SUPERFAMILY 1.75 HMM library and genome assignments server

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SH3-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Families:   SH3-domain [ 50045] (39)


Superfamily statistics
Genomes (724) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,795 44,557 127
Proteins 30,154 34,695 122


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00057040.000002472Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.41Least InformativeInherited
Biological Process (BP)response to stimulus0.0020550Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0063680Least InformativeInherited
Biological Process (BP)developmental process0.0044980Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.000026770.0000000007229Moderately InformativeDirect
Biological Process (BP)signal transduction0.00020210.00000000000002119Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.060520.001819Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.072491Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.037630Moderately InformativeInherited
Biological Process (BP)tissue development0.018020.01126Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.062130.000000005689Moderately InformativeInherited
Biological Process (BP)biological adhesion0.00000055960.0000001371InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00078830InformativeDirect
Biological Process (BP)regulation of organelle organization0.0039220InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.065171InformativeInherited
Biological Process (BP)tissue morphogenesis0.0029190.0000004081InformativeInherited
Biological Process (BP)epithelium development0.14050.006186InformativeInherited
Biological Process (BP)regulation of actin cytoskeleton organization0.0000015730Highly InformativeDirect
Molecular Function (MF)enzyme regulator activity0.00041190Moderately InformativeDirect
Cellular Component (CC)cell junction0.000062080InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.000002472 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0000000007229 Moderately Informative Direct
Biological Process (BP) signal transduction 0.00000000000002119 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0003143 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000000005689 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0.000000000000007347 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000001208 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000003 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000006711 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.000001561 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.00002537 Moderately Informative Direct
Biological Process (BP) nervous system development 0.000298 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000419 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0007209 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0007831 Moderately Informative Direct
Biological Process (BP) organelle organization 0.002248 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001009 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.001819 Moderately Informative Inherited
Biological Process (BP) organ development 0.6617 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.05307 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6261 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.051 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1124 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3905 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.08068 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9895 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.178 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1981 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.006432 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01126 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1823 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01514 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) biological adhesion 0.0000001371 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00001396 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0000004081 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0008141 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) cellular membrane organization 0.0000000000001919 Informative Direct
Biological Process (BP) localization of cell 0.0000000000004776 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000003081 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000000000493 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.00000000006199 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000006197 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000000463 Informative Direct
Biological Process (BP) leukocyte activation 0.0000002257 Informative Direct
Biological Process (BP) generation of neurons 0.0000003074 Informative Direct
Biological Process (BP) muscle structure development 0.0000009638 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000001151 Informative Direct
Biological Process (BP) immune response 0.00000532 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.000009236 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00003393 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00005528 Informative Direct
Biological Process (BP) regulation of cell development 0.00007681 Informative Direct
Biological Process (BP) organelle assembly 0.00008601 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0001109 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001401 Informative Direct
Biological Process (BP) response to bacterium 0.00017 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0004369 Informative Direct
Biological Process (BP) response to wounding 0.0004711 Informative Direct
Biological Process (BP) regulation of cell activation 0.0004916 Informative Direct
Biological Process (BP) muscle tissue development 0.0005943 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0005972 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0006075 Informative Direct
Biological Process (BP) immune effector process 0.0006291 Informative Direct
Biological Process (BP) metal ion transport 0.0009727 Informative Direct
Biological Process (BP) negative regulation of cell death 0.002008 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.008152 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.7892 Informative Inherited
Biological Process (BP) positive regulation of transport 0.02552 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01241 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.01253 Informative Inherited
Biological Process (BP) epithelium development 0.006186 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.5157 Informative Inherited
Biological Process (BP) organ morphogenesis 0.7811 Informative Inherited
Biological Process (BP) sensory organ development 0.1872 Informative Inherited
Biological Process (BP) central nervous system development 0.3026 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) organelle localization 0.09275 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7188 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.004819 Informative Inherited
Biological Process (BP) regulation of growth 0.01889 Informative Inherited
Biological Process (BP) regulation of system process 0.8814 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.2107 Informative Inherited
Biological Process (BP) negative regulation of transport 0.7373 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1991 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2567 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.06219 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.6293 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.5125 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) tube development 0.1359 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.001067 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.4873 Informative Inherited
Biological Process (BP) growth 0.007755 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3692 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9689 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0643 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.7886 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8406 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1753 Informative Inherited
Biological Process (BP) sexual reproduction 0.2362 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1005 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.9912 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.2338 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.9982 Informative Inherited
Biological Process (BP) protein transport 0.02335 Informative Inherited
Biological Process (BP) pigment metabolic process 0.01216 Informative Inherited
Biological Process (BP) defense response 0.002585 Informative Inherited
Biological Process (BP) regulation of immune response 0.8982 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.05274 Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.000000000000007347 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.00000000000005589 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0000000000001674 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0000000000005067 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000000000001099 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000000000005953 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.00000000001336 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.00000000002846 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.0000000001013 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0000000001777 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000001425 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.000000001899 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.000000004531 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.000000005802 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.000000008782 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.000000009134 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000000183 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.0000001971 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0000006275 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.000006594 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000009118 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0.00001347 Highly Informative Direct
Biological Process (BP) cell division 0.00001386 Highly Informative Direct
Biological Process (BP) hemostasis 0.00006713 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00008138 Highly Informative Direct
Biological Process (BP) learning or memory 0.00008358 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0001134 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0002265 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.0002354 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0004044 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0.0004977 Highly Informative Direct
Biological Process (BP) wound healing 0.0005492 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0006251 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.0006914 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0008421 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.1629 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.4382 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.005748 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.474 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.07154 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.005102 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.8124 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.0758 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.001576 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.7053 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.9689 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.1458 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.2037 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 1 Highly Informative Inherited
Biological Process (BP) ear development 0.7362 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.3891 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.598 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01927 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) renal system development 0.006202 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.07928 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.006936 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.006547 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.6401 Highly Informative Inherited
Biological Process (BP) neural precursor cell proliferation 0.005369 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.2413 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.001536 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.04768 Highly Informative Inherited
Biological Process (BP) muscle fiber development 1 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.6226 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) establishment of synaptic vesicle localization 0.2471 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3948 Highly Informative Inherited
Biological Process (BP) regulation of muscle contraction 0.004531 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.4866 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.87 Highly Informative Inherited
Biological Process (BP) stem cell proliferation 0.01468 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.09096 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.7747 Highly Informative Inherited
Biological Process (BP) superoxide metabolic process 0.001507 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.7541 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.7114 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.02732 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.007482 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2499 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1276 Highly Informative Inherited
Biological Process (BP) developmental growth 0.4478 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.1184 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.001811 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.05034 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.9876 Highly Informative Inherited
Biological Process (BP) protein import 0.3007 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 0.00892 Highly Informative Inherited
Biological Process (BP) sensory perception 0.8674 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.001495 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.01082 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 0.01595 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.04899 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.2745 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.02264 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.776 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.006664 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.007421 Highly Informative Inherited
Biological Process (BP) response to fungus 0.05188 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.09046 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.09267 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.00000001133 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000000000003078 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0000002755 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000002851 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000000001262 Informative Direct
Molecular Function (MF) lipid binding 0.0000000005767 Informative Direct
Molecular Function (MF) enzyme binding 0.000003269 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0.0000128 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000163 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.003738 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.3215 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.896 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.08718 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.9226 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.4869 Informative Inherited
Molecular Function (MF) Ras GTPase binding 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.00000000000004697 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.0000002006 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.000001559 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.0001154 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0002648 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0008864 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.004382 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.001058 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.01728 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol binding 0.2948 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.01279 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 1 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.5359 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.00375 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0000001708 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.007771 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.3464 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.8106 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytosol 0.005062 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.000000006753 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00000353 Informative Direct
Cellular Component (CC) endosome 0.0009636 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) microbody 0.5812 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) integral to membrane 0.03753 Informative Inherited
Cellular Component (CC) extracellular matrix 0.373 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000000000007239 Highly Informative Direct
Cellular Component (CC) cilium part 0.000000000005444 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.00000000001929 Highly Informative Direct
Cellular Component (CC) midbody 0.00003878 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.00008715 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0001639 Highly Informative Direct
Cellular Component (CC) dendrite 0.6523 Highly Informative Inherited
Cellular Component (CC) main axon 0.09572 Highly Informative Inherited
Cellular Component (CC) extrinsic to plasma membrane 0.008411 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.004864 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) extracellular matrix part 0.114 Highly Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0.6834 Highly Informative Inherited
Cellular Component (CC) centrosome 0.2346 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4052Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000006272Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0001767Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000003251InformativeDirect
Enzyme Commission (EC)Mitogen-activated protein kinase kinase kinase0.0000000000002472Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.6466Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6733Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.3815Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.7109Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.7327Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7948Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.0852InformativeInherited
Phenotypic Abnormality (PA)Liver abscess0.00003112Highly InformativeDirect
Phenotypic Abnormality (PA)Obstructive lung disease0.0002205Highly InformativeDirect
Phenotypic Abnormality (PA)Cellulitis0.0002477Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0005876Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.08633Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.005626Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01353Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1252Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.8458Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.0004052Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.002019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.00248Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.003806Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.02125Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1395Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1541Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.177Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2293Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.7304Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.8203Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.9886Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.1586InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.3002InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.3461InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.3461InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.3853InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.4224InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.4396InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.5812InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling0.00008548Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular endothelial cell physiology0.0003729Highly InformativeDirect
Mammalian Phenotype (MP)short cochlear hair cell stereocilia0.0005266Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.002069Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.08512Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0252Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0001466Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.5969Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.6343Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0.000381InformativeDirect
Worm Phenotype (WP)protein expression variant0.0009601InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.000009373Highly InformativeDirect
Worm Phenotype (WP)body elongation variant0.0001518Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0007785Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.005831Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.08801Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport0.00001316InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.2956InformativeInherited
Yeast Phenotype (YP)chitin deposition0.0003159Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0002809Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000007803InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00008297InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000003337Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.728Least InformativeInherited
Biological processProtein transport0.000000000000009131Moderately InformativeDirect
Biological processApoptosis0.0000000005349Moderately InformativeDirect
Biological processDifferentiation0.000002271Moderately InformativeDirect
Biological processCell cycle0.0003497Moderately InformativeDirect
Biological processIon transport0.5373Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processCell adhesion0.000000000008185InformativeDirect
Biological processNeurogenesis0.00000000004777InformativeDirect
Biological processMitosis0.0000000007872InformativeDirect
Biological processInflammatory response0.000004213InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processAdaptive immunity0.00000000000002633Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000000000188Highly InformativeDirect
Biological processExocytosis0.0000003803Highly InformativeDirect
Biological processAutophagy0.0003398Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell membrane0.00000009879Moderately InformativeDirect
Cellular componentLysosome0.000001428InformativeDirect
Cellular componentCoated pit0.000000000000005071Highly InformativeDirect
Cellular componentTight junction0.0007944Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000004698Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.00009286InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DomainRepeat0.00002687Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0InformativeDirect
DomainANK repeat0.00000001389InformativeDirect
Molecular functionCalcium0.000001334Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000002748Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationIon channel0.000001289InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.0000000000001306Highly InformativeDirect
Post-translational modificationActin capping0.000000008237Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.000007545Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein glycosylation0.00003511InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001452 SSF50044 Protein matches
Abstract SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [PubMed15335710, PubMed11256992]. They are found in a great variety of intracellular or membrane-associated proteins [PubMed1639195, PubMed14731533, PubMed7531822] for example, in a variety of proteins with enzymatic activity, in adaptor proteins that lack catalytic sequences and in cytoskeletal proteins, such as fodrin and yeast actin binding protein ABP-1.

The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH2-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [PubMed7953536].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH3-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the SH3-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]