SUPERFAMILY 1.75 HMM library and genome assignments server


C-terminal domain of transcriptional repressors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   C-terminal domain of transcriptional repressors [ 50037] (3)
Families:   Biotin repressor (BirA) [ 50038] (2)
  FeoA-like [ 50041] (4)
  Transcriptional repressor protein KorB [ 69242]


Superfamily statistics
Genomes (2,185) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,297 30,642 17
Proteins 4,177 29,703 17


Functional annotation
General category Information
Detailed category Transcription

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.03139Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0001578Moderately InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Molecular functionDNA-binding7.58e-12Moderately InformativeDirect
Molecular functionIron3.065e-06Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationLigase1.095e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)coenzyme A biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008988 SSF50037 Protein matches
Abstract

The C-terminal domain of several bacterial transcriptional repressors show structural homology to one another. These domains are characterised by an SH3-like structure consisting of a partly opened beta-barrel, where the last strand is interrupted by a 3-10 helical turn. The C-terminal domain displays a metal-binding function in DTXR and IDER and may act to stabilizing the dimeric form of the Escherichia coli KorB repressor, thereby enhancing specific operator binding by the repressor. The N-terminal region of these proteins is responsible for binding DNA.

Proteins containing this C-terminal domain include: the Escherichia coli biotin repressor BirA, which has the dual role of a transcriptional repressor of the biotin operator and a biotin-activating enzyme [PubMed1409631, PubMed11353844]; the E. coli RP4 plasmid regulatory protein KorB, which regulates the expression of plasmid genes whose products are involved in the replication, transfer, and inheritance of RP4 [PubMed11711548]; and the diphtheria toxin repressor (DTXR), along with its homologues in the pathogenic bacteria causing tuberculosis (IDER), leprosy, syphilis, and staphylococcal infections, which play important roles in regulating virulence-associated genes [PubMed11320302, PubMed11053439].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal domain of transcriptional repressors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the C-terminal domain of transcriptional repressors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]