SUPERFAMILY 1.75 HMM library and genome assignments server


SMAD/FHA domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Families:   SMAD domain [ 49880] (4)
  FHA domain [ 49885] (11)
  Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]
  EssC N-terminal domain-like [ 141143]


Superfamily statistics
Genomes (1,710) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 15,808 19,439 38
Proteins 15,031 18,302 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.043750.001134Least InformativeInherited
Biological Process (BP)response to stimulus0.0013620Least InformativeInherited
Biological Process (BP)single-organism cellular process0.025450Least InformativeInherited
Molecular Function (MF)binding0.0001010Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.446e-10 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 7.38e-09 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1.693e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 4.631e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 3.826e-05 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0001329 Least Informative Direct
Biological Process (BP) localization 0.07606 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05726 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.001134 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2121 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0.000161 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 7.579e-09 Moderately Informative Direct
Biological Process (BP) immune system process 1.142e-13 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1.806e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 4.721e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.276e-07 Moderately Informative Direct
Biological Process (BP) reproduction 1.281e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.755e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0001049 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0001138 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0003625 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.001159 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01521 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3088 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9799 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.0956 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.393 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3173 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01322 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7037 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1186 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.00181 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.04694 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9243 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01703 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.4768 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.002512 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.5455 Moderately Informative Inherited
Biological Process (BP) gene expression 0.7653 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.4438 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.4902 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.5115 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.766 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8314 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.08142 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.06998 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7307 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.005019 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) microtubule-based process 2.264e-13 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.191e-12 Informative Direct
Biological Process (BP) regulation of cell cycle 2.552e-10 Informative Direct
Biological Process (BP) DNA metabolic process 2.911e-10 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 3.149e-10 Informative Direct
Biological Process (BP) growth 1.391e-08 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.754e-08 Informative Direct
Biological Process (BP) immune response 1.001e-07 Informative Direct
Biological Process (BP) cell cycle process 1.24e-07 Informative Direct
Biological Process (BP) immune effector process 2.695e-07 Informative Direct
Biological Process (BP) chromosome organization 1.026e-06 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 2.685e-06 Informative Direct
Biological Process (BP) cellular component movement 4.95e-06 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 6.316e-06 Informative Direct
Biological Process (BP) transcription, DNA-dependent 3.424e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 4.382e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.598e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 9.927e-05 Informative Direct
Biological Process (BP) regulation of growth 0.0002216 Informative Direct
Biological Process (BP) organelle localization 0.0002635 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0003709 Informative Direct
Biological Process (BP) cell activation 0.0003982 Informative Direct
Biological Process (BP) cardiovascular system development 0.0004099 Informative Direct
Biological Process (BP) protein catabolic process 0.0004365 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0004796 Informative Direct
Biological Process (BP) sexual reproduction 0.0008259 Informative Direct
Biological Process (BP) regulation of cytokine production 0.000935 Informative Direct
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) defense response 0.6675 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) generation of neurons 0.03596 Informative Inherited
Biological Process (BP) cell projection organization 0.6917 Informative Inherited
Biological Process (BP) regulation of immune response 0.4455 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.01096 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.05026 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1308 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.0881 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.09336 Informative Inherited
Biological Process (BP) organ morphogenesis 0.06719 Informative Inherited
Biological Process (BP) embryonic organ development 0.5413 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2338 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.02495 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.8446 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.04296 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9519 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9182 Informative Inherited
Biological Process (BP) locomotion 0.02655 Informative Inherited
Biological Process (BP) single organism reproductive process 0.004725 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.3577 Informative Inherited
Biological Process (BP) RNA processing 0.4743 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03215 Informative Inherited
Biological Process (BP) response to bacterium 0.4979 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2919 Informative Inherited
Biological Process (BP) proteolysis 0.02891 Informative Inherited
Biological Process (BP) cell-cell signaling 0.08455 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.3065 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.06061 Informative Inherited
Biological Process (BP) epithelium development 0.01886 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1347 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.008844 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.289 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 3.052e-13 Highly Informative Direct
Biological Process (BP) regulation of binding 2.222e-12 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 3.539e-09 Highly Informative Direct
Biological Process (BP) double-strand break repair 4.667e-09 Highly Informative Direct
Biological Process (BP) protein ubiquitination 8.665e-09 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 1.538e-08 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 1.804e-07 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 8.49e-07 Highly Informative Direct
Biological Process (BP) developmental growth 2.572e-06 Highly Informative Direct
Biological Process (BP) cell proliferation 9.375e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 3.08e-05 Highly Informative Direct
Biological Process (BP) B cell activation 3.263e-05 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 3.272e-05 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 8.343e-05 Highly Informative Direct
Biological Process (BP) renal system development 0.000109 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0001365 Highly Informative Direct
Biological Process (BP) DNA recombination 0.0003749 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0004028 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0005635 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000654 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 0.6412 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.001184 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.7449 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.02217 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.03337 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.06677 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.6026 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.2549 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.001523 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2649 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4418 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05982 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01349 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.5787 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001656 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.06534 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.001079 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6633 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.1123 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.001265 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.02422 Highly Informative Inherited
Biological Process (BP) cell division 0.01605 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.6775 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.8762 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.01058 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.004137 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.03846 Highly Informative Inherited
Biological Process (BP) gene silencing 0.08958 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1958 Highly Informative Inherited
Biological Process (BP) stem cell development 0.002443 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3223 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.2142 Highly Informative Inherited
Biological Process (BP) cell growth 0.06478 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.2381 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6652 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.1072 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.1901 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.1311 Highly Informative Inherited
Biological Process (BP) mitosis 0.4952 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.008853 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.2502 Highly Informative Inherited
Biological Process (BP) ossification 0.00529 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.007331 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.3054 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.7862 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.001073 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 4.698e-12 Informative Direct
Molecular Function (MF) chromatin binding 1.188e-11 Informative Direct
Molecular Function (MF) DNA binding 2.448e-10 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 4.693e-07 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 6.34e-06 Informative Direct
Molecular Function (MF) nuclease activity 0.0009036 Informative Direct
Molecular Function (MF) protein dimerization activity 0.7273 Informative Inherited
Molecular Function (MF) enzyme binding 0.06158 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.4962 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9034 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1.201e-13 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 2.759e-11 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 8.434e-09 Highly Informative Direct
Molecular Function (MF) transcription factor binding 2.385e-06 Highly Informative Direct
Molecular Function (MF) tubulin binding 2.291e-05 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 4.264e-05 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.000327 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.167 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1.36e-06 Least Informative Direct
Cellular Component (CC) protein complex 0.0009413 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9286 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.004131 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.3303 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.004927 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.03616 Moderately Informative Inherited
Cellular Component (CC) chromosome 4.584e-09 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 6.92e-09 Informative Direct
Cellular Component (CC) nucleoplasm part 0.04176 Informative Inherited
Cellular Component (CC) cell-cell junction 0.006233 Informative Inherited
Cellular Component (CC) microtubule associated complex 2.098e-09 Highly Informative Direct
Cellular Component (CC) adherens junction 8.808e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 9.997e-06 Highly Informative Direct
Cellular Component (CC) nuclear body 0.01891 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.008893 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1289Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases7.375e-15Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red8.23e-09Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation1.841e-12InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.05602Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.04521InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.2793Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the aortic valve0.0006875InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.08886Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1231Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1726Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3707Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.5883Least InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.002329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.01271Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1076Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.1078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.1469Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1795Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3846Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3997Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.5063Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.5193Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.5461Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.8353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation5.095e-05InformativeDirect
Mammalian Phenotype (MP)abnormal chromosome stability0.004178InformativeInherited
Mammalian Phenotype (MP)abnormal preimplantation embryo development0.02571InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.04658InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.05903InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2255InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.2562InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.2942InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.4274InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8316InformativeInherited
Mammalian Phenotype (MP)increased gonad tumor incidence2.922e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development0.0001222Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0002203Highly InformativeDirect
Mammalian Phenotype (MP)absent primordial germ cells0.0007702Highly InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.0009848Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0.004577Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell number0.007799Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.2344Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007819Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.006304Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.0008956Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.06159Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.07533Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0002998InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.02206InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1066InformativeInherited
Worm Phenotype (WP)cuticle development variant2.22e-07Highly InformativeDirect
Worm Phenotype (WP)male tail morphology variant1.188e-05Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant3.954e-05Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001088Highly InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.0001284Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003818Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.003015Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective8.374e-06InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.04473Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1033Least InformativeInherited
Fly Anatomy (FA)cell0.1056Least InformativeInherited
Fly Anatomy (FA)anatomical group0.125Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0002195Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.002293Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.005161Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.01152Moderately InformativeInherited
Fly Anatomy (FA)neuron0.01653Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.0173Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.03263Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.03573Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.1136Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.3083Moderately InformativeInherited
Fly Anatomy (FA)head0.3742Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell0.002005InformativeInherited
Fly Anatomy (FA)prepupa0.00499InformativeInherited
Fly Anatomy (FA)pupa0.006027InformativeInherited
Fly Anatomy (FA)cell component0.008527InformativeInherited
Fly Anatomy (FA)imaginal precursor0.03764InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0001936Highly InformativeDirect
Fly Anatomy (FA)wing disc0.0005086Highly InformativeDirect
Fly Anatomy (FA)synapse0.0008673Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.2034Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Least InformativeInherited
Xenopus ANatomical entity (XAN)heart0.458InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups3.214e-09Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.1375Least InformativeInherited
Enzyme Commission (EC)Lyases0.4124Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.9096Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases3.914e-13Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0002186Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.08029Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen1.357e-08InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen5.585e-12Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases4.092e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation2.553e-07Moderately InformativeDirect
Biological processDifferentiation0.0002414Moderately InformativeDirect
Biological processMitosis2.466e-13InformativeDirect
Biological processMeiosis1.081e-10InformativeDirect
Biological processUbl conjugation pathway2.413e-10InformativeDirect
Biological processInnate immunity1.514e-09InformativeDirect
Biological processAngiogenesis1.886e-06InformativeDirect
Biological processCell adhesion0.0004507InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAntiviral defense2.307e-11Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentChromosome1.668e-14InformativeDirect
Cellular componentTelomere1.799e-07Highly InformativeDirect
DiseaseDisease mutation0.0002297Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger6.333e-12Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding8.486e-05Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator1.208e-08Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.398e-05Moderately InformativeDirect
Post-translational modificationKinase0.02412Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase1.09e-09InformativeDirect
Post-translational modificationChromatin regulator5.426e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0003001Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation5.397e-06InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism2.773e-11Least InformativeDirect
UniPathway (UP)protein ubiquitination9.228e-05Moderately InformativeDirect
UniPathway (UP)plant hormone metabolism5.981e-15InformativeDirect
UniPathway (UP)terpene metabolism2.592e-12InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0Highly InformativeDirect
UniPathway (UP)plant hormone biosynthesis4.524e-16Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008984 SSF49879 Protein matches
Abstract

FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [PubMed11106755, PubMed12121644, PubMed12049740].

SMAD domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway [PubMed11779503]; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling [PubMed9214508]; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [PubMed11483516].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the SMAD/FHA domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]