SUPERFAMILY 1.75 HMM library and genome assignments server


Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (128) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,291 2,703 61
Proteins 2,238 2,668 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)single-organism cellular process3.039e-090Least InformativeDirect
Biological Process (BP)response to stimulus2.197e-080Least InformativeDirect
Biological Process (BP)regulation of cellular process0.64050.4737Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.062070.9788Least InformativeInherited
Biological Process (BP)localization0.17060.02561Least InformativeInherited
Biological Process (BP)protein metabolic process0.43640.3122Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.74581Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.92371Least InformativeInherited
Biological Process (BP)immune system process0.00069450Moderately InformativeDirect
Biological Process (BP)signal transduction0.00083751.559e-12Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis7.874e-073.776e-07Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus00Moderately InformativeDirect
Biological Process (BP)tissue development2.538e-095.963e-10Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process3.039e-118.932e-09Moderately InformativeDirect
Biological Process (BP)response to organic substance04.364e-06Moderately InformativeDirect
Biological Process (BP)regulation of cell communication1.449e-072.371e-11Moderately InformativeDirect
Biological Process (BP)regulation of signaling3.961e-073.007e-11Moderately InformativeDirect
Biological Process (BP)regulation of localization1.556e-056.108e-12Moderately InformativeDirect
Biological Process (BP)single-organism developmental process3.099e-152.007e-10Moderately InformativeDirect
Biological Process (BP)organ development1.503e-056.249e-05Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process5.737e-061.223e-12Moderately InformativeDirect
Biological Process (BP)regulation of developmental process1.483e-140Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus1.306e-090Moderately InformativeDirect
Biological Process (BP)cellular localization0.12850.8261Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process5.182e-070.5181Moderately InformativeInherited
Biological Process (BP)reproduction0.070930.0459Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process1.525e-060.4963Moderately InformativeInherited
Biological Process (BP)cell differentiation00.1584Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.85541Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.10780.2319Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0001380.01373Moderately InformativeInherited
Biological Process (BP)nervous system development10.9429Moderately InformativeInherited
Biological Process (BP)regulation of gene expression2.393e-050.9578Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.58510.5399Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.15960.01254Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.051950.05778Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.34580.000464Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.90860.4346Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.0006990.9712Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0010453.913e-07Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.282e-130InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter1.077e-062.141e-05InformativeDirect
Biological Process (BP)protein phosphorylation0.00014293.252e-07InformativeDirect
Biological Process (BP)nucleocytoplasmic transport4.354e-063.875e-06InformativeDirect
Biological Process (BP)apoptotic process0.00020935.433e-08InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.00030232.155e-11InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process3.474e-100.0006864InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade4.739e-051.63e-10InformativeDirect
Biological Process (BP)positive regulation of gene expression06.768e-12InformativeDirect
Biological Process (BP)regulation of hormone levels6.461e-070.0005768InformativeDirect
Biological Process (BP)cytoplasmic transport0.00086790.0007962InformativeDirect
Biological Process (BP)regulation of lipid metabolic process1.417e-067.968e-08InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis3.457e-062.341e-06InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process4.807e-110.000534InformativeDirect
Biological Process (BP)tube development00InformativeDirect
Biological Process (BP)growth1.2e-081.998e-05InformativeDirect
Biological Process (BP)regulation of locomotion5.426e-111.743e-13InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)chordate embryonic development3.171e-051.667e-07InformativeDirect
Biological Process (BP)positive regulation of catalytic activity1.21e-054.172e-06InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0003271.584e-06InformativeDirect
Biological Process (BP)tissue morphogenesis2.151e-103.091e-12InformativeDirect
Biological Process (BP)positive regulation of developmental process01.53e-14InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process6.063e-114.536e-06InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process4.484e-090InformativeDirect
Biological Process (BP)regulation of cellular component movement1.654e-112.615e-14InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus8.778e-062.921e-12InformativeDirect
Biological Process (BP)cardiovascular system development0.00071241.794e-05InformativeDirect
Biological Process (BP)sensory organ development0.030410.001792InformativeInherited
Biological Process (BP)epithelium development0.014310.06739InformativeInherited
Biological Process (BP)gland development0.0038240.001057InformativeInherited
Biological Process (BP)central nervous system development0.24530.3761InformativeInherited
Biological Process (BP)regulation of cell development11InformativeInherited
Biological Process (BP)protein localization to organelle0.0001190.1291InformativeInherited
Biological Process (BP)regulation of cytokine production0.78160.03864InformativeInherited
Biological Process (BP)organ morphogenesis0.16350.02401InformativeInherited
Biological Process (BP)embryonic organ development0.044153.45e-05InformativeInherited
Biological Process (BP)embryonic morphogenesis0.062599.595e-05InformativeInherited
Biological Process (BP)developmental process involved in reproduction10.916InformativeInherited
Biological Process (BP)protein transport0.23730.1306InformativeInherited
Biological Process (BP)nitrogen compound transport0.0085940.1013InformativeInherited
Biological Process (BP)secretion0.00029230.005587InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.081320.0003282InformativeInherited
Biological Process (BP)cellular component morphogenesis0.45490.5053InformativeInherited
Biological Process (BP)positive regulation of phosphorus metabolic process0.0042162.956e-08InformativeInherited
Biological Process (BP)regulation of kinase activity0.81890.3396InformativeInherited
Biological Process (BP)intracellular signal transduction10.1357InformativeInherited
Biological Process (BP)MAPK cascade0.00011030Highly InformativeDirect
Biological Process (BP)angiogenesis2.898e-061.352e-13Highly InformativeDirect
Biological Process (BP)kidney development1.281e-091.592e-09Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)response to heat4.078e-051.152e-13Highly InformativeDirect
Biological Process (BP)hormone transport1.55e-088.578e-06Highly InformativeDirect
Biological Process (BP)glial cell differentiation0.00015617.647e-07Highly InformativeDirect
Biological Process (BP)protein import2.987e-062.5e-07Highly InformativeDirect
Biological Process (BP)diencephalon development1.16e-061.639e-09Highly InformativeDirect
Biological Process (BP)lung development00Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration9.978e-051.528e-06Highly InformativeDirect
Biological Process (BP)protein localization to nucleus3.276e-078.836e-08Highly InformativeDirect
Biological Process (BP)limb morphogenesis6.455e-095.87e-05Highly InformativeDirect
Biological Process (BP)endocrine system development5.293e-069.511e-07Highly InformativeDirect
Biological Process (BP)amide transport7.217e-086.205e-05Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus7.582e-081.509e-08Highly InformativeDirect
Biological Process (BP)cell fate commitment4.183e-114.627e-10Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process2.252e-068.095e-08Highly InformativeDirect
Biological Process (BP)developmental growth7.146e-060.000658Highly InformativeDirect
Biological Process (BP)inner ear development0.00017961.551e-10Highly InformativeDirect
Biological Process (BP)stem cell development3.785e-052.215e-09Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)nuclear import4.818e-071.905e-08Highly InformativeDirect
Biological Process (BP)epithelial tube morphogenesis01.013e-05Highly InformativeDirect
Biological Process (BP)morphogenesis of a branching epithelium00Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus00Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus1.335e-056.547e-07Highly InformativeDirect
Biological Process (BP)regulation of organ morphogenesis3.209e-082.927e-08Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis0.0035237.819e-08Highly InformativeInherited
Biological Process (BP)signal release7.608e-050.04372Highly InformativeInherited
Biological Process (BP)pattern specification process0.04920.1707Highly InformativeInherited
Biological Process (BP)skeletal system development0.096840.001659Highly InformativeInherited
Biological Process (BP)connective tissue development0.130.001256Highly InformativeInherited
Biological Process (BP)activation of protein kinase activity0.17540.004195Highly InformativeInherited
Molecular Function (MF)binding3.28e-080Least InformativeDirect
Molecular Function (MF)protein binding1.031e-135.279e-05Moderately InformativeDirect
Molecular Function (MF)anion binding1.244e-060.9575Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)glycosaminoglycan binding00Highly InformativeDirect
Molecular Function (MF)sulfur compound binding6.917e-153.802e-14Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.20660.5105Least InformativeInherited
Cellular Component (CC)extracellular region00Moderately InformativeDirect
Cellular Component (CC)cytosol0.00016888.105e-07Moderately InformativeDirect
Cellular Component (CC)extracellular space02.683e-11InformativeDirect
Cellular Component (CC)extracellular matrix4.795e-086.014e-11InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.4737 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9788 Least Informative Inherited
Biological Process (BP) localization 0.02561 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3122 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 1.559e-12 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.776e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 5.963e-10 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 8.932e-09 Moderately Informative Direct
Biological Process (BP) response to organic substance 4.364e-06 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 2.371e-11 Moderately Informative Direct
Biological Process (BP) regulation of signaling 3.007e-11 Moderately Informative Direct
Biological Process (BP) regulation of localization 6.108e-12 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 2.007e-10 Moderately Informative Direct
Biological Process (BP) organ development 6.249e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.223e-12 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 3.913e-07 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000464 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.8076 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8261 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.5181 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1584 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2319 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.4963 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.9712 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6232 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01373 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9578 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9429 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.5399 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0459 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.4346 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01254 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.05778 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 2.141e-05 Informative Direct
Biological Process (BP) protein phosphorylation 3.252e-07 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 3.875e-06 Informative Direct
Biological Process (BP) apoptotic process 5.433e-08 Informative Direct
Biological Process (BP) immune response 1.292e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) steroid metabolic process 0.0007317 Informative Direct
Biological Process (BP) cell proliferation 2.835e-09 Informative Direct
Biological Process (BP) response to wounding 8.028e-06 Informative Direct
Biological Process (BP) positive regulation of signal transduction 2.155e-11 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0006864 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 2.956e-08 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 1.63e-10 Informative Direct
Biological Process (BP) positive regulation of gene expression 6.768e-12 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0005768 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0007962 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 7.968e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 2.341e-06 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000534 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) growth 1.998e-05 Informative Direct
Biological Process (BP) regulation of growth 0.0006403 Informative Direct
Biological Process (BP) locomotion 1.031e-12 Informative Direct
Biological Process (BP) regulation of locomotion 1.743e-13 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) chordate embryonic development 1.667e-07 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 4.172e-06 Informative Direct
Biological Process (BP) single-organism behavior 0.0001013 Informative Direct
Biological Process (BP) embryonic organ development 3.45e-05 Informative Direct
Biological Process (BP) embryonic morphogenesis 9.595e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 1.584e-06 Informative Direct
Biological Process (BP) tissue morphogenesis 3.091e-12 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.53e-14 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 4.536e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0003282 Informative Direct
Biological Process (BP) regulation of cellular component movement 2.615e-14 Informative Direct
Biological Process (BP) localization of cell 2.872e-09 Informative Direct
Biological Process (BP) negative regulation of cell death 1.892e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 2.921e-12 Informative Direct
Biological Process (BP) cardiovascular system development 1.794e-05 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.311 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8489 Informative Inherited
Biological Process (BP) cellular component movement 0.005053 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1271 Informative Inherited
Biological Process (BP) sensory organ development 0.001792 Informative Inherited
Biological Process (BP) epithelium development 0.06739 Informative Inherited
Biological Process (BP) gland development 0.001057 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4495 Informative Inherited
Biological Process (BP) response to external stimulus 0.6716 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.916 Informative Inherited
Biological Process (BP) reproductive system development 0.3389 Informative Inherited
Biological Process (BP) organ morphogenesis 0.02401 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.04407 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1357 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.6089 Informative Inherited
Biological Process (BP) positive regulation of transport 0.2588 Informative Inherited
Biological Process (BP) response to inorganic substance 0.7371 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.006022 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.5581 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1291 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.1089 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.03864 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.001311 Informative Inherited
Biological Process (BP) central nervous system development 0.3761 Informative Inherited
Biological Process (BP) response to other organism 0.02198 Informative Inherited
Biological Process (BP) protein transport 0.1306 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.1013 Informative Inherited
Biological Process (BP) secretion 0.005587 Informative Inherited
Biological Process (BP) regulation of ion transport 0.06333 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.5053 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.3396 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) angiogenesis 1.352e-13 Highly Informative Direct
Biological Process (BP) kidney development 1.592e-09 Highly Informative Direct
Biological Process (BP) regulation of sodium ion transport 2.796e-08 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to heat 1.152e-13 Highly Informative Direct
Biological Process (BP) hormone transport 8.578e-06 Highly Informative Direct
Biological Process (BP) glial cell differentiation 7.647e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0004983 Highly Informative Direct
Biological Process (BP) protein import 2.5e-07 Highly Informative Direct
Biological Process (BP) diencephalon development 1.639e-09 Highly Informative Direct
Biological Process (BP) lung development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 1.528e-06 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0001685 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 3.1e-13 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 3.211e-05 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 8.836e-08 Highly Informative Direct
Biological Process (BP) limb morphogenesis 5.87e-05 Highly Informative Direct
Biological Process (BP) endocrine system development 9.511e-07 Highly Informative Direct
Biological Process (BP) amide transport 6.205e-05 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 1.509e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 4.627e-10 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 8.095e-08 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.0001611 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 7.819e-08 Highly Informative Direct
Biological Process (BP) developmental growth 0.000658 Highly Informative Direct
Biological Process (BP) inner ear development 1.551e-10 Highly Informative Direct
Biological Process (BP) stem cell development 2.215e-09 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.0003519 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000723 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0004009 Highly Informative Direct
Biological Process (BP) nuclear import 1.905e-08 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 5.108e-11 Highly Informative Direct
Biological Process (BP) epithelial tube morphogenesis 1.013e-05 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide hormone stimulus 1.91e-08 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 2.603e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 6.547e-07 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 2.927e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 2.134e-09 Highly Informative Direct
Biological Process (BP) gastrulation 0.3798 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.03469 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.331 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.06134 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.001276 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.004331 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.03087 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.09882 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.01119 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.01973 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.3171 Highly Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.02919 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.02871 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1707 Highly Informative Inherited
Biological Process (BP) signal release 0.04372 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.002878 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.00825 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.005359 Highly Informative Inherited
Biological Process (BP) regulation of stem cell proliferation 0.8367 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3521 Highly Informative Inherited
Biological Process (BP) adult behavior 0.1066 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.01459 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.001659 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001256 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) ossification 0.001089 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.01688 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.004195 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.4742 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.1118 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) protein binding 5.279e-05 Moderately Informative Direct
Molecular Function (MF) cation binding 0.6683 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.9575 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 7.799e-09 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) glycosaminoglycan binding 0 Highly Informative Direct
Molecular Function (MF) sulfur compound binding 3.802e-14 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.5105 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) cytosol 8.105e-07 Moderately Informative Direct
Cellular Component (CC) extracellular space 2.683e-11 Informative Direct
Cellular Component (CC) cell surface 2.333e-05 Informative Direct
Cellular Component (CC) extracellular matrix 6.014e-11 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.07256Least InformativeInherited
Disease Ontology (DO)organ system cancer0.2735Least InformativeInherited
Disease Ontology (DO)endocrine system disease0.0007899Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.001647Moderately InformativeInherited
Disease Ontology (DO)bone disease0.01232Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.03106Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.07948Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1085Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1917Moderately InformativeInherited
Disease Ontology (DO)vascular disease0.3344Moderately InformativeInherited
Disease Ontology (DO)heart disease0.3444Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.3557Moderately InformativeInherited
Disease Ontology (DO)periodontitis0.0001665InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0004674InformativeDirect
Disease Ontology (DO)malaria0.000992InformativeDirect
Disease Ontology (DO)female reproductive system disease0.001384InformativeInherited
Disease Ontology (DO)arthropathy0.01016InformativeInherited
Disease Ontology (DO)lymphoma0.0162InformativeInherited
Disease Ontology (DO)autoimmune disease of cardiovascular system0.02149InformativeInherited
Disease Ontology (DO)vasculitis0.04887InformativeInherited
Disease Ontology (DO)purpura2.335e-05Highly InformativeDirect
Disease Ontology (DO)coronary heart disease4.845e-05Highly InformativeDirect
Disease Ontology (DO)spondylitis0.0003231Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.0004227Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0004422Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.06324Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0009491Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.102Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9046InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.2469Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell migration defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect
Fly Anatomy (FA)late extended germ band embryo0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)surface structure0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.1201Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2562Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure2.079e-07Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.003304Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01638Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.06913Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.4363Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.6496Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region1.709e-11InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm1.199e-06InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle2.655e-06InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction3.422e-05InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0005851InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.01499InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.0282InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.505InformativeInherited
Xenopus ANatomical entity (XAN)limb0.8288InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal arch1.338e-11Highly InformativeDirect
Xenopus ANatomical entity (XAN)fin2.45e-08Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest5.206e-08Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud9.778e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud1.229e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)hyoid crest1.489e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle1.947e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0001621Highly InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0002241Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0002735Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0005941Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.003693Highly InformativeInherited
Xenopus ANatomical entity (XAN)circumblastoporal collar0.0357Highly InformativeInherited

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processNeurogenesis1.024e-05InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseProto-oncogene2.2e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]