SUPERFAMILY 1.75 HMM library and genome assignments server


Galactose-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Galactose-binding domain-like [ 49784]
Superfamily:   Galactose-binding domain-like [ 49785] (32)
Families:   Galactose-binding domain [ 49786] (2)
  Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)
  APC10-like [ 69210] (2)
  delta-Endotoxin, C-terminal domain [ 49796]
  Ephrin receptor ligand binding domain [ 49800] (2)
  beta-Galactosidase/glucuronidase, N-terminal domain [ 49803] (4)
  Chondroitin ABC lyase I, N-terminal domain [ 89236]
  CBM4/9 [ 74893] (3)
  Family 6 carbohydrate binding module, CBM6 [ 69213] (4)
  CBM15 [ 69216]
  Family 17 carbohydrate binding module, CBM17 [ 69219]
  CBM22 [ 49811]
  Family 27 carbohydrate binding module, CBM27 [ 89241] (2)
  Family 29 carbohydrate binding module, CBM29 [ 89244]
  Fucose binding lectin [ 74896]
  N-terminal domain of xrcc1 [ 49814]
  F-box associated region, FBA [ 101585]
  Allantoicase repeat [ 101588]
  PepX C-terminal domain-like [ 69222] (3)
  PA-IL, galactose-binding lectin 1 [ 82022]
  Proprotein convertase P-domain [ 89249] (3)
  Family 28 carbohydrate binding module, CBM28 [ 110122]
  Family 30 carbohydrate binding module, CBM30 (PKD repeat) [ 110125]
  Rhamnogalacturonase B, RhgB, C-terminal domain [ 110128]
  Hypothetical protein AT3g04780/F7O18 27 [ 117108]
  Beta-galactosidase LacA, domains 4 and 5 [ 117111]
  Family 36 carbohydrate binding module, CBM36 [ 117114]
  Extended PAW domain [ 141113]
  CBM11 [ 141116]
  beta-mannanase CBM [ 141119]
  YxiM N-terminal domain-like [ 158963]
  NPCBM-like [ 158966] (2)


Superfamily statistics
Genomes (2,318) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 37,758 93,393 111
Proteins 31,151 80,003 104


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.015011Least InformativeInherited
Biological Process (BP)developmental process0.12163.037e-12Least InformativeInherited
Biological Process (BP)multicellular organismal process0.083633.77e-15Least InformativeInherited
Biological Process (BP)protein metabolic process0.0074450Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0084640.0005532Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0001980.2581Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.48961Moderately InformativeInherited
Biological Process (BP)tissue development0.13420.8899Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.12060.3991Moderately InformativeInherited
Biological Process (BP)organ development0.21660.9019Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.037942.755e-06Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.44242.924e-05Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.57760.1523Moderately InformativeInherited
Biological Process (BP)multi-organism process0.16060.1586Moderately InformativeInherited
Biological Process (BP)reproduction0.0082210.05147Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0056820Moderately InformativeInherited
Biological Process (BP)multi-multicellular organism process9.678e-059.365e-07InformativeDirect
Biological Process (BP)epithelium development0.13990.3132InformativeInherited
Biological Process (BP)tube development0.00076630.01047InformativeInherited
Biological Process (BP)tissue morphogenesis0.010360.01163InformativeInherited
Biological Process (BP)proteolysis0.061960.03218InformativeInherited
Biological Process (BP)protein catabolic process0.00081110.111InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.0013750.000326InformativeInherited
Biological Process (BP)regulation of immune effector process4.248e-110.07808InformativeInherited
Biological Process (BP)gland development0.00050720.001318InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.036190InformativeInherited
Biological Process (BP)phosphorylation0.03120InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.036551InformativeInherited
Biological Process (BP)single organism reproductive process5.133e-050.03914InformativeInherited
Biological Process (BP)regulation of immune response5.928e-051InformativeInherited
Biological Process (BP)regulation of defense response2.733e-081InformativeInherited
Biological Process (BP)regulation of response to external stimulus1.231e-060.002715InformativeInherited
Biological Process (BP)regulation of growth0.017350.001364InformativeInherited
Biological Process (BP)regulation of acute inflammatory response04.835e-07Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response03.921e-06Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.00035220.0001322Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine modification5.268e-070Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00012290Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube5.391e-058.453e-05Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development6.164e-075.045e-12Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development7.64e-073.914e-12Highly InformativeDirect
Biological Process (BP)regulation of protein processing6.517e-121.588e-06Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process0.00015340.007665Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process0.084030.7763Highly InformativeInherited
Biological Process (BP)protein phosphorylation0.058940Highly InformativeInherited
Biological Process (BP)female pregnancy0.085970.02367Highly InformativeInherited
Biological Process (BP)regulation of innate immune response5.413e-110.07997Highly InformativeInherited
Molecular Function (MF)binding0.17790.9326Least InformativeInherited
Molecular Function (MF)hydrolase activity0.85820.00029Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.0023190InformativeInherited
Molecular Function (MF)monosaccharide binding1.996e-150.5101Highly InformativeInherited
Cellular Component (CC)protein complex0.15691Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.11541Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.18881Least InformativeInherited
Cellular Component (CC)extracellular region part7.443e-055.542e-08Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0053511Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex1.152e-064.613e-14InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex1.552e-070.0001442Highly InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex2.796e-070Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.77e-15 Least Informative Direct
Biological Process (BP) developmental process 3.037e-12 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0005532 Least Informative Direct
Biological Process (BP) response to stimulus 0.0006815 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0001023 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4686 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.7634 Least Informative Inherited
Biological Process (BP) cellular protein modification process 2.924e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 6.303e-11 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.755e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.403 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2581 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5578 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.00385 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9123 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8899 Moderately Informative Inherited
Biological Process (BP) system process 0.9999 Moderately Informative Inherited
Biological Process (BP) organ development 0.9019 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003578 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.8553 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.007424 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001314 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.03029 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.0226 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01325 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1586 Moderately Informative Inherited
Biological Process (BP) reproduction 0.05147 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3991 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1523 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 1.919e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 8.382e-08 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0005443 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001235 Informative Direct
Biological Process (BP) biological adhesion 4.104e-06 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 9.123e-06 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of organelle organization 2.48e-06 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) pigment metabolic process 5.238e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.734e-10 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000326 Informative Direct
Biological Process (BP) multi-multicellular organism process 9.365e-07 Informative Direct
Biological Process (BP) generation of neurons 0.0003243 Informative Direct
Biological Process (BP) positive regulation of developmental process 9.744e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 2.056e-09 Informative Direct
Biological Process (BP) localization of cell 8.996e-12 Informative Direct
Biological Process (BP) regulation of nervous system development 2.136e-06 Informative Direct
Biological Process (BP) regulation of cell development 0.0005975 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 2.814e-06 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 7.618e-05 Informative Direct
Biological Process (BP) response to wounding 0.001729 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01474 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01019 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6657 Informative Inherited
Biological Process (BP) epithelium development 0.3132 Informative Inherited
Biological Process (BP) tube development 0.01047 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.01163 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.09263 Informative Inherited
Biological Process (BP) synaptic transmission 0.7439 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.08375 Informative Inherited
Biological Process (BP) regulation of growth 0.001364 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.6031 Informative Inherited
Biological Process (BP) regulation of locomotion 0.05458 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1284 Informative Inherited
Biological Process (BP) sensory organ development 0.01637 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4901 Informative Inherited
Biological Process (BP) regulation of system process 0.5713 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.2578 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5719 Informative Inherited
Biological Process (BP) immune effector process 0.1402 Informative Inherited
Biological Process (BP) secondary metabolic process 0.005622 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) proteolysis 0.03218 Informative Inherited
Biological Process (BP) protein catabolic process 0.111 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.07808 Informative Inherited
Biological Process (BP) gland development 0.001318 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03914 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9664 Informative Inherited
Biological Process (BP) secretion by cell 0.002147 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9046 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.3136 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3795 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1368 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002715 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.02881 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6182 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.0141 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001029 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 1.072e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 2.498e-05 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 4.835e-07 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 3.921e-06 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) exocytosis 0.0001845 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of mitosis 0.0005034 Highly Informative Direct
Biological Process (BP) cell adhesion 2.433e-06 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 2.619e-10 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0001659 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 4.131e-14 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0003383 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0001322 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 1.211e-07 Highly Informative Direct
Biological Process (BP) telencephalon development 2.461e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 3.472e-05 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0 Highly Informative Direct
Biological Process (BP) wound healing 4.868e-05 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.000482 Highly Informative Direct
Biological Process (BP) eye morphogenesis 8.184e-05 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.0002066 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 8.453e-05 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.0001082 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 1.627e-06 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0004531 Highly Informative Direct
Biological Process (BP) mesenchyme development 9.49e-05 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 5.045e-12 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 3.914e-12 Highly Informative Direct
Biological Process (BP) axon development 1.854e-05 Highly Informative Direct
Biological Process (BP) regulation of protein processing 1.588e-06 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.692 Highly Informative Inherited
Biological Process (BP) hemostasis 0.01336 Highly Informative Inherited
Biological Process (BP) coagulation 0.001202 Highly Informative Inherited
Biological Process (BP) protein activation cascade 0.0133 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2753 Highly Informative Inherited
Biological Process (BP) iron ion homeostasis 0.003795 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.008231 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.003185 Highly Informative Inherited
Biological Process (BP) sensory perception 0.7242 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.04203 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.0349 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.07837 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.009932 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.001926 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.005606 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.2216 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.01286 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.08229 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1565 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.007665 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.7763 Highly Informative Inherited
Biological Process (BP) protein processing 0.04014 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.002361 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.05071 Highly Informative Inherited
Biological Process (BP) adult behavior 0.009805 Highly Informative Inherited
Biological Process (BP) learning or memory 0.02668 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.02367 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.001646 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.008094 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.02201 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.009494 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.07997 Highly Informative Inherited
Biological Process (BP) stem cell development 0.3128 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00029 Least Informative Direct
Molecular Function (MF) binding 0.9326 Least Informative Inherited
Molecular Function (MF) transferase activity 0.003133 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) peptidase activity 0.0008388 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.7644 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.3622 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.01858 Informative Inherited
Molecular Function (MF) lipid binding 0.019 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.02963 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 2.633e-11 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 1.8e-05 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.5101 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.1744 Highly Informative Inherited
Molecular Function (MF) calcium ion transmembrane transporter activity 0.007945 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.2066 Highly Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0.001857 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.03809 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 0.8768 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.001802 Highly Informative Inherited
Cellular Component (CC) membrane 0.0002258 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 2.938e-09 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 8.679e-06 Moderately Informative Direct
Cellular Component (CC) cell projection 1.559e-09 Moderately Informative Direct
Cellular Component (CC) extracellular region part 5.542e-08 Moderately Informative Direct
Cellular Component (CC) vesicle 0.009446 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.05911 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.1095 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.4136 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 4.613e-14 Informative Direct
Cellular Component (CC) endosome 8.889e-05 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0001273 Informative Direct
Cellular Component (CC) secretory granule 5.183e-05 Informative Direct
Cellular Component (CC) extracellular matrix 0.0008703 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 4.533e-06 Informative Direct
Cellular Component (CC) neuron projection 1.896e-09 Informative Direct
Cellular Component (CC) cell leading edge 0.001407 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00753 Informative Inherited
Cellular Component (CC) integral to membrane 0.07522 Informative Inherited
Cellular Component (CC) lytic vacuole 0.2062 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.0001442 Highly Informative Direct
Cellular Component (CC) lysosome 0.0006057 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 6.357e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) endosomal part 1.593e-05 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.3023 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.06926 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0161Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.734Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides3.708e-15InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)Furin4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase5.085e-15Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 21.228e-12Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 15.325e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.3556Least InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.005022InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.006563Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.02217Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.03469Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.06716Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.05414Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1792Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.285Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.4139Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7706Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.01455InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.0154InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1983InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.2135InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology2.913e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal axon guidance6.307e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain white matter morphology0.000114Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart and great vessel attachment0.0005008Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0009198Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epididymis morphology0.03261Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.05017Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.1022Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0004258Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.007451Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.783Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8142Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.8426Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.1104InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.7235Least InformativeInherited
Plant ANatomical entity (PAN)fruit5.367e-08InformativeDirect
Plant ANatomical entity (PAN)rosette leaf4.199e-05InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.02162Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.7035InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processHemostasis4.599e-10InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processBlood coagulation4.256e-10Highly InformativeDirect
Biological processOsteogenesis4.578e-07Highly InformativeDirect
Biological processFertilization7.291e-07Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome3.406e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0003732Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseDisease mutation0.0001319Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat6.14e-06Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain1.765e-09Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin2.338e-10InformativeDirect
Molecular functionHeparin-binding2.309e-08InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.643e-10Moderately InformativeDirect
Post-translational modificationProtease9.354e-06Moderately InformativeDirect
Post-translational modificationKinase0.002178Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond4.254e-07Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues2.26e-11Moderately InformativeDirect
Post-translational modificationZymogen1.353e-15InformativeDirect
Post-translational modificationSulfation1.926e-05InformativeDirect
Post-translational modificationProteoglycan0.05762InformativeInherited
Post-translational modificationHeparan sulfate1.396e-13Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002196Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism7.575e-06Least InformativeDirect
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)ureide metabolism0InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)N-glycan degradation0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008979 SSF49785 Protein matches
Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [PubMed2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [PubMed10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [PubMed11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [PubMed10467102].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 65 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 65 hidden Markov models representing the Galactose-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]