SUPERFAMILY 1.75 HMM library and genome assignments server


SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (724) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,795 44,557 127
Proteins 30,154 34,695 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00049851.166e-05Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.40011Least InformativeInherited
Biological Process (BP)response to stimulus0.0018310Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0066290Least InformativeInherited
Biological Process (BP)developmental process0.0043560Least InformativeInherited
Biological Process (BP)regulation of signal transduction2.334e-051.974e-09Moderately InformativeDirect
Biological Process (BP)signal transduction0.0002151.784e-14Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.056860.001346Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.068511Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.037550Moderately InformativeInherited
Biological Process (BP)tissue development0.01810.01643Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.061414.551e-09Moderately InformativeInherited
Biological Process (BP)biological adhesion4.863e-071.194e-07InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00076780InformativeDirect
Biological Process (BP)regulation of organelle organization0.0041910InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.056311InformativeInherited
Biological Process (BP)tissue morphogenesis0.0029792.976e-07InformativeInherited
Biological Process (BP)epithelium development0.13990.008064InformativeInherited
Biological Process (BP)regulation of actin cytoskeleton organization1.463e-060Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity0.00039880Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.166e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 1.974e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 1.784e-14 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 7.113e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 4.551e-09 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 3.135e-14 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.05e-09 Moderately Informative Direct
Biological Process (BP) cellular localization 6.187e-08 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 1.376e-06 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 1.364e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 0.000243 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0003774 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0008375 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.00219 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001184 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001346 Moderately Informative Inherited
Biological Process (BP) organ development 0.6305 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02942 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5868 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1203 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1169 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8376 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1303 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001029 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2076 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1749 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.004411 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01643 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3611 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.8887 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.6978 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01596 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) biological adhesion 1.194e-07 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.629e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 2.976e-07 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0006198 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) cellular membrane organization 1.211e-13 Informative Direct
Biological Process (BP) localization of cell 3.22e-13 Informative Direct
Biological Process (BP) cellular component morphogenesis 3.51e-11 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 4.127e-11 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 4.082e-09 Informative Direct
Biological Process (BP) regulation of nervous system development 6.153e-08 Informative Direct
Biological Process (BP) leukocyte activation 2.242e-07 Informative Direct
Biological Process (BP) generation of neurons 2.743e-07 Informative Direct
Biological Process (BP) muscle structure development 7.973e-07 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 1.685e-06 Informative Direct
Biological Process (BP) immune response 5.912e-06 Informative Direct
Biological Process (BP) positive regulation of protein modification process 5.981e-06 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 8.275e-06 Informative Direct
Biological Process (BP) positive regulation of immune system process 4.313e-05 Informative Direct
Biological Process (BP) regulation of cell development 6.168e-05 Informative Direct
Biological Process (BP) organelle assembly 6.706e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 9.972e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0001053 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0001247 Informative Direct
Biological Process (BP) regulation of locomotion 0.00026 Informative Direct
Biological Process (BP) response to wounding 0.0003837 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000385 Informative Direct
Biological Process (BP) muscle tissue development 0.0003955 Informative Direct
Biological Process (BP) immune effector process 0.0007041 Informative Direct
Biological Process (BP) metal ion transport 0.0008915 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.007675 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.0103 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.6266 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.8025 Informative Inherited
Biological Process (BP) positive regulation of transport 0.02447 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01895 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.002663 Informative Inherited
Biological Process (BP) epithelium development 0.008064 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.3578 Informative Inherited
Biological Process (BP) response to other organism 0.7473 Informative Inherited
Biological Process (BP) organ morphogenesis 0.7777 Informative Inherited
Biological Process (BP) sensory organ development 0.1873 Informative Inherited
Biological Process (BP) central nervous system development 0.2731 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) organelle localization 0.09395 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6697 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.006939 Informative Inherited
Biological Process (BP) regulation of growth 0.01711 Informative Inherited
Biological Process (BP) regulation of system process 0.8417 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.1958 Informative Inherited
Biological Process (BP) negative regulation of transport 0.8166 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1834 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2421 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6064 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.416 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) tube development 0.139 Informative Inherited
Biological Process (BP) single-organism behavior 0.06271 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.4691 Informative Inherited
Biological Process (BP) growth 0.007703 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3839 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9668 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.07578 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.7931 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8607 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1077 Informative Inherited
Biological Process (BP) sexual reproduction 0.151 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1369 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.01287 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.9682 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.2343 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein transport 0.03074 Informative Inherited
Biological Process (BP) pigment metabolic process 0.01251 Informative Inherited
Biological Process (BP) defense response 0.001968 Informative Inherited
Biological Process (BP) regulation of immune response 0.9228 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1227 Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) calcium ion transport 1.844e-13 Highly Informative Direct
Biological Process (BP) protein phosphorylation 1.919e-13 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 1.569e-12 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.346e-12 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 7.018e-12 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 1.775e-11 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 2.109e-11 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 5.107e-11 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 6.461e-11 Highly Informative Direct
Biological Process (BP) chemotaxis 5.892e-10 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 1.056e-09 Highly Informative Direct
Biological Process (BP) cell projection assembly 2.646e-09 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 4.327e-09 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 1.182e-08 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 3.862e-08 Highly Informative Direct
Biological Process (BP) cellular response to peptide 4.073e-08 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 2.946e-07 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 3.714e-07 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 6.999e-07 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 4.305e-06 Highly Informative Direct
Biological Process (BP) female gamete generation 7.089e-06 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 8.939e-06 Highly Informative Direct
Biological Process (BP) cell division 2.909e-05 Highly Informative Direct
Biological Process (BP) hemostasis 6.197e-05 Highly Informative Direct
Biological Process (BP) muscle organ development 6.395e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 6.77e-05 Highly Informative Direct
Biological Process (BP) learning or memory 9.143e-05 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0.0001985 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 0.0003522 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0003526 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0003933 Highly Informative Direct
Biological Process (BP) wound healing 0.0004597 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.0005961 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.000678 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0007879 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.0009551 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.2024 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.005185 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.4978 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.06439 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.7993 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.07633 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.001455 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.7101 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.014 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.9583 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.1462 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.2119 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.9978 Highly Informative Inherited
Biological Process (BP) ear development 0.7262 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.3711 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.6188 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01557 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) renal system development 0.006349 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.08422 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02207 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.006883 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.6535 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.006198 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 1 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.2882 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.001365 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.06117 Highly Informative Inherited
Biological Process (BP) muscle fiber development 1 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.606 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.2476 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3441 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.6306 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.7876 Highly Informative Inherited
Biological Process (BP) stem cell proliferation 0.01754 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.07036 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.7014 Highly Informative Inherited
Biological Process (BP) superoxide metabolic process 0.001405 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.7442 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.707 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.02127 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.004383 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2621 Highly Informative Inherited
Biological Process (BP) innate immune response 0.143 Highly Informative Inherited
Biological Process (BP) developmental growth 0.4625 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.1221 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.001974 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.0475 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.9996 Highly Informative Inherited
Biological Process (BP) protein import 0.4115 Highly Informative Inherited
Biological Process (BP) sensory perception 0.8248 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.001831 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.01277 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.009309 Highly Informative Inherited
Biological Process (BP) regulation of muscle contraction 0.004345 Highly Informative Inherited
Biological Process (BP) cellular transition metal ion homeostasis 0.7466 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.01567 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.04822 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.2703 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.02288 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.755 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.005974 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.007402 Highly Informative Inherited
Biological Process (BP) response to fungus 0.0594 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.095 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.09963 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 7.524e-09 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 9.734e-15 Moderately Informative Direct
Molecular Function (MF) anion binding 2.748e-07 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 2.878e-07 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 1.441e-10 Informative Direct
Molecular Function (MF) lipid binding 1.132e-09 Informative Direct
Molecular Function (MF) enzyme binding 2.798e-06 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 1.454e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.003473 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.3579 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.8766 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.09149 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.9686 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.4439 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 4.159e-14 Highly Informative Direct
Molecular Function (MF) cation channel activity 1.881e-07 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 1.442e-06 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 1.129e-05 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.0001003 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0002105 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0007213 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0008332 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.00419 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.01504 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.3055 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.0108 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.5848 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.003889 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1.528e-07 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.03625 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.2979 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.774 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytosol 0.004262 Moderately Informative Inherited
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) contractile fiber part 5.024e-09 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 3.207e-06 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microbody 0.5761 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) integral to membrane 0.03798 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell-cell junction 0.4503 Informative Inherited
Cellular Component (CC) extracellular matrix 0.3513 Informative Inherited
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 5.296e-14 Highly Informative Direct
Cellular Component (CC) cilium part 1.68e-12 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 4.002e-12 Highly Informative Direct
Cellular Component (CC) midbody 3.57e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 8.487e-05 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0001912 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0003448 Highly Informative Direct
Cellular Component (CC) dendrite 0.6539 Highly Informative Inherited
Cellular Component (CC) main axon 0.1195 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.007119 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.004869 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) extracellular matrix part 0.09773 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.6601 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1955 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases6.272e-08Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C3.251e-15InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase2.472e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.6985Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7294Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.4167Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the liver0.452Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.7391Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.7658Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7892Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.0915InformativeInherited
Phenotypic Abnormality (PA)Liver abscess3.382e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Obstructive lung disease0.0002193Highly InformativeDirect
Phenotypic Abnormality (PA)Cellulitis0.0002724Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0005659Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.09537Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.00515Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01259Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1171Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.8347Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.0003659Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.002126Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.002603Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.004016Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01899Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.1414Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1452Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1659Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1691Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.7109Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7988Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.9845Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.0006663InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel physiology0.1427InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.309InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.334InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.334InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.3868InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4413InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling8.435e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.0003836Highly InformativeDirect
Mammalian Phenotype (MP)short cochlear hair cell stereocilia0.000528Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.00209Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.08771Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0252Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0001466Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.5969Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.6343Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0.000381InformativeDirect
Worm Phenotype (WP)protein expression variant0.0009601InformativeDirect
Worm Phenotype (WP)endomitotic oocytes9.373e-06Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0001518Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0007785Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005831Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.08813Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport1.243e-05InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.2939InformativeInherited
Yeast Phenotype (YP)chitin deposition0.0003146Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0002782Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases7.933e-08InformativeDirect
Enzyme Commission (EC)Hexosyltransferases7.586e-05InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C3.324e-15Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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