SUPERFAMILY 1.75 HMM library and genome assignments server


Cytokine superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Families:   Fibroblast growth factors (FGF) [ 50354] (9)
  Interleukin-1 (IL-1) [ 50362] (5)


Superfamily statistics
Genomes (140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,373 0 61
Proteins 2,318 0 61


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)single-organism cellular process1.082e-086.33e-14Least InformativeDirect
Biological Process (BP)response to stimulus4.378e-100Least InformativeDirect
Biological Process (BP)regulation of cellular process0.67610.5512Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.16031Least InformativeInherited
Biological Process (BP)localization0.17590.01958Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.68190.9603Least InformativeInherited
Biological Process (BP)immune system process0.00063760Moderately InformativeDirect
Biological Process (BP)signal transduction0.0001849.067e-15Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis2.605e-062.628e-06Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus00Moderately InformativeDirect
Biological Process (BP)tissue development6.599e-086.873e-09Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process2.484e-101.176e-08Moderately InformativeDirect
Biological Process (BP)response to organic substance01.366e-05Moderately InformativeDirect
Biological Process (BP)regulation of localization5.261e-059.215e-12Moderately InformativeDirect
Biological Process (BP)positive regulation of molecular function0.00012210.0004104Moderately InformativeDirect
Biological Process (BP)single-organism developmental process08.616e-11Moderately InformativeDirect
Biological Process (BP)organ development5.409e-050.0004311Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process7.914e-062.876e-11Moderately InformativeDirect
Biological Process (BP)regulation of developmental process6.477e-153.722e-15Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus2.637e-090Moderately InformativeDirect
Biological Process (BP)cellular localization0.1670.8355Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process7.15e-100.05598Moderately InformativeInherited
Biological Process (BP)reproduction0.018130.0009315Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process6.205e-070.08684Moderately InformativeInherited
Biological Process (BP)cell differentiation00.1655Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity10.1035Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process17.281e-15Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.92711Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.080990.1109Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.83270.01145Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.0020050.01209Moderately InformativeInherited
Biological Process (BP)organic substance transport0.00039440.01502Moderately InformativeInherited
Biological Process (BP)nervous system development10.8214Moderately InformativeInherited
Biological Process (BP)regulation of gene expression5.133e-050.9192Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.64480.6242Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.22710.0003561Moderately InformativeInherited
Biological Process (BP)regulation of protein phosphorylation1.951e-130InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter1.976e-076.639e-07InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway00InformativeDirect
Biological Process (BP)cell-cell signaling9.99e-112.137e-12InformativeDirect
Biological Process (BP)response to wounding0.00087744.517e-08InformativeDirect
Biological Process (BP)positive regulation of gene expression3.3e-157.899e-12InformativeDirect
Biological Process (BP)regulation of lipid metabolic process1.927e-061.337e-08InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis1.072e-056.162e-06InformativeDirect
Biological Process (BP)positive regulation of protein modification process9.589e-157.952e-06InformativeDirect
Biological Process (BP)tube development00InformativeDirect
Biological Process (BP)growth7.07e-111.334e-06InformativeDirect
Biological Process (BP)regulation of locomotion8.937e-111.87e-13InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process9.589e-157.807e-09InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.00030972.375e-07InformativeDirect
Biological Process (BP)tissue morphogenesis1.929e-092.118e-12InformativeDirect
Biological Process (BP)positive regulation of developmental process09.067e-15InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process1.156e-107.45e-06InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process8.318e-100InformativeDirect
Biological Process (BP)regulation of cellular component movement1.75e-112.604e-14InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus8.344e-072.021e-12InformativeDirect
Biological Process (BP)cardiovascular system development0.00020192.331e-06InformativeDirect
Biological Process (BP)sensory organ development0.037750.002829InformativeInherited
Biological Process (BP)epithelium development0.017130.03589InformativeInherited
Biological Process (BP)gland development0.0029920.0011InformativeInherited
Biological Process (BP)central nervous system development0.22590.207InformativeInherited
Biological Process (BP)cytoplasmic transport0.0034160.001117InformativeInherited
Biological Process (BP)regulation of cell development0.7041InformativeInherited
Biological Process (BP)regulation of growth0.05180.0004141InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.96030.6596InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process7.74e-100.001341InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process3.068e-090.007424InformativeInherited
Biological Process (BP)protein localization to organelle0.00082040.1812InformativeInherited
Biological Process (BP)regulation of kinase activity0.75160.353InformativeInherited
Biological Process (BP)regulation of cytokine production0.80510.03677InformativeInherited
Biological Process (BP)organ morphogenesis0.17260.03624InformativeInherited
Biological Process (BP)embryonic organ development0.02780.0001555InformativeInherited
Biological Process (BP)embryonic morphogenesis0.067695.555e-05InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0020341.54e-09InformativeInherited
Biological Process (BP)secretion by cell0.005430.154InformativeInherited
Biological Process (BP)regulation of hormone levels2.205e-060.001098InformativeInherited
Biological Process (BP)protein transport0.37830.1633InformativeInherited
Biological Process (BP)nitrogen compound transport0.0044940.07017InformativeInherited
Biological Process (BP)cellular component morphogenesis0.48450.6064InformativeInherited
Biological Process (BP)intracellular signal transduction10.2547InformativeInherited
Biological Process (BP)MAPK cascade0.00081280Highly InformativeDirect
Biological Process (BP)angiogenesis7.045e-074.241e-14Highly InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway00Highly InformativeDirect
Biological Process (BP)response to heat9.385e-059.657e-13Highly InformativeDirect
Biological Process (BP)hormone transport7.846e-095.618e-06Highly InformativeDirect
Biological Process (BP)glial cell differentiation0.00010551.263e-06Highly InformativeDirect
Biological Process (BP)protein import2.908e-056.629e-07Highly InformativeDirect
Biological Process (BP)diencephalon development4.413e-064.579e-10Highly InformativeDirect
Biological Process (BP)respiratory tube development4.92e-150Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration7.449e-055.294e-07Highly InformativeDirect
Biological Process (BP)protein localization to nucleus5.608e-063.037e-07Highly InformativeDirect
Biological Process (BP)limb morphogenesis4.57e-097.935e-06Highly InformativeDirect
Biological Process (BP)endocrine system development1.71e-064.094e-07Highly InformativeDirect
Biological Process (BP)amide transport2.683e-084.587e-05Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus1.449e-064.776e-08Highly InformativeDirect
Biological Process (BP)cell fate commitment1.137e-113.271e-10Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process6.154e-072.576e-08Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent2.858e-090.0002688Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube01.688e-10Highly InformativeDirect
Biological Process (BP)inner ear development0.00024591.093e-10Highly InformativeDirect
Biological Process (BP)stem cell development0.00010761.19e-07Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process00Highly InformativeDirect
Biological Process (BP)nuclear import6.396e-065.912e-08Highly InformativeDirect
Biological Process (BP)regulation of cell division1.77e-126.858e-07Highly InformativeDirect
Biological Process (BP)mesenchyme development2.461e-052.931e-08Highly InformativeDirect
Biological Process (BP)respiratory system development1.646e-120Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus00Highly InformativeDirect
Biological Process (BP)renal system development4.517e-141.07e-12Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus9.336e-063.671e-07Highly InformativeDirect
Biological Process (BP)regulation of organ morphogenesis1.047e-081.569e-08Highly InformativeDirect
Biological Process (BP)regulation of striated muscle tissue development13.078e-13Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.32510.02729Highly InformativeInherited
Biological Process (BP)embryonic organ morphogenesis0.0045592.522e-06Highly InformativeInherited
Biological Process (BP)signal release6.394e-080.05641Highly InformativeInherited
Biological Process (BP)pattern specification process0.053430.1239Highly InformativeInherited
Biological Process (BP)developmental growth2.283e-050.001945Highly InformativeInherited
Biological Process (BP)skeletal system development0.097380.002215Highly InformativeInherited
Biological Process (BP)connective tissue development0.11560.001103Highly InformativeInherited
Molecular Function (MF)binding2.971e-090Least InformativeDirect
Molecular Function (MF)anion binding3.898e-080.8935Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding5.311e-141.939e-12InformativeDirect
Molecular Function (MF)sulfur compound binding6.754e-164.568e-15InformativeDirect
Molecular Function (MF)heparin binding1.554e-140Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.14230.1765Least InformativeInherited
Cellular Component (CC)cytosol4.932e-054.056e-08Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular matrix2.756e-081.401e-11InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 6.33e-14 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.5512 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.01958 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9603 Least Informative Inherited
Biological Process (BP) reproduction 0.0009315 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 9.067e-15 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.628e-06 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 6.873e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.176e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.366e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 7.281e-15 Moderately Informative Direct
Biological Process (BP) regulation of localization 9.215e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0004104 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 8.616e-11 Moderately Informative Direct
Biological Process (BP) organ development 0.0004311 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 2.876e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.722e-15 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0003561 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.6701 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8355 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.05598 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.01145 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.01209 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1655 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1035 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1109 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.08684 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5819 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01502 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9192 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.8214 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6242 Moderately Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 6.639e-07 Informative Direct
Biological Process (BP) immune response 1.394e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) cell-cell signaling 2.137e-12 Informative Direct
Biological Process (BP) response to wounding 4.517e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1.54e-09 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 3.247e-09 Informative Direct
Biological Process (BP) positive regulation of gene expression 7.899e-12 Informative Direct
Biological Process (BP) programmed cell death 3.312e-07 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 1.337e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 6.162e-06 Informative Direct
Biological Process (BP) positive regulation of protein modification process 7.952e-06 Informative Direct
Biological Process (BP) tube development 0 Informative Direct
Biological Process (BP) growth 1.334e-06 Informative Direct
Biological Process (BP) regulation of growth 0.0004141 Informative Direct
Biological Process (BP) locomotion 2.975e-13 Informative Direct
Biological Process (BP) regulation of locomotion 1.87e-13 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) single-organism behavior 7.723e-05 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 7.807e-09 Informative Direct
Biological Process (BP) embryonic organ development 0.0001555 Informative Direct
Biological Process (BP) embryonic morphogenesis 5.555e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 2.375e-07 Informative Direct
Biological Process (BP) tissue morphogenesis 2.118e-12 Informative Direct
Biological Process (BP) positive regulation of developmental process 9.067e-15 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 7.45e-06 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 2.604e-14 Informative Direct
Biological Process (BP) localization of cell 1.512e-09 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000516 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.0004172 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 2.021e-12 Informative Direct
Biological Process (BP) cardiovascular system development 2.331e-06 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.247 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9007 Informative Inherited
Biological Process (BP) cellular component movement 0.03437 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1087 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.002829 Informative Inherited
Biological Process (BP) epithelium development 0.03589 Informative Inherited
Biological Process (BP) gland development 0.0011 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.383 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001117 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6596 Informative Inherited
Biological Process (BP) reproductive system development 0.3549 Informative Inherited
Biological Process (BP) organ morphogenesis 0.03624 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1293 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2547 Informative Inherited
Biological Process (BP) regulation of secretion 0.2389 Informative Inherited
Biological Process (BP) positive regulation of transport 0.09366 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.6079 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6627 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001341 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.007424 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4711 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6495 Informative Inherited
Biological Process (BP) regulation of immune response 0.431 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1812 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.4816 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001193 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.2179 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.8125 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.03677 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.001238 Informative Inherited
Biological Process (BP) central nervous system development 0.207 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5075 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) secretion by cell 0.154 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.001098 Informative Inherited
Biological Process (BP) response to other organism 0.01685 Informative Inherited
Biological Process (BP) protein transport 0.1633 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.07017 Informative Inherited
Biological Process (BP) regulation of ion transport 0.03641 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6064 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.353 Informative Inherited
Biological Process (BP) MAPK cascade 0 Highly Informative Direct
Biological Process (BP) angiogenesis 4.241e-14 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to heat 9.657e-13 Highly Informative Direct
Biological Process (BP) hormone transport 5.618e-06 Highly Informative Direct
Biological Process (BP) glial cell differentiation 1.263e-06 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 3.078e-13 Highly Informative Direct
Biological Process (BP) protein import 6.629e-07 Highly Informative Direct
Biological Process (BP) diencephalon development 4.579e-10 Highly Informative Direct
Biological Process (BP) respiratory tube development 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 5.294e-07 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0001278 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.422e-14 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 3.037e-07 Highly Informative Direct
Biological Process (BP) limb morphogenesis 7.935e-06 Highly Informative Direct
Biological Process (BP) endocrine system development 4.094e-07 Highly Informative Direct
Biological Process (BP) amide transport 4.587e-05 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00085 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 2.676e-07 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 1.269e-08 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 4.776e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 3.271e-10 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0007159 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 2.576e-08 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0002688 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 1.155e-05 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 2.522e-06 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 1.688e-10 Highly Informative Direct
Biological Process (BP) inner ear development 1.093e-10 Highly Informative Direct
Biological Process (BP) stem cell development 1.19e-07 Highly Informative Direct
Biological Process (BP) positive regulation of epithelial cell proliferation 0.0003351 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.0001599 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0002361 Highly Informative Direct
Biological Process (BP) nuclear import 5.912e-08 Highly Informative Direct
Biological Process (BP) regulation of cell division 6.858e-07 Highly Informative Direct
Biological Process (BP) mesenchyme development 2.931e-08 Highly Informative Direct
Biological Process (BP) respiratory system development 0 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0007961 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) renal system development 1.07e-12 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 7.239e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 3.671e-07 Highly Informative Direct
Biological Process (BP) cellular response to peptide 2.581e-09 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 1.569e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 2.128e-09 Highly Informative Direct
Biological Process (BP) developmental growth 0.001945 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02729 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2919 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.3476 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.12 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.002162 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.05456 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.00257 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.01443 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.03119 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.003741 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.008485 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.001136 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.1444 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.311 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.05051 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.02083 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1239 Highly Informative Inherited
Biological Process (BP) signal release 0.05641 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.2216 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.0108 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3036 Highly Informative Inherited
Biological Process (BP) adult behavior 0.109 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.03592 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.002215 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.001103 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) ossification 0.002134 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) cation binding 0.7607 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.8935 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 1.508e-09 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1.939e-12 Informative Direct
Molecular Function (MF) sulfur compound binding 4.568e-15 Informative Direct
Molecular Function (MF) copper ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.1765 Least Informative Inherited
Cellular Component (CC) cytosol 4.056e-08 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell surface 1.738e-05 Informative Direct
Cellular Component (CC) extracellular matrix 1.401e-11 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1017Least InformativeInherited
Disease Ontology (DO)organ system cancer0.3521Least InformativeInherited
Disease Ontology (DO)skin disease0.0003339Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.001512Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.04767Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1011Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1204Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1923Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.2028Moderately InformativeInherited
Disease Ontology (DO)periodontitis0.0002023InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.00045InformativeDirect
Disease Ontology (DO)malaria0.001157InformativeInherited
Disease Ontology (DO)female reproductive system disease0.001664InformativeInherited
Disease Ontology (DO)arthropathy0.009836InformativeInherited
Disease Ontology (DO)lymphoma0.0153InformativeInherited
Disease Ontology (DO)vasculitis0.06918InformativeInherited
Disease Ontology (DO)purpura2.66e-05Highly InformativeDirect
Disease Ontology (DO)spondylitis0.0003579Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.0004897Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0005323Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4752Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.5447Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05544Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1971Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.29Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.4624Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4557InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9411InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.0007104Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.0008754Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair growth0.03209Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.05685Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)cell migration defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)abdominal segment0InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect
Fly Anatomy (FA)early extended germ band embryo0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.109Least InformativeInherited
Zebrafish Anatomy (ZA)surface structure0Moderately InformativeDirect
Zebrafish Anatomy (ZA)peripheral nervous system0.0003175InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.1243Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2569Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure4.27e-07Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0.003099Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00331Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.02074Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.4541Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region8.637e-11InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm3.15e-06InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system3.174e-06InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode2.533e-05InformativeDirect
Xenopus ANatomical entity (XAN)notochord6.025e-05InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0001034InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0004117InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.01082InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.01601InformativeInherited
Xenopus ANatomical entity (XAN)tail0.1959InformativeInherited
Xenopus ANatomical entity (XAN)limb0.8315InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest1.828e-07Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge6.634e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)appendage6.65e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud2.193e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle4.227e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0001552Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomodeal-hypophyseal primordium0.0005359Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.0007214Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0009017Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0009401Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processNeurogenesis1.335e-05InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseProto-oncogene2.518e-05Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008996 SSF50353 Protein matches
Abstract

Human basic fibroblast growth factor (hFGF-2)1 is a globular single chain heparin-binding polypeptide synthesized by different cell types and is involved in processes associated with proliferation and differentiation of cells. The determination of the three-dimensional structure of hFGF-2 by x-ray crystallography revealed a complex all beta-sheet protein without any disulphide bond. The overall structure shows strong homology with the fold of interleukin-1 and can be described as a trigonal pyramid with three topological units consisting each of four anti-parallel beta-sheets, giving the molecules internal pseudo three-fold symmetry. Both proteins share only 10-13% sequence identity, but superposition of their carbon backbone involves 9 of the 12 beta-sheet strands, including the anti-parallel beta-sheet incorporating the N- and C-terminal regions of the molecules [PubMed10567376].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Cytokine superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]