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FMN-binding split barrel superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Split barrel-like [ 50474] (3)
Superfamily:   FMN-binding split barrel [ 50475] (4)
Families:   PNP-oxidase like [ 50476] (16)
  NADH:FMN oxidoreductase-like [ 50482] (5)
  UbiD middle domain-like [ 141368]
  MTH863-like [ 159164] (3)


Superfamily statistics
Genomes (2,998) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 19,133 87,129 34
Proteins 18,957 86,498 34


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)nitrogen compound metabolic process0.87691Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.52190.9846Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.2610.7381Least InformativeInherited
Biological Process (BP)biosynthetic process0.53110.5685Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.85650.7435Least InformativeInherited
Biological Process (BP)organophosphate metabolic process0.03390.01766Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.28790.4903Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.0030080.00000317Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process0.00015230.00000005493InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.000026520.0000000001109InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process0.0000098570.00000002806InformativeDirect
Biological Process (BP)vitamin B6 metabolic process0.0000000025270Highly InformativeDirect
Molecular Function (MF)binding0.99191Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.000025890.000006069Moderately InformativeDirect
Molecular Function (MF)cofactor binding0.0012390.0006856InformativeInherited
Molecular Function (MF)transcription factor binding0.00000000052790.00006929Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor0.00000000010070.0000000007199Highly InformativeDirect
Cellular Component (CC)external encapsulating structure0.0020850.003297InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9846 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7381 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5685 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.7435 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0.00000317 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.01766 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.4903 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 0.00000005493 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0000000001109 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0.00000002806 Informative Direct
Biological Process (BP) vitamin B6 metabolic process 0 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.000006069 Moderately Informative Direct
Molecular Function (MF) cofactor binding 0.0006856 Informative Direct
Molecular Function (MF) transcription factor binding 0.00006929 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0.0000000007199 Highly Informative Direct
Cellular Component (CC) external encapsulating structure 0.003297 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.000000000001171Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.000000000000001203InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAromatic hydrocarbons catabolism0.00000003185InformativeDirect
Cellular componentMembrane0.000000002019Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0.0000000008501Moderately InformativeDirect
Molecular functionFMN0InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDecarboxylase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)4-hydroxyphenylacetate degradation0.00000000004214Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009002 SSF50475 Protein matches
Abstract

Sulphate-reducing bacteria possess many redox proteins including some flavoproteins. Flavodoxins are a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential. A novel FMN-binding protein from Desulphovibrio vulgaris has been cloned and crystallised and shown to be composed of 122 amino acids making it the smallest of the known proteins which bind FMN [PubMed10713530]. The exact function of this protein is unknown but it may take part in the electron-transfer pathway. The structure has been shown to contain a FMN-binding split barrel, which is related to the ferredoxin reductase-like FAD-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 30 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FMN-binding split barrel domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 30 hidden Markov models representing the FMN-binding split barrel superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]