SUPERFAMILY 1.75 HMM library and genome assignments server

Trypsin-like serine proteases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Trypsin-like serine proteases [ 50493]
Superfamily:   Trypsin-like serine proteases [ 50494] (4)
Families:   Prokaryotic proteases [ 50495] (15)
  Eukaryotic proteases [ 50514] (47)
  Viral proteases [ 50596] (4)
  Viral cysteine protease of trypsin fold [ 50603] (3)


Superfamily statistics
Genomes (3,095) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 35,766 140,817 291
Proteins 33,545 137,135 291


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.04590.00000000006926Least InformativeInherited
Biological Process (BP)response to stimulus0.63910.0000000005003Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0000011080.02169Least InformativeInherited
Biological Process (BP)defense response0.00012310.0000000772Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.16930.02406Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.015240.002998Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)reproductive process0.82140.614Moderately InformativeInherited
Biological Process (BP)multi-organism process0.27070Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.085920.02068Moderately InformativeInherited
Biological Process (BP)immune system process0.0038240.0002808Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.010390Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)immune response0.00057430.0000003989InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.0011210InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.083880InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.020190.02481InformativeInherited
Biological Process (BP)regulation of response to wounding0.000028120.03338InformativeInherited
Biological Process (BP)single-organism behavior0.04420.004527InformativeInherited
Biological Process (BP)neurological system process0.9520.04791InformativeInherited
Biological Process (BP)sexual reproduction10.7892InformativeInherited
Biological Process (BP)multi-multicellular organism process0.090140.000002704InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.99270.2501InformativeInherited
Biological Process (BP)positive regulation of immune system process0.3910.006925InformativeInherited
Biological Process (BP)regulation of immune response0.76770InformativeInherited
Biological Process (BP)blood circulation0.00000061580.001026InformativeInherited
Biological Process (BP)immune effector process0.15180.0000001815InformativeInherited
Biological Process (BP)cellular component disassembly0.0000000046890.0000000000001849Highly InformativeDirect
Biological Process (BP)collagen metabolic process0.00000000055990.000005787Highly InformativeDirect
Biological Process (BP)multicellular organismal catabolic process0.000000000073430.000001896Highly InformativeDirect
Biological Process (BP)regulation of wound healing0.020770.0000000003543Highly InformativeInherited
Biological Process (BP)negative regulation of response to external stimulus0.002580Highly InformativeInherited
Biological Process (BP)negative regulation of coagulation0.0055030.000000000002296Highly InformativeInherited
Biological Process (BP)negative regulation of hemostasis0.0042040.000000000004902Highly InformativeInherited
Biological Process (BP)negative regulation of response to wounding0.00033840.006106Highly InformativeInherited
Biological Process (BP)extracellular matrix organization10.000000000003838Highly InformativeInherited
Biological Process (BP)learning or memory0.13360.3161Highly InformativeInherited
Biological Process (BP)humoral immune response0.95760.0000000002223Highly InformativeInherited
Biological Process (BP)innate immune response0.78310.00001779Highly InformativeInherited
Biological Process (BP)protein activation cascade0.030460Highly InformativeInherited
Biological Process (BP)inflammatory response0.0091750.5536Highly InformativeInherited
Biological Process (BP)regulation of blood pressure0.00000024990.05459Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.58261Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)anion binding0.85291Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.4461Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)sulfur compound binding0.000087020.01494InformativeInherited
Molecular Function (MF)endopeptidase activity0.00000001660Highly InformativeDirect
Molecular Function (MF)heparin binding0.0000031190.0005772Highly InformativeDirect
Molecular Function (MF)serine hydrolase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part0.000000000000002780Moderately InformativeDirect
Cellular Component (CC)vesicle0.035510.000009391Moderately InformativeInherited
Cellular Component (CC)extracellular space0.000046760.00000000002479InformativeDirect
Cellular Component (CC)secretory granule0.000019080.0000000003316InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.00000000006926 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000005003 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.02169 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0.0002808 Moderately Informative Direct
Biological Process (BP) defense response 0.0000000772 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0000000851 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001785 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000008331 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000000000003305 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.002998 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4451 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.6414 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02406 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.01628 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9105 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01339 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.614 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.02068 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.0000001815 Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune effector process 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) immune response 0.0000003989 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) negative regulation of cell communication 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of defense response 0.0001147 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) regulation of intracellular transport 0 Informative Direct
Biological Process (BP) secretion by cell 0.0001729 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.000002704 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00000000006245 Informative Direct
Biological Process (BP) protein maturation 0.000001599 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.7069 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.3791 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of response to wounding 0.03338 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.02481 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) apoptotic process 0.06049 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.9624 Informative Inherited
Biological Process (BP) sensory organ development 0.6744 Informative Inherited
Biological Process (BP) metal ion transport 0.208 Informative Inherited
Biological Process (BP) ion transmembrane transport 0.382 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2501 Informative Inherited
Biological Process (BP) neurological system process 0.04791 Informative Inherited
Biological Process (BP) response to bacterium 1 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.1113 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.9988 Informative Inherited
Biological Process (BP) regulation of growth 0.01881 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8854 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3032 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2996 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2467 Informative Inherited
Biological Process (BP) sexual reproduction 0.7892 Informative Inherited
Biological Process (BP) single-organism behavior 0.004527 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6516 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.004728 Informative Inherited
Biological Process (BP) blood circulation 0.001026 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.006925 Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 0.00006197 Highly Informative Direct
Biological Process (BP) negative regulation of immune effector process 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) exocytosis 0.000000002104 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0000000002223 Highly Informative Direct
Biological Process (BP) hemostasis 0.0000002507 Highly Informative Direct
Biological Process (BP) fertilization 0.0000001777 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000001054 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000000000001849 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000000000003838 Highly Informative Direct
Biological Process (BP) positive regulation of cyclic nucleotide metabolic process 0.0001424 Highly Informative Direct
Biological Process (BP) negative regulation of defense response 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0 Highly Informative Direct
Biological Process (BP) collagen metabolic process 0.000005787 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.0000000009625 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0 Highly Informative Direct
Biological Process (BP) wound healing 0.00007045 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 0.000001896 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0 Highly Informative Direct
Biological Process (BP) innate immune response 0.00001779 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.000000000001784 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.00001094 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0 Highly Informative Direct
Biological Process (BP) coagulation 0 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.000000000002296 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0000000003543 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.00003394 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.000000000004902 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0 Highly Informative Direct
Biological Process (BP) positive regulation of response to wounding 0.000004926 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.000003115 Highly Informative Direct
Biological Process (BP) ear development 0.002776 Highly Informative Inherited
Biological Process (BP) sensory perception 0.671 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.05636 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.6745 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.4497 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.107 Highly Informative Inherited
Biological Process (BP) negative regulation of response to wounding 0.006106 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.01759 Highly Informative Inherited
Biological Process (BP) zymogen activation 0.2652 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.06791 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.8086 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.009897 Highly Informative Inherited
Biological Process (BP) cell recognition 0.2723 Highly Informative Inherited
Biological Process (BP) adult behavior 0.01353 Highly Informative Inherited
Biological Process (BP) locomotory behavior 1 Highly Informative Inherited
Biological Process (BP) learning or memory 0.3161 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.009468 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.5536 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.05459 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.05752 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.01494 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.01102 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0.0006141 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0005772 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.00001007 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0185 Highly Informative Inherited
Molecular Function (MF) channel regulator activity 0.02565 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.01174 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000009391 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.08393 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.5142 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.00000000002479 Informative Direct
Cellular Component (CC) secretory granule 0.0000000003316 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000000004461 Informative Direct
Cellular Component (CC) vacuolar part 0.8262 Informative Inherited
Cellular Component (CC) nuclear envelope 0.002518 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.005039 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) cell envelope 0.00000006983 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0000001027 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 0.000000001738 Highly Informative Direct
Cellular Component (CC) acrosomal vesicle 0.04218 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.2689Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.000000001469Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.3112Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Flavivirin0.000000000001561InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0.0000000476InformativeDirect
Enzyme Commission (EC)Picornain 3C0.00000000000001101Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin0.000000000468Highly InformativeDirect
Enzyme Commission (EC)Togavirin0.000000008498Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.00000001621Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase0.0000000476Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.0000008542Highly InformativeDirect
Enzyme Commission (EC)Calicivirin0.00002318Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase0.0000507Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00008367Highly InformativeDirect
Enzyme Commission (EC)Plasmin0.0001015Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0001485Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.0002633Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.004128Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.9001Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9807Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.03046Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.5055Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.6954Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.8041Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.9223Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of complement system0.001924InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.04414InformativeInherited
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.1083InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.1268InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.4199InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.4904InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.5533InformativeInherited
Phenotypic Abnormality (PA)Joint hemorrhage0.000008273Highly InformativeDirect
Phenotypic Abnormality (PA)Deep venous thrombosis0.00004077Highly InformativeDirect
Phenotypic Abnormality (PA)Epistaxis0.000597Highly InformativeDirect
Phenotypic Abnormality (PA)Menorrhagia0.000838Highly InformativeDirect
Phenotypic Abnormality (PA)Nephritis0.0009376Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coagulation0.003282Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.02643Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3172Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9822Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2196Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.331Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.5834Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.000003993InformativeDirect
Mammalian Phenotype (MP)fibrosis0.002389InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.01361InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.579InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.935InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0001185Highly InformativeDirect
Mammalian Phenotype (MP)abnormal complement pathway0.0003957Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.000003341Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001136InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.002103Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1439Least InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0004777Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00000008105Least InformativeDirect
Xenopus DEvelopment stage (XDE)tadpole stage0.000001126InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.1124Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0.000000000000003103Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0.0000000000014Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0.00000005089Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.00000006581Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0.00000000002891Least InformativeDirect
Drugbank ATC_code (DB)cardiovascular system0.2825Least InformativeInherited
Drugbank ATC_code (DB)vasoprotectives0.01084Moderately InformativeInherited
Drugbank ATC_code (DB)antivaricose therapy0.0006893InformativeDirect
Drugbank ATC_code (DB)vitamin k and other hemostatics1InformativeInherited
Drugbank ATC_code (DB)vitamin k0.000243Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.9458Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0InformativeDirect
Biological processUbl conjugation pathway0.000000000000003232InformativeDirect
Biological processCytolysis0.0000000002043InformativeDirect
Biological processDNA replication0.0000001146InformativeDirect
Biological processInnate immunity0.001174InformativeInherited
Biological processAcute phase0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processComplement pathway0.000000000000512Highly InformativeDirect
Biological processInhibition of host ISG15 by virus0.000000002092Highly InformativeDirect
Biological processDecay of host mRNAs by virus0.00002943Highly InformativeDirect
Biological processComplement alternate pathway0.00003359Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCapsid protein0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentPeriplasm0.000002569InformativeDirect
Cellular componentHost cytoplasmic vesicle0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0004572Moderately InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainSignal-anchor0.000002619InformativeDirect
DomainKringle0Highly InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionRNA-binding0.0000000000002316Moderately InformativeDirect
Molecular functionViral nucleoprotein0Highly InformativeDirect
Molecular functionGrowth factor binding0.00000000003768Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationExonuclease0.0000000000003852InformativeDirect
Post-translational modificationAntimicrobial0.00000003865InformativeDirect
Post-translational modificationThiol protease0.00002691InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationViral ion channel0Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic0.0000000000001264Highly InformativeDirect
Post-translational modificationAntioxidant0.000000001263Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationMyristate0.00000000003925InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0Highly InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009003 SSF50494 Protein matches
Abstract

This signature recognises a large group of serine and cysteine peptidases (including prokaryotic, eukaryotic and viral), which share a common closed beta barrel structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 103 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Trypsin-like serine proteases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 103 hidden Markov models representing the Trypsin-like serine proteases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]