HSP20-like chaperones superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All beta proteins [ 48724] (174)
Fold:	HSP20-like chaperones [ 49763]
Superfamily:	HSP20-like chaperones [ 49764] (4)
Families:	HSP20 [ 49765]
	Co-chaperone p23-like [ 49768] (2)
	GS domain [ 101580] (2)
	Nuclear movement domain [ 117092] (2)

Superfamily statistics

	Genomes (1,918)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	12,692	19,234	9
Proteins	12,444	19,027	9

Functional annotation

General category	Processes_IC
Detailed category	Protein modification

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	response to stimulus	2.036e-09	0.000386	Least Informative	Direct
Biological Process (BP)	single-organism cellular process	1	1	Least Informative	Inherited
Biological Process (BP)	protein metabolic process	0.02301	0.02043	Least Informative	Inherited
Biological Process (BP)	cellular macromolecule metabolic process	0.1253	0.6518	Least Informative	Inherited
Biological Process (BP)	response to abiotic stimulus	0	0	Moderately Informative	Direct
Biological Process (BP)	response to oxygen-containing compound	0.0001537	2.645e-07	Moderately Informative	Direct
Biological Process (BP)	cellular response to stress	0.7396	0.8701	Moderately Informative	Inherited
Biological Process (BP)	response to oxidative stress	9.839e-05	1.227e-11	Informative	Direct
Biological Process (BP)	response to light stimulus	2.182e-09	3.022e-13	Informative	Direct
Biological Process (BP)	response to inorganic substance	7.042e-09	2.076e-15	Informative	Direct
Biological Process (BP)	protein folding	0	0	Highly Informative	Direct
Biological Process (BP)	response to heat	0	0	Highly Informative	Direct
Biological Process (BP)	response to endoplasmic reticulum stress	0.0009446	1.505e-05	Highly Informative	Direct
Biological Process (BP)	response to hydrogen peroxide	1.39e-09	0	Highly Informative	Direct
Molecular Function (MF)	binding	1	1	Least Informative	Inherited
Molecular Function (MF)	protein binding	0.4718	0.08391	Moderately Informative	Inherited
Molecular Function (MF)	unfolded protein binding	3.828e-09	0	Highly Informative	Direct
Cellular Component (CC)	intracellular non-membrane-bounded organelle	0.1371	1	Least Informative	Inherited
Cellular Component (CC)	cytoplasmic part	1	1	Least Informative	Inherited
Cellular Component (CC)	contractile fiber part	0.0001041	5.578e-08	Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	response to stimulus	0.000386	Least Informative	Direct
Biological Process (BP)	cellular component organization or biogenesis	1	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	1	Least Informative	Inherited
Biological Process (BP)	regulation of cellular process	1	Least Informative	Inherited
Biological Process (BP)	regulation of metabolic process	1	Least Informative	Inherited
Biological Process (BP)	protein metabolic process	0.02043	Least Informative	Inherited
Biological Process (BP)	cellular macromolecule metabolic process	0.6518	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	1	Least Informative	Inherited
Biological Process (BP)	developmental process	1	Least Informative	Inherited
Biological Process (BP)	localization	1	Least Informative	Inherited
Biological Process (BP)	response to abiotic stimulus	0	Moderately Informative	Direct
Biological Process (BP)	response to oxygen-containing compound	2.645e-07	Moderately Informative	Direct
Biological Process (BP)	macromolecular complex subunit organization	0.01762	Moderately Informative	Inherited
Biological Process (BP)	cellular component biogenesis	0.1223	Moderately Informative	Inherited
Biological Process (BP)	regulation of cellular metabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of protein metabolic process	0.1397	Moderately Informative	Inherited
Biological Process (BP)	cellular response to stress	0.8701	Moderately Informative	Inherited
Biological Process (BP)	regulation of cell communication	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of signaling	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of response to stimulus	0.8589	Moderately Informative	Inherited
Biological Process (BP)	regulation of gene expression	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of cellular component organization	0.6146	Moderately Informative	Inherited
Biological Process (BP)	regulation of biosynthetic process	1	Moderately Informative	Inherited
Biological Process (BP)	nervous system development	1	Moderately Informative	Inherited
Biological Process (BP)	cell differentiation	1	Moderately Informative	Inherited
Biological Process (BP)	response to oxidative stress	1.227e-11	Informative	Direct
Biological Process (BP)	response to light stimulus	3.022e-13	Informative	Direct
Biological Process (BP)	response to inorganic substance	2.076e-15	Informative	Direct
Biological Process (BP)	posttranscriptional regulation of gene expression	0.0001366	Informative	Direct
Biological Process (BP)	regulation of cellular catabolic process	0.000446	Informative	Direct
Biological Process (BP)	regulation of organelle organization	0.04089	Informative	Inherited
Biological Process (BP)	regulation of cell cycle process	0.08602	Informative	Inherited
Biological Process (BP)	cellular component movement	0.6705	Informative	Inherited
Biological Process (BP)	locomotion	0.9532	Informative	Inherited
Biological Process (BP)	generation of neurons	0.9243	Informative	Inherited
Biological Process (BP)	localization of cell	0.4643	Informative	Inherited
Biological Process (BP)	protein folding	0	Highly Informative	Direct
Biological Process (BP)	response to heat	0	Highly Informative	Direct
Biological Process (BP)	regulation of proteolysis	0.0003634	Highly Informative	Direct
Biological Process (BP)	regulation of protein stability	6.898e-06	Highly Informative	Direct
Biological Process (BP)	response to endoplasmic reticulum stress	1.505e-05	Highly Informative	Direct
Biological Process (BP)	regulation of protein catabolic process	6.325e-05	Highly Informative	Direct
Biological Process (BP)	response to hydrogen peroxide	0	Highly Informative	Direct
Biological Process (BP)	regulation of translation	0.02642	Highly Informative	Inherited
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	protein binding	0.08391	Moderately Informative	Inherited
Molecular Function (MF)	structural molecule activity	0.05669	Moderately Informative	Inherited
Molecular Function (MF)	protein dimerization activity	0.0009567	Informative	Direct
Molecular Function (MF)	receptor binding	0.4011	Informative	Inherited
Molecular Function (MF)	unfolded protein binding	0	Highly Informative	Direct
Cellular Component (CC)	intracellular non-membrane-bounded organelle	1	Least Informative	Inherited
Cellular Component (CC)	cytoplasmic part	1	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	0.8395	Least Informative	Inherited
Cellular Component (CC)	contractile fiber part	5.578e-08	Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0.00119	Least Informative	Inherited
Enzyme Commission (EC)	Acting on NADH or NADPH	3.112e-11	Moderately Informative	Direct
Enzyme Commission (EC)	With a heme protein as acceptor	0	Highly Informative	Direct

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	nervous system disease	0.1391	Least Informative	Inherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal dominant inheritance	0	Least Informative	Direct
ONset and clinical course (ON)	Slow progression	0	Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the central nervous system	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of muscle physiology	0	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of muscle morphology	0	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the peripheral nervous system	0	Informative	Direct
Phenotypic Abnormality (PA)	Distal muscle weakness	0	Highly Informative	Direct
Phenotypic Abnormality (PA)	Hyporeflexia of lower limbs	0	Highly Informative	Direct
Phenotypic Abnormality (PA)	EMG abnormality	0	Highly Informative	Direct
Phenotypic Abnormality (PA)	Areflexia of lower limbs	3.919e-08	Highly Informative	Direct

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	organism metabolism processing variant	2.794e-07	Least Informative	Direct
Worm Phenotype (WP)	organism environmental stimulus response variant	0.001885	Least Informative	Inherited
Worm Phenotype (WP)	cell physiology variant	0.6655	Least Informative	Inherited
Worm Phenotype (WP)	protein aggregation variant	2.481e-12	Moderately Informative	Direct
Worm Phenotype (WP)	pattern of transgene expression variant	3.113e-10	Moderately Informative	Direct
Worm Phenotype (WP)	endocytic transport defect	0.05195	Moderately Informative	Inherited
Worm Phenotype (WP)	life span variant	0.000232	Informative	Direct
Worm Phenotype (WP)	metal response variant	0.0005115	Informative	Direct
Worm Phenotype (WP)	organism pathogen response variant	0.002029	Informative	Inherited
Worm Phenotype (WP)	pathogen susceptibility increased	1.699e-07	Highly Informative	Direct

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0.1108	Least Informative	Inherited
Plant ANatomical entity (PAN)	pollen tube cell	0.0006324	Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lyases	0.002769	Least Informative	Inherited
Enzyme Commission (EC)	Oxidoreductases	0.01526	Least Informative	Inherited
Enzyme Commission (EC)	Hydrolases	0.4748	Least Informative	Inherited
Enzyme Commission (EC)	Carbon-oxygen lyases	4.895e-05	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0.005128	Moderately Informative	Inherited
Enzyme Commission (EC)	Isomerases	0.04802	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on NADH or NADPH	7.365e-10	Informative	Direct
Enzyme Commission (EC)	Omega peptidases	1.256e-06	Informative	Direct
Enzyme Commission (EC)	Intramolecular oxidoreductases	0.001481	Informative	Inherited
Enzyme Commission (EC)	With a heme protein as acceptor	0	Highly Informative	Direct
Enzyme Commission (EC)	Other intramolecular oxidoreductases	6.399e-11	Highly Informative	Direct

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Differentiation	0.08333	Moderately Informative	Inherited
Biological process	Cell cycle	0.4755	Moderately Informative	Inherited
Biological process	Lipid metabolism	0.7393	Moderately Informative	Inherited
Biological process	Stress response	0	Informative	Direct
Biological process	Ubl conjugation pathway	1.423e-07	Informative	Direct
Biological process	Mitosis	1.646e-05	Informative	Direct
Biological process	Neurogenesis	2.278e-05	Informative	Direct
Biological process	Lipid biosynthesis	0.2291	Informative	Inherited
Biological process	Spermatogenesis	1.583e-05	Highly Informative	Direct
Cellular component	Nucleus	0	Least Informative	Direct
Cellular component	Cytoplasm	0	Least Informative	Direct
Cellular component	Endoplasmic reticulum	1.725e-07	Moderately Informative	Direct
Cellular component	Cytoskeleton	0.0003379	Moderately Informative	Direct
Cellular component	Microtubule	9.366e-05	Informative	Direct
Domain	Transit peptide	0.0004825	Moderately Informative	Direct
Domain	TPR repeat	2.551e-13	Highly Informative	Direct
Molecular function	Zinc	0	Least Informative	Direct
Post-translational modification	Chaperone	0	Informative	Direct
Post-translational modification	Eye lens protein	0	Highly Informative	Direct
Post-translational modification	Phosphoprotein	0	Least Informative	Direct
Post-translational modification	Acetylation	0	Moderately Informative	Direct
Post-translational modification	Methylation	0	Moderately Informative	Direct
Post-translational modification	Oxidation	0	Highly Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	lipid metabolism	0	Least Informative	Direct
UniPathway (UP)	fatty acid metabolism	0	Moderately Informative	Direct
UniPathway (UP)	prostaglandin biosynthesis	0	Highly Informative	Direct

Document: UP annotation of SCOP domains

InterPro annotation

Cross references IPR008978 SSF49764 Protein matches

Abstract
Hsp20 is a mammalian small heat-shock protein family that occurs most abundantly in skeletal muscle and heart. It has a tendency to form dimers, via a disulphide linkage formed by an N-terminal cysteine, low heat stability and a poor chaperoning ability in comparison with other family members. Structurally, this and related proteins contain a beta-sandwich fold consisting of 8 strands in 2 beta-sheets in a greek-key topology [ PubMed 11702068].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a HSP20-like chaperones domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the HSP20-like chaperones superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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HSP20-like chaperones superfamily