SUPERFAMILY 1.75 HMM library and genome assignments server


Galactose-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Galactose-binding domain-like [ 49784]
Superfamily:   Galactose-binding domain-like [ 49785] (32)
Families:   Galactose-binding domain [ 49786] (2)
  Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) [ 49791] (3)
  APC10-like [ 69210] (2)
  delta-Endotoxin, C-terminal domain [ 49796]
  Ephrin receptor ligand binding domain [ 49800] (2)
  beta-Galactosidase/glucuronidase, N-terminal domain [ 49803] (4)
  Chondroitin ABC lyase I, N-terminal domain [ 89236]
  CBM4/9 [ 74893] (3)
  Family 6 carbohydrate binding module, CBM6 [ 69213] (4)
  CBM15 [ 69216]
  Family 17 carbohydrate binding module, CBM17 [ 69219]
  CBM22 [ 49811]
  Family 27 carbohydrate binding module, CBM27 [ 89241] (2)
  Family 29 carbohydrate binding module, CBM29 [ 89244]
  Fucose binding lectin [ 74896]
  N-terminal domain of xrcc1 [ 49814]
  F-box associated region, FBA [ 101585]
  Allantoicase repeat [ 101588]
  PepX C-terminal domain-like [ 69222] (3)
  PA-IL, galactose-binding lectin 1 [ 82022]
  Proprotein convertase P-domain [ 89249] (3)
  Family 28 carbohydrate binding module, CBM28 [ 110122]
  Family 30 carbohydrate binding module, CBM30 (PKD repeat) [ 110125]
  Rhamnogalacturonase B, RhgB, C-terminal domain [ 110128]
  Hypothetical protein AT3g04780/F7O18 27 [ 117108]
  Beta-galactosidase LacA, domains 4 and 5 [ 117111]
  Family 36 carbohydrate binding module, CBM36 [ 117114]
  Extended PAW domain [ 141113]
  CBM11 [ 141116]
  beta-mannanase CBM [ 141119]
  YxiM N-terminal domain-like [ 158963]
  NPCBM-like [ 158966] (2)


Superfamily statistics
Genomes (2,310) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 36,868 0 111
Proteins 30,414 0 104


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.01611Least InformativeInherited
Biological Process (BP)developmental process0.11234.129e-13Least InformativeInherited
Biological Process (BP)multicellular organismal process0.076330Least InformativeInherited
Biological Process (BP)protein metabolic process0.0070010Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0077230.0007001Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00020020.2247Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.48191Moderately InformativeInherited
Biological Process (BP)tissue development0.13110.8796Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.1150.4555Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.19610.2485Moderately InformativeInherited
Biological Process (BP)organ development0.21410.9027Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.12481.761e-14Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.036392.469e-06Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.45174.022e-05Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.56850.1506Moderately InformativeInherited
Biological Process (BP)multi-organism process0.14420.1168Moderately InformativeInherited
Biological Process (BP)reproduction0.0074310.03731Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0060620Moderately InformativeInherited
Biological Process (BP)epithelium development0.14330.3348InformativeInherited
Biological Process (BP)tube development0.00078270.01105InformativeInherited
Biological Process (BP)tissue morphogenesis0.010010.01201InformativeInherited
Biological Process (BP)proteolysis0.061310.02731InformativeInherited
Biological Process (BP)protein catabolic process0.00080770.1414InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.0014660.0006483InformativeInherited
Biological Process (BP)regulation of immune effector process3.711e-110.07092InformativeInherited
Biological Process (BP)gland development0.00052170.001448InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.041920InformativeInherited
Biological Process (BP)phosphorylation0.030330InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.032861InformativeInherited
Biological Process (BP)regulation of response to stress8.219e-050.772InformativeInherited
Biological Process (BP)single organism reproductive process4.956e-050.03759InformativeInherited
Biological Process (BP)regulation of immune response5.927e-051InformativeInherited
Biological Process (BP)regulation of response to external stimulus1.28e-060.002859InformativeInherited
Biological Process (BP)regulation of growth0.013330.001374InformativeInherited
Biological Process (BP)regulation of cell growth3.117e-053.819e-10Highly InformativeDirect
Biological Process (BP)regulation of acute inflammatory response04.063e-07Highly InformativeDirect
Biological Process (BP)regulation of humoral immune response03.234e-06Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.00031370.0002921Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine modification5.078e-070Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.00011220Highly InformativeDirect
Biological Process (BP)branching morphogenesis of an epithelial tube5.207e-058.529e-05Highly InformativeDirect
Biological Process (BP)mammary gland alveolus development6.357e-075.411e-12Highly InformativeDirect
Biological Process (BP)mammary gland epithelium development7.374e-074.057e-12Highly InformativeDirect
Biological Process (BP)regulation of protein processing5.754e-121.293e-06Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process0.00014730.006428Highly InformativeInherited
Biological Process (BP)proteasomal protein catabolic process0.082350.7005Highly InformativeInherited
Biological Process (BP)protein phosphorylation0.058910Highly InformativeInherited
Biological Process (BP)female pregnancy0.087680.02439Highly InformativeInherited
Biological Process (BP)regulation of innate immune response4.732e-110.07232Highly InformativeInherited
Molecular Function (MF)binding0.15020.8432Least InformativeInherited
Molecular Function (MF)hydrolase activity0.84920.0003117Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.0022170InformativeInherited
Molecular Function (MF)monosaccharide binding1.32e-150.4386Highly InformativeInherited
Cellular Component (CC)protein complex0.14841Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.12251Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.18461Least InformativeInherited
Cellular Component (CC)extracellular region part4.643e-059.088e-09Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0054061Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex1.098e-063.203e-14InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex1.589e-070.0001329Highly InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex2.695e-070Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 4.129e-13 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0007001 Least Informative Direct
Biological Process (BP) response to stimulus 0.0002059 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 3.199e-05 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.43 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.6858 Least Informative Inherited
Biological Process (BP) cellular protein modification process 4.022e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 6.624e-11 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.469e-06 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.761e-14 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0009944 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.3838 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2247 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5507 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.003615 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9074 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8796 Moderately Informative Inherited
Biological Process (BP) system process 0.9964 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003548 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.0303 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.02313 Moderately Informative Inherited
Biological Process (BP) organ development 0.9027 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.8409 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.005557 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0191 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1168 Moderately Informative Inherited
Biological Process (BP) reproduction 0.03731 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4555 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2485 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1506 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 1.763e-07 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 5.052e-08 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0006083 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0007581 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001549 Informative Direct
Biological Process (BP) biological adhesion 2.341e-06 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 5.927e-06 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of organelle organization 2.26e-06 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) pigment metabolic process 4.175e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.69e-10 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0006483 Informative Direct
Biological Process (BP) generation of neurons 0.0003609 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.212e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 2.042e-09 Informative Direct
Biological Process (BP) localization of cell 4.866e-12 Informative Direct
Biological Process (BP) regulation of nervous system development 1.906e-06 Informative Direct
Biological Process (BP) regulation of cell development 0.0006149 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 1.853e-06 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0001744 Informative Direct
Biological Process (BP) response to wounding 0.001333 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01447 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01105 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6431 Informative Inherited
Biological Process (BP) epithelium development 0.3348 Informative Inherited
Biological Process (BP) tube development 0.01105 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.01201 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.09389 Informative Inherited
Biological Process (BP) cell-cell signaling 0.07137 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.02806 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.08261 Informative Inherited
Biological Process (BP) regulation of growth 0.001374 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.6043 Informative Inherited
Biological Process (BP) regulation of locomotion 0.05351 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1264 Informative Inherited
Biological Process (BP) sensory organ development 0.01689 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4757 Informative Inherited
Biological Process (BP) regulation of system process 0.5746 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.2353 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.5413 Informative Inherited
Biological Process (BP) immune effector process 0.127 Informative Inherited
Biological Process (BP) secondary metabolic process 0.004744 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) proteolysis 0.02731 Informative Inherited
Biological Process (BP) protein catabolic process 0.1414 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.07092 Informative Inherited
Biological Process (BP) gland development 0.001448 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) regulation of response to stress 0.772 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.03759 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9406 Informative Inherited
Biological Process (BP) secretion by cell 0.002144 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9009 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.2801 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3507 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.1311 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002859 Informative Inherited
Biological Process (BP) cardiovascular system development 0.03072 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5942 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.01308 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 8.464e-06 Highly Informative Direct
Biological Process (BP) angiogenesis 2.771e-05 Highly Informative Direct
Biological Process (BP) regulation of cell growth 3.819e-10 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 4.063e-07 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 3.234e-06 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) exocytosis 0.0001591 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of mitosis 0.0004112 Highly Informative Direct
Biological Process (BP) cell adhesion 1.942e-06 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 7.589e-10 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0001416 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 2.766e-14 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0003037 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0002921 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 9.308e-08 Highly Informative Direct
Biological Process (BP) telencephalon development 2.157e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0 Highly Informative Direct
Biological Process (BP) wound healing 4.638e-05 Highly Informative Direct
Biological Process (BP) eye morphogenesis 6.753e-05 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.0002013 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 8.529e-05 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.0001063 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 1.211e-06 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0004996 Highly Informative Direct
Biological Process (BP) mesenchyme development 9.047e-05 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 5.411e-12 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 4.057e-12 Highly Informative Direct
Biological Process (BP) axon development 2.256e-05 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 1.671e-05 Highly Informative Direct
Biological Process (BP) regulation of protein processing 1.293e-06 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.6914 Highly Informative Inherited
Biological Process (BP) hemostasis 0.01272 Highly Informative Inherited
Biological Process (BP) coagulation 0.001129 Highly Informative Inherited
Biological Process (BP) protein activation cascade 0.01338 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2641 Highly Informative Inherited
Biological Process (BP) iron ion homeostasis 0.003399 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.006784 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.00313 Highly Informative Inherited
Biological Process (BP) sensory perception 0.7313 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.03513 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.007829 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.03082 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.09834 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.0107 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.002021 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.001794 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.1985 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.01074 Highly Informative Inherited
Biological Process (BP) amide biosynthetic process 0.02344 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.07641 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1355 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.006428 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.7005 Highly Informative Inherited
Biological Process (BP) protein processing 0.03928 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.002283 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.05226 Highly Informative Inherited
Biological Process (BP) adult behavior 0.01027 Highly Informative Inherited
Biological Process (BP) learning or memory 0.0248 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.02439 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.001643 Highly Informative Inherited
Biological Process (BP) aminoglycan catabolic process 0.007488 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.02065 Highly Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.008803 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.07232 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2934 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0003117 Least Informative Direct
Molecular Function (MF) binding 0.8432 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) peptidase activity 0.0006813 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.741 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.3433 Informative Inherited
Molecular Function (MF) lipid binding 0.0167 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.02697 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 1.653e-05 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.4386 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.1624 Highly Informative Inherited
Molecular Function (MF) calcium ion transmembrane transporter activity 0.007223 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.1939 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.03643 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 0.8801 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.0016 Highly Informative Inherited
Cellular Component (CC) membrane 3.159e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 1.516e-10 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 8.303e-06 Moderately Informative Direct
Cellular Component (CC) cell projection 6.733e-10 Moderately Informative Direct
Cellular Component (CC) extracellular region part 9.088e-09 Moderately Informative Direct
Cellular Component (CC) vesicle 0.003765 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.04808 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.09102 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.4003 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 3.203e-14 Informative Direct
Cellular Component (CC) endosome 6.63e-05 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0001018 Informative Direct
Cellular Component (CC) secretory granule 5.12e-05 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0004641 Informative Direct
Cellular Component (CC) extracellular matrix 0.0005948 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 3.884e-06 Informative Direct
Cellular Component (CC) neuron projection 1.849e-09 Informative Direct
Cellular Component (CC) cell leading edge 0.001171 Informative Inherited
Cellular Component (CC) integral to membrane 0.07282 Informative Inherited
Cellular Component (CC) lytic vacuole 0.2113 Informative Inherited
Cellular Component (CC) Golgi membrane 0.0003443 Highly Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 0.0001329 Highly Informative Direct
Cellular Component (CC) cell wall 1.374e-05 Highly Informative Direct
Cellular Component (CC) lysosome 0.0005404 Highly Informative Direct
Cellular Component (CC) early endosome 2.906e-13 Highly Informative Direct
Cellular Component (CC) rough endoplasmic reticulum 8.044e-05 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 5.104e-06 Highly Informative Direct
Cellular Component (CC) leading edge membrane 2.493e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0009833 Highly Informative Direct
Cellular Component (CC) endosomal part 1.223e-05 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.3066 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.05904 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0161Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.734Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides3.708e-15InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)Furin4.713e-16Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase5.085e-15Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 21.228e-12Highly InformativeDirect
Enzyme Commission (EC)Proprotein convertase 15.325e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.3515Least InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.004944InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00676Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.02237Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.03435Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.06768Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.05354Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1759Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.282Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.4714Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.77Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.01444InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.01556InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1996InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.2143InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology2.948e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal axon guidance6.321e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain white matter morphology0.0001177Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart and great vessel attachment0.0005104Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.000945Highly InformativeDirect
Mammalian Phenotype (MP)abnormal epididymis morphology0.03164Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.05034Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.1022Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.0004258Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.007451Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.7833Least InformativeInherited
Xenopus ANatomical entity (XAN)central nervous system0.8135Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.8404Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.1055InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.7235Least InformativeInherited
Plant ANatomical entity (PAN)fruit5.367e-08InformativeDirect
Plant ANatomical entity (PAN)rosette leaf4.199e-05InformativeDirect
Plant ANatomical entity (PAN)juvenile vascular leaf0Highly InformativeDirect
Plant ANatomical entity (PAN)adult vascular leaf0Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.02189Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.7033InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processHemostasis4.659e-10InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processBlood coagulation4.31e-10Highly InformativeDirect
Biological processOsteogenesis4.613e-07Highly InformativeDirect
Biological processFertilization7.349e-07Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome3.443e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0003767Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
DiseaseDisease mutation0.0001319Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainRepeat6.415e-06Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain1.787e-09Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionLectin2.399e-10InformativeDirect
Molecular functionHeparin-binding2.345e-08InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.794e-10Moderately InformativeDirect
Post-translational modificationProtease9.921e-06Moderately InformativeDirect
Post-translational modificationKinase0.002187Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond4.726e-07Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues2.442e-11Moderately InformativeDirect
Post-translational modificationZymogen1.349e-15InformativeDirect
Post-translational modificationSulfation1.959e-05InformativeDirect
Post-translational modificationProteoglycan0.05742InformativeInherited
Post-translational modificationHeparan sulfate1.408e-13Highly InformativeDirect
Post-translational modificationPeptidoglycan-anchor0.0002225Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism7.767e-06Least InformativeDirect
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)ureide metabolism0InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)N-glycan degradation0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008979 SSF49785 Protein matches
Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [PubMed2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [PubMed10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [PubMed11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [PubMed10467102].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 65 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 65 hidden Markov models representing the Galactose-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]