SUPERFAMILY 1.75 HMM library and genome assignments server


PDZ domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PDZ domain-like [ 50155]
Superfamily:   PDZ domain-like [ 50156] (6)
Families:   PDZ domain [ 50157] (46)
  Tail specific protease PDZ domain [ 68933] (2)
  HtrA-like serine proteases [ 74933] (4)
  Interleukin 16 [ 50172]
  EpsC C-terminal domain-like [ 159046]
  MTH1368 C-terminal domain-like [ 159049]


Superfamily statistics
Genomes (3,112) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 52,873 139,061 117
Proteins 35,953 105,247 112


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00014640Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00018380Least InformativeDirect
Biological Process (BP)developmental process0.0012470Least InformativeInherited
Biological Process (BP)localization0.040380Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0065180Least InformativeInherited
Biological Process (BP)regulation of cellular process0.014240.007382Least InformativeInherited
Biological Process (BP)response to stimulus0.37571.167e-13Least InformativeInherited
Biological Process (BP)single-organism developmental process0.045140Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.12957.97e-07Moderately InformativeInherited
Biological Process (BP)cellular localization0.047222.924e-11Moderately InformativeInherited
Biological Process (BP)system process0.0026461.043e-13Moderately InformativeInherited
Biological Process (BP)signal transduction0.37780.00226Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.27980.000228Moderately InformativeInherited
Biological Process (BP)growth0.00033596.529e-06InformativeDirect
Biological Process (BP)transmission of nerve impulse0.00098760InformativeDirect
Biological Process (BP)organelle localization0.0011772.317e-09InformativeInherited
Biological Process (BP)cell-cell signaling0.0029280InformativeInherited
Biological Process (BP)vesicle-mediated transport0.036810.7384InformativeInherited
Biological Process (BP)intracellular signal transduction0.0016371.389e-12InformativeInherited
Biological Process (BP)cell junction organization1.244e-050Highly InformativeDirect
Biological Process (BP)small GTPase mediated signal transduction1.915e-052.999e-06Highly InformativeDirect
Biological Process (BP)respiratory system development2.961e-051.113e-06Highly InformativeDirect
Biological Process (BP)establishment of vesicle localization5.361e-051.015e-05Highly InformativeDirect
Biological Process (BP)developmental growth0.0017730.01725Highly InformativeInherited
Biological Process (BP)synaptic vesicle localization1.748e-070.008335Highly InformativeInherited
Molecular Function (MF)binding3.304e-080Least InformativeDirect
Cellular Component (CC)membrane0.00068470Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.018090Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.45881Least InformativeInherited
Cellular Component (CC)cytoskeleton3.877e-050Moderately InformativeDirect
Cellular Component (CC)cell projection0.0008690Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.0014340Moderately InformativeInherited
Cellular Component (CC)basolateral plasma membrane0.00018436.284e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.167e-13 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.007382 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) system process 1.043e-13 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.14e-06 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 2.924e-11 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 7.97e-07 Moderately Informative Direct
Biological Process (BP) organelle organization 5.455e-07 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.000228 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0001774 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 3.186e-09 Moderately Informative Direct
Biological Process (BP) tissue development 8.284e-08 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 6.088e-05 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 7.796e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.0368 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1602 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.663 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.00226 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8217 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01938 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1223 Moderately Informative Inherited
Biological Process (BP) reproduction 0.004476 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.09437 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.003023 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) growth 6.529e-06 Informative Direct
Biological Process (BP) transmission of nerve impulse 0 Informative Direct
Biological Process (BP) organelle localization 2.317e-09 Informative Direct
Biological Process (BP) intracellular signal transduction 1.389e-12 Informative Direct
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0002722 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) epithelium development 7.281e-15 Informative Direct
Biological Process (BP) regulation of cell development 1.422e-14 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.591e-14 Informative Direct
Biological Process (BP) positive regulation of transport 4.075e-14 Informative Direct
Biological Process (BP) embryonic morphogenesis 5.857e-14 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 7.131e-14 Informative Direct
Biological Process (BP) regulation of nervous system development 8.526e-11 Informative Direct
Biological Process (BP) cellular component movement 2.942e-09 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 3.472e-09 Informative Direct
Biological Process (BP) localization of cell 7.619e-09 Informative Direct
Biological Process (BP) secretion by cell 1.199e-08 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.438e-07 Informative Direct
Biological Process (BP) sensory organ development 1.753e-07 Informative Direct
Biological Process (BP) phosphorylation 3.865e-07 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 9.404e-07 Informative Direct
Biological Process (BP) regulation of system process 2.497e-06 Informative Direct
Biological Process (BP) cellular membrane organization 2.641e-06 Informative Direct
Biological Process (BP) cell projection organization 7.692e-06 Informative Direct
Biological Process (BP) regulation of ion transport 4.886e-05 Informative Direct
Biological Process (BP) regulation of anatomical structure size 9.635e-05 Informative Direct
Biological Process (BP) microtubule-based process 0.0003739 Informative Direct
Biological Process (BP) tube development 0.0008301 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.9139 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.003657 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.2083 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.7989 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1098 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1672 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) response to wounding 0.03181 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.001711 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.001484 Informative Inherited
Biological Process (BP) generation of neurons 0.08748 Informative Inherited
Biological Process (BP) anion transport 0.6549 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.007391 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8175 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) protein complex assembly 0.09418 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.01887 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.009876 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.003504 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.02662 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.7384 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.2494 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4817 Informative Inherited
Biological Process (BP) regulation of growth 0.1205 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01063 Informative Inherited
Biological Process (BP) proteolysis 0.002063 Informative Inherited
Biological Process (BP) protein catabolic process 0.03627 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.8427 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.9746 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.104 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) dephosphorylation 0.3145 Informative Inherited
Biological Process (BP) programmed cell death 0.2792 Informative Inherited
Biological Process (BP) gland development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.02541 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) lipid localization 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01333 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1415 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) central nervous system development 0.5273 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.3195 Informative Inherited
Biological Process (BP) muscle system process 0.9829 Informative Inherited
Biological Process (BP) organic acid transport 0.08522 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 0.617 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.04102 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9385 Informative Inherited
Biological Process (BP) leukocyte activation 0.04367 Informative Inherited
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 2.999e-06 Highly Informative Direct
Biological Process (BP) respiratory system development 1.113e-06 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 1.015e-05 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 1.587e-12 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 1.354e-11 Highly Informative Direct
Biological Process (BP) cell adhesion 1.408e-11 Highly Informative Direct
Biological Process (BP) multi-organism behavior 1.571e-11 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 3.913e-11 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1.579e-10 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 4.035e-09 Highly Informative Direct
Biological Process (BP) stem cell proliferation 5.896e-09 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 1.16e-08 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 1.408e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 2.653e-08 Highly Informative Direct
Biological Process (BP) MAPK cascade 4.289e-08 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 1.144e-07 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 9.847e-07 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 1.042e-06 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.263e-06 Highly Informative Direct
Biological Process (BP) signal release 1.388e-06 Highly Informative Direct
Biological Process (BP) wound healing 1.913e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 2.529e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 3.503e-06 Highly Informative Direct
Biological Process (BP) exocytosis 4.244e-06 Highly Informative Direct
Biological Process (BP) actin filament-based movement 4.966e-06 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 2.073e-05 Highly Informative Direct
Biological Process (BP) amide transport 2.65e-05 Highly Informative Direct
Biological Process (BP) epithelial cell development 2.682e-05 Highly Informative Direct
Biological Process (BP) monoamine transport 8.425e-05 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0002643 Highly Informative Direct
Biological Process (BP) inner ear development 0.0002662 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0002756 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.000576 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 1 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.01036 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01455 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.009252 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.1053 Highly Informative Inherited
Biological Process (BP) cell growth 0.0176 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.005434 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) axon development 1 Highly Informative Inherited
Biological Process (BP) renal system development 0.001194 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.1366 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.008295 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.3389 Highly Informative Inherited
Biological Process (BP) cell division 0.07764 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.006076 Highly Informative Inherited
Biological Process (BP) muscle fiber development 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.01725 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.001698 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4412 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.1421 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.001235 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001729 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.5021 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.8175 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.3877 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.6248 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 0.3951 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.4387 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.8093 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.146 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.01703 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.00134 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.08802 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.05384 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.1107 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.00619 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.001425 Highly Informative Inherited
Biological Process (BP) regulation of binding 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.9522 Highly Informative Inherited
Biological Process (BP) hormone transport 0.003762 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.01278 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.008335 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.01351 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.4053 Highly Informative Inherited
Biological Process (BP) amino acid transport 0.03837 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid transport 0.06548 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.5095 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.2252 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.01558 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.01052 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.05488 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 4.935e-12 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.658e-09 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.007096 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.02622 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme binding 3.949e-09 Informative Direct
Molecular Function (MF) peptidase activity 6.868e-08 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 4.985e-06 Informative Direct
Molecular Function (MF) kinase activity 0.0001912 Informative Direct
Molecular Function (MF) receptor binding 0.000372 Informative Direct
Molecular Function (MF) nucleotide binding 0.9276 Informative Inherited
Molecular Function (MF) lipid binding 0.2867 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.4349 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 1.549e-07 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0009131 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.6736 Highly Informative Inherited
Molecular Function (MF) actin binding 1 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.01662 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.2527 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.03824 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.08878 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1444 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 2.121e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.332 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) coated vesicle 0.0006508 Informative Direct
Cellular Component (CC) endosome 0.01867 Informative Inherited
Cellular Component (CC) neuron projection 0.04312 Informative Inherited
Cellular Component (CC) cell-cell junction 0.592 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.4059 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.05548 Informative Inherited
Cellular Component (CC) integral to membrane 0.5493 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) extracellular matrix 0.005407 Informative Inherited
Cellular Component (CC) basolateral plasma membrane 6.284e-12 Highly Informative Direct
Cellular Component (CC) apical junction complex 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) neuron spine 4.558e-12 Highly Informative Direct
Cellular Component (CC) cell envelope 1.406e-11 Highly Informative Direct
Cellular Component (CC) periplasmic space 5.793e-11 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 6.021e-11 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 7.335e-11 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 1.541e-09 Highly Informative Direct
Cellular Component (CC) receptor complex 2.494e-08 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 4.96e-08 Highly Informative Direct
Cellular Component (CC) recycling endosome 1.841e-06 Highly Informative Direct
Cellular Component (CC) nonmotile primary cilium 3.603e-06 Highly Informative Direct
Cellular Component (CC) membrane raft 5.893e-06 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 3.206e-05 Highly Informative Direct
Cellular Component (CC) cilium part 5.983e-05 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0002634 Highly Informative Direct
Cellular Component (CC) contractile ring 0.0004002 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.0005769 Highly Informative Direct
Cellular Component (CC) dendrite 0.0006907 Highly Informative Direct
Cellular Component (CC) sperm part 0.1149 Highly Informative Inherited
Cellular Component (CC) main axon 0.003047 Highly Informative Inherited
Cellular Component (CC) microvillus 0.004294 Highly Informative Inherited
Cellular Component (CC) internal side of plasma membrane 0.04426 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.574 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.003795 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.006767 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.04833 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 1 Highly Informative Inherited
Cellular Component (CC) extracellular matrix part 0.001102 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0003073Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0004756Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase7.522e-10InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation3.399e-07InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.3199InformativeInherited
Enzyme Commission (EC)Nitric-oxide synthase1.896e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.5532Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.2794InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6154Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.5592Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.2512InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum1InformativeInherited
Phenotypic Abnormality (PA)Cerebral cortical atrophy0.0002412Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype2.086e-06Least InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.0583Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3272Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.7394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7998Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.01625InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.01625InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.05395InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.09009InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.4074InformativeInherited
Mammalian Phenotype (MP)craniorachischisis0.0002008Highly InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to addictive substance0.0002581Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1732Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.1942Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.007436Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.0814Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.3735Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.8391Moderately InformativeInherited
Worm Phenotype (WP)VPC competence variant0.004908InformativeInherited
Worm Phenotype (WP)vulva development variant0.01119InformativeInherited
Worm Phenotype (WP)cell division variant0.4874InformativeInherited
Worm Phenotype (WP)presynaptic region morphology variant2.669e-06Highly InformativeDirect
Worm Phenotype (WP)cell membrane morphology variant1.647e-05Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0001852Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0002255Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0002996Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0007785Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0003046InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.7338Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.7362Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7636Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.8968Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.4885Moderately InformativeInherited
Zebrafish Anatomy (ZA)central canal3.074e-05InformativeDirect
Zebrafish Anatomy (ZA)neuroepithelial cell6.642e-05InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups0.007856Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0006652Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase9.706e-10InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0002272InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0005593InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.3862InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen1.105e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation1.648e-13Moderately InformativeDirect
Biological processProtein transport2.309e-12Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processWnt signaling pathway0InformativeDirect
Biological processNeurogenesis3.938e-14InformativeDirect
Biological processStress response1.543e-07InformativeDirect
Biological processChemotaxis2.437e-05InformativeDirect
Biological processCell adhesion4.472e-05InformativeDirect
Biological processSteroid metabolism0.0009277InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processCilium biogenesis/degradation2.719e-14Highly InformativeDirect
Biological processOsteogenesis2.488e-07Highly InformativeDirect
Biological processNeurotransmitter transport1.635e-06Highly InformativeDirect
Biological processCholesterol metabolism3.998e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndosome6.557e-06Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.644e-06Moderately InformativeDirect
Cellular componentGolgi apparatus0.0003038Moderately InformativeDirect
Cellular componentPeriplasm4.558e-10InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentTight junction0Highly InformativeDirect
Cellular componentSynaptosome1.055e-05Highly InformativeDirect
Cellular componentPostsynaptic cell membrane3.811e-05Highly InformativeDirect
Coding sequence diversityAlternative splicing2.36e-13Least InformativeDirect
DiseaseDeafness4.18e-05InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil5.993e-05Moderately InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0008651InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionLipid-binding0.0001189InformativeDirect
Molecular functionGrowth factor binding1.393e-13Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationKinase1Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase3.637e-08InformativeDirect
Post-translational modificationSignal transduction inhibitor1e-06Highly InformativeDirect
Post-translational modificationCytokine3.375e-05Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation3.759e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001478 SSF50156 Protein matches
Abstract

PDZ domains are found in diverse signaling proteins in bacteria, yeasts, plants, insects and vertebrates [PubMed9041651, PubMed9204764]. PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences [PubMed9204764]. In most cases, interaction between a PDZ domain and its target is constitutive, with a binding affinity of 1 to 10 żM. However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane, a compartment where high concentrations of phosphatidylinositol 4,5-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin, CASK, Tiam-1) has been demonstrated.

PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices, A and B, compactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PDZ domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the PDZ domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]