SUPERFAMILY 1.75 HMM library and genome assignments server


Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,552 3,170 61
Proteins 2,497 3,112 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)single-organism cellular process9.859e-095.255e-14Least InformativeDirect
Biological Process (BP)response to stimulus2.213e-100Least InformativeDirect
Biological Process (BP)regulation of cellular process0.62020.5265Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.15151Least InformativeInherited
Biological Process (BP)localization0.19160.02934Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.72121Least InformativeInherited
Biological Process (BP)immune system process0.0001660Moderately InformativeDirect
Biological Process (BP)signal transduction0.00017857.318e-15Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis3.129e-062.674e-06Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus3.258e-150Moderately InformativeDirect
Biological Process (BP)tissue development7.547e-087.714e-09Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process2.64e-101.477e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance02.339e-05Moderately InformativeDirect
Biological Process (BP)regulation of localization5.164e-052.532e-13Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00013690.0004899Moderately InformativeDirect
Biological Process (BP)single-organism developmental process09.166e-11Moderately InformativeDirect
Biological Process (BP)organ development5.931e-050.0004415Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process8.268e-063.954e-11Moderately InformativeDirect
Biological Process (BP)regulation of developmental process3.258e-150Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus2.065e-090Moderately InformativeDirect
Biological Process (BP)cellular localization0.16730.8404Moderately InformativeInherited
Biological Process (BP)reproduction0.02030.001433Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process6.614e-070.08537Moderately InformativeInherited
Biological Process (BP)cell differentiation00.1641Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity10.1046Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process11.945e-14Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.94811Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.082810.1159Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0016980.01094Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.82960.01287Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00045450.01877Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)nervous system development10.8232Moderately InformativeInherited
Biological Process (BP)regulation of gene expression5.709e-050.913Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.680.6575Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process7.583e-080.524Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process3.597e-070.2651Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.22550.0003648Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation2.598e-130InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter1.643e-077.523e-07InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00InformativeDirect
Biological Process (BP)positive regulation of gene expression4.845e-159.588e-12InformativeDirect
Biological Process (BP)regulation of lipid metabolic process2.172e-061.673e-08InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis8.383e-062.743e-05InformativeDirect
Biological Process (BP)positive regulation of protein modification process1.251e-149.463e-06InformativeDirect
Biological Process (BP)tube development00InformativeDirect
Biological Process (BP)growth4.995e-091.501e-05InformativeDirect
Biological Process (BP)regulation of locomotion7.946e-110InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process1.251e-141.031e-08InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00037173.004e-07InformativeDirect
Biological Process (BP)tissue morphogenesis2.165e-092.593e-12InformativeDirect
Biological Process (BP)positive regulation of developmental process03.741e-15InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process1.043e-107.851e-06InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process1.096e-090InformativeDirect
Biological Process (BP)regulation of cellular component movement1.788e-110InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus5.229e-076.257e-13InformativeDirect
Biological Process (BP)cardiovascular system development0.00020992.156e-06InformativeDirect
Biological Process (BP)sensory organ development0.038620.002623InformativeInherited
Biological Process (BP)epithelium development0.015560.0313InformativeInherited
Biological Process (BP)gland development0.0028730.0009682InformativeInherited
Biological Process (BP)central nervous system development0.22210.2186InformativeInherited
Biological Process (BP)cytoplasmic transport0.0037520.001426InformativeInherited
Biological Process (BP)regulation of cell development0.69731InformativeInherited
Biological Process (BP)regulation of growth0.071970.0004234InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.96440.6715InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process6.571e-100.001388InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process3.039e-090.007705InformativeInherited
Biological Process (BP)protein localization to organelle0.0008640.1675InformativeInherited
Biological Process (BP)regulation of kinase activity0.72580.3171InformativeInherited
Biological Process (BP)regulation of cytokine production0.6640.03097InformativeInherited
Biological Process (BP)organ morphogenesis0.18460.0338InformativeInherited
Biological Process (BP)embryonic organ development0.028410.0001514InformativeInherited
Biological Process (BP)embryonic morphogenesis0.066845.808e-05InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0022161.518e-09InformativeInherited
Biological Process (BP)secretion by cell0.0055870.1558InformativeInherited
Biological Process (BP)regulation of hormone levels1.829e-060.00101InformativeInherited
Biological Process (BP)protein transport0.38730.1677InformativeInherited
Biological Process (BP)nitrogen compound transport0.0043270.07796InformativeInherited
Biological Process (BP)cellular component morphogenesis0.47680.605InformativeInherited
Biological Process (BP)intracellular signal transduction10.1994InformativeInherited
Biological Process (BP)MAPK cascade0.00088810Highly InformativeDirect
Biological Process (BP)angiogenesis6.464e-074.112e-14Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)response to heat0.00013351.27e-12Highly InformativeDirect
Biological Process (BP)hormone transport6.713e-096.645e-06Highly InformativeDirect
Biological Process (BP)glial cell differentiation9.473e-051.969e-06Highly InformativeDirect
Biological Process (BP)protein import3.027e-058.632e-07Highly InformativeDirect
Biological Process (BP)diencephalon development4.226e-063.561e-10Highly InformativeDirect
Biological Process (BP)respiratory tube development4.845e-150Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration7.25e-053.541e-05Highly InformativeDirect
Biological Process (BP)protein localization to nucleus6.234e-063.935e-07Highly InformativeDirect
Biological Process (BP)limb morphogenesis4.943e-097.495e-06Highly InformativeDirect
Biological Process (BP)endocrine system development1.58e-063.299e-07Highly InformativeDirect
Biological Process (BP)amide transport2.576e-085.376e-05Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus1.638e-066.075e-08Highly InformativeDirect
Biological Process (BP)cell fate commitment9.842e-122.385e-10Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process4.904e-072.082e-08Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent2.701e-090.0002931Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube01.409e-10Highly InformativeDirect
Biological Process (BP)stem cell development0.00011.452e-07Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)nuclear import6.543e-067.514e-08Highly InformativeDirect
Biological Process (BP)regulation of cell division2.185e-127.338e-07Highly InformativeDirect
Biological Process (BP)mesenchyme development2.609e-053.309e-08Highly InformativeDirect
Biological Process (BP)respiratory system development1.363e-120Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus00Highly InformativeDirect
Biological Process (BP)renal system development3.617e-149.989e-13Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus9.672e-064.275e-07Highly InformativeDirect
Biological Process (BP)regulation of organ morphogenesis1.066e-083.575e-08Highly InformativeDirect
Biological Process (BP)regulation of striated muscle tissue development14.675e-13Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.28080.02771Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.0018650.04318Highly InformativeInherited
Biological Process (BP)ear development0.0035683.995e-09Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.0047242.266e-06Highly InformativeInherited
Biological Process (BP)signal release7.402e-080.05525Highly InformativeInherited
Biological Process (BP)pattern specification process0.057280.1187Highly InformativeInherited
Biological Process (BP)developmental growth1.314e-050.001767Highly InformativeInherited
Biological Process (BP)skeletal system development0.098150.002265Highly InformativeInherited
Biological Process (BP)connective tissue development0.11910.001235Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.10870.3765Highly InformativeInherited
Molecular Function (MF)binding8.07e-090Least InformativeDirect
Molecular Function (MF)anion binding6.191e-080.8714Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding4.251e-141.648e-12InformativeDirect
Molecular Function (MF)sulfur compound binding04.571e-15InformativeDirect
Molecular Function (MF)heparin binding1.202e-140Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.15040.2594Least InformativeInherited
Cellular Component (CC)cytosol7.746e-051.468e-07Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)extracellular matrix3.002e-082.664e-11InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 5.255e-14 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.5265 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.02934 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 7.318e-15 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.674e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 7.714e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.477e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.339e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.945e-14 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.532e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0004899 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 9.166e-11 Moderately Informative Direct
Biological Process (BP) organ development 0.0004415 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 3.954e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0003648 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.6815 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8404 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001433 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.01287 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.01094 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1641 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1046 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1159 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.08537 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5247 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01877 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.913 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.8232 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6575 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.524 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2651 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 7.523e-07 Informative Direct
Biological Process (BP) apoptotic process 7.153e-08 Informative Direct
Biological Process (BP) immune response 5.478e-06 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) response to wounding 5.775e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1.518e-09 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 4.38e-09 Informative Direct
Biological Process (BP) positive regulation of gene expression 9.588e-12 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 1.673e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 2.743e-05 Informative Direct
Biological Process (BP) positive regulation of protein modification process 9.463e-06 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) growth 1.501e-05 Informative Direct
Biological Process (BP) regulation of growth 0.0004234 Informative Direct
Biological Process (BP) locomotion 6.817e-13 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) single-organism behavior 0.0001235 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 1.031e-08 Informative Direct
Biological Process (BP) embryonic organ development 0.0001514 Informative Direct
Biological Process (BP) embryonic morphogenesis 5.808e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 3.004e-07 Informative Direct
Biological Process (BP) tissue morphogenesis 2.593e-12 Informative Direct
Biological Process (BP) gland development 0.0009682 Informative Direct
Biological Process (BP) positive regulation of developmental process 3.741e-15 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 7.851e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) localization of cell 1.597e-09 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0005572 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0006185 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 6.257e-13 Informative Direct
Biological Process (BP) cardiovascular system development 2.156e-06 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.2484 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8965 Informative Inherited
Biological Process (BP) cellular component movement 0.03283 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1036 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.002623 Informative Inherited
Biological Process (BP) epithelium development 0.0313 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.371 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001426 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6715 Informative Inherited
Biological Process (BP) reproductive system development 0.3774 Informative Inherited
Biological Process (BP) organ morphogenesis 0.0338 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1328 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1994 Informative Inherited
Biological Process (BP) regulation of secretion 0.2468 Informative Inherited
Biological Process (BP) negative regulation of transport 0.08057 Informative Inherited
Biological Process (BP) positive regulation of transport 0.09362 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.628 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6589 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001388 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.007705 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5008 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.621 Informative Inherited
Biological Process (BP) regulation of immune response 0.4265 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1675 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.5116 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001744 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.2468 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.8357 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.03097 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) response to other organism 0.01017 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.001524 Informative Inherited
Biological Process (BP) central nervous system development 0.2186 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4716 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) secretion by cell 0.1558 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.00101 Informative Inherited
Biological Process (BP) protein transport 0.1677 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.07796 Informative Inherited
Biological Process (BP) regulation of ion transport 0.03847 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.605 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.3171 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) angiogenesis 4.112e-14 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to heat 1.27e-12 Highly Informative Direct
Biological Process (BP) hormone transport 6.645e-06 Highly Informative Direct
Biological Process (BP) glial cell differentiation 1.969e-06 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 4.675e-13 Highly Informative Direct
Biological Process (BP) protein import 8.632e-07 Highly Informative Direct
Biological Process (BP) diencephalon development 3.561e-10 Highly Informative Direct
Biological Process (BP) neural tube development 0.0006727 Highly Informative Direct
Biological Process (BP) respiratory tube development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 3.541e-05 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0001353 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 2.112e-14 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 3.935e-07 Highly Informative Direct
Biological Process (BP) limb morphogenesis 7.495e-06 Highly Informative Direct
Biological Process (BP) endocrine system development 3.299e-07 Highly Informative Direct
Biological Process (BP) amide transport 5.376e-05 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.0008939 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 5.064e-07 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 6.96e-09 Highly Informative Direct
Biological Process (BP) ear development 3.995e-09 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 6.075e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 2.385e-10 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0007245 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 2.082e-08 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0002931 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 1.475e-05 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 2.266e-06 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 1.409e-10 Highly Informative Direct
Biological Process (BP) stem cell development 1.452e-07 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.0003088 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000145 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0002695 Highly Informative Direct
Biological Process (BP) nuclear import 7.514e-08 Highly Informative Direct
Biological Process (BP) regulation of cell division 7.338e-07 Highly Informative Direct
Biological Process (BP) mesenchyme development 3.309e-08 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0006719 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) renal system development 9.989e-13 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 7.555e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 4.275e-07 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.248e-09 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 3.575e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 3.217e-09 Highly Informative Direct
Biological Process (BP) developmental growth 0.001767 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02771 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.3067 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.3168 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.1194 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.001988 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.05688 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.003077 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.01478 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.03134 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.003321 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.007443 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.005421 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.1423 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.3009 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.04318 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.05551 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01712 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1187 Highly Informative Inherited
Biological Process (BP) signal release 0.05525 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.2177 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01125 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3213 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1059 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.03808 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.002265 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001235 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.9942 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3765 Highly Informative Inherited
Biological Process (BP) ossification 0.002167 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cation binding 0.7883 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.8714 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1.648e-12 Informative Direct
Molecular Function (MF) sulfur compound binding 4.571e-15 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.2594 Least Informative Inherited
Cellular Component (CC) cytosol 1.468e-07 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 2.587e-05 Informative Direct
Cellular Component (CC) extracellular matrix 2.664e-11 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1882Least InformativeInherited
Disease Ontology (DO)organ system cancer0.2786Least InformativeInherited
Disease Ontology (DO)skin disease0.0005018Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0006476Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.005416Moderately InformativeInherited
Disease Ontology (DO)lung disease0.02745Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.05539Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1948Moderately InformativeInherited
Disease Ontology (DO)hemorrhagic disease0.0006187InformativeDirect
Disease Ontology (DO)physical disorder0.0006586InformativeDirect
Disease Ontology (DO)malaria0.001401InformativeInherited
Disease Ontology (DO)lymphoma0.007301InformativeInherited
Disease Ontology (DO)arthropathy0.01096InformativeInherited
Disease Ontology (DO)female reproductive system disease0.1785InformativeInherited
Disease Ontology (DO)purpura3.798e-05Highly InformativeDirect
Disease Ontology (DO)chronic obstructive pulmonary disease0.0002793Highly InformativeDirect
Disease Ontology (DO)spondylitis0.0004704Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.0005902Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.0007222Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0007786Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4744Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.5587Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1984Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2911Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.4583Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4572InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9422InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.0006961Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.0008997Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair growth0.03125Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.05721Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.1131Least InformativeInherited
Zebrafish Anatomy (ZA)surface structure0Moderately InformativeDirect
Zebrafish Anatomy (ZA)peripheral nervous system0.0003516InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.1247Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2565Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure4.778e-07Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0.003135Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.003463Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.02098Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.4577Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region1.088e-10InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm3.523e-06InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system3.762e-06InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode2.846e-05InformativeDirect
Xenopus ANatomical entity (XAN)notochord6.708e-05InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0001111InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0004809InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.01652InformativeInherited
Xenopus ANatomical entity (XAN)tail0.1968InformativeInherited
Xenopus ANatomical entity (XAN)limb0.8311InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest2.86e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge6.628e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage6.647e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud2.186e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle5.647e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0001838Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomodeal-hypophyseal primordium0.0005315Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0008632Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0009503Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0009708Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processNeurogenesis1.326e-05InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseProto-oncogene2.518e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]