SUPERFAMILY 1.75 HMM library and genome assignments server


C2 domain (Calcium/lipid-binding domain, CaLB) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Families:   PLC-like (P variant) [ 49563] (11)
  Synaptotagmin-like (S variant) [ 49575] (10)


Superfamily statistics
Genomes (505) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 46,882 45,964 37
Proteins 31,093 30,598 35


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 3.77e-15 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0006579 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) response to stimulus 9.716e-13 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 8.384e-09 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1.608e-05 Least Informative Direct
Biological Process (BP) developmental process 0.1679 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001966 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7447 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.884e-09 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 6.414e-07 Moderately Informative Direct
Biological Process (BP) immune system process 1.241e-06 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.464e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 2.38e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0002807 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0006582 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.003609 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.001314 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7712 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01336 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.004393 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1414 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001018 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.04624 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1121 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6317 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.7062 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9525 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7817 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.01558 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.004049 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7896 Moderately Informative Inherited
Biological Process (BP) organ development 0.318 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of transport 1.944e-15 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 8.061e-12 Informative Direct
Biological Process (BP) regulation of system process 4.499e-10 Informative Direct
Biological Process (BP) alcohol metabolic process 4.124e-08 Informative Direct
Biological Process (BP) response to wounding 1.478e-07 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.675e-07 Informative Direct
Biological Process (BP) negative regulation of transport 3.358e-07 Informative Direct
Biological Process (BP) organelle localization 3.621e-07 Informative Direct
Biological Process (BP) negative regulation of cell death 4.895e-07 Informative Direct
Biological Process (BP) protein catabolic process 7.182e-07 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 1.115e-06 Informative Direct
Biological Process (BP) leukocyte activation 3.668e-06 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 4.296e-06 Informative Direct
Biological Process (BP) locomotion 6.428e-06 Informative Direct
Biological Process (BP) response to organonitrogen compound 1.587e-05 Informative Direct
Biological Process (BP) cellular membrane organization 4.375e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 6.648e-05 Informative Direct
Biological Process (BP) cellular macromolecular complex assembly 0.0001516 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0001598 Informative Direct
Biological Process (BP) regulation of locomotion 0.000211 Informative Direct
Biological Process (BP) central nervous system development 0.000434 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0006891 Informative Direct
Biological Process (BP) immune response 0.0006964 Informative Direct
Biological Process (BP) regulation of secretion 0.0007128 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0007749 Informative Direct
Biological Process (BP) protein localization to organelle 0.6209 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.001935 Informative Inherited
Biological Process (BP) organophosphate catabolic process 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.5278 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.1549 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.06915 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5778 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.00696 Informative Inherited
Biological Process (BP) metal ion transport 0.1313 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1959 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.005348 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.162 Informative Inherited
Biological Process (BP) regulation of cell development 0.1129 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.7984 Informative Inherited
Biological Process (BP) sensory organ development 0.1948 Informative Inherited
Biological Process (BP) muscle structure development 0.2987 Informative Inherited
Biological Process (BP) muscle tissue development 0.02183 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.1193 Informative Inherited
Biological Process (BP) dephosphorylation 0.9753 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.04462 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.5892 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.003236 Informative Inherited
Biological Process (BP) blood circulation 0.1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.8993 Informative Inherited
Biological Process (BP) organelle assembly 0.6621 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.007948 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.01049 Informative Inherited
Biological Process (BP) regulation of growth 0.4823 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.7888 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.04224 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.009742 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.783 Informative Inherited
Biological Process (BP) phosphorylation 0.1962 Informative Inherited
Biological Process (BP) defense response 0.5622 Informative Inherited
Biological Process (BP) immune effector process 0.01224 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.06837 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.005508 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.8417 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.002739 Informative Inherited
Biological Process (BP) generation of neurons 0.2581 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.05321 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.178 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.003305 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) protein complex assembly 0.1329 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) lipid localization 0.01959 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.9066 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.7836 Informative Inherited
Biological Process (BP) cellular component movement 0.5299 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) gland development 0.486 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.8429 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.001113 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.002098 Informative Inherited
Biological Process (BP) protein transport 0.8847 Informative Inherited
Biological Process (BP) pigment metabolic process 0.7181 Informative Inherited
Biological Process (BP) proteolysis 0.01459 Informative Inherited
Biological Process (BP) cardiovascular system development 0.01531 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.04083 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.5958 Informative Inherited
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) establishment of synaptic vesicle localization 0 Highly Informative Direct
Biological Process (BP) exocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 1.944e-15 Highly Informative Direct
Biological Process (BP) protein ubiquitination 1.888e-13 Highly Informative Direct
Biological Process (BP) signal release 3.114e-12 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 3.257e-12 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 5.672e-10 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 2.419e-08 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 2.782e-08 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 4.381e-08 Highly Informative Direct
Biological Process (BP) regulation of wound healing 5.284e-07 Highly Informative Direct
Biological Process (BP) autophagy 6.355e-07 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 1.69e-06 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 2.41e-06 Highly Informative Direct
Biological Process (BP) response to calcium ion 4.691e-06 Highly Informative Direct
Biological Process (BP) B cell activation 5.092e-06 Highly Informative Direct
Biological Process (BP) calcium ion transport 1.157e-05 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.142e-05 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 2.482e-05 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 2.816e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 3.058e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 3.89e-05 Highly Informative Direct
Biological Process (BP) muscle fiber development 4.984e-05 Highly Informative Direct
Biological Process (BP) wound healing 5.185e-05 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 8.1e-05 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0001019 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.0001503 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0003125 Highly Informative Direct
Biological Process (BP) hormone transport 0.0003885 Highly Informative Direct
Biological Process (BP) organelle fusion 0.0005643 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0006194 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0006687 Highly Informative Direct
Biological Process (BP) coagulation 0.0007676 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0008342 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.004448 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2364 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.2146 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.3686 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to organelle 0.332 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.1499 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.02443 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.009383 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.00215 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.007619 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02813 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1484 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2163 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01058 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.9608 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.01176 Highly Informative Inherited
Biological Process (BP) lipid modification 0.002478 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.3806 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.07028 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3102 Highly Informative Inherited
Biological Process (BP) regulation of cell size 1 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.005732 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.003526 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.3914 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.2811 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.006106 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.002096 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.03095 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.03367 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 1 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.9378 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.01112 Highly Informative Inherited
Biological Process (BP) cilium organization 0.001809 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.08057 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.3031 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.7435 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.005574 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.1658 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.001792 Highly Informative Inherited
Biological Process (BP) ethanolamine-containing compound metabolic process 0.0208 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.001042 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.3472 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.01007 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.00556 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.2496 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.002787 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.004766 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.005655 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.567 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.003357 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.007887 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.002688 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.1552 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.5074 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.03872 Highly Informative Inherited
Biological Process (BP) amide transport 0.03472 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.4982 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.4281 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.00325 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.2894 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.001754 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.04454 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.3413 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.02741 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.07132 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.001439 Highly Informative Inherited
Biological Process (BP) cell division 0.03145 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.01946 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.04364 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 2.869e-09 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.634e-08 Moderately Informative Direct
Molecular Function (MF) cation binding 0.6609 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) lipid binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 1.563e-15 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 1.787e-13 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1.427e-09 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 9.118e-06 Informative Direct
Molecular Function (MF) enzyme binding 0.0004643 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.605 Informative Inherited
Molecular Function (MF) receptor binding 0.2147 Informative Inherited
Molecular Function (MF) amide binding 0.7814 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.09418 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 8.007e-16 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 2.693e-14 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 6.006e-12 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 8.967e-12 Highly Informative Direct
Molecular Function (MF) amino acid binding 3.561e-09 Highly Informative Direct
Molecular Function (MF) channel regulator activity 6.151e-09 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.0001945 Highly Informative Direct
Molecular Function (MF) hormone binding 0.02887 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.2836 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.02435 Highly Informative Inherited
Molecular Function (MF) peptide binding 0.2091 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.4572 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.006036 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2803 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 1.573e-11 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytosol 9.984e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.8795 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.8002 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.07255 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.1004 Moderately Informative Inherited
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell leading edge 5.929e-10 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0008633 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.4491 Informative Inherited
Cellular Component (CC) secretory granule 0.7451 Informative Inherited
Cellular Component (CC) coated vesicle 0.09408 Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 6.033e-06 Highly Informative Direct
Cellular Component (CC) midbody 2.345e-05 Highly Informative Direct
Cellular Component (CC) intrinsic to organelle membrane 4.777e-05 Highly Informative Direct
Cellular Component (CC) symplast 0.0001191 Highly Informative Direct
Cellular Component (CC) cilium part 0.0001762 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0006143 Highly Informative Direct
Cellular Component (CC) centrosome 0.002747 Highly Informative Inherited
Cellular Component (CC) cell body 0.04261 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.8594 Highly Informative Inherited
Cellular Component (CC) sarcolemma 0.01601 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.005268Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase2.869e-12Highly InformativeDirect
Enzyme Commission (EC)Phospholipase D0.0002652Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.09771Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2193Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8254Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.0206Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.1176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.1706Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.1956Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.253Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.4612Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.01664InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.05968InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.8414InformativeInherited
Mammalian Phenotype (MP)increased hamartoma incidence0.0008268Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.0008347Highly InformativeDirect
Mammalian Phenotype (MP)abnormal megakaryocyte morphology0.002472Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.0463Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.3467Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant2.11e-05Least InformativeDirect
Worm Phenotype (WP)cell physiology variant3.817e-05Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.01308Least InformativeInherited
Worm Phenotype (WP)growth variant0.6313Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0004822Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01064Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01341Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01671Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1438Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.168Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant6.343e-07InformativeDirect
Worm Phenotype (WP)organism pathogen response variant1.125e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002363InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0002532InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.0003982InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.0006182InformativeDirect
Worm Phenotype (WP)drug resistant0.005929InformativeInherited
Worm Phenotype (WP)copulation variant0.02844InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.1041InformativeInherited
Worm Phenotype (WP)body length variant0.3511InformativeInherited
Worm Phenotype (WP)body width variant0.4921InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant6.054e-11Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant1.099e-09Highly InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant1.413e-09Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant6.339e-08Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes8.222e-08Highly InformativeDirect
Worm Phenotype (WP)response to injury variant2.093e-07Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant3.224e-06Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant1.751e-05Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant2.01e-05Highly InformativeDirect
Worm Phenotype (WP)growth rate variant2.173e-05Highly InformativeDirect
Worm Phenotype (WP)roller2.202e-05Highly InformativeDirect
Worm Phenotype (WP)ovulation variant3.503e-05Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0001156Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0001307Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0001598Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.1588Least InformativeInherited
Yeast Phenotype (YP)ionic stress resistance0.0008616Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0007841InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell7.056e-05InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage3.891e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.008396Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0009577InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.1928InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.6664InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Lysophospholipase9.4e-13Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0003552Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCell cycle0.0006861Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processInflammatory response0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processAngiogenesis1.047e-14InformativeDirect
Biological processCell adhesion6.134e-10InformativeDirect
Biological processLipid transport1.266e-09InformativeDirect
Biological processChemotaxis1.186e-05InformativeDirect
Biological processNeurogenesis0.0006146InformativeDirect
Biological processSensory transduction0.03261InformativeInherited
Biological processExocytosis0Highly InformativeDirect
Biological processLipid degradation0Highly InformativeDirect
Biological processNeurotransmitter transport1.168e-15Highly InformativeDirect
Biological processFertilization2.425e-10Highly InformativeDirect
Biological processAutophagy2.059e-06Highly InformativeDirect
Biological processCilium biogenesis/degradation1.402e-05Highly InformativeDirect
Biological processVision5.541e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus1.211e-06Least InformativeDirect
Cellular componentCytoplasm0.08423Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum3.583e-10Moderately InformativeDirect
Cellular componentCytoskeleton3.565e-08Moderately InformativeDirect
Cellular componentGolgi apparatus0.0002135Moderately InformativeDirect
Cellular componentSynapse6.361e-10InformativeDirect
Cellular componentLysosome4.325e-07InformativeDirect
Coding sequence diversityAlternative splicing4.35e-06Least InformativeDirect
DiseaseTumor suppressor0.0007162Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil2.956e-13Moderately InformativeDirect
DomainZinc-finger1.033e-11Moderately InformativeDirect
DomainSH2 domain4.542e-12InformativeDirect
DomainSH3 domain4.97e-05InformativeDirect
DomainSignal-anchor0.0002455InformativeDirect
DomainSH3-binding0.0003193InformativeDirect
Molecular functionMetal-binding8.659e-10Least InformativeDirect
Molecular functionZinc1.179e-09Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Post-translational modificationHydrolase3.269e-07Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationTransducer0InformativeDirect
Post-translational modificationProtein phosphatase1.969e-11InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor2.266e-09InformativeDirect
Post-translational modificationChromatin regulator0.0001245InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation2.023e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.01107Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism3.555e-15InformativeDirect
UniPathway (UP)biological regulation0Highly InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis7.557e-12Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008973 SSF49562 Protein matches
Abstract

The Ca2+-dependent, lipid-binding domain (CaLB) has been identified in a number of proteins, for example the amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif [PubMed9665851].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the C2 domain (Calcium/lipid-binding domain, CaLB) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]