SUPERFAMILY 1.75 HMM library and genome assignments server


Galactose-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Galactose-binding domain-like [ 49784]
Superfamily:   Galactose-binding domain-like [ 49785] (32)
Families:   Galactose-binding domain [ 49786] (2)
  Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)
  APC10-like [ 69210] (2)
  delta-Endotoxin, C-terminal domain [ 49796]
  Ephrin receptor ligand binding domain [ 49800] (2)
  beta-Galactosidase/glucuronidase, N-terminal domain [ 49803] (4)
  Chondroitin ABC lyase I, N-terminal domain [ 89236]
  CBM4/9 [ 74893] (3)
  Family 6 carbohydrate binding module, CBM6 [ 69213] (4)
  CBM15 [ 69216]
  Family 17 carbohydrate binding module, CBM17 [ 69219]
  CBM22 [ 49811]
  Family 27 carbohydrate binding module, CBM27 [ 89241] (2)
  Family 29 carbohydrate binding module, CBM29 [ 89244]
  Fucose binding lectin [ 74896]
  N-terminal domain of xrcc1 [ 49814]
  F-box associated region, FBA [ 101585]
  Allantoicase repeat [ 101588]
  PepX C-terminal domain-like [ 69222] (3)
  PA-IL, galactose-binding lectin 1 [ 82022]
  Proprotein convertase P-domain [ 89249] (3)
  Family 28 carbohydrate binding module, CBM28 [ 110122]
  Family 30 carbohydrate binding module, CBM30 (PKD repeat) [ 110125]
  Rhamnogalacturonase B, RhgB, C-terminal domain [ 110128]
  Hypothetical protein AT3g04780/F7O18 27 [ 117108]
  Beta-galactosidase LacA, domains 4 and 5 [ 117111]
  Family 36 carbohydrate binding module, CBM36 [ 117114]
  Extended PAW domain [ 141113]
  CBM11 [ 141116]
  beta-mannanase CBM [ 141119]
  YxiM N-terminal domain-like [ 158963]
  NPCBM-like [ 158966] (2)


Superfamily statistics
Genomes (2,318) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 37,760 93,393 111
Proteins 31,152 80,003 104


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.014961Least InformativeInherited
Biological Process (BP)developmental process0.12536.937e-12Least InformativeInherited
Biological Process (BP)multicellular organismal process0.08591.086e-14Least InformativeInherited
Biological Process (BP)protein metabolic process0.0070520Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0080640.0003403Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00021650.29Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.49491Moderately InformativeInherited
Biological Process (BP)tissue development0.13370.8736Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.12340.4189Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.21060.2412Moderately InformativeInherited
Biological Process (BP)organ development0.21960.8735Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.038463.629e-06Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.4432.336e-05Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.59060.1503Moderately InformativeInherited
Biological Process (BP)multi-organism process0.17670.2086Moderately InformativeInherited
Biological Process (BP)reproduction0.0084460.05443Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0056910Moderately InformativeInherited
Biological Process (BP)multi-multicellular organism process9.473e-058.202e-07InformativeDirect
Biological Process (BP)epithelium development0.14050.3194InformativeInherited
Biological Process (BP)tube development0.00076060.009335InformativeInherited
Biological Process (BP)tissue morphogenesis0.010150.01148InformativeInherited
Biological Process (BP)proteolysis0.061750.04069InformativeInherited
Biological Process (BP)protein catabolic process0.00081150.1243InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.0013390.0003779InformativeInherited
Biological Process (BP)regulation of immune effector process4.385e-110.08314InformativeInherited
Biological Process (BP)gland development0.00048850.001258InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.036640InformativeInherited
Biological Process (BP)phosphorylation0.031020InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.035911InformativeInherited
Biological Process (BP)single organism reproductive process4.987e-050.03777InformativeInherited
Biological Process (BP)regulation of immune response5.887e-051InformativeInherited
Biological Process (BP)regulation of defense response3.161e-081InformativeInherited
Biological Process (BP)regulation of response to external stimulus1.235e-060.003064InformativeInherited
Biological Process (BP)regulation of growth0.017190.001548InformativeInherited
Biological Process (BP)regulation of acute inflammatory response04.865e-07Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response03.811e-06Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.0003380.0001483Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00013050Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube5.158e-057.739e-05Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development6.101e-074.626e-12Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development7.299e-073.594e-12Highly InformativeDirect
Biological Process (BP)regulation of protein processing5.274e-121.6e-06Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process0.00014090.00821Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process0.084120.7779Highly InformativeInherited
Biological Process (BP)protein phosphorylation0.05750Highly InformativeInherited
Biological Process (BP)female pregnancy0.084650.0245Highly InformativeInherited
Biological Process (BP)regulation of innate immune response4.833e-110.08314Highly InformativeInherited
Molecular Function (MF)binding0.17220.9652Least InformativeInherited
Molecular Function (MF)hydrolase activity0.85840.0001504Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.0022960InformativeInherited
Molecular Function (MF)monosaccharide binding1.331e-150.5759Highly InformativeInherited
Cellular Component (CC)protein complex0.15361Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.11711Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.18181Least InformativeInherited
Cellular Component (CC)extracellular region part7.142e-057.358e-08Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0052161Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex1.273e-066.023e-14InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex1.542e-070.0001285Highly InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex3.24e-070Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.086e-14 Least Informative Direct
Biological Process (BP) developmental process 6.937e-12 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0003403 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0003319 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5051 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001125 Least Informative Inherited
Biological Process (BP) localization 0.8012 Least Informative Inherited
Biological Process (BP) cellular protein modification process 2.336e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 1.218e-10 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.629e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0005428 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.3712 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.29 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5051 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.002938 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8752 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8736 Moderately Informative Inherited
Biological Process (BP) system process 0.9975 Moderately Informative Inherited
Biological Process (BP) organ development 0.8735 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.004485 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.8653 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.009357 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001591 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02847 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.02802 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.008667 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2086 Moderately Informative Inherited
Biological Process (BP) reproduction 0.05443 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4189 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2412 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1503 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 2.072e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 7.124e-08 Informative Direct
Biological Process (BP) response to wounding 0.0009028 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0004768 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001229 Informative Direct
Biological Process (BP) biological adhesion 4.429e-06 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.265e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of organelle organization 3.379e-06 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) pigment metabolic process 4.945e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 7.63e-10 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0003779 Informative Direct
Biological Process (BP) multi-multicellular organism process 8.202e-07 Informative Direct
Biological Process (BP) generation of neurons 0.0003866 Informative Direct
Biological Process (BP) positive regulation of developmental process 8.146e-06 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 2.289e-09 Informative Direct
Biological Process (BP) localization of cell 1.108e-11 Informative Direct
Biological Process (BP) regulation of nervous system development 1.837e-06 Informative Direct
Biological Process (BP) regulation of cell development 0.0006674 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.0006717 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 2.726e-06 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 7.669e-05 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.08026 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01356 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01163 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6834 Informative Inherited
Biological Process (BP) epithelium development 0.3194 Informative Inherited
Biological Process (BP) tube development 0.009335 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.01148 Informative Inherited
Biological Process (BP) cation homeostasis 0.02584 Informative Inherited
Biological Process (BP) synaptic transmission 0.7545 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.09134 Informative Inherited
Biological Process (BP) regulation of growth 0.001548 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.628 Informative Inherited
Biological Process (BP) regulation of locomotion 0.03134 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1276 Informative Inherited
Biological Process (BP) sensory organ development 0.01467 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.5233 Informative Inherited
Biological Process (BP) regulation of system process 0.6023 Informative Inherited
Biological Process (BP) peptide metabolic process 0.1095 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.03091 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.572 Informative Inherited
Biological Process (BP) immune effector process 0.1397 Informative Inherited
Biological Process (BP) secondary metabolic process 0.006046 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) proteolysis 0.04069 Informative Inherited
Biological Process (BP) protein catabolic process 0.1243 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.08314 Informative Inherited
Biological Process (BP) gland development 0.001258 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03777 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9832 Informative Inherited
Biological Process (BP) secretion by cell 0.002182 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8944 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.3249 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3914 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1442 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.003064 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.02657 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6195 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.01532 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001142 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 1.017e-05 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 5.594e-15 Highly Informative Direct
Biological Process (BP) angiogenesis 2.408e-05 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 4.865e-07 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 3.811e-06 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) exocytosis 0.0002227 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of mitosis 0.0005309 Highly Informative Direct
Biological Process (BP) cell adhesion 2.194e-06 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 2.506e-10 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0002829 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 2.119e-14 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0002532 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0001483 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 1.442e-07 Highly Informative Direct
Biological Process (BP) telencephalon development 2.55e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 3.509e-05 Highly Informative Direct
Biological Process (BP) neuron projection development 2.17e-10 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 5.317e-07 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 1.178e-07 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 2.793e-14 Highly Informative Direct
Biological Process (BP) wound healing 0.0002179 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.0006301 Highly Informative Direct
Biological Process (BP) eye morphogenesis 8.017e-05 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 7.739e-05 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 2.906e-06 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0007482 Highly Informative Direct
Biological Process (BP) mesenchyme development 9.712e-05 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 4.626e-12 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 3.594e-12 Highly Informative Direct
Biological Process (BP) regulation of protein processing 1.6e-06 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.6972 Highly Informative Inherited
Biological Process (BP) hemostasis 0.01387 Highly Informative Inherited
Biological Process (BP) coagulation 0.001161 Highly Informative Inherited
Biological Process (BP) protein activation cascade 0.01296 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.295 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.3917 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.009776 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.003321 Highly Informative Inherited
Biological Process (BP) sensory perception 0.7129 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.04511 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.03986 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.07381 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.009978 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.001762 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.005618 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.2299 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.01384 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.08408 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1571 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.00821 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.7779 Highly Informative Inherited
Biological Process (BP) protein processing 0.04228 Highly Informative Inherited
Biological Process (BP) cell wall polysaccharide metabolic process 0.06264 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.05564 Highly Informative Inherited
Biological Process (BP) adult behavior 0.009417 Highly Informative Inherited
Biological Process (BP) learning or memory 0.02578 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.0245 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.9948 Highly Informative Inherited
Biological Process (BP) fertilization 0.002108 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.008066 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.02615 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.01012 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.08314 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2975 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0001504 Least Informative Direct
Molecular Function (MF) binding 0.9652 Least Informative Inherited
Molecular Function (MF) transferase activity 0.003285 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.7678 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.3662 Informative Inherited
Molecular Function (MF) peptidase activity 0.001031 Informative Inherited
Molecular Function (MF) lipid binding 0.02103 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.03347 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 3.416e-11 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 1.773e-05 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.5759 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.1749 Highly Informative Inherited
Molecular Function (MF) calcium ion transmembrane transporter activity 0.008067 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.2081 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.03688 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 0.8708 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.002037 Highly Informative Inherited
Cellular Component (CC) membrane 0.0004862 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 4.79e-09 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 7.905e-06 Moderately Informative Direct
Cellular Component (CC) cell projection 4e-09 Moderately Informative Direct
Cellular Component (CC) extracellular region part 7.358e-08 Moderately Informative Direct
Cellular Component (CC) vesicle 0.01022 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.08809 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.1127 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.6548 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 6.023e-14 Informative Direct
Cellular Component (CC) endosome 0.0001075 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0002939 Informative Direct
Cellular Component (CC) secretory granule 5.197e-05 Informative Direct
Cellular Component (CC) extracellular matrix 0.0009402 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 2.47e-06 Informative Direct
Cellular Component (CC) neuron projection 7.267e-10 Informative Direct
Cellular Component (CC) cell leading edge 0.001524 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.007578 Informative Inherited
Cellular Component (CC) integral to membrane 0.07872 Informative Inherited
Cellular Component (CC) lytic vacuole 0.2099 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0.0001285 Highly Informative Direct
Cellular Component (CC) lysosome 0.0006933 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 3.304e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) endosomal part 1.548e-05 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.2963 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.0803 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0161Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.734Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides3.708e-15InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)Furin4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase5.085e-15Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 21.228e-12Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 15.325e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.363Least InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.005081InformativeInherited
Disease Ontology (DO)pancreatic ductal adenocarcinoma2.445e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4082Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.07603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1171Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.163Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2986Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.02878InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia affecting bones of the axial skeleton0.07695InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.0919InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the odontoid process0.0002607Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.0008916Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hip joint0.000895Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00477Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.05468Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.05585Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08401Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.08366Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2522Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2588Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.4067Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.0135InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.2222InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance6.278e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain white matter morphology0.0001309Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart and great vessel attachment0.0006244Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epididymis morphology0.03348Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.06154Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.1022Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0004258Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.007451Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7826Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8143Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.7351Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.04343InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.7235Least InformativeInherited
Plant ANatomical entity (PAN)fruit5.367e-08InformativeDirect
Plant ANatomical entity (PAN)rosette leaf4.199e-05InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.02041Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.7017InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processHemostasis5.444e-10InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processBlood coagulation5.045e-10Highly InformativeDirect
Biological processOsteogenesis4.615e-07Highly InformativeDirect
Biological processFertilization7.353e-07Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome3.842e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000407Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseDisease mutation0.0001377Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat5.841e-06Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain1.803e-09Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin4.021e-10InformativeDirect
Molecular functionHeparin-binding2.341e-08InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.815e-10Moderately InformativeDirect
Post-translational modificationProtease5.882e-06Moderately InformativeDirect
Post-translational modificationKinase0.002322Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond3.058e-07Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues5.66e-12Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationSulfation2.001e-05InformativeDirect
Post-translational modificationProteoglycan0.05768InformativeInherited
Post-translational modificationHeparan sulfate1.416e-13Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002208Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism7.574e-06Least InformativeDirect
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)ureide metabolism0InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)N-glycan degradation0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008979 SSF49785 Protein matches
Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [PubMed2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [PubMed10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [PubMed11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [PubMed10467102].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 65 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 65 hidden Markov models representing the Galactose-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]