SUPERFAMILY 1.75 HMM library and genome assignments server


SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (724) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,795 44,557 127
Proteins 30,154 34,695 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00053888.734e-06Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.40231Least InformativeInherited
Biological Process (BP)response to stimulus0.0020110Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0063680Least InformativeInherited
Biological Process (BP)developmental process0.0044320Least InformativeInherited
Biological Process (BP)regulation of signal transduction2.447e-059.799e-10Moderately InformativeDirect
Biological Process (BP)signal transduction0.00021235.578e-14Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.057620.0008959Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.070181Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.036450Moderately InformativeInherited
Biological Process (BP)tissue development0.017990.01603Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.061323.817e-09Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.12090Moderately InformativeInherited
Biological Process (BP)biological adhesion5.145e-071.306e-07InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00078850InformativeDirect
Biological Process (BP)regulation of organelle organization0.0040390InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.058131InformativeInherited
Biological Process (BP)tissue morphogenesis0.0029544.284e-07InformativeInherited
Biological Process (BP)epithelium development0.140.008099InformativeInherited
Biological Process (BP)regulation of actin cytoskeleton organization1.576e-060Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity0.00040690Moderately InformativeDirect
Cellular Component (CC)cell junction6.006e-050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 8.734e-06 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 9.799e-10 Moderately Informative Direct
Biological Process (BP) signal transduction 5.578e-14 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 9.124e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0008959 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.817e-09 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 3.741e-15 Moderately Informative Direct
Biological Process (BP) regulation of localization 9.189e-10 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 2.063e-08 Moderately Informative Direct
Biological Process (BP) cellular localization 5.002e-08 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 1.626e-06 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 2.344e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0002647 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0003135 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0009378 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0009684 Moderately Informative Direct
Biological Process (BP) organelle organization 0.002696 Moderately Informative Inherited
Biological Process (BP) organ development 0.6372 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.04165 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5919 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.09221 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2073 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.383 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0747 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001155 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9674 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2037 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1763 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.006207 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01603 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3664 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.9282 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.7539 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01573 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) biological adhesion 1.306e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.402e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 4.284e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0006196 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) cellular membrane organization 5.902e-14 Informative Direct
Biological Process (BP) localization of cell 4.279e-13 Informative Direct
Biological Process (BP) cellular component morphogenesis 2.762e-11 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 3.924e-11 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 5.835e-09 Informative Direct
Biological Process (BP) regulation of nervous system development 5.193e-08 Informative Direct
Biological Process (BP) leukocyte activation 2.291e-07 Informative Direct
Biological Process (BP) generation of neurons 2.623e-07 Informative Direct
Biological Process (BP) muscle structure development 7.87e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 9.945e-07 Informative Direct
Biological Process (BP) immune response 5.844e-06 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 8.587e-06 Informative Direct
Biological Process (BP) positive regulation of protein modification process 3.507e-05 Informative Direct
Biological Process (BP) positive regulation of immune system process 4.522e-05 Informative Direct
Biological Process (BP) regulation of cell development 5.688e-05 Informative Direct
Biological Process (BP) organelle assembly 6.889e-05 Informative Direct
Biological Process (BP) regulation of apoptotic process 7.506e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0001093 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001497 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0002751 Informative Direct
Biological Process (BP) muscle tissue development 0.0003948 Informative Direct
Biological Process (BP) response to wounding 0.0004478 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0004762 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0004788 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0005423 Informative Direct
Biological Process (BP) immune effector process 0.0006273 Informative Direct
Biological Process (BP) metal ion transport 0.0008825 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0009843 Informative Direct
Biological Process (BP) negative regulation of cell death 0.002211 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.02837 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.7756 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.7985 Informative Inherited
Biological Process (BP) positive regulation of transport 0.0248 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01291 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.01079 Informative Inherited
Biological Process (BP) epithelium development 0.008099 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.518 Informative Inherited
Biological Process (BP) response to other organism 0.7417 Informative Inherited
Biological Process (BP) organ morphogenesis 0.7678 Informative Inherited
Biological Process (BP) sensory organ development 0.1792 Informative Inherited
Biological Process (BP) central nervous system development 0.2906 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) organelle localization 0.09584 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7261 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.004456 Informative Inherited
Biological Process (BP) regulation of growth 0.01826 Informative Inherited
Biological Process (BP) regulation of system process 0.8653 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.208 Informative Inherited
Biological Process (BP) negative regulation of transport 0.7279 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1803 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2384 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6292 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.3643 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) tube development 0.1343 Informative Inherited
Biological Process (BP) single-organism behavior 0.06704 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.4827 Informative Inherited
Biological Process (BP) growth 0.01075 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3671 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9624 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.06767 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.7951 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8512 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1108 Informative Inherited
Biological Process (BP) sexual reproduction 0.1441 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1373 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.989 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.2239 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.9996 Informative Inherited
Biological Process (BP) protein transport 0.02331 Informative Inherited
Biological Process (BP) pigment metabolic process 0.01185 Informative Inherited
Biological Process (BP) defense response 0.002487 Informative Inherited
Biological Process (BP) regulation of immune response 0.9205 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.07465 Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 1.206e-13 Highly Informative Direct
Biological Process (BP) calcium ion transport 1.79e-13 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 6.301e-13 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 9.85e-13 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.444e-12 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 1.387e-11 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 2.209e-11 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 3.327e-11 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 5.612e-11 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 7.375e-11 Highly Informative Direct
Biological Process (BP) chemotaxis 1.913e-09 Highly Informative Direct
Biological Process (BP) cell projection assembly 3.348e-09 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 4.223e-09 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 9.242e-09 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 2.02e-08 Highly Informative Direct
Biological Process (BP) cellular response to peptide 3.677e-08 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 1.748e-07 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 6.232e-07 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 4.715e-06 Highly Informative Direct
Biological Process (BP) female gamete generation 7.021e-06 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 1.22e-05 Highly Informative Direct
Biological Process (BP) cell division 1.434e-05 Highly Informative Direct
Biological Process (BP) learning or memory 6.247e-05 Highly Informative Direct
Biological Process (BP) hemostasis 6.802e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 7.264e-05 Highly Informative Direct
Biological Process (BP) muscle organ development 9.706e-05 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.000241 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0003601 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0004074 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0.0005007 Highly Informative Direct
Biological Process (BP) wound healing 0.0005122 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.00069 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0006981 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0007904 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.000923 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.1649 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.442 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.005121 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.4972 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.07748 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.005112 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.8307 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.07755 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.001437 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.6943 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.9744 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.1457 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.207 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.9926 Highly Informative Inherited
Biological Process (BP) ear development 0.7363 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.3942 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.6088 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.02001 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) renal system development 0.006376 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.07913 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01067 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.006091 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.6398 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.005358 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 1 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.3604 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.001653 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.05293 Highly Informative Inherited
Biological Process (BP) muscle fiber development 1 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.6372 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.2503 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3708 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.4935 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.8662 Highly Informative Inherited
Biological Process (BP) stem cell proliferation 0.01602 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.0533 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.7603 Highly Informative Inherited
Biological Process (BP) superoxide metabolic process 0.001434 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.7429 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.7087 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.02006 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.003744 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2514 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1319 Highly Informative Inherited
Biological Process (BP) developmental growth 0.4745 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.1251 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.002208 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.04315 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) protein import 0.2989 Highly Informative Inherited
Biological Process (BP) sensory perception 0.8882 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.001673 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.01236 Highly Informative Inherited
Biological Process (BP) regulation of muscle contraction 0.004471 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.01602 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.04918 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.2676 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.02125 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.7665 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.004738 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.006052 Highly Informative Inherited
Biological Process (BP) response to fungus 0.05363 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.09036 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.09258 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1.82e-08 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 6.038e-15 Moderately Informative Direct
Molecular Function (MF) anion binding 2.26e-07 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 2.648e-07 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 1.201e-10 Informative Direct
Molecular Function (MF) lipid binding 4.441e-10 Informative Direct
Molecular Function (MF) enzyme binding 2.496e-06 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 1.337e-05 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 1.641e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.003764 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.3609 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.8823 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.08225 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.942 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.5032 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 4.624e-14 Highly Informative Direct
Molecular Function (MF) cation channel activity 2.052e-07 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 1.591e-06 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.0001038 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0002706 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0007632 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.004155 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.001058 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.0171 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.2739 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.01166 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.5686 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.003779 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1.164e-07 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.008103 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.3395 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.7918 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytosol 0.004487 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) contractile fiber part 7.02e-09 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 3.584e-06 Informative Direct
Cellular Component (CC) endosome 0.000961 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microbody 0.5834 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) integral to membrane 0.03613 Informative Inherited
Cellular Component (CC) extracellular matrix 0.37 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 5.886e-14 Highly Informative Direct
Cellular Component (CC) cilium part 3.456e-12 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 1.898e-11 Highly Informative Direct
Cellular Component (CC) midbody 3.797e-05 Highly Informative Direct
Cellular Component (CC) cell projection membrane 8.164e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0001666 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0002498 Highly Informative Direct
Cellular Component (CC) dendrite 0.6302 Highly Informative Inherited
Cellular Component (CC) main axon 0.1074 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.008167 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.004852 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) extracellular matrix part 0.1036 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.6583 Highly Informative Inherited
Cellular Component (CC) centrosome 0.2296 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases6.272e-08Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C3.251e-15InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase2.472e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.6466Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6715Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.3815Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.7108Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.7328Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7948Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.08529InformativeInherited
Phenotypic Abnormality (PA)Liver abscess3.158e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Obstructive lung disease0.0002231Highly InformativeDirect
Phenotypic Abnormality (PA)Cellulitis0.0002505Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0005933Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.08645Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.005298Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01291Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1163Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.8347Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.0003207Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.002089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.002554Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.003932Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01915Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.1431Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1459Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1543Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1721Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.7132Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.8033Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.9855Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.1411InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.2041InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.3113InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.3417InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.3461InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.3931InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.4366InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4371InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.5857InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling8.261e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.0004413Highly InformativeDirect
Mammalian Phenotype (MP)short cochlear hair cell stereocilia0.0005232Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.001951Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.0854Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0252Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0001466Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.5969Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.6343Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0.000381InformativeDirect
Worm Phenotype (WP)protein expression variant0.0009601InformativeDirect
Worm Phenotype (WP)endomitotic oocytes9.373e-06Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0001518Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0007785Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005831Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.08843Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport1.313e-05InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.2954InformativeInherited
Yeast Phenotype (YP)chitin deposition0.000316Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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