SUPERFAMILY 1.75 HMM library and genome assignments server


Galactose-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Galactose-binding domain-like [ 49784]
Superfamily:   Galactose-binding domain-like [ 49785] (32)
Families:   Galactose-binding domain [ 49786] (2)
  Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)
  APC10-like [ 69210] (2)
  delta-Endotoxin, C-terminal domain [ 49796]
  Ephrin receptor ligand binding domain [ 49800] (2)
  beta-Galactosidase/glucuronidase, N-terminal domain [ 49803] (4)
  Chondroitin ABC lyase I, N-terminal domain [ 89236]
  CBM4/9 [ 74893] (3)
  Family 6 carbohydrate binding module, CBM6 [ 69213] (4)
  CBM15 [ 69216]
  Family 17 carbohydrate binding module, CBM17 [ 69219]
  CBM22 [ 49811]
  Family 27 carbohydrate binding module, CBM27 [ 89241] (2)
  Family 29 carbohydrate binding module, CBM29 [ 89244]
  Fucose binding lectin [ 74896]
  N-terminal domain of xrcc1 [ 49814]
  F-box associated region, FBA [ 101585]
  Allantoicase repeat [ 101588]
  PepX C-terminal domain-like [ 69222] (3)
  PA-IL, galactose-binding lectin 1 [ 82022]
  Proprotein convertase P-domain [ 89249] (3)
  Family 28 carbohydrate binding module, CBM28 [ 110122]
  Family 30 carbohydrate binding module, CBM30 (PKD repeat) [ 110125]
  Rhamnogalacturonase B, RhgB, C-terminal domain [ 110128]
  Hypothetical protein AT3g04780/F7O18 27 [ 117108]
  Beta-galactosidase LacA, domains 4 and 5 [ 117111]
  Family 36 carbohydrate binding module, CBM36 [ 117114]
  Extended PAW domain [ 141113]
  CBM11 [ 141116]
  beta-mannanase CBM [ 141119]
  YxiM N-terminal domain-like [ 158963]
  NPCBM-like [ 158966] (2)


Superfamily statistics
Genomes (1,810) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 31,922 55,315 111
Proteins 26,266 46,991 104


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.0078931Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)developmental process0.24330Least InformativeInherited
Biological Process (BP)multicellular organismal process0.086480Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0057220.005741Least InformativeInherited
Biological Process (BP)protein metabolic process0.0058750Least InformativeInherited
Biological Process (BP)regulation of cellular component organization5.746e-050Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process4.44e-050.3647Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.52931Moderately InformativeInherited
Biological Process (BP)tissue development0.033551Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.087610.06407Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.1680.02449Moderately InformativeInherited
Biological Process (BP)organ development0.13811Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.24450Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.13952.669e-07Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.21340.0005597Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.47060.09588Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0093680.00137Moderately InformativeInherited
Biological Process (BP)multi-organism process0.11860.02098Moderately InformativeInherited
Biological Process (BP)reproduction0.0048330.003752Moderately InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.00096790.0002619InformativeDirect
Biological Process (BP)epithelium development0.13740.07355InformativeInherited
Biological Process (BP)tube development0.0044630.03975InformativeInherited
Biological Process (BP)tissue morphogenesis0.0022820.04486InformativeInherited
Biological Process (BP)proteolysis0.049120.08488InformativeInherited
Biological Process (BP)protein catabolic process0.00054780.02326InformativeInherited
Biological Process (BP)regulation of immune effector process1.103e-110.01653InformativeInherited
Biological Process (BP)gland development0.00016160.001696InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.079467.424e-12InformativeInherited
Biological Process (BP)protein phosphorylation0.17390InformativeInherited
Biological Process (BP)regulation of response to stress0.00012380.7889InformativeInherited
Biological Process (BP)single organism reproductive process1.464e-050.00224InformativeInherited
Biological Process (BP)multi-organism reproductive process0.0089415.271e-11InformativeInherited
Biological Process (BP)regulation of immune response0.00014551InformativeInherited
Biological Process (BP)regulation of response to external stimulus1.685e-060.005139InformativeInherited
Biological Process (BP)peptidyl-tyrosine phosphorylation1.295e-070Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion6.611e-050Highly InformativeDirect
Biological Process (BP)multi-multicellular organism process4.477e-051.253e-08Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development2.901e-071.303e-11Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development7.906e-077.758e-12Highly InformativeDirect
Biological Process (BP)regulation of protein processing3.262e-131.66e-07Highly InformativeDirect
Biological Process (BP)epithelial tube morphogenesis0.00011970.05035Highly InformativeInherited
Biological Process (BP)morphogenesis of a branching epithelium4.45e-050.02716Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process0.06950.6348Highly InformativeInherited
Biological Process (BP)modification-dependent protein catabolic process8.153e-050.002359Highly InformativeInherited
Biological Process (BP)regulation of inflammatory response1.168e-110.07568Highly InformativeInherited
Biological Process (BP)regulation of innate immune response1.103e-110.03798Highly InformativeInherited
Molecular Function (MF)binding0.12950.7167Least InformativeInherited
Molecular Function (MF)hydrolase activity0.82790.001493Least InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.0008250.009891InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.0015440InformativeInherited
Molecular Function (MF)small conjugating protein ligase activity0.00025440.0009599Highly InformativeDirect
Molecular Function (MF)monosaccharide binding2.587e-150.3458Highly InformativeInherited
Cellular Component (CC)protein complex0.18561Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.11641Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.25071Least InformativeInherited
Cellular Component (CC)extracellular region0.00089980Moderately InformativeDirect
Cellular Component (CC)nuclear part0.001051Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex1.201e-067.722e-10InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex2.512e-070.00012Highly InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex3.669e-076.208e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1.498e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0002717 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.49 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.2478 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.005741 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.0005597 Moderately Informative Direct
Biological Process (BP) nervous system development 3.355e-09 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.669e-07 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1.812e-06 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1.549e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.728e-11 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.3647 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1163 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.003093 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.9108 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.00137 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001168 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6794 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.008175 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.4871 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01655 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01045 Moderately Informative Inherited
Biological Process (BP) reproduction 0.003752 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02098 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.3935 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.06407 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.02449 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.09588 Moderately Informative Inherited
Biological Process (BP) protein phosphorylation 0 Informative Direct
Biological Process (BP) cellular component movement 7.001e-11 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 1.012e-05 Informative Direct
Biological Process (BP) response to external stimulus 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 7.424e-12 Informative Direct
Biological Process (BP) biological adhesion 3.986e-05 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 7.205e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) pigment metabolic process 5.317e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 2.284e-12 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0002619 Informative Direct
Biological Process (BP) multi-organism reproductive process 5.271e-11 Informative Direct
Biological Process (BP) secretion 0.0004181 Informative Direct
Biological Process (BP) generation of neurons 0.0004041 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0005298 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0004695 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.045e-07 Informative Direct
Biological Process (BP) regulation of hydrolase activity 8.533e-06 Informative Direct
Biological Process (BP) localization of cell 1.728e-13 Informative Direct
Biological Process (BP) regulation of nervous system development 7.136e-05 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 1.186e-08 Informative Direct
Biological Process (BP) response to wounding 0.001097 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.03358 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) epithelium development 0.07355 Informative Inherited
Biological Process (BP) tube development 0.03975 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.04486 Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.07576 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.9374 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.9328 Informative Inherited
Biological Process (BP) synaptic transmission 0.6603 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.02566 Informative Inherited
Biological Process (BP) sensory organ development 0.05576 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1225 Informative Inherited
Biological Process (BP) regulation of system process 0.6894 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.9343 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.1496 Informative Inherited
Biological Process (BP) immune effector process 0.0752 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) proteolysis 0.08488 Informative Inherited
Biological Process (BP) protein catabolic process 0.02326 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.9695 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.01653 Informative Inherited
Biological Process (BP) regulation of growth 0.006359 Informative Inherited
Biological Process (BP) gland development 0.001696 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.001434 Informative Inherited
Biological Process (BP) regulation of cell development 0.1508 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.003096 Informative Inherited
Biological Process (BP) regulation of response to stress 0.7889 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.00224 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.6352 Informative Inherited
Biological Process (BP) sexual reproduction 0.964 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5735 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.08527 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.005139 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1136 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6241 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.04965 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.01367 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.0005298 Highly Informative Direct
Biological Process (BP) angiogenesis 7.646e-05 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0.0002984 Highly Informative Direct
Biological Process (BP) exocytosis 1.119e-06 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 5.005e-05 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 3.527e-09 Highly Informative Direct
Biological Process (BP) axonogenesis 6.051e-07 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 3.56e-11 Highly Informative Direct
Biological Process (BP) fertilization 3.837e-05 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 1.272e-08 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 6.248e-06 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 2.134e-07 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000265 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell growth 1.632e-05 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 3.929e-05 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 1.481e-11 Highly Informative Direct
Biological Process (BP) wound healing 6.766e-05 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 1.253e-08 Highly Informative Direct
Biological Process (BP) regulation of neuron differentiation 3.605e-06 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 2.256e-12 Highly Informative Direct
Biological Process (BP) eye morphogenesis 9.271e-05 Highly Informative Direct
Biological Process (BP) multi-organism behavior 2.798e-05 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 1.303e-11 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 7.758e-12 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 4.078e-05 Highly Informative Direct
Biological Process (BP) regulation of protein processing 1.66e-07 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.03064 Highly Informative Inherited
Biological Process (BP) hemostasis 0.02431 Highly Informative Inherited
Biological Process (BP) coagulation 0.003833 Highly Informative Inherited
Biological Process (BP) protein activation cascade 0.008162 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1535 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.004351 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.5679 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01455 Highly Informative Inherited
Biological Process (BP) sensory perception 0.7475 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.05035 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.02716 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.004216 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.08859 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.1837 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.2407 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.1225 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.2002 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.01142 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.3382 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.002056 Highly Informative Inherited
Biological Process (BP) innate immune response 0.08794 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.6348 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.002359 Highly Informative Inherited
Biological Process (BP) regulation of cellular component size 0.1183 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.07568 Highly Informative Inherited
Biological Process (BP) protein processing 0.0904 Highly Informative Inherited
Biological Process (BP) stem cell development 0.9953 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.073 Highly Informative Inherited
Biological Process (BP) adult behavior 0.02522 Highly Informative Inherited
Biological Process (BP) learning or memory 0.06437 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.03798 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.0004281 Least Informative Direct
Molecular Function (MF) binding 0.7167 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.001493 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.03082 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) peptidase activity 1.03e-06 Informative Direct
Molecular Function (MF) lipid binding 0.0009237 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1313 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.009891 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.04493 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.02178 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) serine-type peptidase activity 1.204e-10 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0.0009599 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.3458 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.01328 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.06318 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.01058 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 0.9688 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.03736 Highly Informative Inherited
Cellular Component (CC) membrane 1.88e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 2.026e-13 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.0005329 Moderately Informative Direct
Cellular Component (CC) cell projection 3.182e-12 Moderately Informative Direct
Cellular Component (CC) vesicle 0.01043 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.003376 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.04502 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.231 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 7.722e-10 Informative Direct
Cellular Component (CC) endosome 4.652e-05 Informative Direct
Cellular Component (CC) vacuole 0.000896 Informative Direct
Cellular Component (CC) Golgi apparatus 3.347e-05 Informative Direct
Cellular Component (CC) secretory granule 0.0001569 Informative Direct
Cellular Component (CC) extracellular matrix 7.858e-05 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 5.626e-06 Informative Direct
Cellular Component (CC) cell leading edge 2.897e-05 Informative Direct
Cellular Component (CC) cell projection part 6.009e-06 Informative Direct
Cellular Component (CC) neuron part 0 Informative Direct
Cellular Component (CC) external encapsulating structure 0.008763 Informative Inherited
Cellular Component (CC) integral to membrane 0.09324 Informative Inherited
Cellular Component (CC) Golgi membrane 6.248e-06 Highly Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 0.00012 Highly Informative Direct
Cellular Component (CC) cell wall 0.000909 Highly Informative Direct
Cellular Component (CC) lysosome 4.937e-05 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 7.951e-07 Highly Informative Direct
Cellular Component (CC) leading edge membrane 3.28e-08 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 6.208e-12 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0001539 Highly Informative Direct
Cellular Component (CC) endosomal part 2.6e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0261 Highly Informative Inherited
Cellular Component (CC) cell body 0.00188 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.0017 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0161Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.734Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides3.708e-15InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)Furin4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase5.085e-15Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 21.228e-12Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 15.325e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4007Least InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.003786InformativeInherited
Disease Ontology (DO)pancreatic ductal adenocarcinoma2.233e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.408Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.07558Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1153Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the skeleton0.1485Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2883Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3104Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.02887InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting bones of the axial skeleton0.07234InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.08056InformativeInherited
Phenotypic Abnormality (PA)Abnormal metacarpal morphology7.6e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the odontoid process0.0002805Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hip joint0.000736Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the vertebral column0.001002Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.003153Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.08817Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1764Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.07157Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2828Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3458Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.6426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.6543Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron differentiation0.004949InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.04984InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.3677InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology3.893e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal axon guidance6.357e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord dorsal column morphology0.0001663Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain white matter morphology0.0001895Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.01942Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.0205Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.1022Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0004258Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.007451Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7822Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.7965Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)non-neural ectoderm0.006104Highly InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.1473Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)vascular leaf0.9023Least InformativeInherited
Plant ANatomical entity (PAN)fruit4.999e-08InformativeDirect
Plant ANatomical entity (PAN)rosette leaf3.965e-05InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01648Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.7227InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processApoptosis0.0009097Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processXylan degradation0Highly InformativeDirect
Biological processBlood coagulation3.023e-10Highly InformativeDirect
Biological processOsteogenesis2.931e-07Highly InformativeDirect
Biological processFertilization3.419e-07Highly InformativeDirect
Cellular componentMembrane0.1632Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection4.081e-15Moderately InformativeDirect
Cellular componentEndosome7.683e-06Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002357Moderately InformativeDirect
Cellular componentGolgi apparatus0.0008184Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseDisease mutation7.799e-05Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat0.000874Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain3.369e-09Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin7.331e-10InformativeDirect
Molecular functionHeparin-binding2.021e-08InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein2.816e-10Moderately InformativeDirect
Post-translational modificationProtease5.351e-06Moderately InformativeDirect
Post-translational modificationKinase0.001384Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond5.551e-08Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues1.205e-11Moderately InformativeDirect
Post-translational modificationZymogen4.498e-16InformativeDirect
Post-translational modificationSulfation1.852e-05InformativeDirect
Post-translational modificationProteoglycan0.05506InformativeInherited
Post-translational modificationHeparan sulfate1.325e-13Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism2.983e-06Least InformativeDirect
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)(S)-allantoin degradation0Highly InformativeDirect
UniPathway (UP)N-glycan metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008979 SSF49785 Protein matches
Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [PubMed2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [PubMed10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [PubMed11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [PubMed10467102].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 65 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 65 hidden Markov models representing the Galactose-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]