SUPERFAMILY 1.75 HMM library and genome assignments server

SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (725) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,838 44,557 127
Proteins 30,189 34,695 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0006650.000008993Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.18691Least InformativeInherited
Biological Process (BP)developmental process0.0045090Least InformativeInherited
Biological Process (BP)multicellular organismal process0.0020650Least InformativeInherited
Biological Process (BP)response to stimulus0.0019870Least InformativeInherited
Biological Process (BP)single-organism cellular process0.25110Least InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.0000072740Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.000029450.000000002725Moderately InformativeDirect
Biological Process (BP)signal transduction0.00017140.00000000000001071Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.061750.000000004213Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.044490Moderately InformativeInherited
Biological Process (BP)biological adhesion0.000020120.0000001784InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00086330InformativeDirect
Biological Process (BP)embryonic morphogenesis0.0009080.000000117InformativeDirect
Biological Process (BP)regulation of organelle organization0.004470InformativeInherited
Biological Process (BP)regulation of actin cytoskeleton organization0.0000015630Highly InformativeDirect
Biological Process (BP)cell adhesion0.0000066180.00000001325Highly InformativeDirect
Cellular Component (CC)cell junction0.000060640InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.000008993 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.000000000000007248 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000000002725 Moderately Informative Direct
Biological Process (BP) signal transduction 0.00000000000001071 Moderately Informative Direct
Biological Process (BP) tissue development 0.0001924 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000003103 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00000006839 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000004213 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000002378 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00000001199 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000009063 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.00003035 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000345 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00007398 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00029 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0006321 Moderately Informative Direct
Biological Process (BP) defense response 0.0007572 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0007579 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.002516 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2882 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.09487 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3804 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.06752 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0291 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01399 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01155 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.9457 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.7442 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.001284 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1028 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9766 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2741 Moderately Informative Inherited
Biological Process (BP) biological adhesion 0.0000001784 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.000000117 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) tissue morphogenesis 0.000000004694 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000689 Informative Direct
Biological Process (BP) epithelium development 0.0000009703 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000000000000001913 Informative Direct
Biological Process (BP) localization of cell 0.0000000000002315 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00000000004545 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000004415 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000008166 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000001051 Informative Direct
Biological Process (BP) synaptic transmission 0.0000001398 Informative Direct
Biological Process (BP) leukocyte activation 0.0000002013 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.000000295 Informative Direct
Biological Process (BP) generation of neurons 0.0000003425 Informative Direct
Biological Process (BP) muscle structure development 0.000003925 Informative Direct
Biological Process (BP) immune response 0.000006569 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.00000686 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00006264 Informative Direct
Biological Process (BP) organelle assembly 0.00006664 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00009697 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0001123 Informative Direct
Biological Process (BP) metal ion transport 0.0001518 Informative Direct
Biological Process (BP) response to bacterium 0.0001816 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001845 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002622 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0002884 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0003876 Informative Direct
Biological Process (BP) apoptotic process 0.0003951 Informative Direct
Biological Process (BP) regulation of cell activation 0.0005667 Informative Direct
Biological Process (BP) immune effector process 0.0006684 Informative Direct
Biological Process (BP) negative regulation of cell death 0.01141 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7882 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.0142 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.005199 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4681 Informative Inherited
Biological Process (BP) positive regulation of transport 0.05445 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.04341 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.07509 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.01684 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.009681 Informative Inherited
Biological Process (BP) central nervous system development 0.316 Informative Inherited
Biological Process (BP) cell division 0.02886 Informative Inherited
Biological Process (BP) organelle localization 0.06997 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) growth 0.007894 Informative Inherited
Biological Process (BP) neurological system process 0.009559 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2845 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.4864 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.7708 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3017 Informative Inherited
Biological Process (BP) regulation of growth 0.01464 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.2544 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.8227 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6116 Informative Inherited
Biological Process (BP) tube development 0.3345 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cell proliferation 0.01663 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.00906 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.658 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.04624 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein transport 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.004874 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.6989 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.4834 Informative Inherited
Biological Process (BP) single-organism behavior 0.004002 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.7664 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8431 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.1715 Informative Inherited
Biological Process (BP) sexual reproduction 0.2142 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.04444 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 1 Informative Inherited
Biological Process (BP) muscle system process 0.8545 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.9892 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.05498 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.4984 Informative Inherited
Biological Process (BP) pigment metabolic process 0.01195 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.8906 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.001641 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.03716 Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0.00000001325 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000000000000003707 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.000000000000007248 Highly Informative Direct
Biological Process (BP) plasma membrane organization 0.00000000000001752 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.000000000000329 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000000000001225 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000000001883 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000000000003785 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000000000005474 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000000009987 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.0000000004743 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0000000004883 Highly Informative Direct
Biological Process (BP) cytokinesis 0.000000000859 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0000000009236 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.0000000009637 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000001354 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.000000002661 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.000000004512 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.00000001839 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.00000005224 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0000002066 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.0000003 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0000006246 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000007771 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.000003394 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000008729 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0.00001324 Highly Informative Direct
Biological Process (BP) regulation of myeloid leukocyte mediated immunity 0.00002004 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0000516 Highly Informative Direct
Biological Process (BP) hemostasis 0.00006398 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.00008787 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.0001375 Highly Informative Direct
Biological Process (BP) wound healing 0.0001664 Highly Informative Direct
Biological Process (BP) learning or memory 0.0003958 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0004085 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0004318 Highly Informative Direct
Biological Process (BP) kidney development 0.0004354 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0.0004915 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.0006496 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0006743 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0008201 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.1365 Highly Informative Inherited
Biological Process (BP) regulation of ion transmembrane transport 0.01824 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.5146 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.04753 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.006509 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.9218 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.001709 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.7668 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.0204 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.2494 Highly Informative Inherited
Biological Process (BP) regulation of chemotaxis 1 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.1404 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.9963 Highly Informative Inherited
Biological Process (BP) ear development 0.7313 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.7978 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.01144 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01092 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.006548 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.6358 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) stem cell proliferation 0.01476 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.01844 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.01537 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.9598 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.3899 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.03749 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.005102 Highly Informative Inherited
Biological Process (BP) sensory perception 0.3272 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.3776 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.1814 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.06983 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.35 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4598 Highly Informative Inherited
Biological Process (BP) regulation of muscle system process 0.02281 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.8885 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.00558 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) superoxide metabolic process 0.001512 Highly Informative Inherited
Biological Process (BP) cilium organization 0.01957 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.436 Highly Informative Inherited
Biological Process (BP) epidermis development 0.9885 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.07723 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2532 Highly Informative Inherited
Biological Process (BP) innate immune response 0.2173 Highly Informative Inherited
Biological Process (BP) developmental growth 0.2018 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.1167 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.001861 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.02849 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.9999 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.2505 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.4889 Highly Informative Inherited
Biological Process (BP) protein import 0.3744 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.06179 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.001446 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.1126 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.0801 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.01578 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.04912 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.004131 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.02223 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.793 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.7617 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 1 Highly Informative Inherited
Biological Process (BP) response to fungus 0.05032 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.08179 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.08776 Highly Informative Inherited
Biological Process (BP) cell recognition 0.03259 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.000002877 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000002732 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0000003373 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000000002476 Informative Direct
Molecular Function (MF) lipid binding 0.0000000009637 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0000000147 Informative Direct
Molecular Function (MF) enzyme binding 0.000001625 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.0000134 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.00001625 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.7347 Informative Inherited
Molecular Function (MF) receptor binding 0.3624 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) protein complex binding 0.00116 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.9273 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.00000000000003944 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.0000002065 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.00007357 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0008793 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.01708 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.2957 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.01273 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.006784 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.9028 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.5266 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.003713 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00000000804 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.003704 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9551 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) membrane region 0.00000479 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.3026 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) cytosol 0.005742 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.0000000000001767 Informative Direct
Cellular Component (CC) contractile fiber part 0.00000001393 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000002582 Informative Direct
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) microbody 0.5829 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.03861 Informative Inherited
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000000000006654 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.00000000001154 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.00000000002122 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.00000001699 Highly Informative Direct
Cellular Component (CC) ciliary part 0.00000008265 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.000007301 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000146 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00002218 Highly Informative Direct
Cellular Component (CC) midbody 0.00005309 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.00009501 Highly Informative Direct
Cellular Component (CC) main axon 0.05139 Highly Informative Inherited
Cellular Component (CC) integral component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.004943 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000006272Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000003251InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000002472Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.6466Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6733Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.3815Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.7109Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.7327Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7948Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.0852InformativeInherited
Phenotypic Abnormality (PA)Liver abscess0.00003112Highly InformativeDirect
Phenotypic Abnormality (PA)Obstructive lung disease0.0002205Highly InformativeDirect
Phenotypic Abnormality (PA)Cellulitis0.0002477Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0005876Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.08633Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.005626Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01353Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1252Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.8458Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.0004052Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.002019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.00248Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.003806Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.02125Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1395Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1541Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.177Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2293Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.7304Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.8203Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.9886Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.1586InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.3002InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.3461InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.3461InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.3853InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4224InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.4396InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.5812InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling0.00008548Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.0003729Highly InformativeDirect
Mammalian Phenotype (MP)short cochlear hair cell stereocilia0.0005266Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.002069Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.08512Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0252Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0001466Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.5969Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.6343Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0.000381InformativeDirect
Worm Phenotype (WP)protein expression variant0.0009601InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.000009373Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0001518Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0007785Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005831Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.08801Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport0.00001316InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.2956InformativeInherited
Yeast Phenotype (YP)chitin deposition0.0003159Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0002809Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000007803InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00008297InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000003337Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)cardiovascular system0.07255Least InformativeInherited
Drugbank ATC_code (DB)antineoplastic agents0.0000006706Moderately InformativeDirect
Drugbank ATC_code (DB)cardiac therapy0.006056Moderately InformativeInherited
Drugbank ATC_code (DB)protein kinase inhibitors0.000000000001687InformativeDirect
Drugbank ATC_code (DB)spironolactone0.000006688InformativeDirect
Drugbank ATC_code (DB)dihydropyridine derivatives0.00003767InformativeDirect
Drugbank ATC_code (DB)antiarrhythmics, class iii0.0002432InformativeDirect
Drugbank ATC_code (DB)opium alkaloids and derivatives0.0009717InformativeDirect
Drugbank ATC_code (DB)dextromethorphan0.0006804Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.728Least InformativeInherited
Biological processProtein transport0.000000000000009131Moderately InformativeDirect
Biological processApoptosis0.0000000005349Moderately InformativeDirect
Biological processDifferentiation0.000002271Moderately InformativeDirect
Biological processCell cycle0.0003497Moderately InformativeDirect
Biological processIon transport0.5373Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processCell adhesion0.000000000008185InformativeDirect
Biological processNeurogenesis0.00000000004777InformativeDirect
Biological processMitosis0.0000000007872InformativeDirect
Biological processInflammatory response0.000004213InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processAdaptive immunity0.00000000000002633Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000000000188Highly InformativeDirect
Biological processExocytosis0.0000003803Highly InformativeDirect
Biological process