SUPERFAMILY 1.75 HMM library and genome assignments server


Trypsin-like serine proteases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Trypsin-like serine proteases [ 50493]
Superfamily:   Trypsin-like serine proteases [ 50494] (4)
Families:   Prokaryotic proteases [ 50495] (15)
  Eukaryotic proteases [ 50514] (47)
  Viral proteases [ 50596] (4)
  Viral cysteine protease of trypsin fold [ 50603] (3)


Superfamily statistics
Genomes (3,053) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 32,570 80,880 291
Proteins 30,921 78,015 291


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)multicellular organismal process1.91e-060.1056Least InformativeInherited
Biological Process (BP)response to stimulus0.71363.193e-08Least InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.041080.01539Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.1090.001338Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)reproduction0.0041730.3236Moderately InformativeInherited
Biological Process (BP)multi-organism process0.084390Moderately InformativeInherited
Biological Process (BP)system process0.081160.02688Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.22550.6327Moderately InformativeInherited
Biological Process (BP)immune system process0.0030830.000215Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)defense response0.00013270InformativeDirect
Biological Process (BP)immune response0.00058333.274e-07InformativeDirect
Biological Process (BP)blood circulation3.781e-070.0006866InformativeDirect
Biological Process (BP)response to wounding5.577e-077.719e-05InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00046657.952e-06InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.30141InformativeInherited
Biological Process (BP)single-organism behavior0.83931InformativeInherited
Biological Process (BP)multicellular organismal reproductive process10.4489InformativeInherited
Biological Process (BP)immune effector process0.18692.46e-06InformativeInherited
Biological Process (BP)positive regulation of immune system process0.41530.01928InformativeInherited
Biological Process (BP)regulation of immune response0.80140InformativeInherited
Biological Process (BP)cellular component disassembly8.426e-091.204e-13Highly InformativeDirect
Biological Process (BP)extracellular matrix organization1.147e-103.748e-12Highly InformativeDirect
Biological Process (BP)collagen metabolic process7.895e-104.378e-06Highly InformativeDirect
Biological Process (BP)multicellular organismal catabolic process1.037e-101.427e-06Highly InformativeDirect
Biological Process (BP)regulation of coagulation1.203e-050Highly InformativeDirect
Biological Process (BP)regulation of wound healing0.00020623.469e-11Highly InformativeDirect
Biological Process (BP)regulation of hemostasis7.006e-060Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.0077230.3613Highly InformativeInherited
Biological Process (BP)activation of immune response0.83998.037e-08Highly InformativeInherited
Biological Process (BP)humoral immune response0.97813.634e-09Highly InformativeInherited
Biological Process (BP)innate immune response0.77071Highly InformativeInherited
Biological Process (BP)protein activation cascade0.040110Highly InformativeInherited
Biological Process (BP)inflammatory response0.028041Highly InformativeInherited
Biological Process (BP)regulation of blood pressure1.382e-070.0412Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.62191Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)anion binding0.84391Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding5.372e-050.01082InformativeInherited
Molecular Function (MF)sulfur compound binding3.624e-050.008143InformativeInherited
Molecular Function (MF)endopeptidase activity3.05e-080Highly InformativeDirect
Molecular Function (MF)heparin binding3.414e-060.0004889Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part2.676e-150Moderately InformativeDirect
Cellular Component (CC)vesicle0.26080.01798Moderately InformativeInherited
Cellular Component (CC)secretory granule2.82e-052.824e-10InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 3.193e-08 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1056 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0.000215 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 3.389e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 5.123e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 9.376e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.144e-12 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001338 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9241 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.6892 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3236 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.08159 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01539 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) system process 0.02688 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.6327 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) immune effector process 2.46e-06 Informative Direct
Biological Process (BP) regulation of immune effector process 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) immune response 3.274e-07 Informative Direct
Biological Process (BP) blood circulation 0.0006866 Informative Direct
Biological Process (BP) response to wounding 7.719e-05 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 8.753e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 7.952e-06 Informative Direct
Biological Process (BP) regulation of intracellular transport 0 Informative Direct
Biological Process (BP) secretion by cell 0.0001314 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.127e-11 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) cell death 0.01129 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.3252 Informative Inherited
Biological Process (BP) sensory organ development 0.6236 Informative Inherited
Biological Process (BP) metal ion transport 0.1786 Informative Inherited
Biological Process (BP) transmembrane transport 0.7953 Informative Inherited
Biological Process (BP) regulation of defense response 0.003667 Informative Inherited
Biological Process (BP) response to bacterium 1 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.4134 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.09099 Informative Inherited
Biological Process (BP) organ morphogenesis 0.9646 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.932 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.6209 Informative Inherited
Biological Process (BP) regulation of growth 0.03284 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.5546 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.6375 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1029 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.07891 Informative Inherited
Biological Process (BP) regulation of cell development 0.3604 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9189 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1279 Informative Inherited
Biological Process (BP) sexual reproduction 0.4045 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9925 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.4489 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.9667 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.6112 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.01928 Informative Inherited
Biological Process (BP) activation of immune response 8.037e-08 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) regulation of response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) exocytosis 1.569e-09 Highly Informative Direct
Biological Process (BP) humoral immune response 3.634e-09 Highly Informative Direct
Biological Process (BP) hemostasis 2.892e-07 Highly Informative Direct
Biological Process (BP) fertilization 1.179e-07 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 4.915e-07 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0005145 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0003223 Highly Informative Direct
Biological Process (BP) protein processing 0.0007403 Highly Informative Direct
Biological Process (BP) cellular component disassembly 1.204e-13 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 3.748e-12 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) collagen metabolic process 4.378e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 9.109e-10 Highly Informative Direct
Biological Process (BP) wound healing 4.487e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 1.427e-06 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 1.625e-05 Highly Informative Direct
Biological Process (BP) coagulation 0 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0 Highly Informative Direct
Biological Process (BP) interaction with host 1.684e-05 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0 Highly Informative Direct
Biological Process (BP) regulation of wound healing 3.469e-11 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 0.0005429 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 1.996e-06 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.007241 Highly Informative Inherited
Biological Process (BP) inner ear development 0.001155 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.0675 Highly Informative Inherited
Biological Process (BP) sensory perception 0.008711 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.5203 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.04617 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.3613 Highly Informative Inherited
Biological Process (BP) interaction with symbiont 0.02398 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.01524 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.00174 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.001474 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.04609 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.4056 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.8418 Highly Informative Inherited
Biological Process (BP) adult behavior 0.06636 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.9056 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 1 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.0412 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.01082 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.008143 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.2119 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.04784 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 0.005101 Informative Inherited
Molecular Function (MF) endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0.0006185 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0004889 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 1.055e-05 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.01654 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.0132 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.06847 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.05986 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.6901 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.5534 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01798 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 9.401e-10 Informative Direct
Cellular Component (CC) secretory granule 2.824e-10 Informative Direct
Cellular Component (CC) vacuolar part 0.8423 Informative Inherited
Cellular Component (CC) nuclear envelope 0.002142 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.001438 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) cell envelope 7.522e-08 Highly Informative Direct
Cellular Component (CC) nuclear membrane 6.396e-09 Highly Informative Direct
Cellular Component (CC) periplasmic space 3.178e-12 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 2.181e-09 Highly Informative Direct
Cellular Component (CC) sperm part 1.475e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.2689Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an1.469e-09Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.3112Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Flavivirin1.561e-12InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase4.76e-08InformativeDirect
Enzyme Commission (EC)Picornain 3C1.101e-14Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin4.68e-10Highly InformativeDirect
Enzyme Commission (EC)Togavirin8.498e-09Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A1.621e-08Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase4.76e-08Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa8.542e-07Highly InformativeDirect
Enzyme Commission (EC)Calicivirin2.318e-05Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase5.07e-05Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa8.367e-05Highly InformativeDirect
Enzyme Commission (EC)Plasmin0.0001015Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0001485Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.0002633Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1889Least InformativeInherited
Disease Ontology (DO)skin disease0.003211Moderately InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.2467InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.8687Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.9806Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.009841Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.6216Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.02538InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.4643InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.5096InformativeInherited
Phenotypic Abnormality (PA)Joint hemorrhage7.022e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Deep venous thrombosis3.59e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Epistaxis4.14e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coagulation0.001264Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.04386Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.2996Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9899Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2296Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.4418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.59Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.7871Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.9478Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation4.599e-06InformativeDirect
Mammalian Phenotype (MP)abnormal uvea morphology0.01247InformativeInherited
Mammalian Phenotype (MP)pathological neovascularization0.05564InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.9137InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0001246Highly InformativeDirect
Mammalian Phenotype (MP)abnormal complement pathway0.0005808Highly InformativeDirect
Mammalian Phenotype (MP)cardiac fibrosis0.0009085Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant3.341e-06Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.136e-06InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.002039Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1434Least InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0004563Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage8.016e-08Least InformativeDirect
Xenopus DEvelopment stage (XDE)tadpole stage1.063e-06InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.1878Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C1.917e-13Highly InformativeDirect
Enzyme Commission (EC)Flavivirin1.473e-12Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase1.807e-08Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A2.022e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processHost gene expression shutoff by virus0InformativeDirect
Biological processUbl conjugation pathway2.544e-15InformativeDirect
Biological processCytolysis1.496e-10InformativeDirect
Biological processInnate immunity0.0009936InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processComplement pathway9.3e-13Highly InformativeDirect
Biological processDecay of host mRNAs by virus1.27e-12Highly InformativeDirect
Biological processInhibition of host ISG15 by virus2.096e-09Highly InformativeDirect
Biological processComplement alternate pathway4.209e-05Highly InformativeDirect
Biological processVirus endocytosis by host9.504e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCapsid protein0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentPeriplasm2.439e-06InformativeDirect
Cellular componentHost cytoplasmic vesicle0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentViral envelope protein0.0008273Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.000242Moderately InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainSignal-anchor2.467e-06InformativeDirect
DomainKringle0Highly InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionRNA-binding5.378e-12Moderately InformativeDirect
Molecular functionViral nucleoprotein0Highly InformativeDirect
Molecular functionGrowth factor binding3.76e-11Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationExonuclease2.242e-13InformativeDirect
Post-translational modificationAntimicrobial2.814e-08InformativeDirect
Post-translational modificationThiol protease0.0001486InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationViral ion channel0Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic1.076e-13Highly InformativeDirect
Post-translational modificationAntioxidant1.168e-09Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationMyristate4.74e-09InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0Highly InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009003 SSF50494 Protein matches
Abstract

This signature recognises a large group of serine and cysteine peptidases (including prokaryotic, eukaryotic and viral), which share a common closed beta barrel structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 103 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Trypsin-like serine proteases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 103 hidden Markov models representing the Trypsin-like serine proteases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]