SUPERFAMILY 1.75 HMM library and genome assignments server


Trypsin-like serine proteases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Trypsin-like serine proteases [ 50493]
Superfamily:   Trypsin-like serine proteases [ 50494] (4)
Families:   Prokaryotic proteases [ 50495] (15)
  Eukaryotic proteases [ 50514] (47)
  Viral proteases [ 50596] (4)
  Viral cysteine protease of trypsin fold [ 50603] (3)


Superfamily statistics
Genomes (3,088) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,871 0 291
Proteins 32,748 0 291


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)multicellular organismal process8.977e-070.02269Least InformativeInherited
Biological Process (BP)response to stimulus0.5576.169e-11Least InformativeInherited
Biological Process (BP)gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.029820.01134Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.09710.002811Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)reproduction0.0065890.1639Moderately InformativeInherited
Biological Process (BP)multi-organism process0.067110Moderately InformativeInherited
Biological Process (BP)system process0.10440.02013Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.21820.6694Moderately InformativeInherited
Biological Process (BP)immune system process0.0036470.0001354Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)defense response0.00010530InformativeDirect
Biological Process (BP)immune response0.00055653.301e-07InformativeDirect
Biological Process (BP)blood circulation4.801e-070.0007922InformativeDirect
Biological Process (BP)response to wounding2.992e-070.0002509InformativeDirect
Biological Process (BP)cellular component disassembly8.375e-091.99e-13InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00049661.901e-05InformativeDirect
Biological Process (BP)regulation of response to stress0.038760InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.28511InformativeInherited
Biological Process (BP)single-organism behavior0.75871InformativeInherited
Biological Process (BP)multicellular organismal reproductive process10.3119InformativeInherited
Biological Process (BP)immune effector process0.15361.981e-07InformativeInherited
Biological Process (BP)positive regulation of immune system process0.40870.01136InformativeInherited
Biological Process (BP)regulation of immune response0.78020InformativeInherited
Biological Process (BP)extracellular matrix organization7.752e-112.863e-12Highly InformativeDirect
Biological Process (BP)multicellular organismal metabolic process9.791e-101.531e-05Highly InformativeDirect
Biological Process (BP)regulation of coagulation1.35e-050Highly InformativeDirect
Biological Process (BP)regulation of wound healing0.00042699.803e-10Highly InformativeDirect
Biological Process (BP)regulation of hemostasis7.871e-060Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.0066170.4228Highly InformativeInherited
Biological Process (BP)learning or memory0.052860.09101Highly InformativeInherited
Biological Process (BP)activation of immune response0.79953.525e-09Highly InformativeInherited
Biological Process (BP)humoral immune response0.95552.964e-10Highly InformativeInherited
Biological Process (BP)innate immune response0.79921Highly InformativeInherited
Biological Process (BP)protein activation cascade0.037540Highly InformativeInherited
Biological Process (BP)inflammatory response0.025091Highly InformativeInherited
Biological Process (BP)regulation of blood pressure2.989e-070.05379Highly InformativeInherited
Biological Process (BP)leukocyte mediated immunity0.58251Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)anion binding0.8241Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding5.059e-050.01036InformativeInherited
Molecular Function (MF)sulfur compound binding3.238e-050.008133InformativeInherited
Molecular Function (MF)endopeptidase activity2.262e-080Highly InformativeDirect
Molecular Function (MF)heparin binding3.049e-060.0005115Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part1.401e-140Moderately InformativeDirect
Cellular Component (CC)vesicle0.11740.0001835Moderately InformativeInherited
Cellular Component (CC)secretory granule1.978e-052.164e-10InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 6.169e-11 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.02269 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0.0001354 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.123e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.783e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 2.331e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.002811 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7591 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.5125 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1639 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.03044 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01134 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) system process 0.02013 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.6694 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) immune effector process 1.981e-07 Informative Direct
Biological Process (BP) regulation of immune effector process 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) immune response 3.301e-07 Informative Direct
Biological Process (BP) blood circulation 0.0007922 Informative Direct
Biological Process (BP) response to wounding 0.0002509 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) negative regulation of cell communication 0 Informative Direct
Biological Process (BP) cellular component disassembly 1.99e-13 Informative Direct
Biological Process (BP) negative regulation of signaling 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 1.901e-05 Informative Direct
Biological Process (BP) regulation of intracellular transport 0 Informative Direct
Biological Process (BP) secretion by cell 0.0001094 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 6.293e-11 Informative Direct
Biological Process (BP) regulation of response to stress 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.303 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) programmed cell death 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.2848 Informative Inherited
Biological Process (BP) sensory organ development 0.6316 Informative Inherited
Biological Process (BP) metal ion transport 0.1834 Informative Inherited
Biological Process (BP) transmembrane transport 0.821 Informative Inherited
Biological Process (BP) response to other organism 0.1601 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.09508 Informative Inherited
Biological Process (BP) organ morphogenesis 0.9886 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.9253 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.533 Informative Inherited
Biological Process (BP) regulation of growth 0.02159 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.7715 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1644 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0763 Informative Inherited
Biological Process (BP) regulation of cell development 0.3754 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9089 Informative Inherited
Biological Process (BP) single organism reproductive process 0.04474 Informative Inherited
Biological Process (BP) sexual reproduction 0.2495 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.7274 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3119 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.9505 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.5737 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.01136 Informative Inherited
Biological Process (BP) activation of immune response 3.525e-09 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 6.531e-05 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) regulation of translation 0 Highly Informative Direct
Biological Process (BP) exocytosis 9.765e-10 Highly Informative Direct
Biological Process (BP) humoral immune response 2.964e-10 Highly Informative Direct
Biological Process (BP) hemostasis 2.018e-07 Highly Informative Direct
Biological Process (BP) fertilization 1.232e-07 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 6.014e-07 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0005363 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0003615 Highly Informative Direct
Biological Process (BP) protein processing 0.0003248 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 2.863e-12 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 7.901e-10 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0 Highly Informative Direct
Biological Process (BP) wound healing 5.122e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 1.531e-05 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 1.235e-05 Highly Informative Direct
Biological Process (BP) coagulation 0 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0 Highly Informative Direct
Biological Process (BP) regulation of wound healing 9.803e-10 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 2.89e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 2.21e-06 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.001549 Highly Informative Inherited
Biological Process (BP) inner ear development 0.00117 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.07562 Highly Informative Inherited
Biological Process (BP) sensory perception 0.01204 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.6169 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.07296 Highly Informative Inherited
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.4228 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.01527 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.001436 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.1354 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.001215 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.06184 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.5152 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.6115 Highly Informative Inherited
Biological Process (BP) adult behavior 0.01184 Highly Informative Inherited
Biological Process (BP) learning or memory 0.09101 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.8799 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.05379 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.01036 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.008133 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.212 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.04908 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0.0004703 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0005115 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 8.831e-06 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.02274 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.01421 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.009777 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.0001835 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.06341 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.6408 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.4776 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) secretory granule 2.164e-10 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 5.783e-07 Informative Direct
Cellular Component (CC) vacuolar part 0.8277 Informative Inherited
Cellular Component (CC) nuclear envelope 0.002056 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.001156 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) cell envelope 8.986e-08 Highly Informative Direct
Cellular Component (CC) nuclear membrane 7.948e-08 Highly Informative Direct
Cellular Component (CC) periplasmic space 2.246e-12 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 1.845e-09 Highly Informative Direct
Cellular Component (CC) sperm part 1.515e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.2689Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an1.469e-09Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.3112Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Flavivirin1.561e-12InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase4.76e-08InformativeDirect
Enzyme Commission (EC)Picornain 3C1.101e-14Highly InformativeDirect
Enzyme Commission (EC)Hepacivirin4.68e-10Highly InformativeDirect
Enzyme Commission (EC)Togavirin8.498e-09Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A1.621e-08Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase4.76e-08Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa8.542e-07Highly InformativeDirect
Enzyme Commission (EC)Calicivirin2.318e-05Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase5.07e-05Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa8.367e-05Highly InformativeDirect
Enzyme Commission (EC)Plasmin0.0001015Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0001485Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.0002633Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1867Least InformativeInherited
Disease Ontology (DO)skin disease0.003198Moderately InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.2448InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.8688Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9949Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.009786Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.6216Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.02524InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.4649InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.5097InformativeInherited
Phenotypic Abnormality (PA)Joint hemorrhage7.018e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Deep venous thrombosis3.586e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Epistaxis4.131e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coagulation0.001261Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.03298Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.337Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9989Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2093Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2559Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.3475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.5716Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.9562Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation5.021e-06InformativeDirect
Mammalian Phenotype (MP)abnormal uvea morphology0.01359InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.5588InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.9327InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0001284Highly InformativeDirect
Mammalian Phenotype (MP)abnormal complement pathway0.000555Highly InformativeDirect
Mammalian Phenotype (MP)cardiac fibrosis0.0008453Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant3.341e-06Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant1.136e-06InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0.002072Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1442Least InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0004767Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage8.151e-08Least InformativeDirect
Xenopus DEvelopment stage (XDE)tadpole stage1.129e-06InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.1298Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C3.087e-15Highly InformativeDirect
Enzyme Commission (EC)Flavivirin1.42e-12Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase5.077e-08Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A6.566e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.9411Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0InformativeDirect
Biological processUbl conjugation pathway3.002e-15InformativeDirect
Biological processCytolysis2.014e-10InformativeDirect
Biological processDNA replication1.106e-07InformativeDirect
Biological processInnate immunity0.001302InformativeInherited
Biological processAcute phase0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processComplement pathway5.112e-13Highly InformativeDirect
Biological processInhibition of host ISG15 by virus2.087e-09Highly InformativeDirect
Biological processDecay of host mRNAs by virus2.944e-05Highly InformativeDirect
Biological processComplement alternate pathway3.358e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCapsid protein0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentPeriplasm2.461e-06InformativeDirect
Cellular componentHost cytoplasmic vesicle0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityAlternative promoter usage0.0004348Moderately InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainSignal-anchor2.504e-06InformativeDirect
DomainKringle0Highly InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionRNA-binding2.098e-13Moderately InformativeDirect
Molecular functionViral nucleoprotein0Highly InformativeDirect
Molecular functionGrowth factor binding3.804e-11Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationExonuclease3.426e-13InformativeDirect
Post-translational modificationAntimicrobial3.968e-08InformativeDirect
Post-translational modificationThiol protease2.397e-05InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationViral ion channel0Highly InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationAntibiotic1.289e-13Highly InformativeDirect
Post-translational modificationAntioxidant1.178e-09Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationMyristate3.302e-11InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0Highly InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009003 SSF50494 Protein matches
Abstract

This signature recognises a large group of serine and cysteine peptidases (including prokaryotic, eukaryotic and viral), which share a common closed beta barrel structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 103 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Trypsin-like serine proteases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 103 hidden Markov models representing the Trypsin-like serine proteases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]