SUPERFAMILY 1.75 HMM library and genome assignments server

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Concanavalin A-like lectins/glucanases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Concanavalin A-like lectins/glucanases [ 49898]
Superfamily:   Concanavalin A-like lectins/glucanases [ 49899] (25)
Families:   Legume lectins [ 49900] (4)
  Lectin leg-like [ 74904] (3)
  Glycosyl hydrolases family 16 [ 49925] (5)
  Galectin (animal S-lectin) [ 49932] (8)
  Laminin G-like module [ 49944] (6)
  Thrombospondin C-terminal domain [ 101643]
  Pentraxin (pentaxin) [ 49951] (2)
  Calnexin/calreticulin [ 69236]
  vp4 sialic acid binding domain [ 74907]
  Hypothetical protein YesU [ 101646]
  Alginate lyase [ 101649] (3)
  Clostridium neurotoxins, the second last domain [ 49956] (2)
  Exotoxin A, N-terminal domain [ 49962]
  Vibrio cholerae sialidase, N-terminal and insertion domains [ 49965]
  Leech intramolecular trans-sialidase, N-terminal domain [ 49968]
  Trypanosoma sialidase, C-terminal domain [ 82038]
  Glycosyl hydrolase family 7 catalytic core [ 49971]
  Glycosyl hydrolases family 32 C-terminal domain [ 101652] (2)
  Xylanase/endoglucanase 11/12 [ 49978] (2)
  Peptidase A4 [ 101656] (2)
  Alpha-L-arabinofuranosidase B, N-terminal domain [ 110143]
  SPRY domain [ 141154] (5)
  Beta-D-xylosidase C-terminal domain-like [ 141161]
  SO2946-like [ 141167]
  MAM domain [ 141170]


Superfamily statistics
Genomes (2,188) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,020 113,303 236
Proteins 50,626 98,511 228


Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.000020380Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00000000046950Least InformativeDirect
Biological Process (BP)developmental process0.0012960Least InformativeInherited
Biological Process (BP)regulation of cellular process0.46970.4453Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0044360.7478Least InformativeInherited
Biological Process (BP)localization10.00000000003919Least InformativeInherited
Biological Process (BP)multicellular organismal process0.014470Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000000000070750.000001003Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00072910.0000000006217Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000047950Moderately InformativeDirect
Biological Process (BP)cellular localization0.78770.001958Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.8790.1155Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0016650Moderately InformativeInherited
Biological Process (BP)regulation of localization0.067240.000001385Moderately InformativeInherited
Biological Process (BP)tissue development0.081280.02268Moderately InformativeInherited
Biological Process (BP)organ development0.54360.3231Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.15180.03131Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0069131Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.80020.1445Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.11190.00000001264Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.36550.0000000009974Moderately InformativeInherited
Biological Process (BP)system process0.75860.00001192Moderately InformativeInherited
Biological Process (BP)nervous system development0.84610.00000001274Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00.00000000000007357InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.000000000038130.00000009057InformativeDirect
Biological Process (BP)biological adhesion0.00027160InformativeDirect
Biological Process (BP)cell wall organization or biogenesis00.000000008924InformativeDirect
Biological Process (BP)cellular membrane organization0.42190.00000009787InformativeInherited
Biological Process (BP)synaptic transmission0.025540.000007838InformativeInherited
Biological Process (BP)regulation of protein localization0.0001140.06818InformativeInherited
Biological Process (BP)regulation of secretion0.000098040.005853InformativeInherited
Biological Process (BP)muscle tissue development0.0018010.01419InformativeInherited
Biological Process (BP)muscle structure development0.001350.01454InformativeInherited
Biological Process (BP)regulation of cell proliferation0.58810.00007899InformativeInherited
Biological Process (BP)regulation of cell activation0.0044370.002678InformativeInherited
Biological Process (BP)secretion by cell0.057340.000001011InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0022920.2244InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.023710.00000006521InformativeInherited
Biological Process (BP)regulation of nervous system development0.033190.03568InformativeInherited
Biological Process (BP)regulation of growth0.10880.000001333InformativeInherited
Biological Process (BP)regulation of cell development0.086010.002609InformativeInherited
Biological Process (BP)polysaccharide catabolic process0.000000000002140.0000000000000161Highly InformativeDirect
Biological Process (BP)muscle organ development0.00019910.0000039Highly InformativeDirect
Biological Process (BP)cell wall polysaccharide metabolic process0.00000000000044440.000004889Highly InformativeDirect
Biological Process (BP)signal release0.00021870.000001502Highly InformativeDirect
Biological Process (BP)positive regulation of programmed cell death0.00058940.0004861Highly InformativeDirect
Biological Process (BP)muscle fiber development0.000044610.00002557Highly InformativeDirect
Biological Process (BP)regulation of striated muscle cell differentiation0.00043870.0000000000002373Highly InformativeDirect
Biological Process (BP)regulation of mononuclear cell proliferation0.0046950.1035Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.00063011Highly InformativeInherited
Biological Process (BP)regulation of striated muscle tissue development10.0000000001255Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.0095130.00000000000002458Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.00048120.2478Least InformativeInherited
Molecular Function (MF)binding0.097920.0000001243Least InformativeInherited
Molecular Function (MF)transferase activity0.77961Least InformativeInherited
Molecular Function (MF)cation binding0.39330.07789Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.0005270InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups0.0000031030.005179InformativeInherited
Molecular Function (MF)calcium ion binding0.0004010Highly InformativeDirect
Molecular Function (MF)channel regulator activity0.0005360Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring hexosyl groups0.000000076110.1456Highly InformativeInherited
Cellular Component (CC)extracellular region part0.015190Moderately InformativeInherited
Cellular Component (CC)cell surface0.00048630.000009511InformativeDirect
Cellular Component (CC)external encapsulating structure0.0000017790.0008837InformativeDirect
Cellular Component (CC)extracellular matrix0.0000000000001670InformativeDirect
Cellular Component (CC)proteinaceous extracellular matrix0.0000000032220Highly InformativeDirect
Cellular Component (CC)extracellular matrix part0.0000000038350Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000007291 Least Informative Direct
Biological Process (BP) localization 0.00000000003919 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.4453 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.7478 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1585 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) system process 0.00001192 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.000001003 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00000001274 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000001021 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000001385 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0002687 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00000001017 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000006217 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000001264 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0003102 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000009974 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.03131 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1445 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1155 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.001958 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9186 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9143 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06289 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.02268 Moderately Informative Inherited
Biological Process (BP) organ development 0.3231 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.0000000006962 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.00000000000007357 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) defense response 0.000000006068 Informative Direct
Biological Process (BP) immune response 0.0000000305 Informative Direct
Biological Process (BP) synaptic transmission 0.000007838 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000007893 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00000000005282 Informative Direct
Biological Process (BP) cellular membrane organization 0.00000009787 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.00000009057 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000002371 Informative Direct
Biological Process (BP) secretion by cell 0.000001011 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000000000002643 Informative Direct
Biological Process (BP) regulation of growth 0.000001333 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000003615 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00007899 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000006521 Informative Direct
Biological Process (BP) generation of neurons 0.000001609 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00000000000001086 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000000007773 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0002607 Informative Direct
Biological Process (BP) localization of cell 0.000000000000003755 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0003961 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0.0000316 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.000000008924 Informative Direct
Biological Process (BP) cardiovascular system development 0.0009314 Informative Direct
Biological Process (BP) regulation of system process 0.3748 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.005528 Informative Inherited
Biological Process (BP) protein transport 0.3442 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.03921 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.3381 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.6327 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.04552 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3882 Informative Inherited
Biological Process (BP) metal ion transport 0.1608 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) protein oligomerization 0.001135 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.5584 Informative Inherited
Biological Process (BP) gland development 0.8295 Informative Inherited
Biological Process (BP) tube development 0.809 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02044 Informative Inherited
Biological Process (BP) sensory organ development 0.02441 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.001134 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.007104 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1596 Informative Inherited
Biological Process (BP) regulation of cell development 0.002609 Informative Inherited
Biological Process (BP) negative regulation of transport 0.004913 Informative Inherited
Biological Process (BP) regulation of secretion 0.005853 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.03568 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1909 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) muscle structure development 0.01454 Informative Inherited
Biological Process (BP) growth 0.008215 Informative Inherited
Biological Process (BP) embryonic organ development 0.3299 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.6437 Informative Inherited
Biological Process (BP) single-organism behavior 0.2295 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.8007 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5696 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1372 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.2244 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3119 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1244 Informative Inherited
Biological Process (BP) regulation of cell activation 0.002678 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.2418 Informative Inherited
Biological Process (BP) apoptotic process 0.278 Informative Inherited
Biological Process (BP) response to bacterium 0.04817 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4587 Informative Inherited
Biological Process (BP) dephosphorylation 0.07887 Informative Inherited
Biological Process (BP) regulation of protein localization 0.06818 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.01357 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.5077 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.2523 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.573 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3305 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7175 Informative Inherited
Biological Process (BP) muscle system process 0.0833 Informative Inherited
Biological Process (BP) cation homeostasis 0.3124 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.001242 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1786 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.02833 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.02059 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.01419 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.04367 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.005274 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.2522 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9152 Informative Inherited
Biological Process (BP) response to wounding 0.001242 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.0000000000000161 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000000009872 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0002027 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0000000001697 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.00005787 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.00003786 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0006166 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000000002384 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0000039 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000002029 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00006432 Highly Informative Direct
Biological Process (BP) cell wall polysaccharide metabolic process 0.000004889 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00007206 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0000000001255 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.00000000002441 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.00008978 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.000002883 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0007054 Highly Informative Direct
Biological Process (BP) signal release 0.000001502 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.000001814 Highly Informative Direct
Biological Process (BP) neuron projection development 0.00002644 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.000001128 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00000000002792 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0004198 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.000000000001915 Highly Informative Direct
Biological Process (BP) response to drug 0.000003296 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.000003951 Highly Informative Direct
Biological Process (BP) positive regulation of programmed cell death 0.0004861 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.0000268 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0.000005209 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0.0008581 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.000000000001333 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.000004461 Highly Informative Direct
Biological Process (BP) developmental growth 0.0001309 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00000000000002458 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.00002557 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0000001603 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.0003366 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.000165 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.0001556 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.0000000000002373 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0004768 Highly Informative Direct
Biological Process (BP) connective tissue development 0.000001412 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.09825 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.993 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) cellular response to reactive oxygen species 0.2167 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.006284 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.01091 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.02453 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.04387 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.006719 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.02106 Highly Informative Inherited
Biological Process (BP) protein methylation 0.05623 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.01044 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.6281 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01506 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.004055 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.0251 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2413 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.7428 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.7453 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.04367 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.6761 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.1035 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.001014 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.501 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.004756 Highly Informative Inherited
Biological Process (BP) interaction with host 0.009322 Highly Informative Inherited
Biological Process (BP) ossification 0.009187 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.1608 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.01773 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.008331 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.3786 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.0027 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.8767 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.3198 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.2727 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.007668 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.6088 Highly Informative Inherited
Biological Process (BP) membrane fusion 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2301 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) pigment biosynthetic process 0.2679 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.009042 Highly Informative Inherited
Biological Process (BP) stem cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.07693 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.1195 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.09686 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.006428 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.07823 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1861 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.2085 Highly Informative Inherited
Biological Process (BP) B cell activation 0.3204 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.1155 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.001163 Highly Informative Inherited
Biological Process (BP) wound healing 0.1954 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1921 Highly Informative Inherited
Molecular Function (MF) binding 0.0000001243 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.2478 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0002696 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.07789 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.0000007015 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) ligase activity 0.00000002094 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000015 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.00008811 Informative Direct
Molecular Function (MF) molecular transducer activity 0.00000001257 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0008471 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000002322 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.012 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.007846 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.2919 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.005179 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.4815 Informative Inherited
Molecular Function (MF) lipid binding 0.006725 Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.00003829 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0001793 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.000001513 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00000000003917 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.0000000000008522 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0003435 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.000003773 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000002228 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.006181 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.1456 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.004147 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.05529 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00002295 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000005137 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.000255 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00001657 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000002265 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.002851 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.8903 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000001199 Informative Direct
Cellular Component (CC) cell surface 0.000009511 Informative Direct
Cellular Component (CC) cell junction 0.0005505 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0008837 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell leading edge 0.00001721 Informative Direct
Cellular Component (CC) synapse part 0.000001804 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000001155 Informative Direct
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) coated vesicle 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.01306 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 0 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0.00000169 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.000000000005435 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0006463 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000000738 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.02404 Highly Informative Inherited
Cellular Component (CC) nuclear body 0.008777 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.06174 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000000002215Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.1378Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.07915Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000001837InformativeDirect
Enzyme Commission (EC)Cellulose 1,4-beta-cellobiosidase (non-reducing en0Highly InformativeDirect
Enzyme Commission (EC)Bontoxilysin0.000000000000213Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.0001267Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5228Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3891Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.733Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.1571InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2055InformativeInherited
Phenotypic Abnormality (PA)Vitreoretinal degeneration0.0001474Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the epiphyses0.03374Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the femur0.04213Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02371Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8559Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.333Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.8926InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001743Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.07292Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)neuron development variant0.00004145InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.004958InformativeInherited
Worm Phenotype (WP)axon guidance variant0.000004281Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.000005115Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0004903Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0006307Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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