SUPERFAMILY 1.75 HMM library and genome assignments server

Galactose-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Galactose-binding domain-like [ 49784]
Superfamily:   Galactose-binding domain-like [ 49785] (32)
Families:   Galactose-binding domain [ 49786] (2)
  Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)
  APC10-like [ 69210] (2)
  delta-Endotoxin, C-terminal domain [ 49796]
  Ephrin receptor ligand binding domain [ 49800] (2)
  beta-Galactosidase/glucuronidase, N-terminal domain [ 49803] (4)
  Chondroitin ABC lyase I, N-terminal domain [ 89236]
  CBM4/9 [ 74893] (3)
  Family 6 carbohydrate binding module, CBM6 [ 69213] (4)
  CBM15 [ 69216]
  Family 17 carbohydrate binding module, CBM17 [ 69219]
  CBM22 [ 49811]
  Family 27 carbohydrate binding module, CBM27 [ 89241] (2)
  Family 29 carbohydrate binding module, CBM29 [ 89244]
  Fucose binding lectin [ 74896]
  N-terminal domain of xrcc1 [ 49814]
  F-box associated region, FBA [ 101585]
  Allantoicase repeat [ 101588]
  PepX C-terminal domain-like [ 69222] (3)
  PA-IL, galactose-binding lectin 1 [ 82022]
  Proprotein convertase P-domain [ 89249] (3)
  Family 28 carbohydrate binding module, CBM28 [ 110122]
  Family 30 carbohydrate binding module, CBM30 (PKD repeat) [ 110125]
  Rhamnogalacturonase B, RhgB, C-terminal domain [ 110128]
  Hypothetical protein AT3g04780/F7O18 27 [ 117108]
  Beta-galactosidase LacA, domains 4 and 5 [ 117111]
  Family 36 carbohydrate binding module, CBM36 [ 117114]
  Extended PAW domain [ 141113]
  CBM11 [ 141116]
  beta-mannanase CBM [ 141119]
  YxiM N-terminal domain-like [ 158963]
  NPCBM-like [ 158966] (2)


Superfamily statistics
Genomes (2,319) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 37,854 93,393 111
Proteins 31,228 80,003 104


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.020991Least InformativeInherited
Biological Process (BP)multicellular organismal process0.13530.000000000000003707Least InformativeInherited
Biological Process (BP)developmental process0.12630.00000000001044Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.008110.0003242Least InformativeInherited
Biological Process (BP)protein metabolic process0.0077630Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)organ development0.20810.8021Moderately InformativeInherited
Biological Process (BP)tissue development0.031940.7457Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.038210.000003545Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.12390.5406Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.21230.2598Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.63060.1622Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.4440.00005071Moderately InformativeInherited
Biological Process (BP)multi-organism process0.070920.8934Moderately InformativeInherited
Biological Process (BP)reproductive process0.0034220.09112Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.001030.2348Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.039871Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0077470Moderately InformativeInherited
Biological Process (BP)multi-multicellular organism process0.00009680.00000098InformativeDirect
Biological Process (BP)regulation of response to wounding0.00000000036980.000028InformativeDirect
Biological Process (BP)gland development0.0013570.00178InformativeInherited
Biological Process (BP)tissue morphogenesis0.0088810.004639InformativeInherited
Biological Process (BP)epithelium development0.35750.9989InformativeInherited
Biological Process (BP)tube development0.0015630.03602InformativeInherited
Biological Process (BP)proteolysis0.059330.0252InformativeInherited
Biological Process (BP)protein catabolic process0.00078730.1087InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.0013750.0002372InformativeInherited
Biological Process (BP)regulation of immune response0.00033591InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.000018120.07164InformativeInherited
Biological Process (BP)regulation of immune effector process0.000000000045530.08992InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.036470InformativeInherited
Biological Process (BP)phosphorylation0.050810InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.037231InformativeInherited
Biological Process (BP)single organism reproductive process0.00032150.11InformativeInherited
Biological Process (BP)regulation of defense response0.000000031311InformativeInherited
Biological Process (BP)regulation of growth0.015450.001043InformativeInherited
Biological Process (BP)regulation of acute inflammatory response00.0000004907Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response00.000003839Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.00036960.000162Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00012320Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube0.000050930.00007943Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development0.00000049740.000000000004258Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development0.00000072350.0000000000002196Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process0.00014880.004359Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process0.090840.745Highly InformativeInherited
Biological Process (BP)protein phosphorylation0.047160Highly InformativeInherited
Biological Process (BP)female pregnancy0.013290.0000001689Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.000000000063260.1218Highly InformativeInherited
Molecular Function (MF)binding0.17670.9868Least InformativeInherited
Molecular Function (MF)hydrolase activity0.85970.00005754Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.002350InformativeInherited
Molecular Function (MF)monosaccharide binding0.000000000000001340.5769Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.34541Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.17951Least InformativeInherited
Cellular Component (CC)protein complex0.15091Least InformativeInherited
Cellular Component (CC)extracellular region part0.000069410.00000008243Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0042151Moderately InformativeInherited
Cellular Component (CC)transferase complex0.00099670.01254Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.0000016210.0000000000002177InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex0.00000017280.0005805Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000000000003707 Least Informative Direct
Biological Process (BP) developmental process 0.00000000001044 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0003242 Least Informative Direct
Biological Process (BP) response to stimulus 0.001431 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.987 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.008217 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.9035 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00005071 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0000000002765 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0000002903 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000003545 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0005847 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.5391 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.002884 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2598 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003155 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7457 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.8021 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5406 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.3996 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.00253 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001839 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.03022 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.02566 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1622 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.09112 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8934 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3565 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9979 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01318 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2348 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.0000000001227 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 0.0000003318 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0000001344 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00004993 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00008612 Informative Direct
Biological Process (BP) biological adhesion 0.000003082 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00002408 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000138 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) pigment metabolic process 0.00005004 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000001488 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0002372 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.00000098 Informative Direct
Biological Process (BP) single-organism behavior 0.0008148 Informative Direct
Biological Process (BP) generation of neurons 0.0004092 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0001 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000003698 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0004703 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0004832 Informative Direct
Biological Process (BP) protein maturation 0.0000000002265 Informative Direct
Biological Process (BP) localization of cell 0.00000000001385 Informative Direct
Biological Process (BP) regulation of nervous system development 0.00000249 Informative Direct
Biological Process (BP) regulation of cell development 0.0002524 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000004492 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0002649 Informative Direct
Biological Process (BP) regulation of response to wounding 0.000028 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.08924 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01337 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.1531 Informative Inherited
Biological Process (BP) gland development 0.00178 Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.1593 Informative Inherited
Biological Process (BP) cation homeostasis 0.02246 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.004639 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) synaptic transmission 0.1582 Informative Inherited
Biological Process (BP) epithelium development 0.9989 Informative Inherited
Biological Process (BP) tube development 0.03602 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1437 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.07164 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.02959 Informative Inherited
Biological Process (BP) regulation of growth 0.001043 Informative Inherited
Biological Process (BP) sensory organ development 0.005317 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.02844 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.2244 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.7504 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) proteolysis 0.0252 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.03105 Informative Inherited
Biological Process (BP) immune effector process 0.1436 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.534 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.1087 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.08992 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9929 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.001122 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.6112 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) neurological system process 0.1011 Informative Inherited
Biological Process (BP) secretion by cell 0.002072 Informative Inherited
Biological Process (BP) single organism reproductive process 0.11 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.3887 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.4928 Informative Inherited
Biological Process (BP) secondary metabolic process 0.006579 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1941 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.631 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.0161 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001329 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.00001149 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000000000000003707 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000008634 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0.0000004907 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0.000003839 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) exocytosis 0.0002371 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000001453 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000002372 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0000001689 Highly Informative Direct
Biological Process (BP) cell recognition 0 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0002938 Highly Informative Direct
Biological Process (BP) fertilization 0.0006958 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00000000000001071 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0002697 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.000162 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0000000005766 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000003584 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 0.00003546 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0000000001777 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.0000005403 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.00000000000002753 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.000634 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000000000777 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.00008109 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.00007943 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.0001379 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00006151 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000248 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.0001274 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.000000000004258 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0000000000002196 Highly Informative Direct
Biological Process (BP) positive regulation of neuron death 0.00003314 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.03502 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.2646 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.6444 Highly Informative Inherited
Biological Process (BP) hemostasis 0.0138 Highly Informative Inherited
Biological Process (BP) wound healing 0.02049 Highly Informative Inherited
Biological Process (BP) coagulation 0.001263 Highly Informative Inherited
Biological Process (BP) protein activation cascade 0.01736 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.001687 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.07874 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.3499 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.00815 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.008974 Highly Informative Inherited
Biological Process (BP) sensory perception 0.6559 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.5768 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.09092 Highly Informative Inherited
Biological Process (BP) negative regulation of response to wounding 0.2131 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3136 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.07572 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.01462 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.745 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.04536 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1579 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.004359 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2742 Highly Informative Inherited
Biological Process (BP) cell wall polysaccharide metabolic process 0.06268 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3494 Highly Informative Inherited
Biological Process (BP) adult behavior 0.01069 Highly Informative Inherited
Biological Process (BP) learning or memory 0.1174 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.9485 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.4099 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.008941 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.0268 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.01018 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.1218 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.0009609 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.00005754 Least Informative Direct
Molecular Function (MF) binding 0.9868 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.02967 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) peptidase activity 0.0002344 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.02242 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.3699 Informative Inherited
Molecular Function (MF) protein complex binding 0.2614 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.03436 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.000000000000416 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.00001848 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.5769 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.178 Highly Informative Inherited
Molecular Function (MF) calcium ion transmembrane transporter activity 0.007934 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.2207 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.01523 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 0.9549 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.002137 Highly Informative Inherited
Cellular Component (CC) membrane 0.000537 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0000374 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000002569 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000008243 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.0000000006221 Moderately Informative Direct
Cellular Component (CC) vesicle 0.01211 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.02543 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.1151 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.01254 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.0000000000002177 Informative Direct
Cellular Component (CC) endosome 0.0001147 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0002965 Informative Direct
Cellular Component (CC) integral component of membrane 0.00001238 Informative Direct
Cellular Component (CC) secretory granule 0.0001753 Informative Direct
Cellular Component (CC) extracellular matrix 0.0007574 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000002993 Informative Direct
Cellular Component (CC) neuron projection 0.00000000004443 Informative Direct
Cellular Component (CC) transporter complex 0.3215 Informative Inherited
Cellular Component (CC) cell leading edge 0.001552 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.007654 Informative Inherited
Cellular Component (CC) lytic vacuole 0.2216 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.0005805 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.0000001003 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0007368 Highly Informative Direct
Cellular Component (CC) endosomal part 0.00001589 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.6581 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.06019 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0161Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.734Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0.000000000000003708InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)Furin4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase0.000000000000005085Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 20.000000000001228Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 10.00000000005325Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.363Least InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.005081InformativeInherited
Disease Ontology (DO)pancreatic ductal adenocarcinoma0.00002445Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4082Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.07603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1171Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.163Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2986Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.02878InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0.07695InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.0919InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the odontoid process0.0002607Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.0008916Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hip joint0.000895Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00477Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.05468Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.05585Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08401Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.08366Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2522Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2588Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.4067Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.0135InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.2222InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.00006278Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain white matter morphology0.0001309Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart and great vessel attachment0.0006244Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epididymis morphology0.03348Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.06154Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.1022Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0004258Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.007451Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7826Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8143Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.7351Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.04343InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.7235Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.00000005367InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.00004199InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.02041Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.7017InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processHemostasis0.0000000005444InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processBlood coagulation0.0000000005045Highly InformativeDirect
Biological processOsteogenesis0.0000004615Highly InformativeDirect
Biological processFertilization0.0000007353Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.00003842Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000407Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseDisease mutation0.0001377Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.000005841Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain0.000000001803Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin0.0000000004021InformativeDirect
Molecular functionHeparin-binding0.00000002341InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000000003815Moderately InformativeDirect
Post-translational modificationProtease0.000005882Moderately InformativeDirect
Post-translational modificationKinase0.002322Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.0000003058Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.00000000000566Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationSulfation0.00002001InformativeDirect
Post-translational modificationProteoglycan0.05768InformativeInherited
Post-translational modificationHeparan sulfate0.0000000000001416Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002208Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.000007574Least InformativeDirect
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)ureide metabolism0InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)N-glycan degradation0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008979 SSF49785 Protein matches
Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [PubMed2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [PubMed10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [PubMed11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [PubMed10467102].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 65 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 65 hidden Markov models representing the Galactose-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]