SUPERFAMILY 1.75 HMM library and genome assignments server

STI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   STI-like [ 50386] (2)
Families:   Kunitz (STI) inhibitors [ 50387] (7)
  Clostridium neurotoxins, C-terminal domain [ 50399] (2)


Superfamily statistics
Genomes (74) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 484 1,314 22
Proteins 481 1,309 22


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.000000340.1292Least InformativeInherited
Biological Process (BP)regulation of cellular process0.000014880.01767Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.000000031160.00002427Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.00000000041450.000006297Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00000000057460.00001191Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.00000000053520.003343Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0000000069830.001863Moderately InformativeInherited
Biological Process (BP)negative regulation of protein processing0.000000000000083240.00000000001157InformativeDirect
Biological Process (BP)negative regulation of cellular protein metabolic process0.0000000000020870.000000008013InformativeDirect
Biological Process (BP)negative regulation of catalytic activity0.0000000000006570.000000001894InformativeDirect
Biological Process (BP)regulation of peptidase activity0.000000000000036160.00000000003374InformativeDirect
Molecular Function (MF)enzyme regulator activity0.0000000000041250.00000001785Moderately InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.000000000000066070.000000000003983InformativeDirect
Molecular Function (MF)peptidase regulator activity0.000000000000012710.000000000000344InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.00003978 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.1292 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.01767 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1487 Least Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.00002427 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000006297 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00001191 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.003343 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.008519 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.001863 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02784 Moderately Informative Inherited
Biological Process (BP) synaptic transmission 0.0000000002996 Informative Direct
Biological Process (BP) negative regulation of protein processing 0.00000000001157 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.000000008013 Informative Direct
Biological Process (BP) secretion by cell 0.00000000001033 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.000000001894 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.00000000003374 Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.000000000000007248 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.000000000796 Highly Informative Direct
Biological Process (BP) signal release 0.00000000000001752 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0003966 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0.00000001785 Moderately Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.000000000003983 Informative Direct
Molecular Function (MF) peptidase activity 0.00000002873 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.000000000000344 Informative Direct
Molecular Function (MF) endopeptidase activity 0.0000000003179 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0.0000000000004142 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Bontoxilysin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0.000000000000003691InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0.0000000000114Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentHost cytoplasm0.0000000000006696InformativeDirect
Cellular componentHost membrane0.00000000004604InformativeDirect
DomainSignal0.000000000002365Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationProtease0.000001894Moderately InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationMetalloprotease0.0000000000005557InformativeDirect
Post-translational modificationToxin0.000000002137InformativeDirect
Post-translational modificationNeurotoxin0.000000000000006125Highly InformativeDirect
Post-translational modificationStorage protein0.0000000006202Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011065 SSF50386 Protein matches
Abstract

The Kunitz-type soybean trypsin inhibitor (STI) family consists mainly of proteinase inhibitors from Leguminosae seeds [PubMed14705960]. They belong to MEROPS inhibitor family I3, clan IC. They exhibit proteinase inhibitory activity against serine proteinases; trypsin (MEROPS peptidase family S1, ) and subtilisin (MEROPS peptidase family S8, ), thiol proteinases (MEROPS peptidase family C1, ) and aspartic proteinases (MEROPS peptidase family A1, ) [PubMed14705960]. STI has a beta-Trefoil type fold consisting of a closed barrel and a hairpin triplet, with internal pseudo threefold symmetry.

The C-terminal domain of Clostridium spp. neurotoxins have an overfold that is very similar to that of the Kunitz ST1 family. The tetanus toxin binds to the gangliosides receptor, GT1b, and is composed of light and heavy chains, where the light chain is responsible for toxicity; the Kunitz-like domain is found on the C-terminal of the heavy chain, and is responsible for binding to sensitive cells [PubMed11418600].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a STI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the STI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]