SUPERFAMILY 1.75 HMM library and genome assignments server

Nucleic acid-binding proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   OB-fold [ 50198] (16)
Superfamily:   Nucleic acid-binding proteins [ 50249] (16)
Families:   Anticodon-binding domain [ 50250] (2)
  RecG "wedge" domain [ 69259]
  DNA helicase RuvA subunit, N-terminal domain [ 50259]
  Single strand DNA-binding domain, SSB [ 50263] (12)
  Myf domain [ 50277] (6)
  Cold shock DNA-binding domain-like [ 50282] (30)
  TRAM domain [ 101768] (3)
  Hypothetical protein MTH1 (MT0001), insert domain [ 74955]
  DNA ligase/mRNA capping enzyme postcatalytic domain [ 50307] (5)
  Phage ssDNA-binding proteins [ 50315] (3)
  DNA replication initiator (cdc21/cdc54) N-terminal domain [ 89332]
  RNA polymerase subunit RBP8 [ 50321]
  RecO N-terminal domain-like [ 117204]
  TIP49 domain [ 141315]
  SSO2064-like [ 159109]
  RNB domain-like [ 159112] (3)


Superfamily statistics
Genomes (3,255) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 146,651 702,208 241
Proteins 113,581 553,506 208


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00000000006320Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.000000000000095690Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.2470Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)developmental process0.93991Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.031280.0314Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.011970.00000128Least InformativeInherited
Biological Process (BP)regulation of cellular process0.8671Least InformativeInherited
Biological Process (BP)protein metabolic process0.000077511Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.099830Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.093510Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.20540Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.00000000000004707Least InformativeInherited
Biological Process (BP)gene expression00.0000000000001394Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)single-organism organelle organization0.0011060.00000000003892Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.64261Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.15891Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.097950.5742Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.011140.0318Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0071380.04154Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.79911Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.84951Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.72621Moderately InformativeInherited
Biological Process (BP)ribonucleoprotein complex biogenesis0.000082460.0000000001831InformativeDirect
Biological Process (BP)mitochondrion organization0.018460.0000374InformativeInherited
Biological Process (BP)cellular component morphogenesis0.26571InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0065660.0000000000657InformativeInherited
Biological Process (BP)chromosome organization0.28340.0000000005156InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.0092390InformativeInherited
Biological Process (BP)translational initiation0.00000000098860.000000608Highly InformativeDirect
Biological Process (BP)mitochondrion morphogenesis0.00086760.00007625Highly InformativeDirect
Biological Process (BP)regulation of protein complex disassembly0.00041330.01294Highly InformativeInherited
Molecular Function (MF)binding0.00070240Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)structural molecule activity0.0000000000001780.00000000122Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.55530.983Moderately InformativeInherited
Molecular Function (MF)chromatin binding0.00000031380.0000000008462InformativeDirect
Molecular Function (MF)structural constituent of ribosome00InformativeDirect
Molecular Function (MF)DNA binding0.48520.9634InformativeInherited
Molecular Function (MF)nucleotidyltransferase activity0.0016290InformativeInherited
Molecular Function (MF)RNA binding0.077360.009317InformativeInherited
Molecular Function (MF)RNA polymerase activity0.00001060.0001409Highly InformativeDirect
Molecular Function (MF)ribonucleoprotein complex binding0.00037970.0000007751Highly InformativeDirect
Molecular Function (MF)structure-specific DNA binding00Highly InformativeDirect
Molecular Function (MF)mRNA binding0.14910.2206Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00000022060.00000000000000457Least InformativeDirect
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.27591Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle10.268Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex00Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.0000000066130Moderately InformativeDirect
Cellular Component (CC)cytosol0.074270.002395Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.010060.01705Moderately InformativeInherited
Cellular Component (CC)transferase complex0.0012910.007096Moderately InformativeInherited
Cellular Component (CC)nuclear part0.005570Moderately InformativeInherited
Cellular Component (CC)DNA-directed RNA polymerase complex0.00000010360.00000000000003132InformativeDirect
Cellular Component (CC)small ribosomal subunit00.0006323InformativeDirect
Cellular Component (CC)chromosome0.91210InformativeInherited
Cellular Component (CC)mitochondrial matrix0.0000023280.378InformativeInherited
Cellular Component (CC)cytosolic ribosome0.58180.00344InformativeInherited
Cellular Component (CC)nucleoplasm part0.15330.6653InformativeInherited
Cellular Component (CC)DNA-directed RNA polymerase II, core complex0.00000000046570.0000006138Highly InformativeDirect
Cellular Component (CC)cytosolic small ribosomal subunit0.000061160.00000006046Highly InformativeDirect
Cellular Component (CC)cytoplasmic ribonucleoprotein granule0.000045420.00000005577Highly InformativeDirect
Cellular Component (CC)nuclear chromosome part0.034810Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000000004707 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000128 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.0314 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3322 Least Informative Inherited
Biological Process (BP) gene expression 0.0000000000001394 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000006209 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00000000003892 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9314 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0318 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1859 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.26 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.004673 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9438 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.05437 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8327 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.04154 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.02885 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.02881 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.05429 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5742 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) mitochondrion organization 0.0000374 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.000006632 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0000000000657 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0.0000000001831 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.000000000001593 Informative Direct
Biological Process (BP) single organism reproductive process 0.0002313 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000001027 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00004849 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.00006794 Informative Direct
Biological Process (BP) chromosome organization 0.0000000005156 Informative Direct
Biological Process (BP) cell division 0.0005197 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00007575 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.001123 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.9055 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.2073 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) organelle localization 0.9586 Informative Inherited
Biological Process (BP) organelle fission 0.2298 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.03252 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.6295 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) immune effector process 0.7848 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.7861 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.311 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.08601 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.005313 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.7271 Informative Inherited
Biological Process (BP) sexual reproduction 0.02081 Informative Inherited
Biological Process (BP) transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.5334 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.366 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6327 Informative Inherited
Biological Process (BP) DNA replication 0 Highly Informative Direct
Biological Process (BP) double-strand break repair 0 Highly Informative Direct
Biological Process (BP) DNA recombination 0.000002458 Highly Informative Direct
Biological Process (BP) translational initiation 0.000000608 Highly Informative Direct
Biological Process (BP) regulation of translation 0.00000007392 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.000000000000009016 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.0000000003199 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.000000001316 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.00000000024 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.00000000000001071 Highly Informative Direct
Biological Process (BP) gene silencing 0.0000000469 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.000000008376 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0000000008685 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0 Highly Informative Direct
Biological Process (BP) mitochondrion morphogenesis 0.00007625 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.515 Highly Informative Inherited
Biological Process (BP) histone modification 0.9223 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.01451 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1026 Highly Informative Inherited
Biological Process (BP) nucleobase-containing compound transport 0.08022 Highly Informative Inherited
Biological Process (BP) establishment of RNA localization 0.00389 Highly Informative Inherited
Biological Process (BP) B cell activation 0.08165 Highly Informative Inherited
Biological Process (BP) protein methylation 0.235 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.01294 Highly Informative Inherited
Biological Process (BP) stem cell development 0.02142 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.06842 Highly Informative Inherited
Biological Process (BP) nuclear division 0.01571 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.04648 Highly Informative Inherited
Biological Process (BP) mRNA processing 1 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.05286 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.2534 Highly Informative Inherited
Biological Process (BP) cytokinesis 1 Highly Informative Inherited
Biological Process (BP) rRNA processing 0.02714 Highly Informative Inherited
Biological Process (BP) mRNA catabolic process 0.2508 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.5087 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.00000007881 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.00000000122 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.983 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.1077 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 0.0000000008462 Informative Direct
Molecular Function (MF) structural constituent of ribosome 0 Informative Direct
Molecular Function (MF) nuclease activity 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) DNA binding 0.9634 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.1289 Informative Inherited
Molecular Function (MF) RNA binding 0.009317 Informative Inherited
Molecular Function (MF) RNA polymerase activity 0.0001409 Highly Informative Direct
Molecular Function (MF) ribonucleoprotein complex binding 0.0000007751 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) mRNA binding 0.2206 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00000000000000457 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.268 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) cytosol 0.002395 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.01705 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.007096 Moderately Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase complex 0.00000000000003132 Informative Direct
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) small ribosomal subunit 0.0006323 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.378 Informative Inherited
Cellular Component (CC) cytosolic ribosome 0.00344 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.6653 Informative Inherited
Cellular Component (CC) DNA-directed RNA polymerase II, core complex 0.0000006138 Highly Informative Direct
Cellular Component (CC) cytosolic small ribosomal subunit 0.00000006046 Highly Informative Direct
Cellular Component (CC) cytoplasmic ribonucleoprotein granule 0.00000005577 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0 Highly Informative Direct
Cellular Component (CC) nuclear body 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.1092InformativeInherited
Enzyme Commission (EC)Methionine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Aspartate--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Polyribonucleotide nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0.0000000000006306Highly InformativeDirect
Enzyme Commission (EC)mRNA guanylyltransferase0.000000003114Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.003039Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.008761Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1607Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.2519Least InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.0002626Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.001123Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.006391Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.0498Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.0656Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.6923Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.8113Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal chromosome stability0.00000000002952InformativeDirect
Mammalian Phenotype (MP)decreased germ cell number0.00008781InformativeDirect
Mammalian Phenotype (MP)abnormal male germ cell morphology0.0002591InformativeDirect
Mammalian Phenotype (MP)abnormal sex determination0.0003522InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0006155InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.0009253InformativeDirect
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.006191InformativeInherited
Mammalian Phenotype (MP)abnormal female genitalia morphology0.006233InformativeInherited
Mammalian Phenotype (MP)abnormal induced cell death0.0113InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.01465InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.02299InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.00000000000001419Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.00002158Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ovary size0.00002762Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0008172Highly InformativeDirect
Mammalian Phenotype (MP)abnormal female germ cell morphology0.01728Highly InformativeInherited
Mammalian Phenotype (MP)abnormal oogenesis0.01729Highly InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive system physiology0.02199Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.00000000001849Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.7785Least InformativeInherited
Worm Phenotype (WP)growth variant1Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000000001125Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.00002739Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.009473Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.02999Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.0449Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.05699Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.6343Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.8606Moderately InformativeInherited
Worm Phenotype (WP)sick0.000000005096InformativeDirect
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000003473InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0000002454InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00001103InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0002954InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0006507InformativeDirect
Worm Phenotype (WP)chromosome segregation variant0.06895InformativeInherited
Worm Phenotype (WP)cell division variant0.1339InformativeInherited
Worm Phenotype (WP)oocyte number decreased0.0000004784Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0000987Highly InformativeDirect
Worm Phenotype (WP)excessive blebbing early emb0.0001555Highly InformativeDirect
Worm Phenotype (WP)embryonic cell morphology variant0.0002173Highly InformativeDirect
Worm Phenotype (WP)cell cycle variant0.002204Highly InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb0.8074Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0000004111InformativeDirect
Yeast Phenotype (YP)heat sensitivity0.00001067InformativeDirect
Yeast Phenotype (YP)cell cycle progression0.0007043InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.00002316Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.001448Least InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.00005537Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.0003556Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.09888Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups1InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Polyribonucleotide nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)mRNA guanylyltransferase0.000000001532Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.08342Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation1Moderately InformativeInherited
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processProtein biosynthesis0InformativeDirect
Biological processTranscription termination7.057e-16Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentChromosome1InformativeInherited
Cellular componentPrimosome0Highly InformativeDirect
Cellular componentTelomere0.00000001526Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding4.62e-16Least InformativeDirect
Molecular functionMetal-binding0.0000000008916Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functiontRNA-binding0InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationNuclease0.2062Moderately InformativeInherited
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)protein biosynthesis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 131 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleic acid-binding proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 131 hidden Markov models representing the Nucleic acid-binding proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]