SUPERFAMILY 1.75 HMM library and genome assignments server


Galactose-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Galactose-binding domain-like [ 49784]
Superfamily:   Galactose-binding domain-like [ 49785] (32)
Families:   Galactose-binding domain [ 49786] (2)
  Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)
  APC10-like [ 69210] (2)
  delta-Endotoxin, C-terminal domain [ 49796]
  Ephrin receptor ligand binding domain [ 49800] (2)
  beta-Galactosidase/glucuronidase, N-terminal domain [ 49803] (4)
  Chondroitin ABC lyase I, N-terminal domain [ 89236]
  CBM4/9 [ 74893] (3)
  Family 6 carbohydrate binding module, CBM6 [ 69213] (4)
  CBM15 [ 69216]
  Family 17 carbohydrate binding module, CBM17 [ 69219]
  CBM22 [ 49811]
  Family 27 carbohydrate binding module, CBM27 [ 89241] (2)
  Family 29 carbohydrate binding module, CBM29 [ 89244]
  Fucose binding lectin [ 74896]
  N-terminal domain of xrcc1 [ 49814]
  F-box associated region, FBA [ 101585]
  Allantoicase repeat [ 101588]
  PepX C-terminal domain-like [ 69222] (3)
  PA-IL, galactose-binding lectin 1 [ 82022]
  Proprotein convertase P-domain [ 89249] (3)
  Family 28 carbohydrate binding module, CBM28 [ 110122]
  Family 30 carbohydrate binding module, CBM30 (PKD repeat) [ 110125]
  Rhamnogalacturonase B, RhgB, C-terminal domain [ 110128]
  Hypothetical protein AT3g04780/F7O18 27 [ 117108]
  Beta-galactosidase LacA, domains 4 and 5 [ 117111]
  Family 36 carbohydrate binding module, CBM36 [ 117114]
  Extended PAW domain [ 141113]
  CBM11 [ 141116]
  beta-mannanase CBM [ 141119]
  YxiM N-terminal domain-like [ 158963]
  NPCBM-like [ 158966] (2)


Superfamily statistics
Genomes (2,272) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 35,070 55,315 111
Proteins 28,994 46,991 104


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.017711Least InformativeInherited
Biological Process (BP)developmental process0.12089.23e-14Least InformativeInherited
Biological Process (BP)multicellular organismal process0.15110Least InformativeInherited
Biological Process (BP)protein metabolic process0.0074450Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.008360.0009806Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00017750.2781Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.48691Moderately InformativeInherited
Biological Process (BP)tissue development0.12751Moderately InformativeInherited
Biological Process (BP)macromolecule catabolic process0.0047211.252e-06Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.12420.3466Moderately InformativeInherited
Biological Process (BP)organ development0.44831Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.12383.281e-14Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.036771.115e-05Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.19290.0001745Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.58510.1502Moderately InformativeInherited
Biological Process (BP)multi-organism process0.1540.1533Moderately InformativeInherited
Biological Process (BP)reproduction0.0081450.03728Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0066770Moderately InformativeInherited
Biological Process (BP)epithelium development0.14020.1518InformativeInherited
Biological Process (BP)tissue morphogenesis0.0094730.02488InformativeInherited
Biological Process (BP)proteolysis0.061970.01774InformativeInherited
Biological Process (BP)protein catabolic process0.00076920.1088InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.0013880.0003516InformativeInherited
Biological Process (BP)regulation of immune effector process3.37e-110.0686InformativeInherited
Biological Process (BP)gland development0.00053120.001507InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.073780InformativeInherited
Biological Process (BP)phosphorylation0.03060InformativeInherited
Biological Process (BP)single organism reproductive process4.536e-050.02878InformativeInherited
Biological Process (BP)regulation of immune response6.795e-051InformativeInherited
Biological Process (BP)regulation of defense response2.175e-081InformativeInherited
Biological Process (BP)regulation of response to external stimulus1.199e-060.002519InformativeInherited
Biological Process (BP)regulation of growth0.013280.0009718InformativeInherited
Biological Process (BP)regulation of cell growth3.104e-053.009e-10Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response03.151e-06Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine modification4.943e-070Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00011540Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development6.769e-078.444e-12Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development8.194e-074.084e-12Highly InformativeDirect
Biological Process (BP)regulation of protein processing2.303e-128.908e-07Highly InformativeDirect
Biological Process (BP)epithelial tube morphogenesis0.00018670.05584Highly InformativeInherited
Biological Process (BP)morphogenesis of a branching epithelium7.628e-050.02164Highly InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process0.00013820.006461Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process0.095480.714Highly InformativeInherited
Biological Process (BP)regulation of inflammatory response3.545e-110.09907Highly InformativeInherited
Biological Process (BP)protein phosphorylation0.10340Highly InformativeInherited
Biological Process (BP)female pregnancy0.093880.02883Highly InformativeInherited
Biological Process (BP)regulation of innate immune response4.559e-110.07613Highly InformativeInherited
Molecular Function (MF)binding0.17110.9626Least InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.00093750.01705InformativeInherited
Molecular Function (MF)monosaccharide binding2.589e-150.3932Highly InformativeInherited
Molecular Function (MF)small conjugating protein ligase activity0.00030590.001693Highly InformativeInherited
Cellular Component (CC)protein complex0.14911Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0371Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.13881Least InformativeInherited
Cellular Component (CC)extracellular region part0.00087662.482e-07Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0017861Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex1.215e-067.369e-11InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex4.296e-070.0001462Highly InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex3.422e-073.753e-13Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 9.23e-14 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0009806 Least Informative Direct
Biological Process (BP) response to stimulus 0.0002857 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000118 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4628 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.7161 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.0001745 Moderately Informative Direct
Biological Process (BP) nervous system development 2.447e-10 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 1.252e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1.115e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 3.281e-14 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.1629 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2781 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.429 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.003161 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8427 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.9735 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003747 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9601 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02513 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01205 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.9031 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.00972 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.001119 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.01898 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1533 Moderately Informative Inherited
Biological Process (BP) reproduction 0.03728 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3466 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1502 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 7.709e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 5.735e-08 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0007077 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001806 Informative Direct
Biological Process (BP) biological adhesion 5.954e-06 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 3.967e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0002964 Informative Direct
Biological Process (BP) regulation of growth 0.0009718 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) pigment metabolic process 0.0001844 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.087e-10 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0003516 Informative Direct
Biological Process (BP) generation of neurons 0.0004998 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.146e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.204e-09 Informative Direct
Biological Process (BP) localization of cell 2.898e-12 Informative Direct
Biological Process (BP) regulation of nervous system development 1.453e-06 Informative Direct
Biological Process (BP) regulation of cell development 0.0005833 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 2.172e-06 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0002806 Informative Direct
Biological Process (BP) response to wounding 0.002915 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.03101 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.008586 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.8983 Informative Inherited
Biological Process (BP) epithelium development 0.1518 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02488 Informative Inherited
Biological Process (BP) cation homeostasis 0.01341 Informative Inherited
Biological Process (BP) cell-cell signaling 0.05784 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.02282 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.079 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5381 Informative Inherited
Biological Process (BP) regulation of locomotion 0.04473 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1104 Informative Inherited
Biological Process (BP) sensory organ development 0.05449 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3201 Informative Inherited
Biological Process (BP) regulation of system process 0.7836 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.234 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5055 Informative Inherited
Biological Process (BP) immune effector process 0.1306 Informative Inherited
Biological Process (BP) secondary metabolic process 0.01228 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) proteolysis 0.01774 Informative Inherited
Biological Process (BP) protein catabolic process 0.1088 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0686 Informative Inherited
Biological Process (BP) gland development 0.001507 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02878 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) secretion by cell 0.001974 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8801 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1701 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002519 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.05271 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6272 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.01902 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001015 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 1.891e-05 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 1.251e-13 Highly Informative Direct
Biological Process (BP) angiogenesis 2.841e-05 Highly Informative Direct
Biological Process (BP) regulation of cell growth 3.009e-10 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 3.151e-06 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) exocytosis 0.0001859 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 2.524e-06 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.784e-10 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0001112 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 2.78e-14 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0003433 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 7.115e-07 Highly Informative Direct
Biological Process (BP) telencephalon development 2.111e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) neuron projection development 3.715e-11 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 1.207e-06 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 2.022e-10 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 1.263e-14 Highly Informative Direct
Biological Process (BP) wound healing 7.863e-05 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0002037 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 1.722e-05 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0004135 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 8.444e-12 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 4.084e-12 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.0001168 Highly Informative Direct
Biological Process (BP) regulation of protein processing 8.908e-07 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.05598 Highly Informative Inherited
Biological Process (BP) hemostasis 0.02138 Highly Informative Inherited
Biological Process (BP) coagulation 0.003865 Highly Informative Inherited
Biological Process (BP) protein activation cascade 0.0133 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2342 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.3857 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.00579 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.002508 Highly Informative Inherited
Biological Process (BP) sensory perception 0.7392 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.007544 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.0331 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.08462 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.05714 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.05584 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 0.02164 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.002908 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.001556 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.005686 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.1851 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.01154 Highly Informative Inherited
Biological Process (BP) amide biosynthetic process 0.02499 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.05226 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1948 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.006461 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.714 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.09907 Highly Informative Inherited
Biological Process (BP) protein processing 0.05471 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.03412 Highly Informative Inherited
Biological Process (BP) stem cell development 0.9988 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.05762 Highly Informative Inherited
Biological Process (BP) adult behavior 0.01053 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.02883 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.001976 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.009759 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.07613 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0006578 Least Informative Direct
Molecular Function (MF) binding 0.9626 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) peptidase activity 0.0003621 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.7286 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.329 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.01705 Informative Inherited
Molecular Function (MF) lipid binding 0.0366 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.02855 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.3932 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.3869 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.1805 Highly Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0.001693 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.03487 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 0.8826 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.001678 Highly Informative Inherited
Cellular Component (CC) membrane 6.462e-05 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 1.613e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 4.456e-10 Moderately Informative Direct
Cellular Component (CC) extracellular region part 2.482e-07 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 7.758e-11 Moderately Informative Direct
Cellular Component (CC) vesicle 0.02769 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.03825 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.08029 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.3127 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 7.369e-11 Informative Direct
Cellular Component (CC) endosome 0.0004476 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0002061 Informative Direct
Cellular Component (CC) secretory granule 5.828e-05 Informative Direct
Cellular Component (CC) external encapsulating structure 0.000496 Informative Direct
Cellular Component (CC) extracellular matrix 0.000656 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 6.114e-06 Informative Direct
Cellular Component (CC) neuron projection 7.847e-10 Informative Direct
Cellular Component (CC) cell leading edge 0.001216 Informative Inherited
Cellular Component (CC) integral to membrane 0.07566 Informative Inherited
Cellular Component (CC) Golgi membrane 0.0004653 Highly Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 0.0001462 Highly Informative Direct
Cellular Component (CC) cell wall 1.759e-05 Highly Informative Direct
Cellular Component (CC) early endosome 1.514e-11 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 5.274e-06 Highly Informative Direct
Cellular Component (CC) leading edge membrane 2.985e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 3.753e-13 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0009449 Highly Informative Direct
Cellular Component (CC) endosomal part 1.242e-05 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.2793 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.06451 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0161Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.734Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides3.708e-15InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)Furin4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase5.085e-15Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 21.228e-12Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 15.325e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.3543Least InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.004964InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.004115Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08902Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.09244Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.05491Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1802Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.4675Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.6174Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.006417InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.01217InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1897InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.1976InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology2.829e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal axon guidance7.338e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain white matter morphology0.0001187Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart and great vessel attachment0.0002915Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0006318Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epididymis morphology0.03177Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.05699Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.1022Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0004258Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.007451Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7838Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8074Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.8213Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.0845InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.7235Least InformativeInherited
Plant ANatomical entity (PAN)fruit5.367e-08InformativeDirect
Plant ANatomical entity (PAN)rosette leaf4.199e-05InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.02205Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.7018InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processHemostasis4.683e-10InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processBlood coagulation4.339e-10Highly InformativeDirect
Biological processOsteogenesis4.637e-07Highly InformativeDirect
Biological processFertilization6.447e-07Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection7.186e-15Moderately InformativeDirect
Cellular componentEndosome3.099e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0003085Moderately InformativeDirect
Cellular componentGolgi apparatus0.0009772Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseDisease mutation0.0001175Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat4.979e-06Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain1.783e-09Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin2.006e-10InformativeDirect
Molecular functionHeparin-binding2.347e-08InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.4e-10Moderately InformativeDirect
Post-translational modificationProtease1.176e-05Moderately InformativeDirect
Post-translational modificationKinase0.002026Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond3.693e-07Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues2.446e-11Moderately InformativeDirect
Post-translational modificationZymogen1.354e-15InformativeDirect
Post-translational modificationSulfation2.01e-05InformativeDirect
Post-translational modificationProteoglycan0.05839InformativeInherited
Post-translational modificationHeparan sulfate1.409e-13Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002263Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism5.912e-10Least InformativeDirect
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)ureide metabolism1.902e-10Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008979 SSF49785 Protein matches
Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [PubMed2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [PubMed10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [PubMed11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [PubMed10467102].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 65 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 65 hidden Markov models representing the Galactose-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]