SUPERFAMILY 1.73 HMM library and genome assignments server


Nucleic acid-binding proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (165)
Fold:   OB-fold [ 50198] (12)
  barrel, closed or partly opened n=5, S=10 or S=8; greek-key
Superfamily:   Nucleic acid-binding proteins [ 50249] (14)
Families:   Anticodon-binding domain [ 50250] (2)
  barrel, closed; n=5, S=10
  RecG "wedge" domain [ 69259]
  DNA helicase RuvA subunit, N-terminal domain [ 50259]
  barrel, closed; n=5, S=10
  Single strand DNA-binding domain, SSB [ 50263] (12)
  barrel, closed; n=5, S=10
  Myf domain [ 50277] (6)
  Cold shock DNA-binding domain-like [ 50282] (22)
  barrel, closed; n=5, S=8
  TRAM domain [ 101768] (3)
  Pfam 01938
  Hypothetical protein MTH1 (MT0001), insert domain [ 74955]
  DNA ligase/mRNA capping enzyme postcatalytic domain [ 50307] (5)
  Phage ssDNA-binding proteins [ 50315] (3)
  barrel, open; n*=5, S*=8; the members' structures vary greater that those from cellular organisms
  DNA replication initiator (cdc21/cdc54) N-terminal domain [ 89332]
  RNA polymerase subunit RBP8 [ 50321]
  duplication; contains tandem repeat of two incomplete OB-folds; forms a single barrel; n=8, S=10
  RecO N-terminal domain-like [ 117204]
  N-terminal part of Pfam 02565
  TIP49 domain [ 141315]
  N-terminal part of Pfam 06068; the RuvA-like OB-fold domain in RuvB-like eukaryotic proteins


Superfamily statistics
Genomes (1,235) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 50,673 52,530 193
Proteins 41,325 43,679 174


Functional annotation
General category Information
Detailed category DNA replication/repair

Function annotation of SCOP domain superfamilies

Jump to [ Top of page · SCOP classification · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 106 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleic acid-binding proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 106 hidden Markov models representing the Nucleic acid-binding proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]