SUPERFAMILY 1.73 HMM library and genome assignments server


Galactose-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (165)
Fold:   Galactose-binding domain-like [ 49784]
  sandwich; 9 strands in 2 sheets; jelly-roll
Superfamily:   Galactose-binding domain-like [ 49785] (30)
Families:   Galactose-binding domain [ 49786] (2)
  Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)
  APC10-like [ 69210] (2)
  Pfam 03256
  delta-Endotoxin, C-terminal domain [ 49796]
  Ligand-binding domain of the ephb2 receptor tyrosine kinase [ 49800]
  beta-Galactosidase/glucuronidase, N-terminal domain [ 49803] (2)
  Chondroitin ABC lyase I, N-terminal domain [ 89236]
  CBM4/9 [ 74893] (3)
  Family 6 carbohydrate binding module, CBM6 [ 69213] (4)
  CBM15 [ 69216]
  Family 17 carbohydrate binding module, CBM17 [ 69219]
  CBM22 [ 49811]
  CBM family 22, formerly x6b domain
  Family 27 carbohydrate binding module, CBM27 [ 89241] (2)
  Family 29 carbohydrate binding module, CBM29 [ 89244]
  Fucose binding lectin [ 74896]
  N-terminal domain of xrcc1 [ 49814]
  F-box associated region, FBA [ 101585]
  Allantoicase repeat [ 101588]
  PepX C-terminal domain-like [ 69222] (3)
  PA-IL, galactose-binding lectin 1 [ 82022]
  a truncated form of this fold lacking one of the N-terminal strands
  Proprotein convertase P-domain [ 89249] (3)
  a truncated form of this fold lacking one of the N-terminal strands
  Family 28 carbohydrate binding module, CBM28 [ 110122]
  Family 30 carbohydrate binding module, CBM30 (PKD repeat) [ 110125]
  Rhamnogalacturonase B, RhgB, C-terminal domain [ 110128]
  Hypothetical protein AT3g04780/F7O18 27 [ 117108]
  Pfam 06201; DUF1000
  Beta-galactosidase LacA, domains 4 and 5 [ 117111]
  duplication: tandem repeat of two similar domains; some sequence similarity to the beta-Galactosidase/glucuronidase N-terminal domain (scop_fa 49803)
  Family 36 carbohydrate binding module, CBM36 [ 117114]
  Extended PAW domain [ 141113]
  single domain; the N-terminal half is covered by Pfam 04721; DUF750 (Smart 00613; PAW), the C-terminal half by PfamB 028386
  CBM11 [ 141116]
  Pfam 03425; Carbohydrate binding domain (family 11)
  beta-mannanase CBM [ 141119]


Superfamily statistics
Genomes (908) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 16,431 13,396 93
Proteins 13,899 10,978 89


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Function annotation of SCOP domain superfamilies
InterPro annotation
Cross references IPR008979 SSF49785 Protein matches
Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [PubMed2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [PubMed10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [PubMed11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [PubMed10467102].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the Galactose-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]