 Informative Direct
Biological Process (BP) secretion by cell 0.0001755 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.000001848 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00000000007065 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.3693 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) apoptotic process 0.07241 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.308 Informative Inherited
Biological Process (BP) sensory organ development 0.6768 Informative Inherited
Biological Process (BP) metal ion transport 0.2104 Informative Inherited
Biological Process (BP) transmembrane transport 0.8585 Informative Inherited
Biological Process (BP) response to bacterium 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.1106 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.9615 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4926 Informative Inherited
Biological Process (BP) regulation of growth 0.02344 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.8433 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.7889 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1671 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1023 Informative Inherited
Biological Process (BP) regulation of cell development 0.4651 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9847 Informative Inherited
Biological Process (BP) single organism reproductive process 0.06344 Informative Inherited
Biological Process (BP) sexual reproduction 0.2547 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.7757 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3071 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.9748 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.6709 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.009605 Informative Inherited
Biological Process (BP) blood circulation 0.001016 Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 0.00006188 Highly Informative Direct
Biological Process (BP) negative regulation of immune effector process 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) exocytosis 0.00000000199 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0000000002352 Highly Informative Direct
Biological Process (BP) hemostasis 0.0000002557 Highly Informative Direct
Biological Process (BP) fertilization 0.0000001943 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000001019 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0007661 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0004825 Highly Informative Direct
Biological Process (BP) protein processing 0.0003734 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000000000002071 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000000000004246 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.0000000008396 Highly Informative Direct
Biological Process (BP) wound healing 0.00006901 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0.00001743 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.00001087 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0 Highly Informative Direct
Biological Process (BP) coagulation 0 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0 Highly Informative Direct
Biological Process (BP) interaction with host 0.000005534 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0000000006088 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.00003475 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.000002824 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.001496 Highly Informative Inherited
Biological Process (BP) ear development 0.00286 Highly Informative Inherited
Biological Process (BP) sensory perception 0.01071 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.5966 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.106 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.4492 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.01817 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.001867 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.05257 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.527 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.6266 Highly Informative Inherited
Biological Process (BP) adult behavior 0.01362 Highly Informative Inherited
Biological Process (BP) learning or memory 0.09393 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.8802 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.05056 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.01196 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.01007 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.2389 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.05763 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0.0006179 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0005805 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.00001015 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.0242 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.01678 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.01163 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000007436 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.08449 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.8088 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.524 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.00000000002869 Informative Direct
Cellular Component (CC) secretory granule 0.0000000003503 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000000002732 Informative Direct
Cellular Component (CC) vacuolar part 0.8521 Informative Inherited
Cellular Component (CC) nuclear envelope 0.002605 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.005183 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) cell envelope 0.00000007864 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0000001066 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 0.000000001817 Highly Informative Direct
Cellular Component (CC) sperm part 0.00002295 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.2689Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.000000001469Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.3112Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Flavivirin0.000000000001561InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0.0000000476InformativeDirect
Enzyme Commission (EC)Picornain 3C0.00000000000001101Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin0.000000000468Highly InformativeDirect
Enzyme Commission (EC)Togavirin0.000000008498Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.00000001621Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase0.0000000476Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.0000008542Highly InformativeDirect
Enzyme Commission (EC)Calicivirin0.00002318Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase0.0000507Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00008367Highly InformativeDirect
Enzyme Commission (EC)Plasmin0.0001015Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0001485Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.0002633Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.004128Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.9001Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9807Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.03046Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.5055Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.6954Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.8041Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.9223Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of complement system0.001924InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.04414InformativeInherited
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.1083InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.1268InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.4199InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.4904InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.5533InformativeInherited
Phenotypic Abnormality (PA)Joint hemorrhage0.000008273Highly InformativeDirect
Phenotypic Abnormality (PA)Deep venous thrombosis0.00004077Highly InformativeDirect
Phenotypic Abnormality (PA)Epistaxis0.000597Highly InformativeDirect
Phenotypic Abnormality (PA)Menorrhagia0.000838Highly InformativeDirect
Phenotypic Abnormality (PA)Nephritis0.0009376Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coagulation0.003282Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.02643Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3172Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9822Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2196Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.331Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.5834Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.000003993InformativeDirect
Mammalian Phenotype (MP)fibrosis0.002389InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.01361InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.579InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.935InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0001185Highly InformativeDirect
Mammalian Phenotype (MP)abnormal complement pathway0.0003957Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.000003341Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001136InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.002103Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1439Least InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0004777Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00000008105Least InformativeDirect
Xenopus DEvelopment stage (XDE)tadpole stage0.000001126InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.1124Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0.000000000000003103Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0.0000000000014Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0.00000005089Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.00000006581Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.9458Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0InformativeDirect
Biological processUbl conjugation pathway0.000000000000003232InformativeDirect
Biological processCytolysis0.0000000002043InformativeDirect
Biological processDNA replication0.0000001146InformativeDirect
Biological processInnate immunity0.001174InformativeInherited
Biological processAcute phase0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processComplement pathway0.000000000000512Highly InformativeDirect
Biological processInhibition of host ISG15 by virus0.000000002092Highly InformativeDirect
Biological processDecay of host mRNAs by virus0.00002943Highly InformativeDirect
Biological processComplement alternate pathway0.00003359Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCapsid protein0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentPeriplasm0.000002569InformativeDirect
Cellular componentHost cytoplasmic vesicle0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0004572Moderately InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainSignal-anchor0.000002619InformativeDirect
DomainKringle0Highly InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionRNA-binding0.0000000000002316Moderately InformativeDirect
Molecular functionViral nucleoprotein0Highly InformativeDirect
Molecular functionGrowth factor binding0.00000000003768Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationExonuclease0.0000000000003852InformativeDirect
Post-translational modificationAntimicrobial0.00000003865InformativeDirect
Post-translational modificationThiol protease0.00002691InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationViral ion channel0Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic0.0000000000001264Highly InformativeDirect
Post-translational modificationAntioxidant0.000000001263Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationMyristate0.00000000003925InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0Highly InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009003 SSF50494 Protein matches
Abstract

This signature recognises a large group of serine and cysteine peptidases (including prokaryotic, eukaryotic and viral), which share a common closed beta barrel structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 103 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Trypsin-like serine proteases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 103 hidden Markov models representing the Trypsin-like serine proteases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]