SUPERFAMILY 1.75 HMM library and genome assignments server


SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (674) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 36,307 33,378 127
Proteins 28,248 25,865 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00078947.468e-05Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.41861Least InformativeInherited
Biological Process (BP)response to stimulus0.0030120Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0061330Least InformativeInherited
Biological Process (BP)developmental process0.0059530Least InformativeInherited
Biological Process (BP)regulation of signal transduction3.087e-054.128e-09Moderately InformativeDirect
Biological Process (BP)signal transduction0.00023390Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.055920.0002904Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.070671Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.040950Moderately InformativeInherited
Biological Process (BP)tissue development0.016960.09382Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.060072.344e-07Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.12061.095e-11Moderately InformativeInherited
Biological Process (BP)biological adhesion6.234e-074.155e-06InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00088590InformativeDirect
Biological Process (BP)regulation of organelle organization0.0045330InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.058061InformativeInherited
Biological Process (BP)tissue morphogenesis0.0027146.871e-06InformativeInherited
Biological Process (BP)epithelium development0.14020.1037InformativeInherited
Biological Process (BP)regulation of actin cytoskeleton organization1.936e-060Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity0.0005110Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 7.468e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 4.128e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001919 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0002904 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.344e-07 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.095e-11 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 3.13e-10 Moderately Informative Direct
Biological Process (BP) regulation of localization 8.385e-09 Moderately Informative Direct
Biological Process (BP) cellular localization 1.435e-05 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 3.1e-05 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 6.78e-05 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0006275 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.08328 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01732 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.31 Moderately Informative Inherited
Biological Process (BP) organ development 0.7465 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.05774 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6937 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8635 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1574 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2993 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8301 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2003 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.04824 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.008362 Moderately Informative Inherited
Biological Process (BP) tissue development 0.09382 Moderately Informative Inherited
Biological Process (BP) reproduction 0.4581 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.91 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.6542 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01897 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.002056 Moderately Informative Inherited
Biological Process (BP) biological adhesion 4.155e-06 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 3.913e-06 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) tissue morphogenesis 6.871e-06 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0005109 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) localization of cell 2.443e-13 Informative Direct
Biological Process (BP) cell activation 3.264e-11 Informative Direct
Biological Process (BP) cellular component morphogenesis 2.057e-10 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 6.169e-10 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 7.498e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.849e-08 Informative Direct
Biological Process (BP) muscle structure development 8.109e-08 Informative Direct
Biological Process (BP) membrane organization 2.443e-07 Informative Direct
Biological Process (BP) organelle assembly 1.892e-06 Informative Direct
Biological Process (BP) cell-cell signaling 4.789e-06 Informative Direct
Biological Process (BP) generation of neurons 1.018e-05 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 1.672e-05 Informative Direct
Biological Process (BP) immune response 4.595e-05 Informative Direct
Biological Process (BP) muscle tissue development 5.21e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 7.529e-05 Informative Direct
Biological Process (BP) positive regulation of immune system process 8.562e-05 Informative Direct
Biological Process (BP) transmission of nerve impulse 0.0001083 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000109 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001097 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0001528 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0003187 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0003802 Informative Direct
Biological Process (BP) metal ion transport 0.0007069 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0007295 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.007186 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.0117 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.59 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.664 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6544 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1509 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01079 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.9296 Informative Inherited
Biological Process (BP) cation homeostasis 0.01232 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.001794 Informative Inherited
Biological Process (BP) epithelium development 0.1037 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1682 Informative Inherited
Biological Process (BP) defense response 0.005968 Informative Inherited
Biological Process (BP) response to bacterium 0.002875 Informative Inherited
Biological Process (BP) regulation of cell development 0.01438 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.04716 Informative Inherited
Biological Process (BP) cardiovascular system development 0.8373 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) organelle localization 0.05222 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.6764 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.1371 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.571 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.005585 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.5772 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) response to wounding 0.001368 Informative Inherited
Biological Process (BP) immune effector process 0.003745 Informative Inherited
Biological Process (BP) secondary metabolic process 0.8213 Informative Inherited
Biological Process (BP) growth 0.01346 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7489 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of growth 0.1692 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.6565 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5138 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2029 Informative Inherited
Biological Process (BP) sexual reproduction 0.2441 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1723 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.7662 Informative Inherited
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.183 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein transport 0.02235 Informative Inherited
Biological Process (BP) pigment metabolic process 0.0864 Informative Inherited
Biological Process (BP) regulation of immune response 0.9043 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 1.931e-15 Highly Informative Direct
Biological Process (BP) phagocytosis 2.78e-14 Highly Informative Direct
Biological Process (BP) calcium ion transport 5.401e-14 Highly Informative Direct
Biological Process (BP) cell junction organization 1.22e-13 Highly Informative Direct
Biological Process (BP) protein phosphorylation 3.884e-13 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 2.166e-12 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 6.494e-12 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 3.892e-11 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.527e-10 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 1.821e-10 Highly Informative Direct
Biological Process (BP) activation of immune response 1.94e-10 Highly Informative Direct
Biological Process (BP) chemotaxis 2.622e-10 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 7.351e-10 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 8.977e-10 Highly Informative Direct
Biological Process (BP) cellular response to peptide 1.213e-08 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 1.55e-08 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 2.37e-08 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 9.236e-08 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 9.316e-08 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 2.644e-07 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 2.839e-07 Highly Informative Direct
Biological Process (BP) response to ethanol 5.694e-07 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 8.011e-07 Highly Informative Direct
Biological Process (BP) cell projection assembly 2.348e-06 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 8.044e-06 Highly Informative Direct
Biological Process (BP) plasma membrane organization 2.147e-05 Highly Informative Direct
Biological Process (BP) muscle organ development 3.201e-05 Highly Informative Direct
Biological Process (BP) hemostasis 4.907e-05 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 7.056e-05 Highly Informative Direct
Biological Process (BP) female gamete generation 9.504e-05 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.0001346 Highly Informative Direct
Biological Process (BP) cell division 0.000138 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.0003242 Highly Informative Direct
Biological Process (BP) interaction with symbiont 0.0003428 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0003923 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 0.000433 Highly Informative Direct
Biological Process (BP) wound healing 0.0004648 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.000595 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 0.0007018 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0007953 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.00091 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 0.0009679 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.08064 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.2686 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.02483 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.511 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.006453 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.8631 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.6307 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.08846 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.1775 Highly Informative Inherited
Biological Process (BP) inner ear development 0.1046 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.279 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.374 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.002795 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) renal system development 0.02835 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02139 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.3534 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.4479 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.1193 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.08993 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.5795 Highly Informative Inherited
Biological Process (BP) regulation of muscle contraction 0.01171 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.8737 Highly Informative Inherited
Biological Process (BP) negative regulation of neuron death 0.00195 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.1393 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.1259 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.8847 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.4801 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.2142 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.001406 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.7849 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1518 Highly Informative Inherited
Biological Process (BP) developmental growth 0.8895 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.003744 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.003991 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.1502 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.4307 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.01326 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.76 Highly Informative Inherited
Biological Process (BP) development of primary male sexual characteristics 0.1066 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.7791 Highly Informative Inherited
Biological Process (BP) protein import 0.3461 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.03774 Highly Informative Inherited
Biological Process (BP) sensory perception 0.2099 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.003277 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.002596 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.013 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.00933 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9938 Highly Informative Inherited
Biological Process (BP) fatty acid derivative metabolic process 0.03957 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.1024 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.002009 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.245 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.008913 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.5966 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 1 Highly Informative Inherited
Biological Process (BP) response to fungus 0.04939 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.3816 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.715 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 3.372e-13 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 3.807e-08 Moderately Informative Direct
Molecular Function (MF) anion binding 5.752e-08 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 5.942e-11 Informative Direct
Molecular Function (MF) lipid binding 2.617e-10 Informative Direct
Molecular Function (MF) enzyme binding 5.207e-07 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 6.692e-06 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.002031 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.166 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.7731 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.09567 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.8619 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 4.534e-15 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 5.743e-07 Highly Informative Direct
Molecular Function (MF) protein complex binding 9.988e-06 Highly Informative Direct
Molecular Function (MF) ion channel activity 1.887e-05 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.0001492 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0002162 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0005844 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0007024 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.003111 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.01194 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.2791 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.007007 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.472 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1.245e-09 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.01743 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0007485 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.807 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.9651 Moderately Informative Inherited
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 4.436e-15 Informative Direct
Cellular Component (CC) contractile fiber part 4.004e-09 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 2.302e-07 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microbody 0.5115 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) integral to membrane 0.03835 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) microtubule organizing center part 7.98e-13 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 3.541e-12 Highly Informative Direct
Cellular Component (CC) synaptic membrane 2.328e-11 Highly Informative Direct
Cellular Component (CC) cilium 6.569e-09 Highly Informative Direct
Cellular Component (CC) cell division site part 3.02e-08 Highly Informative Direct
Cellular Component (CC) ruffle 3.654e-08 Highly Informative Direct
Cellular Component (CC) lateral plasma membrane 2.078e-06 Highly Informative Direct
Cellular Component (CC) microbody membrane 2.473e-05 Highly Informative Direct
Cellular Component (CC) cell projection membrane 4.353e-05 Highly Informative Direct
Cellular Component (CC) membrane raft 7.636e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 7.755e-05 Highly Informative Direct
Cellular Component (CC) contractile ring 0.0001636 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.0006894 Highly Informative Direct
Cellular Component (CC) microbody part 0.003955 Highly Informative Inherited
Cellular Component (CC) neuron spine 0.005462 Highly Informative Inherited
Cellular Component (CC) dendrite 0.7882 Highly Informative Inherited
Cellular Component (CC) axon part 0.1512 Highly Informative Inherited
Cellular Component (CC) microvillus 0.5579 Highly Informative Inherited
Cellular Component (CC) internal side of plasma membrane 0.002653 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.003879 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.004322 Highly Informative Inherited
Cellular Component (CC) myosin complex 0.07779 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) centrosome 0.07787 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases6.272e-08Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C3.251e-15InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase2.472e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.6322Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6674Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.3339Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.4486Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.5175Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.6312Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.7955Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.1295InformativeInherited
Phenotypic Abnormality (PA)Cellulitis1.849e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Liver abscess3.995e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Obstructive lung disease0.0002278Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0006646Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.1062Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.003573Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.008978Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08856Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6108Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.7973Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.0004357Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.002281Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.002797Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.003414Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.004234Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.02207Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.1172Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1542Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1913Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.6193Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.8156Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.08957InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.2467InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.3198InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.3198InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.3742InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.4126InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4268InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.6288InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling9.827e-05Highly InformativeDirect
Mammalian Phenotype (MP)short cochlear hair cell stereocilia0.0005286Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.000618Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.002439Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.0873Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0252Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0001466Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.5969Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.6343Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0.000381InformativeDirect
Worm Phenotype (WP)protein expression variant0.0009601InformativeDirect
Worm Phenotype (WP)endomitotic oocytes9.373e-06Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0001518Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0007785Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005831Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.07643Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport6.524e-05InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.2532InformativeInherited
Yeast Phenotype (YP)endocytosis3.41e-07Highly InformativeDirect
Yeast Phenotype (YP)chitin deposition0.000298Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inhe