SUPERFAMILY 1.75 HMM library and genome assignments server

Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,552 3,170 61
Proteins 2,497 3,112 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.000022650.00000000000006944Least InformativeDirect
Biological Process (BP)response to stimulus0.0000000002160Least InformativeDirect
Biological Process (BP)regulation of cellular process0.62590.1731Least InformativeInherited
Biological Process (BP)single-organism cellular process0.00039560.001552Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.087730.8239Least InformativeInherited
Biological Process (BP)localization0.2240.04192Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.7371Least InformativeInherited
Biological Process (BP)immune system process0.00016030Moderately InformativeDirect
Biological Process (BP)signal transduction0.00016030.00000000000001414Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.0000032690.000002752Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.0000000000000032510Moderately InformativeDirect
Biological Process (BP)tissue development0.0000000053860.000000000002327Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000000012930.00000009167Moderately InformativeDirect
Biological Process (BP)response to organic substance00.00003189Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000022160.0000000000001592Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00012430.000203Moderately InformativeDirect
Biological Process (BP)organ development0.000000038940.000004233Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.000040130.000000000001122Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.00049280.00000005792Moderately InformativeDirect
Biological Process (BP)regulation of developmental process00Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0000000025650.000000000000001913Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0000000041780.3304Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00000085160.4841Moderately InformativeInherited
Biological Process (BP)cellular localization0.000095930.06604Moderately InformativeInherited
Biological Process (BP)cell differentiation00.1653Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity10.2216Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000002410.298Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00055981Moderately InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.037260.000000003491Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.95121Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.19750.2504Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.50170.002695Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.000009460.00115Moderately InformativeInherited
Biological Process (BP)nervous system development10.8728Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00046860.02005Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.68290.6673Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.00000023040.000001065InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00000000021820.000911InformativeDirect
Biological Process (BP)positive regulation of gene expression0.000000000000027370.0000000006803InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.00000069550.000000007958InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0000042960.00008416InformativeDirect
Biological Process (BP)tube development00InformativeDirect
Biological Process (BP)growth0.000000005020.00001489InformativeDirect
Biological Process (BP)regulation of locomotion0.000000000078020InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.0000000000000032510.0000155InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00038460.0000003917InformativeDirect
Biological Process (BP)tissue morphogenesis0.00000000022870.0000000000003025InformativeDirect
Biological Process (BP)positive regulation of developmental process00.000000000000007248InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process00InformativeDirect
Biological Process (BP)regulation of cellular component movement0.0000000000190InformativeDirect
Biological Process (BP)regulation of transferase activity0.00000067120.0000000009229InformativeDirect
Biological Process (BP)cardiovascular system development0.00022050.000002348InformativeDirect
Biological Process (BP)positive regulation of intracellular signal transduction0.000098290.0000000003713InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.0000000032080.007704InformativeInherited
Biological Process (BP)cytoplasmic transport0.0044080.002158InformativeInherited
Biological Process (BP)single-organism intracellular transport0.12990.04182InformativeInherited
Biological Process (BP)sensory organ development0.020380.001248InformativeInherited
Biological Process (BP)epithelium development0.0043740.05885InformativeInherited
Biological Process (BP)regulation of cell development0.58040.4538InformativeInherited
Biological Process (BP)regulation of growth0.062080.0003207InformativeInherited
Biological Process (BP)positive regulation of RNA metabolic process0.0000000000090490.001226InformativeInherited
Biological Process (BP)single-organism cellular localization0.0040920.00002712InformativeInherited
Biological Process (BP)nitrogen compound transport0.0037950.08036InformativeInherited
Biological Process (BP)embryonic morphogenesis0.031060.00001541InformativeInherited
Biological Process (BP)protein localization to organelle0.00093850.1668InformativeInherited
Biological Process (BP)regulation of cytokine production0.73620.05253InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.012210.00002375InformativeInherited
Biological Process (BP)organ morphogenesis0.10460.01562InformativeInherited
Biological Process (BP)embryonic organ development0.016410.00007054InformativeInherited
Biological Process (BP)regulation of hormone levels0.0000018420.001036InformativeInherited
Biological Process (BP)secretion by cell0.0012550.05771InformativeInherited
Biological Process (BP)gland development0.0070540.00000006703InformativeInherited
Biological Process (BP)central nervous system development0.25730.2469InformativeInherited
Biological Process (BP)protein transport0.24330.2743InformativeInherited
Biological Process (BP)cellular component morphogenesis0.61260.7725InformativeInherited
Biological Process (BP)angiogenesis0.00000010880.000000000000007248Highly InformativeDirect
Biological Process (BP)kidney development00.000000000000007248Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)response to heat0.00019790.000000000003047Highly InformativeDirect
Biological Process (BP)hormone transport0.000000012520.000007085Highly InformativeDirect
Biological Process (BP)glial cell differentiation0.000084640.000001742Highly InformativeDirect
Biological Process (BP)protein import0.000048460.0000009074Highly InformativeDirect
Biological Process (BP)diencephalon development0.00000048720.0000000004657Highly InformativeDirect
Biological Process (BP)respiratory tube development00Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.000079980.0000201Highly InformativeDirect
Biological Process (BP)limb morphogenesis0.000000002540.00000007194Highly InformativeDirect
Biological Process (BP)endocrine system development0.0000016270.0000003746Highly InformativeDirect
Biological Process (BP)amide transport0.000000049580.00005574Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus0.00012470.00004214Highly InformativeDirect
Biological Process (BP)cell fate commitment0.0000000000073020.0000000001433Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.000016370.000001484Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.000000043420.000000004867Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-templated0.0000000074550.000117Highly InformativeDirect
Biological Process (BP)developmental growth0.00000290.0007847Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube00.0000000001438Highly InformativeDirect
Biological Process (BP)stem cell development0.000085270.00000009931Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)positive regulation of cell division0.000000000025780.0000000001101Highly InformativeDirect
Biological Process (BP)mesenchyme development0.0000072530.00000005986Highly InformativeDirect
Biological Process (BP)respiratory system development0.0000000000014710Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus00Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus0.000012860.0000005271Highly InformativeDirect
Biological Process (BP)single-organism nuclear import0.0000015330.00000006595Highly InformativeDirect
Biological Process (BP)regulation of alcohol biosynthetic process0.000000000068750.000000000000107Highly InformativeDirect
Biological Process (BP)regulation of organ morphogenesis0.000000012630.0000002553Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis0.0045930.000002252Highly InformativeInherited
Biological Process (BP)positive regulation of growth0.050540.004665Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.30620.05489Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.011430.1054Highly InformativeInherited
Biological Process (BP)ear development0.0034170.000000003779Highly InformativeInherited
Biological Process (BP)signal release0.43511Highly InformativeInherited
Biological Process (BP)pattern specification process0.060630.1426Highly InformativeInherited
Biological Process (BP)columnar/cuboidal epithelial cell differentiation0.0012660.0008653Highly InformativeInherited
Biological Process (BP)skeletal system development0.099670.00248Highly InformativeInherited
Biological Process (BP)connective tissue development0.14580.00354Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.096940.3378Highly InformativeInherited
Molecular Function (MF)binding0.0000000097180Least InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.0000088910.0008198Moderately InformativeDirect
Molecular Function (MF)anion binding0.000000062220.8754Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding0.0000000000000026380.00000000000001361InformativeDirect
Molecular Function (MF)heparin binding0.000000000000011470Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding00Highly InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)extracellular matrix0.000000026520.00000000002077InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.00000000000006944 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0.04192 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1731 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001552 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.8239 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0.00000000000001414 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000002752 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.000000000002327 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000009167 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00003189 Moderately Informative Direct
Biological Process (BP) reproductive process 0.0002055 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000000000001592 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.000203 Moderately Informative Direct
Biological Process (BP) organ development 0.000004233 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000001122 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00000005792 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.000000003491 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000000000001913 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.3304 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4841 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06604 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1653 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.2216 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3776 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.00115 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2504 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.8728 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01044 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.02005 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6673 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.001604 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.298 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.002695 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000001065 Informative Direct
Biological Process (BP) apoptotic process 0.00000007569 Informative Direct
Biological Process (BP) immune response 0.000005 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) cell proliferation 0.00000000001454 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000911 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0000000006803 Informative Direct
Biological Process (BP) phosphorylation 0.00001125 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000000007958 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00008416 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00002375 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) growth 0.00001489 Informative Direct
Biological Process (BP) regulation of growth 0.0003207 Informative Direct
Biological Process (BP) locomotion 0.0000000000006378 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0.00006299 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000155 Informative Direct
Biological Process (BP) embryonic organ development 0.00007054 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00001541 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000003917 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000000000003025 Informative Direct
Biological Process (BP) gland development 0.00000006703 Informative Direct
Biological Process (BP) regulation of cell activation 0.00009012 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000000000007248 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0000000009229 Informative Direct
Biological Process (BP) localization of cell 0.00000000101 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0001974 Informative Direct
Biological Process (BP) cardiovascular system development 0.000002348 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0.0000000003713 Informative Direct
Biological Process (BP) single-organism cellular localization 0.00002712 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.2259 Informative Inherited
Biological Process (BP) cell cycle process 0.7363 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.007704 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.002158 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.04182 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6067 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1073 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9102 Informative Inherited
Biological Process (BP) cellular component movement 0.002466 Informative Inherited
Biological Process (BP) sensory organ development 0.001248 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.9379 Informative Inherited
Biological Process (BP) negative regulation of transport 0.04086 Informative Inherited
Biological Process (BP) regulation of cell development 0.4538 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.09235 Informative Inherited
Biological Process (BP) regulation of secretion 0.1913 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.4957 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4142 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6695 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 0.001226 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1238 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1047 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.08036 Informative Inherited
Biological Process (BP) positive regulation of transport 0.08992 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.6608 Informative Inherited
Biological Process (BP) regulation of immune response 0.7113 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1668 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001812 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.9135 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.7066 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.8096 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.05253 Informative Inherited
Biological Process (BP) response to bacterium 0.003258 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) central nervous system development 0.2469 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01972 Informative Inherited
Biological Process (BP) reproductive structure development 0.4234 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.001036 Informative Inherited
Biological Process (BP) secretion by cell 0.05771 Informative Inherited
Biological Process (BP) regulation of ion transport 0.05838 Informative Inherited
Biological Process (BP) single-organism behavior 0.008685 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.8944 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.6579 Informative Inherited
Biological Process (BP) protein transport 0.2743 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7725 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01562 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3154 Informative Inherited
Biological Process (BP) epithelium development 0.05885 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4667 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3542 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.002072 Informative Inherited
Biological Process (BP) MAPK cascade 0.00000389 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000000000000007248 Highly Informative Direct
Biological Process (BP) kidney development 0.000000000000007248 Highly Informative Direct
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.0008653 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0004575 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to heat 0.000000000003047 Highly Informative Direct
Biological Process (BP) hormone transport 0.000007085 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.000001742 Highly Informative Direct
Biological Process (BP) protein import 0.0000009074 Highly Informative Direct
Biological Process (BP) diencephalon development 0.0000000004657 Highly Informative Direct
Biological Process (BP) neural tube development 0.0005225 Highly Informative Direct
Biological Process (BP) respiratory tube development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0000201 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0001365 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.00000000000002422 Highly Informative Direct
Biological Process (BP) limb morphogenesis 0.00000007194 Highly Informative Direct
Biological Process (BP) endocrine system development 0.0000003746 Highly Informative Direct
Biological Process (BP) amide transport 0.00005574 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0008001 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000000758 Highly Informative Direct
Biological Process (BP) ear development 0.000000003779 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.00004214 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.00003671 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0000000001433 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.000001484 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.000000004867 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.000117 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.00001457 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000002252 Highly Informative Direct
Biological Process (BP) developmental growth 0.0007847 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0000000001438 Highly Informative Direct
Biological Process (BP) stem cell development 0.00000009931 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.0002783 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.0001424 Highly Informative Direct
Biological Process (BP) positive regulation of cell division 0.0000000001101 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.00000005986 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0006992 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000005271 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000000002274 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.00000006595 Highly Informative Direct
Biological Process (BP) regulation of alcohol biosynthetic process 0.000000000000107 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0001044 Highly Informative Direct
Biological Process (BP) regulation of protein targeting 0.000008669 Highly Informative Direct
Biological Process (BP) response to transition metal nanoparticle 0.00000296 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0000002553 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.004665 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05489 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.00252 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.3019 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.2825 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.2795 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.004898 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.07296 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.08335 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.009017 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.005538 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.1394 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.1054 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.3499 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01596 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.2456 Highly Informative Inherited
Biological Process (BP) signal release 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.1116 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01383 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1426 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.003838 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1215 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1338 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.08659 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.03622 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.03716 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.00248 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.00354 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.9872 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3378 Highly Informative Inherited
Biological Process (BP) ossification 0.003142 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0008198 Moderately Informative Direct
Molecular Function (MF) cation binding 0.7868 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.8754 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00000000000001361 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.423 Least Informative Inherited
Cellular Component (CC) cytosol 0.000001756 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0.00005732 Informative Direct
Cellular Component (CC) extracellular matrix 0.00000000002077 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1932Least InformativeInherited
Disease Ontology (DO)organ system cancer0.213Least InformativeInherited
Disease Ontology (DO)skin disease0.0003372Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0006633Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.005351Moderately InformativeInherited
Disease Ontology (DO)obstructive lung disease0.006559Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.0441Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1949Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.2209Moderately InformativeInherited
Disease Ontology (DO)chronic obstructive pulmonary disease0.0002125InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0004843InformativeDirect
Disease Ontology (DO)physical disorder0.0005132InformativeDirect
Disease Ontology (DO)malaria0.001154InformativeInherited
Disease Ontology (DO)lymphoma0.007268InformativeInherited
Disease Ontology (DO)arthropathy0.01089InformativeInherited
Disease Ontology (DO)female reproductive system disease0.179InformativeInherited
Disease Ontology (DO)purpura0.00002904Highly InformativeDirect
Disease Ontology (DO)spondylitis0.0003888Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.0004843Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0005826Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.0005953Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.478Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.5715Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05596Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.2002Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2919Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.457Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4518InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.0006993Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.0009076Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair growth0.03223Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.05839Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.1095Least InformativeInherited
Zebrafish Anatomy (ZA)paired fin0.0002051Moderately InformativeDirect
Zebrafish Anatomy (ZA)peripheral nervous system0.000329InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.1247Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2567Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.0000004986Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0.003173Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.003503Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.02111Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.461Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.0000000001134InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000003535InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.000004227InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.00002876InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00006686InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0001141InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0004799InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.01289InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.01773InformativeInherited
Xenopus ANatomical entity (XAN)tail0.1973InformativeInherited
Xenopus ANatomical entity (XAN)limb0.8308InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.0000003366Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage0.000006635Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.000007536Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00002182Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.00006387Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0002073Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomodeal-hypophyseal primordium0.0005273Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0008938Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0009695Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0009755Highly InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)cardiovascular system0.002537Least InformativeInherited
Drugbank ATC_code (DB)vasoprotectives0.000004621Moderately InformativeDirect
Drugbank ATC_code (DB)antivaricose therapy0.0000002379InformativeDirect
Drugbank ATC_code (DB)pentosan polysulfate sodium0.0000000001765Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processNeurogenesis0.00001393InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseProto-oncogene0.00002483Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]