SUPERFAMILY 1.75 HMM library and genome assignments server


SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (713) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 37,015 44,557 127
Proteins 28,806 34,695 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00044180.00005167Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.40831Least InformativeInherited
Biological Process (BP)response to stimulus0.0015910Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0065180Least InformativeInherited
Biological Process (BP)developmental process0.0039790Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.000020930.000000007172Moderately InformativeDirect
Biological Process (BP)signal transduction0.00021530.00000000000001253Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.057080.002486Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.069491Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.038890Moderately InformativeInherited
Biological Process (BP)tissue development0.017610.005407Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.059540.0000000114Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.12150.00000000000001077Moderately InformativeInherited
Biological Process (BP)biological adhesion0.00000043590.00001864InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00081610InformativeDirect
Biological Process (BP)regulation of organelle organization0.0041060InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.056191InformativeInherited
Biological Process (BP)tissue morphogenesis0.0028830.0000001299InformativeInherited
Biological Process (BP)epithelium development0.14330.01054InformativeInherited
Biological Process (BP)regulation of actin cytoskeleton organization0.0000013740Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity0.00037870Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.00005167 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.000000007172 Moderately Informative Direct
Biological Process (BP) signal transduction 0.00000000000001253 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0004206 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000114 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.00000000000001077 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0.000000000003097 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000005948 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.000005792 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000007968 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00003338 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.004601 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001453 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.002486 Moderately Informative Inherited
Biological Process (BP) organ development 0.7414 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.07136 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7439 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1169 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3171 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8829 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2018 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.00114 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.005498 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.001241 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2461 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3796 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.002749 Moderately Informative Inherited
Biological Process (BP) tissue development 0.005407 Moderately Informative Inherited
Biological Process (BP) reproduction 0.361 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.8776 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.6834 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01722 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.004127 Moderately Informative Inherited
Biological Process (BP) biological adhesion 0.00001864 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.000005774 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000001299 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0001898 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) cellular membrane organization 0.00000000000005694 Informative Direct
Biological Process (BP) cellular component movement 0.000000000000149 Informative Direct
Biological Process (BP) localization of cell 0.00000000002677 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000000003354 Informative Direct
Biological Process (BP) cell-cell signaling 0.000000006876 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000009165 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000152 Informative Direct
Biological Process (BP) muscle structure development 0.0000002412 Informative Direct
Biological Process (BP) transmission of nerve impulse 0.0000004461 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000005249 Informative Direct
Biological Process (BP) regulation of nervous system development 0.000001012 Informative Direct
Biological Process (BP) generation of neurons 0.000001063 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.000006168 Informative Direct
Biological Process (BP) organelle assembly 0.000008959 Informative Direct
Biological Process (BP) leukocyte activation 0.00001131 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.000025 Informative Direct
Biological Process (BP) immune response 0.00004546 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00008354 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0001253 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0001443 Informative Direct
Biological Process (BP) regulation of locomotion 0.0002591 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0003269 Informative Direct
Biological Process (BP) regulation of cell development 0.0003377 Informative Direct
Biological Process (BP) response to wounding 0.0003414 Informative Direct
Biological Process (BP) muscle tissue development 0.0003684 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0004941 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0004947 Informative Direct
Biological Process (BP) immune effector process 0.0008078 Informative Direct
Biological Process (BP) metal ion transport 0.0008127 Informative Direct
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.008008 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.01439 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7048 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1813 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01908 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.9166 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.002366 Informative Inherited
Biological Process (BP) epithelium development 0.01054 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.156 Informative Inherited
Biological Process (BP) response to other organism 0.9357 Informative Inherited
Biological Process (BP) organ morphogenesis 0.6983 Informative Inherited
Biological Process (BP) sensory organ development 0.1495 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) organelle localization 0.02264 Informative Inherited
Biological Process (BP) regulation of growth 0.01201 Informative Inherited
Biological Process (BP) regulation of system process 0.8397 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.4463 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4786 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5557 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.5832 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.024 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.4335 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) tube development 0.1118 Informative Inherited
Biological Process (BP) single-organism behavior 0.1328 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.4602 Informative Inherited
Biological Process (BP) growth 0.002384 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.586 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9563 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0213 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.7522 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.9104 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.09811 Informative Inherited
Biological Process (BP) sexual reproduction 0.1271 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1318 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.01317 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.9628 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.202 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein transport 0.0305 Informative Inherited
Biological Process (BP) pigment metabolic process 0.01178 Informative Inherited
Biological Process (BP) defense response 0.003599 Informative Inherited
Biological Process (BP) regulation of immune response 0.9354 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.09596 Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00000000000001761 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0.00000000000002935 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0000000000001306 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0000000000001779 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000000000002438 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.000000000003952 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 0.000000000005391 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0.00000000003029 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.00000000004686 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.00000000006167 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000000001469 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000001784 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000000001059 Highly Informative Direct
Biological Process (BP) activation of immune response 0.000000001368 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.000000004084 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000000007566 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00000003759 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.00000005745 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.00000009913 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0.0000003055 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.0000003083 Highly Informative Direct
Biological Process (BP) response to ethanol 0.0000007954 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0000008355 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000001628 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000005259 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0.000008855 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00001012 Highly Informative Direct
Biological Process (BP) cell division 0.00002241 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00002371 Highly Informative Direct
Biological Process (BP) hemostasis 0.0000523 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00006215 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0.0001251 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 0.0001296 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.0002841 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0003093 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0003334 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.0003759 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0003885 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0003892 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0003894 Highly Informative Direct
Biological Process (BP) wound healing 0.0004338 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.1859 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.004042 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.4443 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.04105 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.589 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.00351 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.7081 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.6452 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.01155 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.9608 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.1292 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.2202 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.8784 Highly Informative Inherited
Biological Process (BP) inner ear development 0.1734 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.2428 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.5198 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01009 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) renal system development 0.004204 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.0677 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02288 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.007128 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.00333 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.988 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.2272 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.01968 Highly Informative Inherited
Biological Process (BP) muscle fiber development 1 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.05641 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.6854 Highly Informative Inherited
Biological Process (BP) regulation of muscle contraction 0.003991 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.9606 Highly Informative Inherited
Biological Process (BP) stem cell proliferation 0.009904 Highly Informative Inherited
Biological Process (BP) negative regulation of neuron death 0.002586 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.1397 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.7937 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.0692 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.87 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) superoxide metabolic process 0.001579 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.5277 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.6649 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.02132 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.001602 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2635 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1362 Highly Informative Inherited
Biological Process (BP) developmental growth 0.6963 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.005756 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.2382 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.03241 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.9429 Highly Informative Inherited
Biological Process (BP) protein import 0.3586 Highly Informative Inherited
Biological Process (BP) sensory perception 0.5887 Highly Informative Inherited
Biological Process (BP) axon development 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.002239 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.01204 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.009271 Highly Informative Inherited
Biological Process (BP) cellular transition metal ion homeostasis 0.7483 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.01561 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.04804 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.2263 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.01936 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.6334 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.002881 Highly Informative Inherited
Biological Process (BP) response to fungus 0.02489 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.3386 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.6862 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000000001402 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0000002086 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000002336 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.0000000009388 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000000009765 Informative Direct
Molecular Function (MF) enzyme binding 0.000005965 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.00001364 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.003291 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.335 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.8056 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.08697 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.4413 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.00000000000003868 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.0000001716 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.000001354 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.00001126 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00006997 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0002096 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0007182 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0008608 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.003309 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.01409 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.3072 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.011 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.7388 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.003698 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000000008901 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.03768 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.1745 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.7826 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytosol 0.001633 Moderately Informative Inherited
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000000000001352 Informative Direct
Cellular Component (CC) contractile fiber part 0.000000002394 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0000001861 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microbody 0.5611 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) integral to membrane 0.03867 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell-cell junction 0.8704 Informative Inherited
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) nonmotile primary cilium 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000000000004729 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.0000000000003062 Highly Informative Direct
Cellular Component (CC) cilium part 0.0000000000009556 Highly Informative Direct
Cellular Component (CC) microtubule organizing center part 0.00000000000187 Highly Informative Direct
Cellular Component (CC) ruffle 0.00000003372 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 0.0000007753 Highly Informative Direct
Cellular Component (CC) midbody 0.00003173 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.00004833 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00008069 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.0001214 Highly Informative Direct
Cellular Component (CC) membrane raft 0.00013 Highly Informative Direct
Cellular Component (CC) contractile ring 0.0001927 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.0005624 Highly Informative Direct
Cellular Component (CC) microbody part 0.004675 Highly Informative Inherited
Cellular Component (CC) neuron spine 0.01533 Highly Informative Inherited
Cellular Component (CC) dendrite 0.8377 Highly Informative Inherited
Cellular Component (CC) main axon 0.1208 Highly Informative Inherited
Cellular Component (CC) microvillus 0.5784 Highly Informative Inherited
Cellular Component (CC) internal side of plasma membrane 0.003859 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.005696 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.00387 Highly Informative Inherited
Cellular Component (CC) myosin complex 0.08393 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) apical junction complex 0.01592 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1292 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000006272Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000003251InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000002472Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.6322Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6652Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.3337Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.5175Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.6311Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7884Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.7956Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.1291InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.00001847Highly InformativeDirect
Phenotypic Abnormality (PA)Liver abscess0.00003986Highly InformativeDirect
Phenotypic Abnormality (PA)Obstructive lung disease0.0002286Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0006605Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.1062Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.005423Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01242Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.12Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.8367Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.000408Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.00217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.002663Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.003993Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0184Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.1418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1649Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.7104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7996Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.9854Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.1391InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.3104InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.3314InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.3314InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.3855InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.4269InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4342InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.6214InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling0.00008538Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.000408Highly InformativeDirect
Mammalian Phenotype (MP)short cochlear hair cell stereocilia0.0005357Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.002142Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.0889Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0252Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0001466Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.5969Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.6343Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0.000381InformativeDirect
Worm Phenotype (WP)protein expression variant0.0009601InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.000009373Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0001518Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0007785Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005831Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.0835Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport0.00007341InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.2779InformativeInherited
Yeast Phenotype (YP)endocytosis0.0000003558Highly InformativeDirect
Yeast Phenotype (YP)chitin deposition0.0003141Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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