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Spermadhesin, CUB domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   CUB-like [ 49853] (3)
Superfamily:   Spermadhesin, CUB domain [ 49854]
Families:   Spermadhesin, CUB domain [ 49855] (5)


Superfamily statistics
Genomes (208) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 20,858 20,268 8
Proteins 8,466 8,560 7


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000000001778 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000004129 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000005107 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002009 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.5024 Least Informative Inherited
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00000009177 Moderately Informative Direct
Biological Process (BP) signal transduction 0.00000255 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000335 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00006146 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00006649 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7907 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.006186 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1392 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.00301 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.1293 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.5457 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.671 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01829 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3428 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.03832 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01193 Moderately Informative Inherited
Biological Process (BP) reproduction 0.6944 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8817 Moderately Informative Inherited
Biological Process (BP) immune system process 0.001837 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000000007347 Informative Direct
Biological Process (BP) locomotion 0.0000000000003211 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000000003043 Informative Direct
Biological Process (BP) regulation of growth 0.0000000003747 Informative Direct
Biological Process (BP) cardiovascular system development 0.0000000005708 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000005028 Informative Direct
Biological Process (BP) cellular component movement 0.00000002797 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00000003833 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00000006964 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000001952 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0000002379 Informative Direct
Biological Process (BP) localization of cell 0.0000002387 Informative Direct
Biological Process (BP) defense response 0.0000005835 Informative Direct
Biological Process (BP) tube development 0.000003309 Informative Direct
Biological Process (BP) single-organism behavior 0.000003719 Informative Direct
Biological Process (BP) embryonic organ development 0.000005403 Informative Direct
Biological Process (BP) regulation of cell development 0.00002964 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00003391 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00007621 Informative Direct
Biological Process (BP) proteolysis 0.00008591 Informative Direct
Biological Process (BP) organ morphogenesis 0.0001417 Informative Direct
Biological Process (BP) immune effector process 0.0003079 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0004337 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.002967 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.3745 Informative Inherited
Biological Process (BP) synaptic transmission 0.9016 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.2206 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.06983 Informative Inherited
Biological Process (BP) generation of neurons 0.008175 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.002715 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to lipid 0.2646 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.325 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.05948 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.04868 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.001209 Informative Inherited
Biological Process (BP) central nervous system development 0.6799 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.1183 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.2048 Informative Inherited
Biological Process (BP) epithelium development 0.08147 Informative Inherited
Biological Process (BP) immune response 0.00218 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.00205 Informative Inherited
Biological Process (BP) regulation of immune response 0.461 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9929 Informative Inherited
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) regulation of cell size 0 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000000000001114 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0000000000001519 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.000000000000327 Highly Informative Direct
Biological Process (BP) protein activation cascade 0.000000000001656 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00000000006227 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000000342 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0000000008732 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 0.0000002036 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0000005808 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0000005889 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0000007874 Highly Informative Direct
Biological Process (BP) skeletal system development 0.000000963 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.000006791 Highly Informative Direct
Biological Process (BP) neuron projection development 0.000008201 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.00001694 Highly Informative Direct
Biological Process (BP) female pregnancy 0.00002061 Highly Informative Direct
Biological Process (BP) adult behavior 0.00003111 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.0001676 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.0002063 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.0002514 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0002577 Highly Informative Direct
Biological Process (BP) innate immune response 0.0004886 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000963 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.01512 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.4899 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.07383 Highly Informative Inherited
Biological Process (BP) stem cell development 0.06561 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.08877 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01297 Highly Informative Inherited
Molecular Function (MF) binding 0.4243 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.01186 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.9867 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) receptor activity 0.000000001914 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0003738 Informative Direct
Molecular Function (MF) enzyme binding 0.6029 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.7155 Informative Inherited
Molecular Function (MF) kinase activity 0.8375 Informative Inherited
Molecular Function (MF) serine hydrolase activity 0.0000000000001848 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.4006 Highly Informative Inherited
Cellular Component (CC) membrane 0.0001601 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000000000002439 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000000000004905 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0001555 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0001962 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.3228 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.1506 Moderately Informative Inherited
Cellular Component (CC) secretory granule 0.00000006339 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00008113 Informative Direct
Cellular Component (CC) integral to membrane 0.000161 Informative Direct
Cellular Component (CC) extracellular space 0.0007269 Informative Direct
Cellular Component (CC) cell surface 0.0007557 Informative Direct
Cellular Component (CC) neuron projection 0.03527 Informative Inherited
Cellular Component (CC) cell body 0.00000000333 Highly Informative Direct
Cellular Component (CC) main axon 0.01644 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.01181 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0003183Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.000000000008539InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.000000000003399Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.000000000003399Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.4079Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3321Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.03599InformativeInherited
Mammalian Phenotype (MP)abnormal Purkinje cell innervation0.000185Highly InformativeDirect
Mammalian Phenotype (MP)abnormal excitatory postsynaptic currents0.0004599Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.0000005539Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.00000007493InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.000005697Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0002623Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.00000000000748InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0002585InformativeDirect
Enzyme Commission (EC)Enteropeptidase0.000000004284Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processProtein transport0.0004196Moderately InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processEndocytosis0.00000000001032InformativeDirect
Biological processNeurogenesis0.0000000007237InformativeDirect
Biological processAngiogenesis0.0000000123InformativeDirect
Biological processWnt signaling pathway0.00000006155InformativeDirect
Biological processCell adhesion0.00008007InformativeDirect
Biological processFertilization2.372e-16Highly InformativeDirect
Biological processComplement pathway0.0000000000001773Highly InformativeDirect
Cellular componentMembrane0.000000000001117Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000005064Moderately InformativeDirect
Cellular componentCoated pit0.0000000003397Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.02403Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSushi0Highly InformativeDirect
DomainLaminin EGF-like domain0.00000000000002655Highly InformativeDirect
DomainKringle0.000000003032Highly InformativeDirect
DomainKelch repeat0.0000001793Highly InformativeDirect
Molecular functionZinc0.00001422Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionLectin0.0001066InformativeDirect
Post-translational modificationHydrolase4.449e-16Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationSerine protease0.000002163InformativeDirect
Post-translational modificationMetalloprotease0.0001126InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.000000000005763Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationZymogen0.0000000001431InformativeDirect
Post-translational modificationProteoglycan0.005316InformativeInherited
Post-translational modificationHeparan sulfate0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000859 SSF49854 Protein matches
Abstract

The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins, many of which are developmentally regulated [PubMed8510165, PubMed2026272]. These proteins are involved in a diverse range of functions, including complement activation, developmental patterning, tissue repair, axon guidance and angiogenesis, cell signalling, fertilisation, haemostasis, inflammation, neurotransmission, receptor-mediated endocytosis, and tumour suppression [PubMed17335815, PubMed17051152]. Many CUB-containing proteins are peptidases belonging to MEROPS peptidase families M12A (astacin) and S1A (chymotrypsin). Proteins containing a CUB domain include:

  • Mammalian complement subcomponents C1s/C1r, which form the calcium-dependent complex C1, the first component of the classical pathway of the complement system.
  • Cricetidae sp. (Hamster) serine protease Casp, which degrades type I and IV collagen and fibronectin in the presence of calcium.
  • Mammalian complement-activating component of Ra-reactive factor (RARF), a protease that cleaves the C4 component of complement.
  • Vertebrate enteropeptidase , a type II membrane protein of the intestinal brush border, which activates trypsinogen.
  • Vertebrate bone morphogenic protein 1 (BMP-1), a protein which induces cartilage and bone formation and expresses metalloendopeptidase activity.
  • Sea urchin blastula proteins BP10 and SpAN.
  • Caenorhabditis elegans hypothetical proteins F42A10.8 and R151.5.
  • Neuropilin (A5 antigen), a calcium-independent cell adhesion molecule that functions during the formation of certain neuronal circuits.
  • Fibropellins I and III from Strongylocentrotus purpuratus (Purple sea urchin).
  • Mammalian hyaluronate-binding protein TSG-6 (or PS4), a serum and growth factor induced protein.
  • Mammalian spermadhesins.
  • Xenopus laevis embryonic protein UVS.2, which is expressed during dorsoanterior development.

Several of the above proteins consist of a catalytic domain together with several CUB domains interspersed by calcium-binding EGF domains. Some CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding partners. For example, in the complement proteases, the CUB domains mediate dimerisation and binding to collagen-like regions of target proteins (e.g. C1q for C1r/C1s). The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two disulphide bridges (C1-C2, C3-C4). The CUB1 domains of C1s and Map19 have calcium-binding sites [PubMed17446170].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Spermadhesin, CUB domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Spermadhesin, CUB domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]