SUPERFAMILY 1.75 HMM library and genome assignments server

SMAD/FHA domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Families:   SMAD domain [ 49880] (4)
  FHA domain [ 49885] (11)
  Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]
  EssC N-terminal domain-like [ 141143]


Superfamily statistics
Genomes (1,754) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 16,912 35,177 38
Proteins 16,133 30,400 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)growth0.00010130.0000004982InformativeDirect
Molecular Function (MF)binding0.0026610Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0000006299 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000003004 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000003263 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000000002753 Least Informative Direct
Biological Process (BP) developmental process 0.00000000000003082 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000000182 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00000004154 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000001109 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00004335 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0003307 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.04995 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.3189 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3007 Least Informative Inherited
Biological Process (BP) localization 0.2816 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0.00008918 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.000008257 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000000000007003 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000000002052 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000001231 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000001095 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.000006018 Moderately Informative Direct
Biological Process (BP) reproductive process 0.00001589 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00003477 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00004218 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00005401 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0002281 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.0009326 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.5434 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.009005 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.007427 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01611 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2957 Moderately Informative Inherited
Biological Process (BP) defense response 0.659 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.004742 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3299 Moderately Informative Inherited
Biological Process (BP) tissue development 0.002018 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2944 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.112 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.141 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8658 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.506 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.5714 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9885 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.6325 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2427 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2655 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9766 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9493 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1082 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.2984 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.8162 Moderately Informative Inherited
Biological Process (BP) gene expression 0.8758 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7899 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.002821 Moderately Informative Inherited
Biological Process (BP) growth 0.0000004982 Informative Direct
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) microtubule-based process 0.000000000000003707 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000000007654 Informative Direct
Biological Process (BP) cell proliferation 0.000000001684 Informative Direct
Biological Process (BP) cellular component movement 0.00000009715 Informative Direct
Biological Process (BP) immune effector process 0.0000002951 Informative Direct
Biological Process (BP) immune response 0.0000003673 Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0000003912 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0000005969 Informative Direct
Biological Process (BP) defense response to other organism 0.0000008028 Informative Direct
Biological Process (BP) chromosome organization 0.00000292 Informative Direct
Biological Process (BP) cell division 0.000003547 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000004767 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.000009705 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.00006345 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00007812 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0001325 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0001367 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0001437 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0001896 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001902 Informative Direct
Biological Process (BP) regulation of growth 0.0001974 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0002478 Informative Direct
Biological Process (BP) organelle localization 0.000326 Informative Direct
Biological Process (BP) phosphorylation 0.0004032 Informative Direct
Biological Process (BP) cardiovascular system development 0.0004223 Informative Direct
Biological Process (BP) epithelium development 0.0006903 Informative Direct
Biological Process (BP) protein catabolic process 0.0007321 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0.006571 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.03315 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell projection organization 0.3949 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.9465 Informative Inherited
Biological Process (BP) regulation of immune response 0.4268 Informative Inherited
Biological Process (BP) response to cytokine 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.04503 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.08891 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.15 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.7205 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) proteolysis 0.04391 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.152 Informative Inherited
Biological Process (BP) generation of neurons 0.8894 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) tube development 0.01097 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.1069 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.07391 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.03966 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.8661 Informative Inherited
Biological Process (BP) leukocyte activation 0.01266 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) RNA processing 0.5011 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.4801 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.6987 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.001944 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) response to bacterium 0.4157 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) locomotion 0.05976 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.6971 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1461 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.004844 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2745 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.346 Informative Inherited
Biological Process (BP) sexual reproduction 0.1886 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02905 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.003671 Informative Inherited
Biological Process (BP) organelle fission 0.01159 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.0174 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.02623 Informative Inherited
Biological Process (BP) embryonic organ development 0.4994 Informative Inherited
Biological Process (BP) organ morphogenesis 0.05576 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4355 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.000000000000706 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00000000001198 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0000000002816 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000000009605 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.00000001221 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.0000000134 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00000002214 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.00000005262 Highly Informative Direct
Biological Process (BP) germ cell development 0.0000003344 Highly Informative Direct
Biological Process (BP) developmental growth 0.000001193 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.000001634 Highly Informative Direct
Biological Process (BP) DNA recombination 0.000002189 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.000002641 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.00001207 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000349 Highly Informative Direct
Biological Process (BP) B cell activation 0.00003713 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00008523 Highly Informative Direct
Biological Process (BP) in utero embryonic development 0.000202 Highly Informative Direct
Biological Process (BP) histone modification 0.0002245 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0002401 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0002632 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0003437 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0006757 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.2263 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.03745 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.00211 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.7582 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.01399 Highly Informative Inherited
Biological Process (BP) negative regulation of cell division 0.04737 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.1195 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2463 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.003264 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05164 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.002289 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1002 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.02585 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.7695 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.003881 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.001501 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.05057 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.4879 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.002844 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.202 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.03086 Highly Informative Inherited
Biological Process (BP) stem cell development 0.002849 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.8524 Highly Informative Inherited
Biological Process (BP) gene silencing 0.04333 Highly Informative Inherited
Biological Process (BP) cell growth 0.03375 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01587 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4001 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6434 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.1459 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.907 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.2938 Highly Informative Inherited
Biological Process (BP) nuclear division 0.6663 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.02919 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.00263 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.001049 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.008069 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.004491 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.2509 Highly Informative Inherited
Biological Process (BP) kidney development 0.008704 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.6623 Highly Informative Inherited
Biological Process (BP) ossification 0.006778 Highly Informative Inherited
Biological Process (BP) DNA integrity checkpoint 0.5036 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.4456 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.4684 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0003029 Moderately Informative Direct
Molecular Function (MF) chromatin binding 0.000000000001104 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0.000000000005129 Informative Direct
Molecular Function (MF) DNA binding 0.0000000002438 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.00000967 Informative Direct
Molecular Function (MF) enzyme binding 0.139 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.5901 Informative Inherited
Molecular Function (MF) protein complex binding 0.004639 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.1156 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0.00000000009444 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.000002856 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000003368 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00001762 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.0007978 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.07035 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.0000964 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0001433 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.3034 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.01058 Least Informative Inherited
Cellular Component (CC) cell projection 0.8393 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.007309 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01962 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.7309 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.0000000008194 Informative Direct
Cellular Component (CC) chromosome 0.00000003225 Informative Direct
Cellular Component (CC) neuron projection 0.0007666 Informative Direct
Cellular Component (CC) nucleoplasm part 0.6278 Informative Inherited
Cellular Component (CC) cell junction 0.006176 Informative Inherited
Cellular Component (CC) microtubule associated complex 0.000000003419 Highly Informative Direct
Cellular Component (CC) adherens junction 0.00005455 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0001845 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1289Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000000007375Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.00000000823Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000001841InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.05899Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.06412InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.1356Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.167Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lip0.2038InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper lip0.025Highly InformativeInherited
Phenotypic Abnormality (PA)Oral cleft0.06334Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.09227Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1743Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1766Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3797Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6045Least InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.002617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.01232Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.02499Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1065Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.148Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4436Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.4987Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.5122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.5394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.6817Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.7064Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.00004285InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.002838InformativeInherited
Mammalian Phenotype (MP)abnormal chromosome stability0.003706InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.03935InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.05105InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.05303InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.06949InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.09097InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.1944InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2409InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.4381InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8263InformativeInherited
Mammalian Phenotype (MP)increased gonad tumor incidence0.0000004516Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development0.0001389Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.000147Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0002428Highly InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.000979Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.003742Highly InformativeInherited
Mammalian Phenotype (MP)premature aging0.004637Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.2323Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007819Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.006304Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.0008956Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.06159Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.07533Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0002998InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.02206InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1066InformativeInherited
Worm Phenotype (WP)cuticle development variant0.000000222Highly InformativeDirect
Worm Phenotype (WP)male tail morphology variant0.00001188Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.00003954Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001088Highly InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.0001284Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003818Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.003015Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective0.000002399InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.03186Least InformativeInherited
Fly Anatomy (FA)adult0.0412Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.05919Least InformativeInherited
Fly Anatomy (FA)cell0.1281Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1572Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0.0006715Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.00962Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.02108Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.02789Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.04658Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.05204Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.05664Moderately InformativeInherited
Fly Anatomy (FA)adult head0.09821Moderately InformativeInherited
Fly Anatomy (FA)ommatidium0.0002932InformativeDirect
Fly Anatomy (FA)prepupa0.001381InformativeInherited
Fly Anatomy (FA)pupa0.001806InformativeInherited
Fly Anatomy (FA)germline stem cell0.00185InformativeInherited
Fly Anatomy (FA)ovariole0.006252InformativeInherited
Fly Anatomy (FA)imaginal precursor0.03318InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0001022Highly InformativeDirect
Fly Anatomy (FA)wing disc0.0001854Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.2098Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.9995Least InformativeInherited
Xenopus ANatomical entity (XAN)heart0.461InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.000000006213Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.06722Least InformativeInherited
Enzyme Commission (EC)Lyases0.4394Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.933Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000000000003887Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0002448Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.08761Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0000000004562InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.00000000000006578Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0.000004757Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0.0000002597Moderately InformativeDirect
Biological processDifferentiation0.0003022Moderately InformativeDirect
Biological processMitosis0.0000000000001946InformativeDirect
Biological processMeiosis0.0000000001696InformativeDirect
Biological processUbl conjugation pathway0.0000000003176InformativeDirect
Biological processInnate immunity0.000000002006InformativeDirect
Biological processAngiogenesis0.000002036InformativeDirect
Biological processVirulence0.0002118InformativeDirect
Biological processCell adhesion0.0005128InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAntiviral defense0.00000000002925Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentChromosome0.00000000000002426InformativeDirect
Cellular componentTelomere0.0000002948Highly InformativeDirect
DiseaseDisease mutation0.0001377Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.00000000001136Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.0003733Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0.00000001474Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000155Moderately InformativeDirect
Post-translational modificationKinase0.02737Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.000000001299InformativeDirect
Post-translational modificationChromatin regulator0.0000000705InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0001533Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000005322InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000000000885Least InformativeDirect
UniPathway (UP)protein ubiquitination0.00009733Moderately InformativeDirect
UniPathway (UP)plant hormone metabolism0InformativeDirect
UniPathway (UP)terpene metabolism0.00000000000002837InformativeDirect
UniPathway (UP)plant hormone biosynthesis0Highly InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008984 SSF49879 Protein matches
Abstract

FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [PubMed11106755, PubMed12121644, PubMed12049740].

SMAD domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway [PubMed11779503]; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling [PubMed9214508]; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [PubMed11483516].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the SMAD/FHA domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]