SUPERFAMILY 1.75 HMM library and genome assignments server

Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,552 3,170 61
Proteins 2,497 3,112 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.000022650.00000000000006944Least InformativeDirect
Biological Process (BP)response to stimulus0.0000000002160Least InformativeDirect
Biological Process (BP)regulation of cellular process0.62590.1731Least InformativeInherited
Biological Process (BP)single-organism cellular process0.00039560.001552Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.087730.8239Least InformativeInherited
Biological Process (BP)localization0.2240.04192Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.7371Least InformativeInherited
Biological Process (BP)immune system process0.00016030Moderately InformativeDirect
Biological Process (BP)signal transduction0.00016030.00000000000001414Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.0000032690.000002752Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.0000000000000032510Moderately InformativeDirect
Biological Process (BP)tissue development0.0000000053860.000000000002327Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000000012930.00000009167Moderately InformativeDirect
Biological Process (BP)response to organic substance00.00003189Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000022160.0000000000001592Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00012430.000203Moderately InformativeDirect
Biological Process (BP)organ development0.000000038940.000004233Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.000040130.000000000001122Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.00049280.00000005792Moderately InformativeDirect
Biological Process (BP)regulation of developmental process00Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0000000025650.000000000000001913Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0000000041780.3304Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00000085160.4841Moderately InformativeInherited
Biological Process (BP)cellular localization0.000095930.06604Moderately InformativeInherited
Biological Process (BP)cell differentiation00.1653Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity10.2216Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000002410.298Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00055981Moderately InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.037260.000000003491Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.95121Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.19750.2504Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.50170.002695Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.000009460.00115Moderately InformativeInherited
Biological Process (BP)nervous system development10.8728Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00046860.02005Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.68290.6673Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.00000023040.000001065InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.00000000021820.000911InformativeDirect
Biological Process (BP)positive regulation of gene expression0.000000000000027370.0000000006803InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.00000069550.000000007958InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0000042960.00008416InformativeDirect
Biological Process (BP)tube development00InformativeDirect
Biological Process (BP)growth0.000000005020.00001489InformativeDirect
Biological Process (BP)regulation of locomotion0.000000000078020InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.0000000000000032510.0000155InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00038460.0000003917InformativeDirect
Biological Process (BP)tissue morphogenesis0.00000000022870.0000000000003025InformativeDirect
Biological Process (BP)positive regulation of developmental process00.000000000000007248InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process00InformativeDirect
Biological Process (BP)regulation of cellular component movement0.0000000000190InformativeDirect
Biological Process (BP)regulation of transferase activity0.00000067120.0000000009229InformativeDirect
Biological Process (BP)cardiovascular system development0.00022050.000002348InformativeDirect
Biological Process (BP)positive regulation of intracellular signal transduction0.000098290.0000000003713InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.0000000032080.007704InformativeInherited
Biological Process (BP)cytoplasmic transport0.0044080.002158InformativeInherited
Biological Process (BP)single-organism intracellular transport0.12990.04182InformativeInherited
Biological Process (BP)sensory organ development0.020380.001248InformativeInherited
Biological Process (BP)epithelium development0.0043740.05885InformativeInherited
Biological Process (BP)regulation of cell development0.58040.4538InformativeInherited
Biological Process (BP)regulation of growth0.062080.0003207InformativeInherited
Biological Process (BP)positive regulation of RNA metabolic process0.0000000000090490.001226InformativeInherited
Biological Process (BP)single-organism cellular localization0.0040920.00002712InformativeInherited
Biological Process (BP)nitrogen compound transport0.0037950.08036InformativeInherited
Biological Process (BP)embryonic morphogenesis0.031060.00001541InformativeInherited
Biological Process (BP)protein localization to organelle0.00093850.1668InformativeInherited
Biological Process (BP)regulation of cytokine production0.73620.05253InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.012210.00002375InformativeInherited
Biological Process (BP)organ morphogenesis0.10460.01562InformativeInherited
Biological Process (BP)embryonic organ development0.016410.00007054InformativeInherited
Biological Process (BP)regulation of hormone levels0.0000018420.001036InformativeInherited
Biological Process (BP)secretion by cell0.0012550.05771InformativeInherited
Biological Process (BP)gland development0.0070540.00000006703InformativeInherited
Biological Process (BP)central nervous system development0.25730.2469InformativeInherited
Biological Process (BP)protein transport0.24330.2743InformativeInherited
Biological Process (BP)cellular component morphogenesis0.61260.7725InformativeInherited
Biological Process (BP)angiogenesis0.00000010880.000000000000007248Highly InformativeDirect
Biological Process (BP)kidney development00.000000000000007248Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)response to heat0.00019790.000000000003047Highly InformativeDirect
Biological Process (BP)hormone transport0.000000012520.000007085Highly InformativeDirect
Biological Process (BP)glial cell differentiation0.000084640.000001742Highly InformativeDirect
Biological Process (BP)protein import0.000048460.0000009074Highly InformativeDirect
Biological Process (BP)diencephalon development0.00000048720.0000000004657Highly InformativeDirect
Biological Process (BP)respiratory tube development00Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration0.000079980.0000201Highly InformativeDirect
Biological Process (BP)limb morphogenesis0.000000002540.00000007194Highly InformativeDirect
Biological Process (BP)endocrine system development0.0000016270.0000003746Highly InformativeDirect
Biological Process (BP)amide transport0.000000049580.00005574Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus0.00012470.00004214Highly InformativeDirect
Biological Process (BP)cell fate commitment0.0000000000073020.0000000001433Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.000016370.000001484Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.000000043420.000000004867Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-templated0.0000000074550.000117Highly InformativeDirect
Biological Process (BP)developmental growth0.00000290.0007847Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube00.0000000001438Highly InformativeDirect
Biological Process (BP)stem cell development0.000085270.00000009931Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)positive regulation of cell division0.000000000025780.0000000001101Highly InformativeDirect
Biological Process (BP)mesenchyme development0.0000072530.00000005986Highly InformativeDirect
Biological Process (BP)respiratory system development0.0000000000014710Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus00Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus0.000012860.0000005271Highly InformativeDirect
Biological Process (BP)single-organism nuclear import0.0000015330.00000006595Highly InformativeDirect
Biological Process (BP)regulation of alcohol biosynthetic process0.000000000068750.000000000000107Highly InformativeDirect
Biological Process (BP)regulation of organ morphogenesis0.000000012630.0000002553Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis0.0045930.000002252Highly InformativeInherited
Biological Process (BP)positive regulation of growth0.050540.004665Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.30620.05489Highly InformativeInherited
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.011430.1054Highly InformativeInherited
Biological Process (BP)ear development0.0034170.000000003779Highly InformativeInherited
Biological Process (BP)signal release0.43511Highly InformativeInherited
Biological Process (BP)pattern specification process0.060630.1426Highly InformativeInherited
Biological Process (BP)columnar/cuboidal epithelial cell differentiation0.0012660.0008653Highly InformativeInherited
Biological Process (BP)skeletal system development0.099670.00248Highly InformativeInherited
Biological Process (BP)connective tissue development0.14580.00354Highly InformativeInherited
Biological Process (BP)cell morphogenesis involved in differentiation0.096940.3378Highly InformativeInherited
Molecular Function (MF)binding0.0000000097180Least InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.0000088910.0008198Moderately InformativeDirect
Molecular Function (MF)anion binding0.000000062220.8754Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)sulfur compound binding0.0000000000000026380.00000000000001361InformativeDirect
Molecular Function (MF)heparin binding0.000000000000011470Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding00Highly InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)extracellular matrix0.000000026520.00000000002077InformativeDirect

Document: GO annotation of SCOP domains