SUPERFAMILY 1.75 HMM library and genome assignments server


C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Families:   PLC-like (P variant) [ 49563] (11)
  Synaptotagmin-like (S variant) [ 49575] (10)


Superfamily statistics
Genomes (494) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 44,278 0 37
Proteins 29,363 0 35


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.722e-15 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000837 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) response to stimulus 2.11e-13 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 6.011e-09 Least Informative Direct
Biological Process (BP) single-organism metabolic process 5.445e-05 Least Informative Direct
Biological Process (BP) developmental process 0.1611 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001648 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8276 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.681e-09 Moderately Informative Direct
Biological Process (BP) immune system process 6.247e-07 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 8.866e-07 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.578e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.24e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0002372 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0008194 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.002847 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.001737 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7429 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.007784 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.00905 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.09739 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001128 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.0361 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1163 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8125 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6612 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9456 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7788 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.02322 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.004245 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.848 Moderately Informative Inherited
Biological Process (BP) organ development 0.2214 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) transmission of nerve impulse 0 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 6.595e-12 Informative Direct
Biological Process (BP) regulation of system process 1.531e-10 Informative Direct
Biological Process (BP) alcohol metabolic process 3.175e-08 Informative Direct
Biological Process (BP) response to wounding 1.524e-07 Informative Direct
Biological Process (BP) organelle localization 1.552e-07 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 3.419e-07 Informative Direct
Biological Process (BP) negative regulation of cell death 3.52e-07 Informative Direct
Biological Process (BP) protein catabolic process 7.479e-07 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 2.168e-06 Informative Direct
Biological Process (BP) leukocyte activation 3.594e-06 Informative Direct
Biological Process (BP) locomotion 7.651e-06 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 8.578e-06 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.973e-05 Informative Direct
Biological Process (BP) cellular membrane organization 3.089e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.26e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 5.838e-05 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001823 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.000222 Informative Direct
Biological Process (BP) central nervous system development 0.0003529 Informative Direct
Biological Process (BP) regulation of secretion 0.0005105 Informative Direct
Biological Process (BP) immune response 0.0005808 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0006486 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0006757 Informative Direct
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8029 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.001904 Informative Inherited
Biological Process (BP) cellular component disassembly 0.1631 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.4784 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1553 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.06134 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.6064 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.005981 Informative Inherited
Biological Process (BP) metal ion transport 0.1264 Informative Inherited
Biological Process (BP) response to inorganic substance 0.2078 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.005262 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1939 Informative Inherited
Biological Process (BP) regulation of cell development 0.1403 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.7945 Informative Inherited
Biological Process (BP) sensory organ development 0.1811 Informative Inherited
Biological Process (BP) muscle structure development 0.9098 Informative Inherited
Biological Process (BP) muscle tissue development 0.01462 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1248 Informative Inherited
Biological Process (BP) dephosphorylation 0.9604 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.03759 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.6448 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.004762 Informative Inherited
Biological Process (BP) blood circulation 0.0948 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.9048 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) organelle assembly 0.3385 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.007093 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.008901 Informative Inherited
Biological Process (BP) regulation of growth 0.3921 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.8678 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.04291 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.006122 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.7633 Informative Inherited
Biological Process (BP) phosphorylation 0.1604 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.7708 Informative Inherited
Biological Process (BP) defense response 0.5511 Informative Inherited
Biological Process (BP) immune effector process 0.01248 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.5714 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.06805 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.005875 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.8193 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.002291 Informative Inherited
Biological Process (BP) generation of neurons 0.2802 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.04447 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.4396 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.003924 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) protein complex assembly 0.1023 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) lipid localization 0.01548 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.9024 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.7942 Informative Inherited
Biological Process (BP) cellular component movement 0.5814 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) gland development 0.4793 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.9027 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.001527 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.002165 Informative Inherited
Biological Process (BP) protein transport 0.8867 Informative Inherited
Biological Process (BP) pigment metabolic process 0.6978 Informative Inherited
Biological Process (BP) proteolysis 0.01535 Informative Inherited
Biological Process (BP) cardiovascular system development 0.01481 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.03563 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.5819 Informative Inherited
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 0 Highly Informative Direct
Biological Process (BP) exocytosis 0 Highly Informative Direct
Biological Process (BP) protein ubiquitination 1.352e-13 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 3.377e-12 Highly Informative Direct
Biological Process (BP) signal release 5.407e-12 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 4.048e-10 Highly Informative Direct
Biological Process (BP) synaptic vesicle localization 1.022e-08 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 2.864e-08 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 3.153e-08 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 5.636e-08 Highly Informative Direct
Biological Process (BP) autophagy 3.913e-07 Highly Informative Direct
Biological Process (BP) regulation of wound healing 6.18e-07 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 1.498e-06 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 2.604e-06 Highly Informative Direct
Biological Process (BP) plasma membrane organization 4.045e-06 Highly Informative Direct
Biological Process (BP) response to calcium ion 4.494e-06 Highly Informative Direct
Biological Process (BP) B cell activation 4.738e-06 Highly Informative Direct
Biological Process (BP) calcium ion transport 8.97e-06 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 1.643e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 1.744e-05 Highly Informative Direct
Biological Process (BP) activation of immune response 2.664e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 3.19e-05 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 3.911e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 3.953e-05 Highly Informative Direct
Biological Process (BP) muscle fiber development 4.084e-05 Highly Informative Direct
Biological Process (BP) wound healing 4.851e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 5.393e-05 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 8.593e-05 Highly Informative Direct
Biological Process (BP) response to ethanol 9.36e-05 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 9.579e-05 Highly Informative Direct
Biological Process (BP) hormone transport 0.0003945 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0005816 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0005864 Highly Informative Direct
Biological Process (BP) coagulation 0.0006129 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0006267 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000688 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.000707 Highly Informative Direct
Biological Process (BP) immune response-regulating signaling pathway 0.0008406 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.001843 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2423 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.2176 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.3899 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.2569 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.02441 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.008369 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.001657 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.008707 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02872 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1489 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2097 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01125 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.9935 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.03274 Highly Informative Inherited
Biological Process (BP) lipid modification 0.001968 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.3786 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.06741 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.2854 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.007139 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.00346 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.2234 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.00643 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.001215 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.03209 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.9498 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.00959 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.7421 Highly Informative Inherited
Biological Process (BP) cilium organization 0.001713 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.0858 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.2704 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.005708 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.19 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.1623 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.003016 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.02059 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.3294 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.009758 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.00509 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.2302 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.002456 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01081 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.01156 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.565 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.00307 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.007415 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.002102 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.15 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.4735 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.03798 Highly Informative Inherited
Biological Process (BP) amide transport 0.0337 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.4674 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.4314 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.0034 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2886 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.00158 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.04176 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.3209 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.0268 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.06895 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.001285 Highly Informative Inherited
Biological Process (BP) cell division 0.02834 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.05362 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 2.902e-09 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 3.473e-08 Moderately Informative Direct
Molecular Function (MF) cation binding 0.6534 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 7.982e-16 Informative Direct
Molecular Function (MF) enzyme activator activity 3.071e-15 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 2.214e-13 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.434e-09 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 5.035e-06 Informative Direct
Molecular Function (MF) enzyme binding 0.0002249 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.6021 Informative Inherited
Molecular Function (MF) receptor binding 0.2012 Informative Inherited
Molecular Function (MF) amide binding 0.7783 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.09153 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 2.751e-14 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 7.81e-12 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 1.603e-11 Highly Informative Direct
Molecular Function (MF) amino acid binding 2.95e-09 Highly Informative Direct
Molecular Function (MF) channel regulator activity 5.355e-09 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0001852 Highly Informative Direct
Molecular Function (MF) hormone binding 0.0307 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.2759 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.0219 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.2051 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3607 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.005801 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.07364 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 4.313e-12 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 4.798e-05 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.1004 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.7662 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.09608 Moderately Informative Inherited
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell leading edge 5.227e-10 Informative Direct
Cellular Component (CC) secretory granule 0.7436 Informative Inherited
Cellular Component (CC) coated vesicle 0.09268 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.429 Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 6.301e-06 Highly Informative Direct
Cellular Component (CC) nonmotile primary cilium 7.809e-06 Highly Informative Direct
Cellular Component (CC) midbody 2.21e-05 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 4.31e-05 Highly Informative Direct
Cellular Component (CC) symplast 9.375e-05 Highly Informative Direct
Cellular Component (CC) cilium part 0.0001574 Highly Informative Direct
Cellular Component (CC) leading edge membrane 0.0002775 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0006122 Highly Informative Direct
Cellular Component (CC) ruffle 0.000863 Highly Informative Direct
Cellular Component (CC) cell body 0.04423 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.8582 Highly Informative Inherited
Cellular Component (CC) sarcolemma 0.01758 Highly Informative Inherited
Cellular Component (CC) centrosome 0.002508 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center part 0.02307 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.005268Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase2.869e-12Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0.0002652Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.09947Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2181Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8275Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.02174Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.1186Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1712Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.2542Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.4661Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.01695InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.06051InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.8412InformativeInherited
Mammalian Phenotype (MP)increased hamartoma incidence0.0008316Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.0008547Highly InformativeDirect
Mammalian Phenotype (MP)abnormal megakaryocyte morphology0.00239Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.04631Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.3469Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant2.11e-05Least InformativeDirect
Worm Phenotype (WP)cell physiology variant3.817e-05Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.01308Least InformativeInherited
Worm Phenotype (WP)growth variant0.6313Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0004822Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01064Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01341Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01671Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1438Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.168Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant6.343e-07InformativeDirect
Worm Phenotype (WP)organism pathogen response variant1.125e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002363InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0002532InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0003982InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.0006182InformativeDirect
Worm Phenotype (WP)drug resistant0.005929InformativeInherited
Worm Phenotype (WP)copulation variant0.02844InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.1041InformativeInherited
Worm Phenotype (WP)body length variant0.3511InformativeInherited
Worm Phenotype (WP)body width variant0.4921InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant6.054e-11Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant1.099e-09Highly InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant1.413e-09Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant6.339e-08Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes8.222e-08Highly InformativeDirect
Worm Phenotype (WP)response to injury variant2.093e-07Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant3.224e-06Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant1.751e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant2.01e-05Highly InformativeDirect
Worm Phenotype (WP)growth rate variant2.173e-05Highly InformativeDirect
Worm Phenotype (WP)roller2.202e-05Highly InformativeDirect
Worm Phenotype (WP)ovulation variant3.503e-05Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0001156Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0001307Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0001598Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.1584Least InformativeInherited
Yeast Phenotype (YP)ionic stress resistance0.0008572Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell7.056e-05InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage3.891e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.008437Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0009667InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.1934InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.6674InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase9.599e-13Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0003569Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCell cycle0.0006991Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processAngiogenesis1.091e-14InformativeDirect
Biological processCell adhesion6.286e-10InformativeDirect
Biological processLipid transport1.287e-09InformativeDirect
Biological processChemotaxis1.201e-05InformativeDirect
Biological processNeurogenesis0.0006201InformativeDirect
Biological processSensory transduction0.03283InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processNeurotransmitter transport1.166e-15Highly InformativeDirect
Biological processFertilization2.451e-10Highly InformativeDirect
Biological processAutophagy2.083e-06Highly InformativeDirect
Biological processCilium biogenesis/degradation1.413e-05Highly InformativeDirect
Biological processVision5.586e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus1.263e-06Least InformativeDirect
Cellular componentCytoplasm0.08598Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum3.679e-10Moderately InformativeDirect
Cellular componentCytoskeleton3.595e-08Moderately InformativeDirect
Cellular componentGolgi apparatus0.0002163Moderately InformativeDirect
Cellular componentSynapse6.356e-10InformativeDirect
Cellular componentLysosome4.37e-07InformativeDirect
Coding sequence diversityAlternative splicing4.374e-06Least InformativeDirect
DiseaseTumor suppressor0.0007162Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil3.064e-13Moderately InformativeDirect
DomainZinc-finger1.137e-11Moderately InformativeDirect
DomainSH2 domain4.668e-12InformativeDirect
DomainSH3 domain5.067e-05InformativeDirect
DomainSignal-anchor0.0002535InformativeDirect
DomainSH3-binding0.0003219InformativeDirect
Molecular functionMetal-binding8.579e-10Least InformativeDirect
Molecular functionZinc1.225e-09Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationHydrolase3.167e-07Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationProtein phosphatase1.975e-11InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor2.301e-09InformativeDirect
Post-translational modificationChromatin regulator0.0001261InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation1.71e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.01084Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism3.559e-15InformativeDirect
UniPathway (UP)biological regulation0Highly InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis7.819e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008973 SSF49562 Protein matches
Abstract

The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [PubMed9665851].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the C2 domain (Calcium/lipid-binding domain, CaLB) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]